Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors

Autores
Geoghegan, Sarah; Erviti, Anabella; Caballero, Mauricio Tomás; Vallone, Fernando Daniel; Zanone, Stella M.; Ves Losada, Juan; Bianchi, Alejandra; Acosta, Patricio Leandro; Talarico, Laura Beatriz; Ferretti, Adrian; Grimaldi, Luciano Alva; Sancilio, Andrea; Dueñas, Karina; Sastre, Gustavo; Rodriguez, Andrea; Ferrero, Fernando; Barboza, Edgar; Gago, Guadalupe Fernández; Nocito, Celina; Flamenco, Edgardo; Perez, Alberto Rodriguez; Rebec, Beatriz; Ferolla, Fausto Martín; Libster, Romina Paula; Karron, Ruth A.; Bergel, Eduardo; Polack, Fernando Pedro
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Rationale: Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important cause of death in infants in the developing world. The relative contribution of social, biologic, and clinical risk factors to RSV mortality in low-income regions is unclear. Objectives: To determine the burden and risk factors for mortality due to RSV in a low-income population of 84,840 infants. Methods: This was a prospective, population-based, crosssectional, multicenter study conducted between 2011 and 2013. Hospitalizations and deaths due to severe lower respiratory tract illness (LRTI) were recorded during the RSV season. All-cause hospital deaths and community deaths were monitored. Risk factors for respiratory failure (RF) and mortality due to RSV were assessed using a hierarchical, logistic regression model. Measurements and Main Results: A total of 2,588 (65.5%) infants with severe LRTI were infected with RSV. A total of 157 infants (148 postneonatal) experienced RF or died with RSV. RSV LRTI accounted for 57% fatal LRTI tested for the virus. A diagnosis of sepsis (odds ratio [OR], 17.03; 95% confidence interval [CI], 13.14-21.16 for RF) (OR, 119.39; 95% CI, 50.98-273.34 for death) and pneumothorax (OR, 17.15; 95% CI, 13.07-21.01 for RF) (OR, 65.49; 95% CI, 28.90-139.17 for death) were the main determinants of poor outcomes. Conclusions: RSV was the most frequent cause of mortality in lowincome postneonatal infants. RF and death due to RSV LRTI, almost exclusively associated with prematurity and cardiopulmonary diseases in industrialized countries, primarily affect term infants in a developing world environment. Poor outcomes at hospitals are frequent and associated with the cooccurrence of bacterial sepsis and clinically significant pneumothoraxes.
Fil: Geoghegan, Sarah. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Erviti, Anabella. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vallone, Fernando Daniel. Región Sanitaria I. - Gobierno de la Provincia de Buenos Aires. Ministerio de Salud. Region Sanitaria I.; Argentina
Fil: Zanone, Stella M.. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Ves Losada, Juan. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Bianchi, Alejandra. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Acosta, Patricio Leandro. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Talarico, Laura Beatriz. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferretti, Adrian. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Grimaldi, Luciano Alva. Hospital Melendez; Argentina
Fil: Sancilio, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Dueñas, Karina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Sastre, Gustavo. Hospital Zonal General de Agudos Descentralizado Evita; Argentina
Fil: Rodriguez, Andrea. Hospital Zonal General de Agudos Descentralizado Evita; Argentina
Fil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Barboza, Edgar. Hospital Zonal General de Agudos Dr. Narciso Lopez; Argentina
Fil: Gago, Guadalupe Fernández. Hospital de Niños de la Plata; Argentina
Fil: Nocito, Celina. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito"; Argentina
Fil: Flamenco, Edgardo. Hospital Zonal General de Agudos Dr. Arturo Onativia; Argentina
Fil: Perez, Alberto Rodriguez. Hospital Zonal General de Agudos Dr. Alberto Eurnekian; Argentina
Fil: Rebec, Beatriz. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal General de Agudos Presidente Peron; Argentina
Fil: Ferolla, Fausto Martín. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Karron, Ruth A.. No especifíca;
Fil: Bergel, Eduardo. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina. Vanderbilt University; Estados Unidos
Materia
BACTERIAL SUPERINFECTIONS
MORTALITY
PNEUMOTHORAX
RESPIRATORY SYNCYTIAL VIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117698
Acceder
id CONICETDig_4ab0f734c2f092492cf8a045898b8a1a
oai_identifier_str oai:ri.conicet.gov.ar:11336/117698
