Detection of Taenia solium DNA in the urine of neurocysticercosis patients

Autores
Toribio, Luz; Romano, Miryam de Los Angeles; Scott, Alan L.; Gonzales, Isidro; Saavedra, Herbert; Garcia, Hector H.; Shiff, Clive
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neurocysticercosis (NCC), caused by Taenia solium larvae that reside in the central nervous system, results in serious public health and medical issues in many regions of the world. Current diagnosis of NCC is complex requiring both serology and costly neuroimaging of parasitic cysts in the brain. This diagnostic pipeline can be problematic in resource-constrained settings. There is an unmet need for a highly sensitive and clinically informative diagnostic test to complement the present diagnostic approaches. Here, we report that T. solium–derived cell-free DNA is readily detectable in the urine of patients with the subarachnoid and parenchymal forms of NCC, and discuss the potential utility of this approach in enhancing and refining T. solium diagnostics.
Fil: Toribio, Luz. Universidad Peruana Cayetano Heredia; Perú
Fil: Romano, Miryam de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. University Johns Hopkins; Estados Unidos
Fil: Scott, Alan L.. University Johns Hopkins; Estados Unidos
Fil: Gonzales, Isidro. Instituto Nacional de Ciencias Neurológicas; Perú
Fil: Saavedra, Herbert. Instituto Nacional de Ciencias Neurológicas; Perú
Fil: Garcia, Hector H.. Universidad Peruana Cayetano Heredia; Perú. Instituto Nacional de Ciencias Neurológicas; Perú
Fil: Shiff, Clive. University Johns Hopkins; Estados Unidos
Materia
TAENIA SOLIUM
REAL TIME PCR
NEUROCYSTICERCOSIS
DNA IN URINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120405
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Detection of Taenia solium DNA in the urine of neurocysticercosis patientsToribio, LuzRomano, Miryam de Los AngelesScott, Alan L.Gonzales, IsidroSaavedra, HerbertGarcia, Hector H.Shiff, CliveTAENIA SOLIUMREAL TIME PCRNEUROCYSTICERCOSISDNA IN URINEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Neurocysticercosis (NCC), caused by Taenia solium larvae that reside in the central nervous system, results in serious public health and medical issues in many regions of the world. Current diagnosis of NCC is complex requiring both serology and costly neuroimaging of parasitic cysts in the brain. This diagnostic pipeline can be problematic in resource-constrained settings. There is an unmet need for a highly sensitive and clinically informative diagnostic test to complement the present diagnostic approaches. Here, we report that T. solium–derived cell-free DNA is readily detectable in the urine of patients with the subarachnoid and parenchymal forms of NCC, and discuss the potential utility of this approach in enhancing and refining T. solium diagnostics.Fil: Toribio, Luz. Universidad Peruana Cayetano Heredia; PerúFil: Romano, Miryam de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. University Johns Hopkins; Estados UnidosFil: Scott, Alan L.. University Johns Hopkins; Estados UnidosFil: Gonzales, Isidro. Instituto Nacional de Ciencias Neurológicas; PerúFil: Saavedra, Herbert. Instituto Nacional de Ciencias Neurológicas; PerúFil: Garcia, Hector H.. Universidad Peruana Cayetano Heredia; Perú. Instituto Nacional de Ciencias Neurológicas; PerúFil: Shiff, Clive. University Johns Hopkins; Estados UnidosAmerican Society of Tropical Medicine and Hygiene2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120405Toribio, Luz; Romano, Miryam de Los Angeles; Scott, Alan L.; Gonzales, Isidro; Saavedra, Herbert; et al.; Detection of Taenia solium DNA in the urine of neurocysticercosis patients; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 100; 2; 6-2019; 327-3290002-9637CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0706?emailalert=trueinfo:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.18-0706info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:10:03Zoai:ri.conicet.gov.ar:11336/120405instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:10:03.769CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Detection of Taenia solium DNA in the urine of neurocysticercosis patients
title Detection of Taenia solium DNA in the urine of neurocysticercosis patients
spellingShingle Detection of Taenia solium DNA in the urine of neurocysticercosis patients
Toribio, Luz
TAENIA SOLIUM
REAL TIME PCR
NEUROCYSTICERCOSIS
DNA IN URINE
title_short Detection of Taenia solium DNA in the urine of neurocysticercosis patients
title_full Detection of Taenia solium DNA in the urine of neurocysticercosis patients
title_fullStr Detection of Taenia solium DNA in the urine of neurocysticercosis patients
title_full_unstemmed Detection of Taenia solium DNA in the urine of neurocysticercosis patients
title_sort Detection of Taenia solium DNA in the urine of neurocysticercosis patients
dc.creator.none.fl_str_mv Toribio, Luz
Romano, Miryam de Los Angeles
Scott, Alan L.
