Brain antioxidant responses to acute iron and copper intoxications in rats

Autores
Semprine, Jimena Vanina; Ferrarotti, Nidia; Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Fuda, Julián; Torti, Horacio; Castro Parodi, Mauricio; Damiano, Alicia Ermelinda; Boveris, Alberto Antonio; Repetto, Marisa G.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dose- and time-dependent antioxidant responses to Fe (0–60 mg kg−1) and Cu overloads (0–30 mg kg−1) in rat brains are described by the C50 and the t1/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with a t1/2 of 9–10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo chemiluminescence had similar time courses. The C50 for brain chemiluminescence, GSH and hydrophilic and lipophilic antioxidants were in similar ranges (32–36 μg Fe g−1 brain and 10–18 μg Cu g−1 brain), which indicated a unique free-radical mediated process for each metal. The brain concentration of hydrophilic and lipophilic antioxidants decreased after Fe and Cu loads; hydrophilic antioxidants decreased by 46–68% with a t1/2 of 10–11 h and lipophilic antioxidants decreased by 75–45% with a t1/2 of 10–12 h. Cu,Zn-SOD and CAT activities and the protein expression were adaptively increased (100–90% after Fe and Cu loads), with a t1/2 of 8–12 h. GPx-4 activity decreased after both metal loads by 73–27% with a t1/2 of 8–4 h with decreased protein expression.
Fil: Semprine, Jimena Vanina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrarotti, Nidia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina
Fil: Musacco Sebio, Rosario Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Saporito Magriñá, Christian Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fuda, Julián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Torti, Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Castro Parodi, Mauricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
Fil: Damiano, Alicia Ermelinda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
Fil: Boveris, Alberto Antonio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Repetto, Marisa G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina
Materia
Iron
Cupper
Sod
Catalase
Gpx
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14062

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network_name_str CONICET Digital (CONICET)
spelling Brain antioxidant responses to acute iron and copper intoxications in ratsSemprine, Jimena VaninaFerrarotti, NidiaMusacco Sebio, Rosario NataliaSaporito Magriñá, Christian MartínFuda, JuliánTorti, HoracioCastro Parodi, MauricioDamiano, Alicia ErmelindaBoveris, Alberto AntonioRepetto, Marisa G.IronCupperSodCatalaseGpxhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Dose- and time-dependent antioxidant responses to Fe (0–60 mg kg−1) and Cu overloads (0–30 mg kg−1) in rat brains are described by the C50 and the t1/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with a t1/2 of 9–10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo chemiluminescence had similar time courses. The C50 for brain chemiluminescence, GSH and hydrophilic and lipophilic antioxidants were in similar ranges (32–36 μg Fe g−1 brain and 10–18 μg Cu g−1 brain), which indicated a unique free-radical mediated process for each metal. The brain concentration of hydrophilic and lipophilic antioxidants decreased after Fe and Cu loads; hydrophilic antioxidants decreased by 46–68% with a t1/2 of 10–11 h and lipophilic antioxidants decreased by 75–45% with a t1/2 of 10–12 h. Cu,Zn-SOD and CAT activities and the protein expression were adaptively increased (100–90% after Fe and Cu loads), with a t1/2 of 8–12 h. GPx-4 activity decreased after both metal loads by 73–27% with a t1/2 of 8–4 h with decreased protein expression.Fil: Semprine, Jimena Vanina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferrarotti, Nidia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; ArgentinaFil: Musacco Sebio, Rosario Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Saporito Magriñá, Christian Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fuda, Julián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Torti, Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Castro Parodi, Mauricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; ArgentinaFil: Damiano, Alicia Ermelinda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; ArgentinaFil: Boveris, Alberto Antonio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Repetto, Marisa G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; ArgentinaRoyal Society Of Chemistry2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14062Semprine, Jimena Vanina; Ferrarotti, Nidia; Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Fuda, Julián; et al.; Brain antioxidant responses to acute iron and copper intoxications in rats; Royal Society Of Chemistry; Metallomics; 6; 11; 8-2014; 2083-20891756-5901enginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/MT/C4MT00159A#!divAbstractinfo:eu-repo/semantics/altIdentifier/doi/ 10.1039/c4mt00159ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:01Zoai:ri.conicet.gov.ar:11336/14062instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:01.732CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Brain antioxidant responses to acute iron and copper intoxications in rats
title Brain antioxidant responses to acute iron and copper intoxications in rats
spellingShingle Brain antioxidant responses to acute iron and copper intoxications in rats
Semprine, Jimena Vanina
Iron
Cupper
Sod
Catalase
Gpx
title_short Brain antioxidant responses to acute iron and copper intoxications in rats
title_full Brain antioxidant responses to acute iron and copper intoxications in rats
title_fullStr Brain antioxidant responses to acute iron and copper intoxications in rats
title_full_unstemmed Brain antioxidant responses to acute iron and copper intoxications in rats
title_sort Brain antioxidant responses to acute iron and copper intoxications in rats
dc.creator.none.fl_str_mv Semprine, Jimena Vanina
Ferrarotti, Nidia
Musacco Sebio, Rosario Natalia
Saporito Magriñá, Christian Martín
Fuda, Julián
Torti, Horacio
Castro Parodi, Mauricio
Damiano, Alicia Ermelinda
Boveris, Alberto Antonio
Repetto, Marisa G.
