Adverse neuro-immune–endocrine interactions in patients with active tuberculosis

Autores
Bottasso, Oscar Adelmo; Bay, Maria Luisa; Besedovsky, Hugo; del Rey, Adriana
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The nervous, endocrine and immune systems play a crucial role in maintaining homeostasis and interact with each other for a successful defensive strategy against injurious agents. However, the situation is different in long-term diseases with marked inflammation, in which defensive mechanisms become altered. In the case of tuberculosis (TB), this is highlighted by several facts: an imbalance of plasma immune and endocrine mediators, that results in an adverse environment for mounting an adequate response against mycobacteria and controlling inflammation; the demonstration that dehidroepiandrosterone (DHEA) secretion by a human adrenal cell line can be inhibited by culture supernatants from Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells – PBMC – of TB patients, with this effect being partly reverted when neutralizing transforming growth factor-β in such supernantants; the in vitro effects of adrenal steroids on the specific immune response of PBMC from TB patients, that is a cortisol inhibition of mycobacterial antigen-driven lymphoproliferation and interferon-γ production as well as a suppression of TGF-β production in DHEA-treated PBMC; and lastly the demonstration that immune and endocrine compounds participating in the regulation of energy sources and immune activity correlated with the consumption state of TB patients. Collectively, immune-endocrine disturbances of TB patients are involved in critical components of disease pathology with implications in the impaired clinical status and unfavorable disease outcome. This article is part of a Special Issue entitled ‘Neuroinflammation in neurodegeneration and neurodysfunction’.
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina
Fil: Besedovsky, Hugo. Institute für Physiologie und Pathophysiologie; Alemania
Fil: del Rey, Adriana. Institute für Physiologie und Pathophysiologie; Alemania
Materia
Tuberculosis
Neuroscience
Immune-Endocrine Interactions
Regulation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15247
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Adverse neuro-immune–endocrine interactions in patients with active tuberculosisBottasso, Oscar AdelmoBay, Maria LuisaBesedovsky, Hugodel Rey, AdrianaTuberculosisNeuroscienceImmune-Endocrine InteractionsRegulationhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The nervous, endocrine and immune systems play a crucial role in maintaining homeostasis and interact with each other for a successful defensive strategy against injurious agents. However, the situation is different in long-term diseases with marked inflammation, in which defensive mechanisms become altered. In the case of tuberculosis (TB), this is highlighted by several facts: an imbalance of plasma immune and endocrine mediators, that results in an adverse environment for mounting an adequate response against mycobacteria and controlling inflammation; the demonstration that dehidroepiandrosterone (DHEA) secretion by a human adrenal cell line can be inhibited by culture supernatants from Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells – PBMC – of TB patients, with this effect being partly reverted when neutralizing transforming growth factor-β in such supernantants; the in vitro effects of adrenal steroids on the specific immune response of PBMC from TB patients, that is a cortisol inhibition of mycobacterial antigen-driven lymphoproliferation and interferon-γ production as well as a suppression of TGF-β production in DHEA-treated PBMC; and lastly the demonstration that immune and endocrine compounds participating in the regulation of energy sources and immune activity correlated with the consumption state of TB patients. Collectively, immune-endocrine disturbances of TB patients are involved in critical components of disease pathology with implications in the impaired clinical status and unfavorable disease outcome. This article is part of a Special Issue entitled ‘Neuroinflammation in neurodegeneration and neurodysfunction’.Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Cs.medicas; ArgentinaFil: Besedovsky, Hugo. Institute für Physiologie und Pathophysiologie; AlemaniaFil: del Rey, Adriana. Institute für Physiologie und Pathophysiologie; AlemaniaElsevier Inc2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15247Bottasso, Oscar Adelmo; Bay, Maria Luisa; Besedovsky, Hugo; del Rey, Adriana; Adverse neuro-immune–endocrine interactions in patients with active tuberculosis; Elsevier Inc; Molecular And Cellular Neurosciences.; 53; 3-2013; 77-851044-7431enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.mcn.2012.11.002info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1044743112002011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:47Zoai:ri.conicet.gov.ar:11336/15247instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:47.733CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
title Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
spellingShingle Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
Bottasso, Oscar Adelmo
Tuberculosis
Neuroscience
