Brain antioxidant responses to acute iron and copper intoxications in rats
- Autores
- Semprine, Jimena Vanina; Ferrarotti, Nidia; Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Fuda, Julián; Torti, Horacio; Castro Parodi, Mauricio; Damiano, Alicia Ermelinda; Boveris, Alberto Antonio; Repetto, Marisa G.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Dose- and time-dependent antioxidant responses to Fe (0–60 mg kg−1) and Cu overloads (0–30 mg kg−1) in rat brains are described by the C50 and the t1/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with a t1/2 of 9–10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo chemiluminescence had similar time courses. The C50 for brain chemiluminescence, GSH and hydrophilic and lipophilic antioxidants were in similar ranges (32–36 μg Fe g−1 brain and 10–18 μg Cu g−1 brain), which indicated a unique free-radical mediated process for each metal. The brain concentration of hydrophilic and lipophilic antioxidants decreased after Fe and Cu loads; hydrophilic antioxidants decreased by 46–68% with a t1/2 of 10–11 h and lipophilic antioxidants decreased by 75–45% with a t1/2 of 10–12 h. Cu,Zn-SOD and CAT activities and the protein expression were adaptively increased (100–90% after Fe and Cu loads), with a t1/2 of 8–12 h. GPx-4 activity decreased after both metal loads by 73–27% with a t1/2 of 8–4 h with decreased protein expression.
Fil: Semprine, Jimena Vanina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrarotti, Nidia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina
Fil: Musacco Sebio, Rosario Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Saporito Magriñá, Christian Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fuda, Julián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Torti, Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Castro Parodi, Mauricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
Fil: Damiano, Alicia Ermelinda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
Fil: Boveris, Alberto Antonio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Repetto, Marisa G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina - Materia
-
Iron
Cupper
Sod
Catalase
Gpx - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/14062
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Brain antioxidant responses to acute iron and copper intoxications in ratsSemprine, Jimena VaninaFerrarotti, NidiaMusacco Sebio, Rosario NataliaSaporito Magriñá, Christian MartínFuda, JuliánTorti, HoracioCastro Parodi, MauricioDamiano, Alicia ErmelindaBoveris, Alberto AntonioRepetto, Marisa G.IronCupperSodCatalaseGpxhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Dose- and time-dependent antioxidant responses to Fe (0–60 mg kg−1) and Cu overloads (0–30 mg kg−1) in rat brains are described by the C50 and the t1/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with a t1/2 of 9–10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo chemiluminescence had similar time courses. The C50 for brain chemiluminescence, GSH and hydrophilic and lipophilic antioxidants were in similar ranges (32–36 μg Fe g−1 brain and 10–18 μg Cu g−1 brain), which indicated a unique free-radical mediated process for each metal. The brain concentration of hydrophilic and lipophilic antioxidants decreased after Fe and Cu loads; hydrophilic antioxidants decreased by 46–68% with a t1/2 of 10–11 h and lipophilic antioxidants decreased by 75–45% with a t1/2 of 10–12 h. Cu,Zn-SOD and CAT activities and the protein expression were adaptively increased (100–90% after Fe and Cu loads), with a t1/2 of 8–12 h. GPx-4 activity decreased after both metal loads by 73–27% with a t1/2 of 8–4 h with decreased protein expression.Fil: Semprine, Jimena Vanina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferrarotti, Nidia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; ArgentinaFil: Musacco Sebio, Rosario Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Saporito Magriñá, Christian Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fuda, Julián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Torti, Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Castro Parodi, Mauricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; ArgentinaFil: Damiano, Alicia Ermelinda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; ArgentinaFil: Boveris, Alberto Antonio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Repetto, Marisa G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; ArgentinaRoyal Society Of Chemistry2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14062Semprine, Jimena Vanina; Ferrarotti, Nidia; Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Fuda, Julián; et al.; Brain antioxidant responses to acute iron and copper intoxications in rats; Royal Society Of Chemistry; Metallomics; 6; 11; 8-2014; 2083-20891756-5901enginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/MT/C4MT00159A#!divAbstractinfo:eu-repo/semantics/altIdentifier/doi/ 10.1039/c4mt00159ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:01Zoai:ri.conicet.gov.ar:11336/14062instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:01.732CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Brain antioxidant responses to acute iron and copper intoxications in rats |
title |
Brain antioxidant responses to acute iron and copper intoxications in rats |
spellingShingle |