Gonzales, Isidro
Saavedra, Herbert
Garcia, Hector H.
Shiff, Clive
author Toribio, Luz
author_facet Toribio, Luz
Romano, Miryam de Los Angeles
Scott, Alan L.
Gonzales, Isidro
Saavedra, Herbert
Garcia, Hector H.
Shiff, Clive
author_role author
author2 Romano, Miryam de Los Angeles
Scott, Alan L.
Gonzales, Isidro
Saavedra, Herbert
Garcia, Hector H.
Shiff, Clive
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv TAENIA SOLIUM
REAL TIME PCR
NEUROCYSTICERCOSIS
DNA IN URINE
topic TAENIA SOLIUM
REAL TIME PCR
NEUROCYSTICERCOSIS
DNA IN URINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neurocysticercosis (NCC), caused by Taenia solium larvae that reside in the central nervous system, results in serious public health and medical issues in many regions of the world. Current diagnosis of NCC is complex requiring both serology and costly neuroimaging of parasitic cysts in the brain. This diagnostic pipeline can be problematic in resource-constrained settings. There is an unmet need for a highly sensitive and clinically informative diagnostic test to complement the present diagnostic approaches. Here, we report that T. solium–derived cell-free DNA is readily detectable in the urine of patients with the subarachnoid and parenchymal forms of NCC, and discuss the potential utility of this approach in enhancing and refining T. solium diagnostics.
Fil: Toribio, Luz. Universidad Peruana Cayetano Heredia; Perú
Fil: Romano, Miryam de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. University Johns Hopkins; Estados Unidos
Fil: Scott, Alan L.. University Johns Hopkins; Estados Unidos
Fil: Gonzales, Isidro. Instituto Nacional de Ciencias Neurológicas; Perú
Fil: Saavedra, Herbert. Instituto Nacional de Ciencias Neurológicas; Perú
Fil: Garcia, Hector H.. Universidad Peruana Cayetano Heredia; Perú. Instituto Nacional de Ciencias Neurológicas; Perú
Fil: Shiff, Clive. University Johns Hopkins; Estados Unidos
description Neurocysticercosis (NCC), caused by Taenia solium larvae that reside in the central nervous system, results in serious public health and medical issues in many regions of the world. Current diagnosis of NCC is complex requiring both serology and costly neuroimaging of parasitic cysts in the brain. This diagnostic pipeline can be problematic in resource-constrained settings. There is an unmet need for a highly sensitive and clinically informative diagnostic test to complement the present diagnostic approaches. Here, we report that T. solium–derived cell-free DNA is readily detectable in the urine of patients with the subarachnoid and parenchymal forms of NCC, and discuss the potential utility of this approach in enhancing and refining T. solium diagnostics.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120405
Toribio, Luz; Romano, Miryam de Los Angeles; Scott, Alan L.; Gonzales, Isidro; Saavedra, Herbert; et al.; Detection of Taenia solium DNA in the urine of neurocysticercosis patients; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 100; 2; 6-2019; 327-329
0002-9637
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120405
identifier_str_mv Toribio, Luz; Romano, Miryam de Los Angeles; Scott, Alan L.; Gonzales, Isidro; Saavedra, Herbert; et al.; Detection of Taenia solium DNA in the urine of neurocysticercosis patients; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 100; 2; 6-2019; 327-329
0002-9637
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0706?emailalert=true
info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.18-0706
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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