Clinical and molecular study of a case of severe radio-sensitivity

Autores
Ocolotobiche, Eliana Evelina; Cordoba, Elisa Eugenia; Güerci, Alba Mabel
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A case of a patient with a breast intraductal tumor is presented. The patient underwent surgical quadrantectomy and axillary lymph node dissection and subsequently received Anthracycline treatment and 3D radiotherapy following a standard fractionation protocol. This case was characterized by the development of grade III dermal toxicity, some associated genetic polymorphisms and DNA damage were analyzed. We concluded that radiotoxicity is a multifactorial phenotype that should be addressed in a broader context, considering not only intrinsic variables but also criteria such as breast size, body mass index and concomitant treatments, among others.
Fil: Ocolotobiche, Eliana Evelina. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cordoba, Elisa Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes.; Argentina
Fil: Güerci, Alba Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Materia
RADIATION THERAPY
RADIOSENSITIVITY
ACUTE EFFECTS
RADIATION THERAPY
RADIOSENSITIVITY
ACUTE EFFECTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123864
Acceder
id CONICETDig_8e1493d546d2365a769c9f2c662d27d6
oai_identifier_str oai:ri.conicet.gov.ar:11336/123864
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Clinical and molecular study of a case of severe radio-sensitivityOcolotobiche, Eliana EvelinaCordoba, Elisa EugeniaGüerci, Alba MabelRADIATION THERAPYRADIOSENSITIVITYACUTE EFFECTSRADIATION THERAPYRADIOSENSITIVITYACUTE EFFECTShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3A case of a patient with a breast intraductal tumor is presented. The patient underwent surgical quadrantectomy and axillary lymph node dissection and subsequently received Anthracycline treatment and 3D radiotherapy following a standard fractionation protocol. This case was characterized by the development of grade III dermal toxicity, some associated genetic polymorphisms and DNA damage were analyzed. We concluded that radiotoxicity is a multifactorial phenotype that should be addressed in a broader context, considering not only intrinsic variables but also criteria such as breast size, body mass index and concomitant treatments, among others.Fil: Ocolotobiche, Eliana Evelina. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cordoba, Elisa Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes.; ArgentinaFil: Güerci, Alba Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaMedCrave2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123864Ocolotobiche, Eliana Evelina; Cordoba, Elisa Eugenia; Güerci, Alba Mabel; Clinical and molecular study of a case of severe radio-sensitivity; MedCrave; International Journal of Radiology and Radiation Therapy; 6; 12-2019; 234-2362574-8084CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15406/ijrrt.2019.06.00253info:eu-repo/semantics/altIdentifier/url/http://medcraveonline.com/IJRRT/clinical-and-molecular-study-of-a-case-of-severe-radio-sensitivity.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-05-06T16:36:25Zoai:ri.conicet.gov.ar:11336/123864instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-05-06 16:36:26.141CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical and molecular study of a case of severe radio-sensitivity
title Clinical and molecular study of a case of severe radio-sensitivity
spellingShingle Clinical and molecular study of a case of severe radio-sensitivity
Ocolotobiche, Eliana Evelina
RADIATION THERAPY
RADIOSENSITIVITY
ACUTE EFFECTS
RADIATION THERAPY
RADIOSENSITIVITY
ACUTE EFFECTS
title_short Clinical and molecular study of a case of severe radio-sensitivity
title_full Clinical and molecular study of a case of severe radio-sensitivity
title_fullStr Clinical and molecular study of a case of severe radio-sensitivity
title_full_unstemmed Clinical and molecular study of a case of severe radio-sensitivity
title_sort Clinical and molecular study of a case of severe radio-sensitivity
dc.creator.none.fl_str_mv Ocolotobiche, Eliana Evelina
Cordoba, Elisa Eugenia
Güerci, Alba Mabel
author Ocolotobiche, Eliana Evelina
author_facet Ocolotobiche, Eliana Evelina
Cordoba, Elisa Eugenia
Güerci, Alba Mabel
author_role author
author2 Cordoba, Elisa Eugenia
Güerci, Alba Mabel
author2_role author
author
dc.subject.none.fl_str_mv RADIATION THERAPY
RADIOSENSITIVITY
ACUTE EFFECTS
RADIATION THERAPY
RADIOSENSITIVITY
ACUTE EFFECTS
topic RADIATION THERAPY
RADIOSENSITIVITY
ACUTE EFFECTS
RADIATION THERAPY
RADIOSENSITIVITY
ACUTE EFFECTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A case of a patient with a breast intraductal tumor is presented. The patient underwent surgical quadrantectomy and axillary lymph node dissection and subsequently received Anthracycline treatment and 3D radiotherapy following a standard fractionation protocol. This case was characterized by the development of grade III dermal toxicity, some associated genetic polymorphisms and DNA damage were analyzed. We concluded that radiotoxicity is a multifactorial phenotype that should be addressed in a broader context, considering not only intrinsic variables but also criteria such as breast size, body mass index and concomitant treatments, among others.
Fil: Ocolotobiche, Eliana Evelina. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cordoba, Elisa Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes.; Argentina
Fil: Güerci, Alba Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
description A case of a patient with a breast intraductal tumor is presented. The patient underwent surgical quadrantectomy and axillary lymph node dissection and subsequently received Anthracycline treatment and 3D radiotherapy following a standard fractionation protocol. This case was characterized by the development of grade III dermal toxicity, some associated genetic polymorphisms and DNA damage were analyzed. We concluded that radiotoxicity is a multifactorial phenotype that should be addressed in a broader context, considering not only intrinsic variables but also criteria such as breast size, body mass index and concomitant treatments, among others.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123864
Ocolotobiche, Eliana Evelina; Cordoba, Elisa Eugenia; Güerci, Alba Mabel; Clinical and molecular study of a case of severe radio-sensitivity; MedCrave; International Journal of Radiology and Radiation Therapy; 6; 12-2019; 234-236
2574-8084
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123864
identifier_str_mv Ocolotobiche, Eliana Evelina; Cordoba, Elisa Eugenia; Güerci, Alba Mabel; Clinical and molecular study of a case of severe radio-sensitivity; MedCrave; International Journal of Radiology and Radiation Therapy; 6; 12-2019; 234-236
2574-8084
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.15406/ijrrt.2019.06.00253
info:eu-repo/semantics/altIdentifier/url/http://medcraveonline.com/IJRRT/clinical-and-molecular-study-of-a-case-of-severe-radio-sensitivity.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MedCrave
publisher.none.fl_str_mv MedCrave
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1864650017902428160
score 13.1485815

Publicaciones similares