Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage

Autores
Gonzalez, Jimena Soledad; Alvarez, Vera Alejandra
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The technological advances in material science are not enough to overcome the challenge of construct a material be able to replace the cartilage. The designed material has to meet the mechanical properties of cartilage and has to be capable to be integrated to the articulation. Articular cartilage damage is a persistent and increasing problem which affects millions of people worldwide. Poly vinyl alcohol (PVA) hydrogels are promising implants, due to their similar properties as soft tissue, however their low mechanical resistance and durability together with its lack to integrate with the surrounding tissue restrict their application in this area. The poor adhesion can be solved by the development a composite hydrogel with bioactive and biocompatible filler, as hydroxyapatite (HA). The aim of this work was to obtain and characterize (physical, chemical and mechanical) PVA/HA composite hydrogels for potential application as articular replacement. Hence composite hydrogels were prepared with the adding of different amount of HA in an aqueous solution of PVA and subsequent freezing-thawing cycles. It was observed that the adding of the HA modified the physical and chemical features of the hydrogel, promoted the material crosslinking and stability. Moreover, it was found that the mechanical properties (compression, tension and nanoindentation) of the hydrogels were improved by the addition of HA. All these result indicate that these materials could be used as a potential cartilage replacement. However, further in vitro and in vivo studies are mandatory for future possible clinical applications and are actually being carried out.
Fil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
Composite Hydrogel
Poly Vinyl Alcohol
Freezing-Thawing
Mechanical Properties
Cartilage Replacement
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27999
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/27999
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilageGonzalez, Jimena SoledadAlvarez, Vera AlejandraComposite HydrogelPoly Vinyl AlcoholFreezing-ThawingMechanical PropertiesCartilage Replacementhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The technological advances in material science are not enough to overcome the challenge of construct a material be able to replace the cartilage. The designed material has to meet the mechanical properties of cartilage and has to be capable to be integrated to the articulation. Articular cartilage damage is a persistent and increasing problem which affects millions of people worldwide. Poly vinyl alcohol (PVA) hydrogels are promising implants, due to their similar properties as soft tissue, however their low mechanical resistance and durability together with its lack to integrate with the surrounding tissue restrict their application in this area. The poor adhesion can be solved by the development a composite hydrogel with bioactive and biocompatible filler, as hydroxyapatite (HA). The aim of this work was to obtain and characterize (physical, chemical and mechanical) PVA/HA composite hydrogels for potential application as articular replacement. Hence composite hydrogels were prepared with the adding of different amount of HA in an aqueous solution of PVA and subsequent freezing-thawing cycles. It was observed that the adding of the HA modified the physical and chemical features of the hydrogel, promoted the material crosslinking and stability. Moreover, it was found that the mechanical properties (compression, tension and nanoindentation) of the hydrogels were improved by the addition of HA. All these result indicate that these materials could be used as a potential cartilage replacement. However, further in vitro and in vivo studies are mandatory for future possible clinical applications and are actually being carried out.Fil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaElsevier Science2014-02-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/27999Gonzalez, Jimena Soledad; Alvarez, Vera Alejandra; Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage; Elsevier Science; Journal Of The Mechanical Behavior Of Biomedical Materials; 34; 2-2-2014; 47-561751-6161CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1751616114000204info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmbbm.2014.01.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:47Zoai:ri.conicet.gov.ar:11336/27999instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:47.962CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage
title Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage
spellingShingle Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage
Gonzalez, Jimena Soledad
Composite Hydrogel
Poly Vinyl Alcohol
Freezing-Thawing
Mechanical Properties
Cartilage Replacement
title_short Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage
title_full Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage
title_fullStr Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage
title_full_unstemmed Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage
title_sort Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage
dc.creator.none.fl_str_mv Gonzalez, Jimena Soledad
Alvarez, Vera Alejandra
author Gonzalez, Jimena Soledad
author_facet Gonzalez, Jimena Soledad
Alvarez, Vera Alejandra
author_role author
author2 Alvarez, Vera Alejandra
author2_role author
dc.subject.none.fl_str_mv Composite Hydrogel
Poly Vinyl Alcohol
Freezing-Thawing
Mechanical Properties
Cartilage Replacement
topic Composite Hydrogel
Poly Vinyl Alcohol
Freezing-Thawing
Mechanical Properties
Cartilage Replacement
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The technological advances in material science are not enough to overcome the challenge of construct a material be able to replace the cartilage. The designed material has to meet the mechanical properties of cartilage and has to be capable to be integrated to the articulation. Articular cartilage damage is a persistent and increasing problem which affects millions of people worldwide. Poly vinyl alcohol (PVA) hydrogels are promising implants, due to their similar properties as soft tissue, however their low mechanical resistance and durability together with its lack to integrate with the surrounding tissue restrict their application in this area. The poor adhesion can be solved by the development a composite hydrogel with bioactive and biocompatible filler, as hydroxyapatite (HA). The aim of this work was to obtain and characterize (physical, chemical and mechanical) PVA/HA composite hydrogels for potential application as articular replacement. Hence composite hydrogels were prepared with the adding of different amount of HA in an aqueous solution of PVA and subsequent freezing-thawing cycles. It was observed that the adding of the HA modified the physical and chemical features of the hydrogel, promoted the material crosslinking and stability. Moreover, it was found that the mechanical properties (compression, tension and nanoindentation) of the hydrogels were improved by the addition of HA. All these result indicate that these materials could be used as a potential cartilage replacement. However, further in vitro and in vivo studies are mandatory for future possible clinical applications and are actually being carried out.
Fil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description The technological advances in material science are not enough to overcome the challenge of construct a material be able to replace the cartilage. The designed material has to meet the mechanical properties of cartilage and has to be capable to be integrated to the articulation. Articular cartilage damage is a persistent and increasing problem which affects millions of people worldwide. Poly vinyl alcohol (PVA) hydrogels are promising implants, due to their similar properties as soft tissue, however their low mechanical resistance and durability together with its lack to integrate with the surrounding tissue restrict their application in this area. The poor adhesion can be solved by the development a composite hydrogel with bioactive and biocompatible filler, as hydroxyapatite (HA). The aim of this work was to obtain and characterize (physical, chemical and mechanical) PVA/HA composite hydrogels for potential application as articular replacement. Hence composite hydrogels were prepared with the adding of different amount of HA in an aqueous solution of PVA and subsequent freezing-thawing cycles. It was observed that the adding of the HA modified the physical and chemical features of the hydrogel, promoted the material crosslinking and stability. Moreover, it was found that the mechanical properties (compression, tension and nanoindentation) of the hydrogels were improved by the addition of HA. All these result indicate that these materials could be used as a potential cartilage replacement. However, further in vitro and in vivo studies are mandatory for future possible clinical applications and are actually being carried out.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27999
Gonzalez, Jimena Soledad; Alvarez, Vera Alejandra; Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage; Elsevier Science; Journal Of The Mechanical Behavior Of Biomedical Materials; 34; 2-2-2014; 47-56
1751-6161
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27999
identifier_str_mv Gonzalez, Jimena Soledad; Alvarez, Vera Alejandra; Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage; Elsevier Science; Journal Of The Mechanical Behavior Of Biomedical Materials; 34; 2-2-2014; 47-56
1751-6161
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1751616114000204
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmbbm.2014.01.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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