Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years

Autores
Caballero, Mauricio Tomás; Satav, Ashish; Gill, Christopher J.; Omer, Saad B.; Pieciak, Rachel C.; Kazi, Abdul Momin; Simões, Eric Af; Polack, Fernando Pedro
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background. Estimating the real impact of respiratory syncytial virus (RSV) disease is key for the development of vaccines and treatments. Ascertaining the burden of community mortality due to RSV is challenging due to the lack of primary data. Therefore, conducting observational studies to determine the factors associated with community mortality due to the virus in developing countries is important. Objective. Our aim in this study was to describe the obstacles, gaps, and challenges that investigators face in low-income, vulnerable regions in 4 developing countries on 3 continents. Results. The main obstacles and challenges of ascertaining community mortality due to RSV were defining strategies to consent families for testing before burial, sampling individuals at the household level, supporting bereaved parents with different cultural and religious backgrounds, establishing tailored strategies for studies in challenging settings, and integrating RSV mortality data from nasopharyngeal samples. Conclusion. Detailed logistical planning based on population sociodemographic information, grief counseling, staff training, and a multidisciplinary approach with adequate laboratory infrastructure is critical to successful observational community-based RSV studies.
Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Satav, Ashish. Mahatma Gandhi Tribal Hospital; India
Fil: Gill, Christopher J.. University of Boston. School of Medicine; Estados Unidos
Fil: Omer, Saad B.. University of Yale. School of Medicine; Estados Unidos
Fil: Pieciak, Rachel C.. University of Boston. School of Medicine; Estados Unidos
Fil: Kazi, Abdul Momin. Aga Khan University; Pakistán
Fil: Simões, Eric Af. University of Colorado. School of Medicine; Estados Unidos
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
Materia
CHALLENGES
COMMUNITY MORTALITY
RESPIRATORY SYNCYTIAL VIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/155110
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 yearsCaballero, Mauricio TomásSatav, AshishGill, Christopher J.Omer, Saad B.Pieciak, Rachel C.Kazi, Abdul MominSimões, Eric AfPolack, Fernando PedroCHALLENGESCOMMUNITY MORTALITYRESPIRATORY SYNCYTIAL VIRUShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background. Estimating the real impact of respiratory syncytial virus (RSV) disease is key for the development of vaccines and treatments. Ascertaining the burden of community mortality due to RSV is challenging due to the lack of primary data. Therefore, conducting observational studies to determine the factors associated with community mortality due to the virus in developing countries is important. Objective. Our aim in this study was to describe the obstacles, gaps, and challenges that investigators face in low-income, vulnerable regions in 4 developing countries on 3 continents. Results. The main obstacles and challenges of ascertaining community mortality due to RSV were defining strategies to consent families for testing before burial, sampling individuals at the household level, supporting bereaved parents with different cultural and religious backgrounds, establishing tailored strategies for studies in challenging settings, and integrating RSV mortality data from nasopharyngeal samples. Conclusion. Detailed logistical planning based on population sociodemographic information, grief counseling, staff training, and a multidisciplinary approach with adequate laboratory infrastructure is critical to successful observational community-based RSV studies.Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Satav, Ashish. Mahatma Gandhi Tribal Hospital; IndiaFil: Gill, Christopher J.. University of Boston. School of Medicine; Estados UnidosFil: Omer, Saad B.. University of Yale. School of Medicine; Estados UnidosFil: Pieciak, Rachel C.. University of Boston. School of Medicine; Estados UnidosFil: Kazi, Abdul Momin. Aga Khan University; PakistánFil: Simões, Eric Af. University of Colorado. School of Medicine; Estados UnidosFil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; ArgentinaUniversity of Chicago Press2021-09-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/155110Caballero, Mauricio Tomás; Satav, Ashish; Gill, Christopher J.; Omer, Saad B.; Pieciak, Rachel C.; et al.; Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years; University of Chicago Press; Clinical Infectious Diseases; 73; 3; 2-9-2021; 248-2541058-48381537-6591CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/cid/ciab487info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cid/article/73/Supplement_3/S248/6362479info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:20Zoai:ri.conicet.gov.ar:11336/155110instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:20.341CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
spellingShingle Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
Caballero, Mauricio Tomás
CHALLENGES
COMMUNITY MORTALITY
RESPIRATORY SYNCYTIAL VIRUS
title_short Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title_full Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title_fullStr Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title_full_unstemmed Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
title_sort Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years
dc.creator.none.fl_str_mv Caballero, Mauricio Tomás
Satav, Ashish
Gill, Christopher J.
