Increased MMP-2 in healthy postmenopausal women

Autores
Muzzio, Maria Luz; Miksztowicz, Verónica Julieta; Repetto, Esteban Martín; Brites, Fernando Daniel; Berg, Gabriela Alicia; Schreier, Laura Ester
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Matrix metalloproteases 2 (MMP-2) and 9 (MMP-9) are involved in the atherosclerosis process. The objective of the study was to evaluate MMP-2 and MMP-9 activities and other circulating inflammatory factors in healthy postmenopausal women (PMW) as a model of subclinical atherosclerosis. Methods: Twenty-three PMW and 13 premenopausal women (PreMW) were selected following established criteria. The main measurements in plasma samples were: lipid –lipoprotein profile, high-sensitivity C-reactive protein (hs-CRP) (immunoturbidimetry), soluble vascular cellular adhesion molecules (sVCAM-1) enzyme-linked immunosorbent assay and MMP activity by zymography. Results: The relative areas of MMP-2 were increased in PMW: 1.1 (0.1) versus 0.6 (0.05), P , 0.02. MMP-9 was only detected in three PMWand one PreMW. MMP-2 correlated with HDL-cholesterol (r ¼ 20.51), triglycerides (r ¼ 0.67), apolipoprotein B (r ¼ 0.47), hs-CRP (r ¼ 0.42), homeostasis model assessment (r ¼ 0.53) and waist circumference (r ¼ 0.40), at least P , 0.02. sVCAM-1 showed no difference between groups: 28.7 (5.5) versus 35.5 (20) ng/mL, but correlated with MMP-2 and hs-CRP (r ¼ 0.46 and r ¼ 0.48 respectively, P , 0.05). Conclusions: In postmenopause, the increase in MMP-2 reflects the systemic specific inflammatory process that accompanies atherogenesis.
Fil: Muzzio, Maria Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Repetto, Esteban Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Materia
Metalloproteases
Atherosclerosis
postmenopausal
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268999
Acceder
id CONICETDig_8c649cd224ef5be3d1715342474cf499
oai_identifier_str oai:ri.conicet.gov.ar:11336/268999
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Increased MMP-2 in healthy postmenopausal womenMuzzio, Maria LuzMiksztowicz, Verónica JulietaRepetto, Esteban MartínBrites, Fernando DanielBerg, Gabriela AliciaSchreier, Laura EsterMetalloproteasesAtherosclerosispostmenopausalhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Matrix metalloproteases 2 (MMP-2) and 9 (MMP-9) are involved in the atherosclerosis process. The objective of the study was to evaluate MMP-2 and MMP-9 activities and other circulating inflammatory factors in healthy postmenopausal women (PMW) as a model of subclinical atherosclerosis. Methods: Twenty-three PMW and 13 premenopausal women (PreMW) were selected following established criteria. The main measurements in plasma samples were: lipid –lipoprotein profile, high-sensitivity C-reactive protein (hs-CRP) (immunoturbidimetry), soluble vascular cellular adhesion molecules (sVCAM-1) enzyme-linked immunosorbent assay and MMP activity by zymography. Results: The relative areas of MMP-2 were increased in PMW: 1.1 (0.1) versus 0.6 (0.05), P , 0.02. MMP-9 was only detected in three PMWand one PreMW. MMP-2 correlated with HDL-cholesterol (r ¼ 20.51), triglycerides (r ¼ 0.67), apolipoprotein B (r ¼ 0.47), hs-CRP (r ¼ 0.42), homeostasis model assessment (r ¼ 0.53) and waist circumference (r ¼ 0.40), at least P , 0.02. sVCAM-1 showed no difference between groups: 28.7 (5.5) versus 35.5 (20) ng/mL, but correlated with MMP-2 and hs-CRP (r ¼ 0.46 and r ¼ 0.48 respectively, P , 0.05). Conclusions: In postmenopause, the increase in MMP-2 reflects the systemic specific inflammatory process that accompanies atherogenesis.Fil: Muzzio, Maria Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Repetto, Esteban Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaSAGE Publications2011-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268999Muzzio, Maria Luz; Miksztowicz, Verónica Julieta; Repetto, Esteban Martín; Brites, Fernando Daniel; Berg, Gabriela Alicia; et al.; Increased MMP-2 in healthy postmenopausal women; SAGE Publications; Annals Of Clinical Biochemistry; 49; 1; 10-2011; 75-790004-5632CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1258/acb.2011.011041info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:09Zoai:ri.conicet.gov.ar:11336/268999instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:09.799CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Increased MMP-2 in healthy postmenopausal women
title Increased MMP-2 in healthy postmenopausal women
spellingShingle Increased MMP-2 in healthy postmenopausal women
Muzzio, Maria Luz
Metalloproteases
Atherosclerosis
postmenopausal
title_short Increased MMP-2 in healthy postmenopausal women