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mortality due to Respiratory Syncytial Virus. Burden and Risk FactorsGeoghegan, SarahErviti, AnabellaCaballero, Mauricio TomásVallone, Fernando DanielZanone, Stella M.Ves Losada, JuanBianchi, AlejandraAcosta, Patricio LeandroTalarico, Laura BeatrizFerretti, AdrianGrimaldi, Luciano AlvaSancilio, AndreaDueñas, KarinaSastre, GustavoRodriguez, AndreaFerrero, FernandoBarboza, EdgarGago, Guadalupe FernándezNocito, CelinaFlamenco, EdgardoPerez, Alberto RodriguezRebec, BeatrizFerolla, Fausto MartínLibster, Romina PaulaKarron, Ruth A.Bergel, EduardoPolack, Fernando PedroBACTERIAL SUPERINFECTIONSMORTALITYPNEUMOTHORAXRESPIRATORY SYNCYTIAL VIRUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Rationale: Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important cause of death in infants in the developing world. The relative contribution of social, biologic, and clinical risk factors to RSV mortality in low-income regions is unclear. Objectives: To determine the burden and risk factors for mortality due to RSV in a low-income population of 84,840 infants. Methods: This was a prospective, population-based, crosssectional, multicenter study conducted between 2011 and 2013. Hospitalizations and deaths due to severe lower respiratory tract illness (LRTI) were recorded during the RSV season. All-cause hospital deaths and community deaths were monitored. Risk factors for respiratory failure (RF) and mortality due to RSV were assessed using a hierarchical, logistic regression model. Measurements and Main Results: A total of 2,588 (65.5%) infants with severe LRTI were infected with RSV. A total of 157 infants (148 postneonatal) experienced RF or died with RSV. RSV LRTI accounted for 57% fatal LRTI tested for the virus. A diagnosis of sepsis (odds ratio [OR], 17.03; 95% confidence interval [CI], 13.14-21.16 for RF) (OR, 119.39; 95% CI, 50.98-273.34 for death) and pneumothorax (OR, 17.15; 95% CI, 13.07-21.01 for RF) (OR, 65.49; 95% CI, 28.90-139.17 for death) were the main determinants of poor outcomes. Conclusions: RSV was the most frequent cause of mortality in lowincome postneonatal infants. RF and death due to RSV LRTI, almost exclusively associated with prematurity and cardiopulmonary diseases in industrialized countries, primarily affect term infants in a developing world environment. Poor outcomes at hospitals are frequent and associated with the cooccurrence of bacterial sepsis and clinically significant pneumothoraxes.Fil: Geoghegan, Sarah. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Erviti, Anabella. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vallone, Fernando Daniel. Región Sanitaria I. - Gobierno de la Provincia de Buenos Aires. Ministerio de Salud. Region Sanitaria I.; ArgentinaFil: Zanone, Stella M.. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Ves Losada, Juan. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Bianchi, Alejandra. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Acosta, Patricio Leandro. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Talarico, Laura Beatriz. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferretti, Adrian. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Grimaldi, Luciano Alva. Hospital Melendez; ArgentinaFil: Sancilio, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Dueñas, Karina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Sastre, Gustavo. Hospital Zonal General de Agudos Descentralizado Evita; ArgentinaFil: Rodriguez, Andrea. Hospital Zonal General de Agudos Descentralizado Evita; ArgentinaFil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Barboza, Edgar. Hospital Zonal General de Agudos Dr. Narciso Lopez; ArgentinaFil: Gago, Guadalupe Fernández. Hospital de Niños de la Plata; ArgentinaFil: Nocito, Celina. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito"; ArgentinaFil: Flamenco, Edgardo. Hospital Zonal General de Agudos Dr. Arturo Onativia; ArgentinaFil: Perez, Alberto Rodriguez. Hospital Zonal General de Agudos Dr. Alberto Eurnekian; ArgentinaFil: Rebec, Beatriz. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal General de Agudos Presidente Peron; ArgentinaFil: Ferolla, Fausto Martín. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Karron, Ruth A.. No especifíca;Fil: Bergel, Eduardo. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina. Vanderbilt University; Estados UnidosAmerican Thoracic Society2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117698Geoghegan, Sarah; Erviti, Anabella; Caballero, Mauricio Tomás; Vallone, Fernando Daniel; Zanone, Stella M.; et al.; Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors; American Thoracic Society; American Journal of Respiratory and Critical Care Medicine; 195; 1; 1-2017; 96-1031073-449XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.atsjournals.org/doi/10.1164/rccm.201603-0658OCinfo:eu-repo/semantics/altIdentifier/doi/10.1164/rccm.201603-0658OCinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:53Zoai:ri.conicet.gov.ar:11336/117698instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:53.815CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors
title Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors
spellingShingle Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors
Geoghegan, Sarah
BACTERIAL SUPERINFECTIONS
MORTALITY
PNEUMOTHORAX
RESPIRATORY SYNCYTIAL VIRUS
title_short Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors
title_full Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors
title_fullStr Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors
title_full_unstemmed Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors
title_sort Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors
dc.creator.none.fl_str_mv Geoghegan, Sarah
Erviti, Anabella
Caballero, Mauricio Tomás
Vallone, Fernando Daniel
Zanone, Stella M.
