Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study

Autores
Caballero, Mauricio Tomás; Bianchi, Alejandra Silvina; Diaz Grigaites, Sebastian; de la Iglesia Niveyro, Paola Ximena; Nuño, Alejandra; Valle, Sandra; Afarian, Gabriela; Esperante, Sebastian; Ferreti, Adrián; Jares Baglivo, Sofía; De Luca, Julián; Álvarez Paggi, Damián Jorge; Diamanti, Adriana; Bassat, Quique; Polack, Fernando Pedro
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background. Many deaths in infants from low-middle income countries (LMICs) occur at home or upon arrival to health facilities. Although acute lower respiratory tract illness plays an important role in community mortality, the accuracy of mortality rates due to respiratory syncytial virus (RSV) remains unknown. Methods. An active surveillance study among children aged under 5 years old (U5) was performed in Buenos Aires, Argentina, between January and December 2019, to define the burden and role of RSV in childhood community mortality. Results. A total of 63 families of children U5 participated in the study. Based on a combined approach of tissue sampling, verbal autopsies, and expert’s analysis, RSV infection was found in the causal chain of 11 from 12 cases with positive molecular biology results in respiratory samples. The estimated mortality rate due to RSV among infants was 0.27 deaths/1000 live births. The mean age of RSV-related household deaths was 2.8 months of age (standard deviation [SD] 1.7), and 8/12 were male infants (66.7%). Dying at home from RSV was associated with Streptococcus pneumoniae and/or Moraxella catarrhalis lung coinfection (75%), living in slums and settlement (odds ratio [OR], 17.09; 95% confidence interval [CI], 1.3–219.2), and other underlying comorbidities (OR, 14.87; 95% CI, 1.3–164.6). Conclusions. Infant community mortality rates due to RSV are higher than those reported in industrialized countries and similar to those reported in hospital-based studies in the same catchment population.
Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Bianchi, Alejandra Silvina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Diaz Grigaites, Sebastian. Gobierno de la Provincia de Buenos Aires. Ministerio Publico. Ministerio Publico Fiscal. Instituto de Ciencias Forenses de Lomas de Zamora.; Argentina
Fil: de la Iglesia Niveyro, Paola Ximena. Hospital Italiano; Argentina
Fil: Nuño, Alejandra. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Valle, Sandra. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Afarian, Gabriela. Gobierno de la Provincia de Buenos Aires. Ministerio Publico. Ministerio Publico Fiscal. Instituto de Ciencias Forenses de Lomas de Zamora.; Argentina
Fil: Esperante, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Ferreti, Adrián. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Jares Baglivo, Sofía. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: De Luca, Julián. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Álvarez Paggi, Damián Jorge. Comisión Nacional de Investigación Científica y Tecnológica; Chile. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Diamanti, Adriana. Gobierno de la Provincia de Buenos Aires. Ministerio Publico. Ministerio Publico Fiscal. Instituto de Ciencias Forenses de Lomas de Zamora.; Argentina
Fil: Bassat, Quique. Universidad de Barcelona; España. Centro de investigação de Saúde de Manhiça; Mozambique. Institució Catalana de Recerca i Estudis Avancats; España. Hospital Sant Joan de Deu Barcelona; España. Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública; España
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
Materia
INFANT COMMUNITY MORTALITY
ACUTE RESPIRATORY INFECTIONS
RESPIRATORY SYNCYTIAL VIRUS
MINIMAL INVASIVE TISSUE SAMPLING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/155185

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network_name_str CONICET Digital (CONICET)
spelling Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance studyCaballero, Mauricio TomásBianchi, Alejandra SilvinaDiaz Grigaites, Sebastiande la Iglesia Niveyro, Paola XimenaNuño, AlejandraValle, SandraAfarian, GabrielaEsperante, SebastianFerreti, AdriánJares Baglivo, SofíaDe Luca, JuliánÁlvarez Paggi, Damián JorgeDiamanti, AdrianaBassat, QuiquePolack, Fernando PedroINFANT COMMUNITY MORTALITYACUTE RESPIRATORY INFECTIONSRESPIRATORY SYNCYTIAL VIRUSMINIMAL INVASIVE TISSUE SAMPLINGhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background. Many deaths in infants from low-middle income countries (LMICs) occur at home or upon arrival to health facilities. Although acute lower respiratory tract illness plays an important role in community mortality, the accuracy of mortality rates due to respiratory syncytial virus (RSV) remains unknown. Methods. An active surveillance study among children aged under 5 years old (U5) was performed in Buenos Aires, Argentina, between January and December 2019, to define the burden and role of RSV in childhood community mortality. Results. A total of 63 families of children U5 participated in the study. Based on a combined approach of tissue sampling, verbal autopsies, and expert’s analysis, RSV infection was found in the causal chain of 11 from 12 cases with positive molecular biology results in respiratory samples. The estimated mortality rate due to RSV among infants was 0.27 deaths/1000 live births. The mean age of RSV-related household deaths was 2.8 months of age (standard deviation [SD] 1.7), and 8/12 were male infants (66.7%). Dying at home from RSV was associated with Streptococcus pneumoniae and/or Moraxella catarrhalis lung coinfection (75%), living in slums and settlement (odds ratio [OR], 17.09; 95% confidence interval [CI], 1.3–219.2), and other underlying comorbidities (OR, 14.87; 95% CI, 1.3–164.6). Conclusions. Infant community mortality rates due to RSV are higher than those reported in industrialized countries and similar to those reported in hospital-based studies in the same catchment population.Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Bianchi, Alejandra Silvina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Diaz Grigaites, Sebastian. Gobierno de la Provincia de Buenos Aires. Ministerio Publico. Ministerio Publico Fiscal. Instituto de Ciencias Forenses de Lomas de Zamora.; ArgentinaFil: de la Iglesia Niveyro, Paola Ximena. Hospital Italiano; ArgentinaFil: Nuño, Alejandra. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Valle, Sandra. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Afarian, Gabriela. Gobierno de la Provincia de Buenos Aires. Ministerio Publico. Ministerio Publico Fiscal. Instituto de Ciencias Forenses de Lomas de Zamora.; ArgentinaFil: Esperante, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Ferreti, Adrián. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Jares Baglivo, Sofía. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: De Luca, Julián. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Álvarez Paggi, Damián Jorge. Comisión Nacional de Investigación Científica y Tecnológica; Chile. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Diamanti, Adriana. Gobierno de la Provincia de Buenos Aires. Ministerio Publico. Ministerio Publico Fiscal. Instituto de Ciencias Forenses de Lomas de Zamora.; ArgentinaFil: Bassat, Quique. Universidad de Barcelona; España. Centro de investigação de Saúde de Manhiça; Mozambique. Institució Catalana de Recerca i Estudis Avancats; España. Hospital Sant Joan de Deu Barcelona; España. Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública; EspañaFil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; ArgentinaOxford University Press2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/155185Caballero, Mauricio Tomás; Bianchi, Alejandra Silvina; Diaz Grigaites, Sebastian; de la Iglesia Niveyro, Paola Ximena; Nuño, Alejandra; et al.; Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study; Oxford University Press; Clinical Infectious Diseases; 73; 3; 9-2021; 210-2171058-4838CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cid/article/73/Supplement_3/S210/6362478info:eu-repo/semantics/altIdentifier/doi/10.1093/cid/ciab497info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:11Zoai:ri.conicet.gov.ar:11336/155185instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:11.731CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study
title Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study
spellingShingle Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study
Caballero, Mauricio Tomás
INFANT COMMUNITY MORTALITY
ACUTE RESPIRATORY INFECTIONS
RESPIRATORY SYNCYTIAL VIRUS
MINIMAL INVASIVE TISSUE SAMPLING
title_short Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study
title_full Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study
title_fullStr Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study
title_full_unstemmed Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study
title_sort Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study
dc.creator.none.fl_str_mv Caballero, Mauricio Tomás
Bianchi, Alejandra Silvina
Diaz Grigaites, Sebastian
de la Iglesia Niveyro, Paola Ximena
Nuño, Alejandra
Valle, Sandra
Afarian, Gabriela
Esperante, Sebastian
Ferreti, Adrián
Jares Baglivo, Sofía
De Luca, Julián
Álvarez Paggi, Damián Jorge
Diamanti, Adriana
Bassat, Quique
Polack, Fernando Pedro
author Caballero, Mauricio Tomás
author_facet Caballero, Mauricio Tomás
Bianchi, Alejandra Silvina
Diaz Grigaites, Sebastian
de la Iglesia Niveyro, Paola Ximena
Nuño, Alejandra
Valle, Sandra
Afarian, Gabriela
Esperante, Sebastian
Ferreti, Adrián
Jares Baglivo, Sofía
De Luca, Julián
Álvarez Paggi, Damián Jorge
Diamanti, Adriana
Bassat, Quique
Polack, Fernando Pedro
author_role author
author2 Bianchi, Alejandra Silvina
Diaz Grigaites, Sebastian
de la Iglesia Niveyro, Paola Ximena
Nuño, Alejandra
Valle, Sandra
Afarian, Gabriela
Esperante, Sebastian
Ferreti, Adrián
Jares Baglivo, Sofía
De Luca, Julián
Álvarez Paggi, Damián Jorge
Diamanti, Adriana
Bassat, Quique
Polack, Fernando Pedro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv INFANT COMMUNITY MORTALITY
ACUTE RESPIRATORY INFECTIONS
RESPIRATORY SYNCYTIAL VIRUS
MINIMAL INVASIVE TISSUE SAMPLING
topic INFANT COMMUNITY MORTALITY
ACUTE RESPIRATORY INFECTIONS
RESPIRATORY SYNCYTIAL VIRUS
MINIMAL INVASIVE TISSUE SAMPLING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background. Many deaths in infants from low-middle income countries (LMICs) occur at home or upon arrival to health facilities. Although acute lower respiratory tract illness plays an important role in community mortality, the accuracy of mortality rates due to respiratory syncytial virus (RSV) remains unknown. Methods. An active surveillance study among children aged under 5 years old (U5) was performed in Buenos Aires, Argentina, between January and December 2019, to define the burden and role of RSV in childhood community mortality. Results. A total of 63 families of children U5 participated in the study. Based on a combined approach of tissue sampling, verbal autopsies, and expert’s analysis, RSV infection was found in the causal chain of 11 from 12 cases with positive molecular biology results in respiratory samples. The estimated mortality rate due to RSV among infants was 0.27 deaths/1000 live births. The mean age of RSV-related household deaths was 2.8 months of age (standard deviation [SD] 1.7), and 8/12 were male infants (66.7%). Dying at home from RSV was associated with Streptococcus pneumoniae and/or Moraxella catarrhalis lung coinfection (75%), living in slums and settlement (odds ratio [OR], 17.09; 95% confidence interval [CI], 1.3–219.2), and other underlying comorbidities (OR, 14.87; 95% CI, 1.3–164.6). Conclusions. Infant community mortality rates due to RSV are higher than those reported in industrialized countries and similar to those reported in hospital-based studies in the same catchment population.
Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Bianchi, Alejandra Silvina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Diaz Grigaites, Sebastian. Gobierno de la Provincia de Buenos Aires. Ministerio Publico. Ministerio Publico Fiscal. Instituto de Ciencias Forenses de Lomas de Zamora.; Argentina
Fil: de la Iglesia Niveyro, Paola Ximena. Hospital Italiano; Argentina
Fil: Nuño, Alejandra. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Valle, Sandra. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Afarian, Gabriela. Gobierno de la Provincia de Buenos Aires. Ministerio Publico. Ministerio Publico Fiscal. Instituto de Ciencias Forenses de Lomas de Zamora.; Argentina
Fil: Esperante, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Ferreti, Adrián. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Jares Baglivo, Sofía. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: De Luca, Julián. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Álvarez Paggi, Damián Jorge. Comisión Nacional de Investigación Científica y Tecnológica; Chile. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Diamanti, Adriana. Gobierno de la Provincia de Buenos Aires. Ministerio Publico. Ministerio Publico Fiscal. Instituto de Ciencias Forenses de Lomas de Zamora.; Argentina
Fil: Bassat, Quique. Universidad de Barcelona; España. Centro de investigação de Saúde de Manhiça; Mozambique. Institució Catalana de Recerca i Estudis Avancats; España. Hospital Sant Joan de Deu Barcelona; España. Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública; España
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
description Background. Many deaths in infants from low-middle income countries (LMICs) occur at home or upon arrival to health facilities. Although acute lower respiratory tract illness plays an important role in community mortality, the accuracy of mortality rates due to respiratory syncytial virus (RSV) remains unknown. Methods. An active surveillance study among children aged under 5 years old (U5) was performed in Buenos Aires, Argentina, between January and December 2019, to define the burden and role of RSV in childhood community mortality. Results. A total of 63 families of children U5 participated in the study. Based on a combined approach of tissue sampling, verbal autopsies, and expert’s analysis, RSV infection was found in the causal chain of 11 from 12 cases with positive molecular biology results in respiratory samples. The estimated mortality rate due to RSV among infants was 0.27 deaths/1000 live births. The mean age of RSV-related household deaths was 2.8 months of age (standard deviation [SD] 1.7), and 8/12 were male infants (66.7%). Dying at home from RSV was associated with Streptococcus pneumoniae and/or Moraxella catarrhalis lung coinfection (75%), living in slums and settlement (odds ratio [OR], 17.09; 95% confidence interval [CI], 1.3–219.2), and other underlying comorbidities (OR, 14.87; 95% CI, 1.3–164.6). Conclusions. Infant community mortality rates due to RSV are higher than those reported in industrialized countries and similar to those reported in hospital-based studies in the same catchment population.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/155185
Caballero, Mauricio Tomás; Bianchi, Alejandra Silvina; Diaz Grigaites, Sebastian; de la Iglesia Niveyro, Paola Ximena; Nuño, Alejandra; et al.; Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study; Oxford University Press; Clinical Infectious Diseases; 73; 3; 9-2021; 210-217
1058-4838
CONICET Digital
CONICET
url http://hdl.handle.net/11336/155185
identifier_str_mv Caballero, Mauricio Tomás; Bianchi, Alejandra Silvina; Diaz Grigaites, Sebastian; de la Iglesia Niveyro, Paola Ximena; Nuño, Alejandra; et al.; Community Mortality due to Respiratory Syncytial Virus in Argentina: Population-based surveillance study; Oxford University Press; Clinical Infectious Diseases; 73; 3; 9-2021; 210-217
1058-4838
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1093/cid/ciab497
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https://creativecommons.org/licenses/by/2.5/ar/
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
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