title_full Increased MMP-2 in healthy postmenopausal women
title_fullStr Increased MMP-2 in healthy postmenopausal women
title_full_unstemmed Increased MMP-2 in healthy postmenopausal women
title_sort Increased MMP-2 in healthy postmenopausal women
dc.creator.none.fl_str_mv Muzzio, Maria Luz
Miksztowicz, Verónica Julieta
Repetto, Esteban Martín
Brites, Fernando Daniel
Berg, Gabriela Alicia
Schreier, Laura Ester
author Muzzio, Maria Luz
author_facet Muzzio, Maria Luz
Miksztowicz, Verónica Julieta
Repetto, Esteban Martín
Brites, Fernando Daniel
Berg, Gabriela Alicia
Schreier, Laura Ester
author_role author
author2 Miksztowicz, Verónica Julieta
Repetto, Esteban Martín
Brites, Fernando Daniel
Berg, Gabriela Alicia
Schreier, Laura Ester
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Metalloproteases
Atherosclerosis
postmenopausal
topic Metalloproteases
Atherosclerosis
postmenopausal
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Matrix metalloproteases 2 (MMP-2) and 9 (MMP-9) are involved in the atherosclerosis process. The objective of the study was to evaluate MMP-2 and MMP-9 activities and other circulating inflammatory factors in healthy postmenopausal women (PMW) as a model of subclinical atherosclerosis. Methods: Twenty-three PMW and 13 premenopausal women (PreMW) were selected following established criteria. The main measurements in plasma samples were: lipid –lipoprotein profile, high-sensitivity C-reactive protein (hs-CRP) (immunoturbidimetry), soluble vascular cellular adhesion molecules (sVCAM-1) enzyme-linked immunosorbent assay and MMP activity by zymography. Results: The relative areas of MMP-2 were increased in PMW: 1.1 (0.1) versus 0.6 (0.05), P , 0.02. MMP-9 was only detected in three PMWand one PreMW. MMP-2 correlated with HDL-cholesterol (r ¼ 20.51), triglycerides (r ¼ 0.67), apolipoprotein B (r ¼ 0.47), hs-CRP (r ¼ 0.42), homeostasis model assessment (r ¼ 0.53) and waist circumference (r ¼ 0.40), at least P , 0.02. sVCAM-1 showed no difference between groups: 28.7 (5.5) versus 35.5 (20) ng/mL, but correlated with MMP-2 and hs-CRP (r ¼ 0.46 and r ¼ 0.48 respectively, P , 0.05). Conclusions: In postmenopause, the increase in MMP-2 reflects the systemic specific inflammatory process that accompanies atherogenesis.
Fil: Muzzio, Maria Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Repetto, Esteban Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
description Background: Matrix metalloproteases 2 (MMP-2) and 9 (MMP-9) are involved in the atherosclerosis process. The objective of the study was to evaluate MMP-2 and MMP-9 activities and other circulating inflammatory factors in healthy postmenopausal women (PMW) as a model of subclinical atherosclerosis. Methods: Twenty-three PMW and 13 premenopausal women (PreMW) were selected following established criteria. The main measurements in plasma samples were: lipid –lipoprotein profile, high-sensitivity C-reactive protein (hs-CRP) (immunoturbidimetry), soluble vascular cellular adhesion molecules (sVCAM-1) enzyme-linked immunosorbent assay and MMP activity by zymography. Results: The relative areas of MMP-2 were increased in PMW: 1.1 (0.1) versus 0.6 (0.05), P , 0.02. MMP-9 was only detected in three PMWand one PreMW. MMP-2 correlated with HDL-cholesterol (r ¼ 20.51), triglycerides (r ¼ 0.67), apolipoprotein B (r ¼ 0.47), hs-CRP (r ¼ 0.42), homeostasis model assessment (r ¼ 0.53) and waist circumference (r ¼ 0.40), at least P , 0.02. sVCAM-1 showed no difference between groups: 28.7 (5.5) versus 35.5 (20) ng/mL, but correlated with MMP-2 and hs-CRP (r ¼ 0.46 and r ¼ 0.48 respectively, P , 0.05). Conclusions: In postmenopause, the increase in MMP-2 reflects the systemic specific inflammatory process that accompanies atherogenesis.
publishDate 2011
dc.date.none.fl_str_mv 2011-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268999
Muzzio, Maria Luz; Miksztowicz, Verónica Julieta; Repetto, Esteban Martín; Brites, Fernando Daniel; Berg, Gabriela Alicia; et al.; Increased MMP-2 in healthy postmenopausal women; SAGE Publications; Annals Of Clinical Biochemistry; 49; 1; 10-2011; 75-79
0004-5632
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268999
identifier_str_mv Muzzio, Maria Luz; Miksztowicz, Verónica Julieta; Repetto, Esteban Martín; Brites, Fernando Daniel; Berg, Gabriela Alicia; et al.; Increased MMP-2 in healthy postmenopausal women; SAGE Publications; Annals Of Clinical Biochemistry; 49; 1; 10-2011; 75-79
0004-5632
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1258/acb.2011.011041
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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