Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients

Autores
Muzzio, María Luz; Miksztowicz, Verónica Julieta; Brites, Fernando Daniel; Aguilar Martinez, Daniel; Repetto, Esteban Martin; Wikinski, Regina; Tavella, Marcelo Andres; Schreier, Laura Ester; Berg, Gabriela Alicia
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background and Aims: Many studies suggest that the different steps of the atherosclerotic process may be mediated by metalloproteases (MMPs). MMP-9 and MMP-2, which are highly expressed in the vulnerable regions of the atherosclerotic plaques, have been suggested to be causally involved in plaque rupture. In another manner linked with LDL, lipoprotein-associated phospholipase A2 (Lp-PLA2) hydrolyzes phospholipids generating proinflammatory and proatherogenic products. Our aim was to evaluate plasma activity of MMP-2 and 9, as well as Lp-PLA2, in subjects with coronary artery stenosis in comparison with controls and to correlate these activities with lipoprotein profile and general biomarkers of inflammation. Methods: Forty two subjects who had undergone coronary angiography were divided into two groups: patients with coronary vessels with at least 45% stenosis (CAD [coronary artery disease], n = 24) and patients without angiographically detectable coronary artery disease (controls, n = 18). Plasma activity of MMP-2 and MMP-9 was measured and correlated with markers of systemic inflammation (hs-CRP), subendothelial inflammation (Lp-PLA2) and lipoprotein profile. Results: Plasma activity of both MMPs was consistently higher in patients than in controls (p <0.01). Pro-MMP-2 (r = 0.34, p <0.01) and MMP-9 (r = 0.51, p <0.02) activities correlated with apoprotein B. Pro-MMP-2 correlated with hs-CRP (r = 0.47, p <0.01) and inversely with HDL cholesterol (r = –0.35, p <0.02). No differences were observed in Lp-PLA2 between patients and controls (15.2 ± 4.0 vs. 15.4 ± 4.5 μmol/mL/h, p = NS, respectively), and no correlation was observed with MMPs. Conclusions: MMP activity was higher in CAD than in controls. The correlation observed between pro-MMP-2 and high-sensitive C-reactive protein (hs-CRP) may be due to specific systemic inflammatory processes. No correlation was observed between Lp-PLA2 and MMPs.
Fil: Muzzio, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aguilar Martinez, Daniel. Universidad Nacional de La Plata; Argentina
Fil: Repetto, Esteban Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wikinski, Regina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Tavella, Marcelo Andres. Universidad Nacional de La Plata; Argentina
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Metalloproteases
Plaque Vulnerability
Lp-Pla2 Lipoproteins
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20194
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/20194
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patientsMuzzio, María LuzMiksztowicz, Verónica JulietaBrites, Fernando DanielAguilar Martinez, DanielRepetto, Esteban MartinWikinski, ReginaTavella, Marcelo AndresSchreier, Laura EsterBerg, Gabriela AliciaMetalloproteasesPlaque VulnerabilityLp-Pla2 Lipoproteinshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background and Aims: Many studies suggest that the different steps of the atherosclerotic process may be mediated by metalloproteases (MMPs). MMP-9 and MMP-2, which are highly expressed in the vulnerable regions of the atherosclerotic plaques, have been suggested to be causally involved in plaque rupture. In another manner linked with LDL, lipoprotein-associated phospholipase A2 (Lp-PLA2) hydrolyzes phospholipids generating proinflammatory and proatherogenic products. Our aim was to evaluate plasma activity of MMP-2 and 9, as well as Lp-PLA2, in subjects with coronary artery stenosis in comparison with controls and to correlate these activities with lipoprotein profile and general biomarkers of inflammation. Methods: Forty two subjects who had undergone coronary angiography were divided into two groups: patients with coronary vessels with at least 45% stenosis (CAD [coronary artery disease], n = 24) and patients without angiographically detectable coronary artery disease (controls, n = 18). Plasma activity of MMP-2 and MMP-9 was measured and correlated with markers of systemic inflammation (hs-CRP), subendothelial inflammation (Lp-PLA2) and lipoprotein profile. Results: Plasma activity of both MMPs was consistently higher in patients than in controls (p <0.01). Pro-MMP-2 (r = 0.34, p <0.01) and MMP-9 (r = 0.51, p <0.02) activities correlated with apoprotein B. Pro-MMP-2 correlated with hs-CRP (r = 0.47, p <0.01) and inversely with HDL cholesterol (r = –0.35, p <0.02). No differences were observed in Lp-PLA2 between patients and controls (15.2 ± 4.0 vs. 15.4 ± 4.5 μmol/mL/h, p = NS, respectively), and no correlation was observed with MMPs. Conclusions: MMP activity was higher in CAD than in controls. The correlation observed between pro-MMP-2 and high-sensitive C-reactive protein (hs-CRP) may be due to specific systemic inflammatory processes. No correlation was observed between Lp-PLA2 and MMPs.Fil: Muzzio, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aguilar Martinez, Daniel. Universidad Nacional de La Plata; ArgentinaFil: Repetto, Esteban Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Wikinski, Regina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Tavella, Marcelo Andres. Universidad Nacional de La Plata; ArgentinaFil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Inc2009-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20194Muzzio, María Luz; Miksztowicz, Verónica Julieta; Brites, Fernando Daniel; Aguilar Martinez, Daniel; Repetto, Esteban Martin; et al.; Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients; Elsevier Inc; Archives Of Medical Research (eletronico); 40; 1; 1-2009; 48-530188-4409CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0188440908002567info:eu-repo/semantics/altIdentifier/doi/10.1016/j.arcmed.2008.10.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:21Zoai:ri.conicet.gov.ar:11336/20194instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:22.216CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
title Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
spellingShingle Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
Muzzio, María Luz
Metalloproteases
Plaque Vulnerability
Lp-Pla2 Lipoproteins
title_short Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
title_full Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
title_fullStr Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
title_full_unstemmed Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
title_sort Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
dc.creator.none.fl_str_mv Muzzio, María Luz
Miksztowicz, Verónica Julieta
Brites, Fernando Daniel
Aguilar Martinez, Daniel
Repetto, Esteban Martin
Wikinski, Regina
Tavella, Marcelo Andres
Schreier, Laura Ester
Berg, Gabriela Alicia
author Muzzio, María Luz
author_facet Muzzio, María Luz
Miksztowicz, Verónica Julieta
Brites, Fernando Daniel
Aguilar Martinez, Daniel
Repetto, Esteban Martin
Wikinski, Regina
Tavella, Marcelo Andres
Schreier, Laura Ester
Berg, Gabriela Alicia
author_role author
author2 Miksztowicz, Verónica Julieta
Brites, Fernando Daniel
Aguilar Martinez, Daniel
Repetto, Esteban Martin
Wikinski, Regina
Tavella, Marcelo Andres
Schreier, Laura Ester
Berg, Gabriela Alicia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Metalloproteases
Plaque Vulnerability
Lp-Pla2 Lipoproteins
topic Metalloproteases
Plaque Vulnerability
Lp-Pla2 Lipoproteins
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background and Aims: Many studies suggest that the different steps of the atherosclerotic process may be mediated by metalloproteases (MMPs). MMP-9 and MMP-2, which are highly expressed in the vulnerable regions of the atherosclerotic plaques, have been suggested to be causally involved in plaque rupture. In another manner linked with LDL, lipoprotein-associated phospholipase A2 (Lp-PLA2) hydrolyzes phospholipids generating proinflammatory and proatherogenic products. Our aim was to evaluate plasma activity of MMP-2 and 9, as well as Lp-PLA2, in subjects with coronary artery stenosis in comparison with controls and to correlate these activities with lipoprotein profile and general biomarkers of inflammation. Methods: Forty two subjects who had undergone coronary angiography were divided into two groups: patients with coronary vessels with at least 45% stenosis (CAD [coronary artery disease], n = 24) and patients without angiographically detectable coronary artery disease (controls, n = 18). Plasma activity of MMP-2 and MMP-9 was measured and correlated with markers of systemic inflammation (hs-CRP), subendothelial inflammation (Lp-PLA2) and lipoprotein profile. Results: Plasma activity of both MMPs was consistently higher in patients than in controls (p <0.01). Pro-MMP-2 (r = 0.34, p <0.01) and MMP-9 (r = 0.51, p <0.02) activities correlated with apoprotein B. Pro-MMP-2 correlated with hs-CRP (r = 0.47, p <0.01) and inversely with HDL cholesterol (r = –0.35, p <0.02). No differences were observed in Lp-PLA2 between patients and controls (15.2 ± 4.0 vs. 15.4 ± 4.5 μmol/mL/h, p = NS, respectively), and no correlation was observed with MMPs. Conclusions: MMP activity was higher in CAD than in controls. The correlation observed between pro-MMP-2 and high-sensitive C-reactive protein (hs-CRP) may be due to specific systemic inflammatory processes. No correlation was observed between Lp-PLA2 and MMPs.
