Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters

Autores
Cárdenas, Graciela; Valdez, Ricardo; Sáenz, Brenda; Bottasso, Oscar Adelmo; Fragoso, Gladis; Sciutto, Edda; Romano, Marta; Fleury, Agnès
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neurocysticercosis (NC) is a parasitic disease caused by the infiltration of the larval stage of Taenia solium in the central nervous system. Clinical presentations are heterogeneous and particularly depend, on the age and gender of the host. We designed a clinical study to evaluate the hormonal changes associated with neurocysticercosis and the relationships between disease heterogeneity, endocrine and immunological status. A total of 50 patients and 22 healthy subjects were included. A precise clinical and radiological description of disease for each patient was recorded. A broad hormonal profile was assessed for each participant and, in a sub-group of patients, immunological features were also evaluated. Compared with controls, all patients had lower dehydroepiandrosterone (DHEA) concentration; male patients also had lower concentrations of 17β-estradiol and higher concentrations of luteinising hormone (LH). In the clinically severe patients, lower concentrations of progesterone and androstenedione were found in women. Higher concentrations of follicle stimulating hormone (FSH) and lower concentrations of testosterone were found in men when compared with the less clinically severe patients. Significant correlations were found between estradiol and IL-10 in male patients, and between dehydroepiandrosterone (DHEA) and IL-1β, and androstenedione and IL-17 in female patients. To our knowledge the present study constitutes the first demonstration that the presence of T. solium larvae in the central nervous system can modify the host environment by the induction of endocrine and immunological changes. These results provide a stimulating background to analyse the repercussions of these changes on the course of the disease and on patient reproductive health.
Fil: Cárdenas, Graciela. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Valdez, Ricardo. CINVESTAV; México
Fil: Sáenz, Brenda. Universidad Nacional Autónoma de México; México
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Fragoso, Gladis. Universidad Nacional Autónoma de México; México
Fil: Sciutto, Edda. Universidad Nacional Autónoma de México; México
Fil: Romano, Marta. CINVESTAV; México
Fil: Fleury, Agnès. Universidad Nacional Autónoma de México; México. Instituto Nacional de Neurología y Neurocirugía; México
Materia
Cisticercosis
Regulación inmuno-endócrina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268542
Acceder
id CONICETDig_8f05fedf429379e190cd74b9ec200718
oai_identifier_str oai:ri.conicet.gov.ar:11336/268542
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parametersCárdenas, GracielaValdez, RicardoSáenz, BrendaBottasso, Oscar AdelmoFragoso, GladisSciutto, EddaRomano, MartaFleury, AgnèsCisticercosisRegulación inmuno-endócrinahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Neurocysticercosis (NC) is a parasitic disease caused by the infiltration of the larval stage of Taenia solium in the central nervous system. Clinical presentations are heterogeneous and particularly depend, on the age and gender of the host. We designed a clinical study to evaluate the hormonal changes associated with neurocysticercosis and the relationships between disease heterogeneity, endocrine and immunological status. A total of 50 patients and 22 healthy subjects were included. A precise clinical and radiological description of disease for each patient was recorded. A broad hormonal profile was assessed for each participant and, in a sub-group of patients, immunological features were also evaluated. Compared with controls, all patients had lower dehydroepiandrosterone (DHEA) concentration; male patients also had lower concentrations of 17β-estradiol and higher concentrations of luteinising hormone (LH). In the clinically severe patients, lower concentrations of progesterone and androstenedione were found in women. Higher concentrations of follicle stimulating hormone (FSH) and lower concentrations of testosterone were found in men when compared with the less clinically severe patients. Significant correlations were found between estradiol and IL-10 in male patients, and between dehydroepiandrosterone (DHEA) and IL-1β, and androstenedione and IL-17 in female patients. To our knowledge the present study constitutes the first demonstration that the presence of T. solium larvae in the central nervous system can modify the host environment by the induction of endocrine and immunological changes. These results provide a stimulating background to analyse the repercussions of these changes on the course of the disease and on patient reproductive health.Fil: Cárdenas, Graciela. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Valdez, Ricardo. CINVESTAV; MéxicoFil: Sáenz, Brenda. Universidad Nacional Autónoma de México; MéxicoFil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Fragoso, Gladis. Universidad Nacional Autónoma de México; MéxicoFil: Sciutto, Edda. Universidad Nacional Autónoma de México; MéxicoFil: Romano, Marta. CINVESTAV; MéxicoFil: Fleury, Agnès. Universidad Nacional Autónoma de México; México. Instituto Nacional de Neurología y Neurocirugía; MéxicoElsevier2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268542Cárdenas, Graciela; Valdez, Ricardo; Sáenz, Brenda; Bottasso, Oscar Adelmo; Fragoso, Gladis; et al.; Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters; Elsevier; International Journal for Parasitology; 42; 2; 2-2012; 171-1760020-7519CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijpara.2011.11.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0020751911003018info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:54:00Zoai:ri.conicet.gov.ar:11336/268542instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:54:01.164CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters
title Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters
