Global Respiratory Syncytial Virus-Related Infant Community Deaths

• Autores: Mazur, Natalie I.; Löwensteyn, Yvette N.; Willemsen, Joukje E.; Gill, Christopher J.; Forman, Leah; Mwananyanda, Lawrence M.; Blau, Dianna M.; Breiman, Robert F.; Madhi, Shabir A.; Mahtab, Sana; Gurley, Emily S.; El Arifeen, Shams; Assefa, Nega; Scott, J. Anthony G.; Onyango, Dickens; Tippet Barr, Beth A.; Kotloff, Karen L.; Sow, Samba O.; Mandomando, Inacio; Ogbuanu, Ikechukwu; Jambai, Amara; Bassat, Quique; Thamthitiwat, Somsak; Gentile, Angela; Lucion, Maria Florencia; Pires, Márcia Rosane; De Paris, Fernanda; Gordon, Aubree; Sánchez, José Félix; Caballero, Mauricio Tomás
• Año de publicación: 2021
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: COMMUNITY DEATH; LOWER RESPIRATORY TRACT INFECTION; RESPIRATORY SYNCYTIAL VIRUS
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Background. Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in lowand lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods. The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results. We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). Conclusions. We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.
Fil: Mazur, Natalie I.. University Medical Center Utrecht; Países Bajos
Fil: Löwensteyn, Yvette N.. University Medical Center Utrecht; Países Bajos
Fil: Willemsen, Joukje E.. University Medical Center Utrecht; Países Bajos
Fil: Gill, Christopher J.. Boston University School of Public Health; Estados Unidos
Fil: Forman, Leah. Boston University School of Public Health; Estados Unidos
Fil: Mwananyanda, Lawrence M.. Boston University School of Public Health; Estados Unidos
Fil: Blau, Dianna M.. Centers for Disease Control and Prevention; Estados Unidos
Fil: Breiman, Robert F.. University of Emory; Estados Unidos
Fil: Madhi, Shabir A.. University of the Witwatersrand; Sudáfrica. South African Medical Research Council; Sudáfrica
Fil: Mahtab, Sana. University of the Witwatersrand; Sudáfrica
Fil: Gurley, Emily S.. University Johns Hopkins; Estados Unidos. International Centre For Diarrhoeal Disease Research; Bangladesh
Fil: El Arifeen, Shams. International Centre For Diarrhoeal Disease Research; Bangladesh
Fil: Assefa, Nega. Haramaya University; Haití
Fil: Scott, J. Anthony G.. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Onyango, Dickens. Kisumu County Department Of Health; Kenia
Fil: Tippet Barr, Beth A.. Centers For Disease Control; Kenia
Fil: Kotloff, Karen L.. University Of Maryland School Of Medicine; Estados Unidos
Fil: Sow, Samba O.. Center For Vaccine Development; Malí
Fil: Mandomando, Inacio. Centro de Investigação em Saúde de Manhiça; Mozambique. Instituto Nacional de Saude; Mozambique
Fil: Ogbuanu, Ikechukwu. Crown Agents Sierra Leone; Sierra Leona
Fil: Jambai, Amara. Ministry Of Health And Sanitation; Sierra Leona
Fil: Bassat, Quique. Centro de Investigação em Saúde de Manhiça; Mozambique. Hospital Clínic–Universitat de Barcelona; España. Institució Catalana de Recerca i Estudis Avancats; España. Hospital Sant Joan de Deu Barcelona; España. Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública; España
Fil: Thamthitiwat, Somsak. RSV GOLD Study Group Collaborators - University Medical Center Utrecht; Países Bajos
Fil: Gentile, Angela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. RSV GOLD Study Group Collaborators - University Medical Center Utrecht; Países Bajos
Fil: Lucion, Maria Florencia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. RSV GOLD Study Group Collaborators - University Medical Center Utrecht; Países Bajos
Fil: Pires, Márcia Rosane. RSV GOLD Study Group Collaborators - University Medical Center Utrecht; Países Bajos
Fil: De Paris, Fernanda. RSV GOLD Study Group Collaborators - University Medical Center Utrecht; Países Bajos
Fil: Gordon, Aubree. RSV GOLD Study Group Collaborators - University Medical Center Utrecht; Países Bajos
Fil: Sánchez, José Félix. RSV GOLD Study Group Collaborators - University Medical Center Utrecht; Países Bajos
Fil: Caballero, Mauricio Tomás. Fundación P/e/est y Trat D/l/enfer Neurológicas Infant; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina