Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers

Autores
Almeida Marrero, Verónica; Bethlehem, Fleur; Longo, Sara; Bertolino, María Candelaria; Torres, Tomás; Huskens, Jurriaan; de la Escosura, Andrés
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)-nanocarrier system that binds efficiently to siglec-10, a member of the CD33 family of siglecs (sialic acid (SA)-binding immunoglobulin-like lectins). In particular, a zinc phthalocyanine derivative bearing three SA moieties (PcSA) has been incorporated in the membrane of small unilamellar vesicles (SUVs), retaining its photophysical properties upon insertion into the SUV's membrane. The interaction of these biohybrid systems with human siglec-10-displaying supported lipid bilayers (SLBs) has shown the occurrence of weakly multivalent, superselective interactions between vesicle and SLB. The SLB therefore acts as an excellent cell membrane mimic, while the binding with PS-loaded SUVs shows the potential for targeting siglec-expressing cells with photosensitizing nanocarriers.
Fil: Almeida Marrero, Verónica. Universidad Autónoma de Madrid; España
Fil: Bethlehem, Fleur. Universiteit Twente (ut); . University of Twente. Faculty of Science and Technology; Países Bajos
Fil: Longo, Sara. Universiteit Twente (ut); . University of Twente. Faculty of Science and Technology; Países Bajos
Fil: Bertolino, María Candelaria. Universiteit Twente (ut); . University of Twente. Faculty of Science and Technology; Países Bajos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Torres, Tomás. Universidad Autónoma de Madrid; España. IMDEA Nanoscience; España
Fil: Huskens, Jurriaan. University of Twente. Faculty of Science and Technology; Países Bajos
Fil: de la Escosura, Andrés. Universidad Autónoma de Madrid; España. Institute for Advanced Research in Chemistry; España
Materia
LIPOSOME NANOCARRIERS
MULTIVALENCY
PHOTOSENSITIZER
SIGLECS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/218082
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/218082
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriersAlmeida Marrero, VerónicaBethlehem, FleurLongo, SaraBertolino, María CandelariaTorres, TomásHuskens, Jurriaande la Escosura, AndrésLIPOSOME NANOCARRIERSMULTIVALENCYPHOTOSENSITIZERSIGLECShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)-nanocarrier system that binds efficiently to siglec-10, a member of the CD33 family of siglecs (sialic acid (SA)-binding immunoglobulin-like lectins). In particular, a zinc phthalocyanine derivative bearing three SA moieties (PcSA) has been incorporated in the membrane of small unilamellar vesicles (SUVs), retaining its photophysical properties upon insertion into the SUV's membrane. The interaction of these biohybrid systems with human siglec-10-displaying supported lipid bilayers (SLBs) has shown the occurrence of weakly multivalent, superselective interactions between vesicle and SLB. The SLB therefore acts as an excellent cell membrane mimic, while the binding with PS-loaded SUVs shows the potential for targeting siglec-expressing cells with photosensitizing nanocarriers.Fil: Almeida Marrero, Verónica. Universidad Autónoma de Madrid; EspañaFil: Bethlehem, Fleur. Universiteit Twente (ut); . University of Twente. Faculty of Science and Technology; Países BajosFil: Longo, Sara. Universiteit Twente (ut); . University of Twente. Faculty of Science and Technology; Países BajosFil: Bertolino, María Candelaria. Universiteit Twente (ut); . University of Twente. Faculty of Science and Technology; Países Bajos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Torres, Tomás. Universidad Autónoma de Madrid; España. IMDEA Nanoscience; EspañaFil: Huskens, Jurriaan. University of Twente. Faculty of Science and Technology; Países BajosFil: de la Escosura, Andrés. Universidad Autónoma de Madrid; España. Institute for Advanced Research in Chemistry; EspañaWiley VCH Verlag2022-07-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218082Almeida Marrero, Verónica; Bethlehem, Fleur; Longo, Sara; Bertolino, María Candelaria; Torres, Tomás; et al.; Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers; Wiley VCH Verlag; Angewandte Chemie; 61; 31; 02-7-2022; 1-81433-78511521-3773CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/anie.202206900info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/anie.202206900info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:00:31Zoai:ri.conicet.gov.ar:11336/218082instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:00:31.659CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers
title Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers
spellingShingle Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers
Almeida Marrero, Verónica
LIPOSOME NANOCARRIERS
MULTIVALENCY
PHOTOSENSITIZER
SIGLECS
title_short Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers
title_full Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers
title_fullStr Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers
title_full_unstemmed Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers
title_sort Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers
dc.creator.none.fl_str_mv Almeida Marrero, Verónica
Bethlehem, Fleur
Longo, Sara
Bertolino, María Candelaria
Torres, Tomás
Huskens, Jurriaan
de la Escosura, Andrés
author Almeida Marrero, Verónica
author_facet Almeida Marrero, Verónica
Bethlehem, Fleur
Longo, Sara
Bertolino, María Candelaria
Torres, Tomás
Huskens, Jurriaan
de la Escosura, Andrés
author_role author
author2 Bethlehem, Fleur
Longo, Sara
Bertolino, María Candelaria
Torres, Tomás
Huskens, Jurriaan
de la Escosura, Andrés
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv LIPOSOME NANOCARRIERS
MULTIVALENCY
PHOTOSENSITIZER
SIGLECS
topic LIPOSOME NANOCARRIERS
MULTIVALENCY
PHOTOSENSITIZER
SIGLECS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)-nanocarrier system that binds efficiently to siglec-10, a member of the CD33 family of siglecs (sialic acid (SA)-binding immunoglobulin-like lectins). In particular, a zinc phthalocyanine derivative bearing three SA moieties (PcSA) has been incorporated in the membrane of small unilamellar vesicles (SUVs), retaining its photophysical properties upon insertion into the SUV's membrane. The interaction of these biohybrid systems with human siglec-10-displaying supported lipid bilayers (SLBs) has shown the occurrence of weakly multivalent, superselective interactions between vesicle and SLB. The SLB therefore acts as an excellent cell membrane mimic, while the binding with PS-loaded SUVs shows the potential for targeting siglec-expressing cells with photosensitizing nanocarriers.
Fil: Almeida Marrero, Verónica. Universidad Autónoma de Madrid; España
Fil: Bethlehem, Fleur. Universiteit Twente (ut); . University of Twente. Faculty of Science and Technology; Países Bajos
Fil: Longo, Sara. Universiteit Twente (ut); . University of Twente. Faculty of Science and Technology; Países Bajos
Fil: Bertolino, María Candelaria. Universiteit Twente (ut); . University of Twente. Faculty of Science and Technology; Países Bajos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Torres, Tomás. Universidad Autónoma de Madrid; España. IMDEA Nanoscience; España
Fil: Huskens, Jurriaan. University of Twente. Faculty of Science and Technology; Países Bajos
Fil: de la Escosura, Andrés. Universidad Autónoma de Madrid; España. Institute for Advanced Research in Chemistry; España
description The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)-nanocarrier system that binds efficiently to siglec-10, a member of the CD33 family of siglecs (sialic acid (SA)-binding immunoglobulin-like lectins). In particular, a zinc phthalocyanine derivative bearing three SA moieties (PcSA) has been incorporated in the membrane of small unilamellar vesicles (SUVs), retaining its photophysical properties upon insertion into the SUV's membrane. The interaction of these biohybrid systems with human siglec-10-displaying supported lipid bilayers (SLBs) has shown the occurrence of weakly multivalent, superselective interactions between vesicle and SLB. The SLB therefore acts as an excellent cell membrane mimic, while the binding with PS-loaded SUVs shows the potential for targeting siglec-expressing cells with photosensitizing nanocarriers.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/218082
Almeida Marrero, Verónica; Bethlehem, Fleur; Longo, Sara; Bertolino, María Candelaria; Torres, Tomás; et al.; Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers; Wiley VCH Verlag; Angewandte Chemie; 61; 31; 02-7-2022; 1-8
1433-7851
1521-3773
CONICET Digital
CONICET
url http://hdl.handle.net/11336/218082
identifier_str_mv Almeida Marrero, Verónica; Bethlehem, Fleur; Longo, Sara; Bertolino, María Candelaria; Torres, Tomás; et al.; Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers; Wiley VCH Verlag; Angewandte Chemie; 61; 31; 02-7-2022; 1-8
1433-7851
1521-3773
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/anie.202206900
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/anie.202206900
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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