Omer, Saad B.
Pieciak, Rachel C.
Kazi, Abdul Momin
Simões, Eric Af
Polack, Fernando Pedro
author Caballero, Mauricio Tomás
author_facet Caballero, Mauricio Tomás
Satav, Ashish
Gill, Christopher J.
Omer, Saad B.
Pieciak, Rachel C.
Kazi, Abdul Momin
Simões, Eric Af
Polack, Fernando Pedro
author_role author
author2 Satav, Ashish
Gill, Christopher J.
Omer, Saad B.
Pieciak, Rachel C.
Kazi, Abdul Momin
Simões, Eric Af
Polack, Fernando Pedro
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHALLENGES
COMMUNITY MORTALITY
RESPIRATORY SYNCYTIAL VIRUS
topic CHALLENGES
COMMUNITY MORTALITY
RESPIRATORY SYNCYTIAL VIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background. Estimating the real impact of respiratory syncytial virus (RSV) disease is key for the development of vaccines and treatments. Ascertaining the burden of community mortality due to RSV is challenging due to the lack of primary data. Therefore, conducting observational studies to determine the factors associated with community mortality due to the virus in developing countries is important. Objective. Our aim in this study was to describe the obstacles, gaps, and challenges that investigators face in low-income, vulnerable regions in 4 developing countries on 3 continents. Results. The main obstacles and challenges of ascertaining community mortality due to RSV were defining strategies to consent families for testing before burial, sampling individuals at the household level, supporting bereaved parents with different cultural and religious backgrounds, establishing tailored strategies for studies in challenging settings, and integrating RSV mortality data from nasopharyngeal samples. Conclusion. Detailed logistical planning based on population sociodemographic information, grief counseling, staff training, and a multidisciplinary approach with adequate laboratory infrastructure is critical to successful observational community-based RSV studies.
Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Satav, Ashish. Mahatma Gandhi Tribal Hospital; India
Fil: Gill, Christopher J.. University of Boston. School of Medicine; Estados Unidos
Fil: Omer, Saad B.. University of Yale. School of Medicine; Estados Unidos
Fil: Pieciak, Rachel C.. University of Boston. School of Medicine; Estados Unidos
Fil: Kazi, Abdul Momin. Aga Khan University; Pakistán
Fil: Simões, Eric Af. University of Colorado. School of Medicine; Estados Unidos
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
description Background. Estimating the real impact of respiratory syncytial virus (RSV) disease is key for the development of vaccines and treatments. Ascertaining the burden of community mortality due to RSV is challenging due to the lack of primary data. Therefore, conducting observational studies to determine the factors associated with community mortality due to the virus in developing countries is important. Objective. Our aim in this study was to describe the obstacles, gaps, and challenges that investigators face in low-income, vulnerable regions in 4 developing countries on 3 continents. Results. The main obstacles and challenges of ascertaining community mortality due to RSV were defining strategies to consent families for testing before burial, sampling individuals at the household level, supporting bereaved parents with different cultural and religious backgrounds, establishing tailored strategies for studies in challenging settings, and integrating RSV mortality data from nasopharyngeal samples. Conclusion. Detailed logistical planning based on population sociodemographic information, grief counseling, staff training, and a multidisciplinary approach with adequate laboratory infrastructure is critical to successful observational community-based RSV studies.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/155110
Caballero, Mauricio Tomás; Satav, Ashish; Gill, Christopher J.; Omer, Saad B.; Pieciak, Rachel C.; et al.; Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years; University of Chicago Press; Clinical Infectious Diseases; 73; 3; 2-9-2021; 248-254
1058-4838
1537-6591
CONICET Digital
CONICET
url http://hdl.handle.net/11336/155110
identifier_str_mv Caballero, Mauricio Tomás; Satav, Ashish; Gill, Christopher J.; Omer, Saad B.; Pieciak, Rachel C.; et al.; Challenges of assessing community mortality due to respiratory viruses in children aged less than 5 years; University of Chicago Press; Clinical Infectious Diseases; 73; 3; 2-9-2021; 248-254
1058-4838
1537-6591
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/cid/ciab487
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cid/article/73/Supplement_3/S248/6362479
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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