author Semprine, Jimena Vanina
author_facet Semprine, Jimena Vanina
Ferrarotti, Nidia
Musacco Sebio, Rosario Natalia
Saporito Magriñá, Christian Martín
Fuda, Julián
Torti, Horacio
Castro Parodi, Mauricio
Damiano, Alicia Ermelinda
Boveris, Alberto Antonio
Repetto, Marisa G.
author_role author
author2 Ferrarotti, Nidia
Musacco Sebio, Rosario Natalia
Saporito Magriñá, Christian Martín
Fuda, Julián
Torti, Horacio
Castro Parodi, Mauricio
Damiano, Alicia Ermelinda
Boveris, Alberto Antonio
Repetto, Marisa G.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Iron
Cupper
Sod
Catalase
Gpx
topic Iron
Cupper
Sod
Catalase
Gpx
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Dose- and time-dependent antioxidant responses to Fe (0–60 mg kg−1) and Cu overloads (0–30 mg kg−1) in rat brains are described by the C50 and the t1/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with a t1/2 of 9–10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo chemiluminescence had similar time courses. The C50 for brain chemiluminescence, GSH and hydrophilic and lipophilic antioxidants were in similar ranges (32–36 μg Fe g−1 brain and 10–18 μg Cu g−1 brain), which indicated a unique free-radical mediated process for each metal. The brain concentration of hydrophilic and lipophilic antioxidants decreased after Fe and Cu loads; hydrophilic antioxidants decreased by 46–68% with a t1/2 of 10–11 h and lipophilic antioxidants decreased by 75–45% with a t1/2 of 10–12 h. Cu,Zn-SOD and CAT activities and the protein expression were adaptively increased (100–90% after Fe and Cu loads), with a t1/2 of 8–12 h. GPx-4 activity decreased after both metal loads by 73–27% with a t1/2 of 8–4 h with decreased protein expression.
Fil: Semprine, Jimena Vanina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrarotti, Nidia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina
Fil: Musacco Sebio, Rosario Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Saporito Magriñá, Christian Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fuda, Julián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Torti, Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Castro Parodi, Mauricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
Fil: Damiano, Alicia Ermelinda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
Fil: Boveris, Alberto Antonio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Repetto, Marisa G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina
description Dose- and time-dependent antioxidant responses to Fe (0–60 mg kg−1) and Cu overloads (0–30 mg kg−1) in rat brains are described by the C50 and the t1/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with a t1/2 of 9–10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo chemiluminescence had similar time courses. The C50 for brain chemiluminescence, GSH and hydrophilic and lipophilic antioxidants were in similar ranges (32–36 μg Fe g−1 brain and 10–18 μg Cu g−1 brain), which indicated a unique free-radical mediated process for each metal. The brain concentration of hydrophilic and lipophilic antioxidants decreased after Fe and Cu loads; hydrophilic antioxidants decreased by 46–68% with a t1/2 of 10–11 h and lipophilic antioxidants decreased by 75–45% with a t1/2 of 10–12 h. Cu,Zn-SOD and CAT activities and the protein expression were adaptively increased (100–90% after Fe and Cu loads), with a t1/2 of 8–12 h. GPx-4 activity decreased after both metal loads by 73–27% with a t1/2 of 8–4 h with decreased protein expression.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14062
Semprine, Jimena Vanina; Ferrarotti, Nidia; Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Fuda, Julián; et al.; Brain antioxidant responses to acute iron and copper intoxications in rats; Royal Society Of Chemistry; Metallomics; 6; 11; 8-2014; 2083-2089
1756-5901
url http://hdl.handle.net/11336/14062
identifier_str_mv Semprine, Jimena Vanina; Ferrarotti, Nidia; Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Fuda, Julián; et al.; Brain antioxidant responses to acute iron and copper intoxications in rats; Royal Society Of Chemistry; Metallomics; 6; 11; 8-2014; 2083-2089
1756-5901
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/MT/C4MT00159A#!divAbstract
info:eu-repo/semantics/altIdentifier/doi/ 10.1039/c4mt00159a
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society Of Chemistry
publisher.none.fl_str_mv Royal Society Of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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