Immune-Endocrine Interactions
Regulation
title_short Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
title_full Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
title_fullStr Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
title_full_unstemmed Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
title_sort Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
dc.creator.none.fl_str_mv Bottasso, Oscar Adelmo
Bay, Maria Luisa
Besedovsky, Hugo
del Rey, Adriana
author Bottasso, Oscar Adelmo
author_facet Bottasso, Oscar Adelmo
Bay, Maria Luisa
Besedovsky, Hugo
del Rey, Adriana
author_role author
author2 Bay, Maria Luisa
Besedovsky, Hugo
del Rey, Adriana
author2_role author
author
author
dc.subject.none.fl_str_mv Tuberculosis
Neuroscience
Immune-Endocrine Interactions
Regulation
topic Tuberculosis
Neuroscience
Immune-Endocrine Interactions
Regulation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The nervous, endocrine and immune systems play a crucial role in maintaining homeostasis and interact with each other for a successful defensive strategy against injurious agents. However, the situation is different in long-term diseases with marked inflammation, in which defensive mechanisms become altered. In the case of tuberculosis (TB), this is highlighted by several facts: an imbalance of plasma immune and endocrine mediators, that results in an adverse environment for mounting an adequate response against mycobacteria and controlling inflammation; the demonstration that dehidroepiandrosterone (DHEA) secretion by a human adrenal cell line can be inhibited by culture supernatants from Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells – PBMC – of TB patients, with this effect being partly reverted when neutralizing transforming growth factor-β in such supernantants; the in vitro effects of adrenal steroids on the specific immune response of PBMC from TB patients, that is a cortisol inhibition of mycobacterial antigen-driven lymphoproliferation and interferon-γ production as well as a suppression of TGF-β production in DHEA-treated PBMC; and lastly the demonstration that immune and endocrine compounds participating in the regulation of energy sources and immune activity correlated with the consumption state of TB patients. Collectively, immune-endocrine disturbances of TB patients are involved in critical components of disease pathology with implications in the impaired clinical status and unfavorable disease outcome. This article is part of a Special Issue entitled ‘Neuroinflammation in neurodegeneration and neurodysfunction’.
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina
Fil: Besedovsky, Hugo. Institute für Physiologie und Pathophysiologie; Alemania
Fil: del Rey, Adriana. Institute für Physiologie und Pathophysiologie; Alemania
description The nervous, endocrine and immune systems play a crucial role in maintaining homeostasis and interact with each other for a successful defensive strategy against injurious agents. However, the situation is different in long-term diseases with marked inflammation, in which defensive mechanisms become altered. In the case of tuberculosis (TB), this is highlighted by several facts: an imbalance of plasma immune and endocrine mediators, that results in an adverse environment for mounting an adequate response against mycobacteria and controlling inflammation; the demonstration that dehidroepiandrosterone (DHEA) secretion by a human adrenal cell line can be inhibited by culture supernatants from Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells – PBMC – of TB patients, with this effect being partly reverted when neutralizing transforming growth factor-β in such supernantants; the in vitro effects of adrenal steroids on the specific immune response of PBMC from TB patients, that is a cortisol inhibition of mycobacterial antigen-driven lymphoproliferation and interferon-γ production as well as a suppression of TGF-β production in DHEA-treated PBMC; and lastly the demonstration that immune and endocrine compounds participating in the regulation of energy sources and immune activity correlated with the consumption state of TB patients. Collectively, immune-endocrine disturbances of TB patients are involved in critical components of disease pathology with implications in the impaired clinical status and unfavorable disease outcome. This article is part of a Special Issue entitled ‘Neuroinflammation in neurodegeneration and neurodysfunction’.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15247
Bottasso, Oscar Adelmo; Bay, Maria Luisa; Besedovsky, Hugo; del Rey, Adriana; Adverse neuro-immune–endocrine interactions in patients with active tuberculosis; Elsevier Inc; Molecular And Cellular Neurosciences.; 53; 3-2013; 77-85
1044-7431
url http://hdl.handle.net/11336/15247
identifier_str_mv Bottasso, Oscar Adelmo; Bay, Maria Luisa; Besedovsky, Hugo; del Rey, Adriana; Adverse neuro-immune–endocrine interactions in patients with active tuberculosis; Elsevier Inc; Molecular And Cellular Neurosciences.; 53; 3-2013; 77-85
1044-7431
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mcn.2012.11.002
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1044743112002011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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