Fil: Muzzio, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aguilar Martinez, Daniel. Universidad Nacional de La Plata; Argentina
Fil: Repetto, Esteban Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wikinski, Regina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Tavella, Marcelo Andres. Universidad Nacional de La Plata; Argentina
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background and Aims: Many studies suggest that the different steps of the atherosclerotic process may be mediated by metalloproteases (MMPs). MMP-9 and MMP-2, which are highly expressed in the vulnerable regions of the atherosclerotic plaques, have been suggested to be causally involved in plaque rupture. In another manner linked with LDL, lipoprotein-associated phospholipase A2 (Lp-PLA2) hydrolyzes phospholipids generating proinflammatory and proatherogenic products. Our aim was to evaluate plasma activity of MMP-2 and 9, as well as Lp-PLA2, in subjects with coronary artery stenosis in comparison with controls and to correlate these activities with lipoprotein profile and general biomarkers of inflammation. Methods: Forty two subjects who had undergone coronary angiography were divided into two groups: patients with coronary vessels with at least 45% stenosis (CAD [coronary artery disease], n = 24) and patients without angiographically detectable coronary artery disease (controls, n = 18). Plasma activity of MMP-2 and MMP-9 was measured and correlated with markers of systemic inflammation (hs-CRP), subendothelial inflammation (Lp-PLA2) and lipoprotein profile. Results: Plasma activity of both MMPs was consistently higher in patients than in controls (p <0.01). Pro-MMP-2 (r = 0.34, p <0.01) and MMP-9 (r = 0.51, p <0.02) activities correlated with apoprotein B. Pro-MMP-2 correlated with hs-CRP (r = 0.47, p <0.01) and inversely with HDL cholesterol (r = –0.35, p <0.02). No differences were observed in Lp-PLA2 between patients and controls (15.2 ± 4.0 vs. 15.4 ± 4.5 μmol/mL/h, p = NS, respectively), and no correlation was observed with MMPs. Conclusions: MMP activity was higher in CAD than in controls. The correlation observed between pro-MMP-2 and high-sensitive C-reactive protein (hs-CRP) may be due to specific systemic inflammatory processes. No correlation was observed between Lp-PLA2 and MMPs.
publishDate 2009
dc.date.none.fl_str_mv 2009-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20194
Muzzio, María Luz; Miksztowicz, Verónica Julieta; Brites, Fernando Daniel; Aguilar Martinez, Daniel; Repetto, Esteban Martin; et al.; Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients; Elsevier Inc; Archives Of Medical Research (eletronico); 40; 1; 1-2009; 48-53
0188-4409
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20194
identifier_str_mv Muzzio, María Luz; Miksztowicz, Verónica Julieta; Brites, Fernando Daniel; Aguilar Martinez, Daniel; Repetto, Esteban Martin; et al.; Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients; Elsevier Inc; Archives Of Medical Research (eletronico); 40; 1; 1-2009; 48-53
0188-4409
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0188440908002567
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.arcmed.2008.10.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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