Ves Losada, Juan
Bianchi, Alejandra
Acosta, Patricio Leandro
Talarico, Laura Beatriz
Ferretti, Adrian
Grimaldi, Luciano Alva
Sancilio, Andrea
Dueñas, Karina
Sastre, Gustavo
Rodriguez, Andrea
Ferrero, Fernando
Barboza, Edgar
Gago, Guadalupe Fernández
Nocito, Celina
Flamenco, Edgardo
Perez, Alberto Rodriguez
Rebec, Beatriz
Ferolla, Fausto Martín
Libster, Romina Paula
Karron, Ruth A.
Bergel, Eduardo
Polack, Fernando Pedro
author Geoghegan, Sarah
author_facet Geoghegan, Sarah
Erviti, Anabella
Caballero, Mauricio Tomás
Vallone, Fernando Daniel
Zanone, Stella M.
Ves Losada, Juan
Bianchi, Alejandra
Acosta, Patricio Leandro
Talarico, Laura Beatriz
Ferretti, Adrian
Grimaldi, Luciano Alva
Sancilio, Andrea
Dueñas, Karina
Sastre, Gustavo
Rodriguez, Andrea
Ferrero, Fernando
Barboza, Edgar
Gago, Guadalupe Fernández
Nocito, Celina
Flamenco, Edgardo
Perez, Alberto Rodriguez
Rebec, Beatriz
Ferolla, Fausto Martín
Libster, Romina Paula
Karron, Ruth A.
Bergel, Eduardo
Polack, Fernando Pedro
author_role author
author2 Erviti, Anabella
Caballero, Mauricio Tomás
Vallone, Fernando Daniel
Zanone, Stella M.
Ves Losada, Juan
Bianchi, Alejandra
Acosta, Patricio Leandro
Talarico, Laura Beatriz
Ferretti, Adrian
Grimaldi, Luciano Alva
Sancilio, Andrea
Dueñas, Karina
Sastre, Gustavo
Rodriguez, Andrea
Ferrero, Fernando
Barboza, Edgar
Gago, Guadalupe Fernández
Nocito, Celina
Flamenco, Edgardo
Perez, Alberto Rodriguez
Rebec, Beatriz
Ferolla, Fausto Martín
Libster, Romina Paula
Karron, Ruth A.
Bergel, Eduardo
Polack, Fernando Pedro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BACTERIAL SUPERINFECTIONS
MORTALITY
PNEUMOTHORAX
RESPIRATORY SYNCYTIAL VIRUS
topic BACTERIAL SUPERINFECTIONS
MORTALITY
PNEUMOTHORAX
RESPIRATORY SYNCYTIAL VIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Rationale: Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important cause of death in infants in the developing world. The relative contribution of social, biologic, and clinical risk factors to RSV mortality in low-income regions is unclear. Objectives: To determine the burden and risk factors for mortality due to RSV in a low-income population of 84,840 infants. Methods: This was a prospective, population-based, crosssectional, multicenter study conducted between 2011 and 2013. Hospitalizations and deaths due to severe lower respiratory tract illness (LRTI) were recorded during the RSV season. All-cause hospital deaths and community deaths were monitored. Risk factors for respiratory failure (RF) and mortality due to RSV were assessed using a hierarchical, logistic regression model. Measurements and Main Results: A total of 2,588 (65.5%) infants with severe LRTI were infected with RSV. A total of 157 infants (148 postneonatal) experienced RF or died with RSV. RSV LRTI accounted for 57% fatal LRTI tested for the virus. A diagnosis of sepsis (odds ratio [OR], 17.03; 95% confidence interval [CI], 13.14-21.16 for RF) (OR, 119.39; 95% CI, 50.98-273.34 for death) and pneumothorax (OR, 17.15; 95% CI, 13.07-21.01 for RF) (OR, 65.49; 95% CI, 28.90-139.17 for death) were the main determinants of poor outcomes. Conclusions: RSV was the most frequent cause of mortality in lowincome postneonatal infants. RF and death due to RSV LRTI, almost exclusively associated with prematurity and cardiopulmonary diseases in industrialized countries, primarily affect term infants in a developing world environment. Poor outcomes at hospitals are frequent and associated with the cooccurrence of bacterial sepsis and clinically significant pneumothoraxes.
Fil: Geoghegan, Sarah. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Erviti, Anabella. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vallone, Fernando Daniel. Región Sanitaria I. - Gobierno de la Provincia de Buenos Aires. Ministerio de Salud. Region Sanitaria I.; Argentina
Fil: Zanone, Stella M.. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Ves Losada, Juan. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Bianchi, Alejandra. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Acosta, Patricio Leandro. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Talarico, Laura Beatriz. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferretti, Adrian. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Grimaldi, Luciano Alva. Hospital Melendez; Argentina
Fil: Sancilio, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Dueñas, Karina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Sastre, Gustavo. Hospital Zonal General de Agudos Descentralizado Evita; Argentina
Fil: Rodriguez, Andrea. Hospital Zonal General de Agudos Descentralizado Evita; Argentina
Fil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Barboza, Edgar. Hospital Zonal General de Agudos Dr. Narciso Lopez; Argentina
Fil: Gago, Guadalupe Fernández. Hospital de Niños de la Plata; Argentina
Fil: Nocito, Celina. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito"; Argentina
Fil: Flamenco, Edgardo. Hospital Zonal General de Agudos Dr. Arturo Onativia; Argentina
Fil: Perez, Alberto Rodriguez. Hospital Zonal General de Agudos Dr. Alberto Eurnekian; Argentina
Fil: Rebec, Beatriz. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal General de Agudos Presidente Peron; Argentina
Fil: Ferolla, Fausto Martín. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Karron, Ruth A.. No especifíca;
Fil: Bergel, Eduardo. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina. Vanderbilt University; Estados Unidos
description Rationale: Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important cause of death in infants in the developing world. The relative contribution of social, biologic, and clinical risk factors to RSV mortality in low-income regions is unclear. Objectives: To determine the burden and risk factors for mortality due to RSV in a low-income population of 84,840 infants. Methods: This was a prospective, population-based, crosssectional, multicenter study conducted between 2011 and 2013. Hospitalizations and deaths due to severe lower respiratory tract illness (LRTI) were recorded during the RSV season. All-cause hospital deaths and community deaths were monitored. Risk factors for respiratory failure (RF) and mortality due to RSV were assessed using a hierarchical, logistic regression model. Measurements and Main Results: A total of 2,588 (65.5%) infants with severe LRTI were infected with RSV. A total of 157 infants (148 postneonatal) experienced RF or died with RSV. RSV LRTI accounted for 57% fatal LRTI tested for the virus. A diagnosis of sepsis (odds ratio [OR], 17.03; 95% confidence interval [CI], 13.14-21.16 for RF) (OR, 119.39; 95% CI, 50.98-273.34 for death) and pneumothorax (OR, 17.15; 95% CI, 13.07-21.01 for RF) (OR, 65.49; 95% CI, 28.90-139.17 for death) were the main determinants of poor outcomes. Conclusions: RSV was the most frequent cause of mortality in lowincome postneonatal infants. RF and death due to RSV LRTI, almost exclusively associated with prematurity and cardiopulmonary diseases in industrialized countries, primarily affect term infants in a developing world environment. Poor outcomes at hospitals are frequent and associated with the cooccurrence of bacterial sepsis and clinically significant pneumothoraxes.
publishDate 2017
dc.date.none.fl_str_mv 2017-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117698
Geoghegan, Sarah; Erviti, Anabella; Caballero, Mauricio Tomás; Vallone, Fernando Daniel; Zanone, Stella M.; et al.; Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors; American Thoracic Society; American Journal of Respiratory and Critical Care Medicine; 195; 1; 1-2017; 96-103
1073-449X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117698
identifier_str_mv Geoghegan, Sarah; Erviti, Anabella; Caballero, Mauricio Tomás; Vallone, Fernando Daniel; Zanone, Stella M.; et al.; Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors; American Thoracic Society; American Journal of Respiratory and Critical Care Medicine; 195; 1; 1-2017; 96-103
1073-449X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.atsjournals.org/doi/10.1164/rccm.201603-0658OC
info:eu-repo/semantics/altIdentifier/doi/10.1164/rccm.201603-0658OC
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv American Thoracic Society
publisher.none.fl_str_mv American Thoracic Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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