spellingShingle Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters
Cárdenas, Graciela
Cisticercosis
Regulación inmuno-endócrina
title_short Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters
title_full Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters
title_fullStr Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters
title_full_unstemmed Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters
title_sort Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters
dc.creator.none.fl_str_mv Cárdenas, Graciela
Valdez, Ricardo
Sáenz, Brenda
Bottasso, Oscar Adelmo
Fragoso, Gladis
Sciutto, Edda
Romano, Marta
Fleury, Agnès
author Cárdenas, Graciela
author_facet Cárdenas, Graciela
Valdez, Ricardo
Sáenz, Brenda
Bottasso, Oscar Adelmo
Fragoso, Gladis
Sciutto, Edda
Romano, Marta
Fleury, Agnès
author_role author
author2 Valdez, Ricardo
Sáenz, Brenda
Bottasso, Oscar Adelmo
Fragoso, Gladis
Sciutto, Edda
Romano, Marta
Fleury, Agnès
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cisticercosis
Regulación inmuno-endócrina
topic Cisticercosis
Regulación inmuno-endócrina
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neurocysticercosis (NC) is a parasitic disease caused by the infiltration of the larval stage of Taenia solium in the central nervous system. Clinical presentations are heterogeneous and particularly depend, on the age and gender of the host. We designed a clinical study to evaluate the hormonal changes associated with neurocysticercosis and the relationships between disease heterogeneity, endocrine and immunological status. A total of 50 patients and 22 healthy subjects were included. A precise clinical and radiological description of disease for each patient was recorded. A broad hormonal profile was assessed for each participant and, in a sub-group of patients, immunological features were also evaluated. Compared with controls, all patients had lower dehydroepiandrosterone (DHEA) concentration; male patients also had lower concentrations of 17β-estradiol and higher concentrations of luteinising hormone (LH). In the clinically severe patients, lower concentrations of progesterone and androstenedione were found in women. Higher concentrations of follicle stimulating hormone (FSH) and lower concentrations of testosterone were found in men when compared with the less clinically severe patients. Significant correlations were found between estradiol and IL-10 in male patients, and between dehydroepiandrosterone (DHEA) and IL-1β, and androstenedione and IL-17 in female patients. To our knowledge the present study constitutes the first demonstration that the presence of T. solium larvae in the central nervous system can modify the host environment by the induction of endocrine and immunological changes. These results provide a stimulating background to analyse the repercussions of these changes on the course of the disease and on patient reproductive health.
Fil: Cárdenas, Graciela. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Valdez, Ricardo. CINVESTAV; México
Fil: Sáenz, Brenda. Universidad Nacional Autónoma de México; México
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Fragoso, Gladis. Universidad Nacional Autónoma de México; México
Fil: Sciutto, Edda. Universidad Nacional Autónoma de México; México
Fil: Romano, Marta. CINVESTAV; México
Fil: Fleury, Agnès. Universidad Nacional Autónoma de México; México. Instituto Nacional de Neurología y Neurocirugía; México
description Neurocysticercosis (NC) is a parasitic disease caused by the infiltration of the larval stage of Taenia solium in the central nervous system. Clinical presentations are heterogeneous and particularly depend, on the age and gender of the host. We designed a clinical study to evaluate the hormonal changes associated with neurocysticercosis and the relationships between disease heterogeneity, endocrine and immunological status. A total of 50 patients and 22 healthy subjects were included. A precise clinical and radiological description of disease for each patient was recorded. A broad hormonal profile was assessed for each participant and, in a sub-group of patients, immunological features were also evaluated. Compared with controls, all patients had lower dehydroepiandrosterone (DHEA) concentration; male patients also had lower concentrations of 17β-estradiol and higher concentrations of luteinising hormone (LH). In the clinically severe patients, lower concentrations of progesterone and androstenedione were found in women. Higher concentrations of follicle stimulating hormone (FSH) and lower concentrations of testosterone were found in men when compared with the less clinically severe patients. Significant correlations were found between estradiol and IL-10 in male patients, and between dehydroepiandrosterone (DHEA) and IL-1β, and androstenedione and IL-17 in female patients. To our knowledge the present study constitutes the first demonstration that the presence of T. solium larvae in the central nervous system can modify the host environment by the induction of endocrine and immunological changes. These results provide a stimulating background to analyse the repercussions of these changes on the course of the disease and on patient reproductive health.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268542
Cárdenas, Graciela; Valdez, Ricardo; Sáenz, Brenda; Bottasso, Oscar Adelmo; Fragoso, Gladis; et al.; Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters; Elsevier; International Journal for Parasitology; 42; 2; 2-2012; 171-176
0020-7519
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268542
identifier_str_mv Cárdenas, Graciela; Valdez, Ricardo; Sáenz, Brenda; Bottasso, Oscar Adelmo; Fragoso, Gladis; et al.; Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters; Elsevier; International Journal for Parasitology; 42; 2; 2-2012; 171-176
0020-7519
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijpara.2011.11.009
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0020751911003018
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.25334

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