Brain antioxidant responses to acute iron and copper intoxications in rats Semprine, Jimena Vanina Iron Cupper Sod Catalase Gpx |
title_short |
Brain antioxidant responses to acute iron and copper intoxications in rats |
title_full |
Brain antioxidant responses to acute iron and copper intoxications in rats |
title_fullStr |
Brain antioxidant responses to acute iron and copper intoxications in rats |
title_full_unstemmed |
Brain antioxidant responses to acute iron and copper intoxications in rats |
title_sort |
Brain antioxidant responses to acute iron and copper intoxications in rats |
dc.creator.none.fl_str_mv |
Semprine, Jimena Vanina Ferrarotti, Nidia Musacco Sebio, Rosario Natalia Saporito Magriñá, Christian Martín Fuda, Julián Torti, Horacio Castro Parodi, Mauricio Damiano, Alicia Ermelinda Boveris, Alberto Antonio Repetto, Marisa G. |
author |
Semprine, Jimena Vanina |
author_facet |
Semprine, Jimena Vanina Ferrarotti, Nidia Musacco Sebio, Rosario Natalia Saporito Magriñá, Christian Martín Fuda, Julián Torti, Horacio Castro Parodi, Mauricio Damiano, Alicia Ermelinda Boveris, Alberto Antonio Repetto, Marisa G. |
author_role |
author |
author2 |
Ferrarotti, Nidia Musacco Sebio, Rosario Natalia Saporito Magriñá, Christian Martín Fuda, Julián Torti, Horacio Castro Parodi, Mauricio Damiano, Alicia Ermelinda Boveris, Alberto Antonio Repetto, Marisa G. |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Iron Cupper Sod Catalase Gpx |
topic |
Iron Cupper Sod Catalase Gpx |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Dose- and time-dependent antioxidant responses to Fe (0–60 mg kg−1) and Cu overloads (0–30 mg kg−1) in rat brains are described by the C50 and the t1/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with a t1/2 of 9–10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo chemiluminescence had similar time courses. The C50 for brain chemiluminescence, GSH and hydrophilic and lipophilic antioxidants were in similar ranges (32–36 μg Fe g−1 brain and 10–18 μg Cu g−1 brain), which indicated a unique free-radical mediated process for each metal. The brain concentration of hydrophilic and lipophilic antioxidants decreased after Fe and Cu loads; hydrophilic antioxidants decreased by 46–68% with a t1/2 of 10–11 h and lipophilic antioxidants decreased by 75–45% with a t1/2 of 10–12 h. Cu,Zn-SOD and CAT activities and the protein expression were adaptively increased (100–90% after Fe and Cu loads), with a t1/2 of 8–12 h. GPx-4 activity decreased after both metal loads by 73–27% with a t1/2 of 8–4 h with decreased protein expression. Fil: Semprine, Jimena Vanina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ferrarotti, Nidia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina Fil: Musacco Sebio, Rosario Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Saporito Magriñá, Christian Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Fuda, Julián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Torti, Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Castro Parodi, Mauricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina Fil: Damiano, Alicia Ermelinda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina Fil: Boveris, Alberto Antonio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Repetto, Marisa G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General E Inorgánica; Argentina |
description |
Dose- and time-dependent antioxidant responses to Fe (0–60 mg kg−1) and Cu overloads (0–30 mg kg−1) in rat brains are described by the C50 and the t1/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50–80%) with a t1/2 of 9–10 h for GSH and of 4 h for GSH/GSSG for both metals. The GSH/GSSG ratio was the most sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo chemiluminescence had similar time courses. The C50 for brain chemiluminescence, GSH and hydrophilic and lipophilic antioxidants were in similar ranges (32–36 μg Fe g−1 brain and 10–18 μg Cu g−1 brain), which indicated a unique free-radical mediated process for each metal. The brain concentration of hydrophilic and lipophilic antioxidants decreased after Fe and Cu loads; hydrophilic antioxidants decreased by 46–68% with a t1/2 of 10–11 h and lipophilic antioxidants decreased by 75–45% with a t1/2 of 10–12 h. Cu,Zn-SOD and CAT activities and the protein expression were adaptively increased (100–90% after Fe and Cu loads), with a t1/2 of 8–12 h. GPx-4 activity decreased after both metal loads by 73–27% with a t1/2 of 8–4 h with decreased protein expression. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/14062 Semprine, Jimena Vanina; Ferrarotti, Nidia; Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Fuda, Julián; et al.; Brain antioxidant responses to acute iron and copper intoxications in rats; Royal Society Of Chemistry; Metallomics; 6; 11; 8-2014; 2083-2089 1756-5901 |
url |
http://hdl.handle.net/11336/14062 |
identifier_str_mv |
Semprine, Jimena Vanina; Ferrarotti, Nidia; Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Fuda, Julián; et al.; Brain antioxidant responses to acute iron and copper intoxications in rats; Royal Society Of Chemistry; Metallomics; 6; 11; 8-2014; 2083-2089 1756-5901 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/MT/C4MT00159A#!divAbstract info:eu-repo/semantics/altIdentifier/doi/ 10.1039/c4mt00159a |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society Of Chemistry |
publisher.none.fl_str_mv |
Royal Society Of Chemistry |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |