Increased adiposity impairs vascular function in postmenopausal women in hemodialysis

Autores
Santos, Juan C.; Lepera, Mabel; Fernández Serra, Rocío; Alanoca, Saul Pablo; Quipildor, Daniel Franco; de Piero Belmonte, Alexia Juliana; Joo Turoni, Claudio Martín; Peral de Bruno, Maria; Juncos, Luis A.; Marañón, Rodrigo Oscar
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study examines the impact of increased body fat on vascular function in postmenopausal women and old men with chronic kidney disease (CKD) undergoing hemodialysis. We included 34 postmenopausal women with CKD under hemodialysis (PMW-CKD-HDys) and 31 age-matched men with CKD also under hemodialysis (M-CKD-HDys). We assessed blood pressure and endothelial function (EFn) through measurements of flow-mediated dilation (FMD). We also evaluated systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI), fat total index (FTI), and lean total index (LTI). A subgroup of patients with CKD-HDys infected with COVID 19 were also evaluated on their endothelial function. Our findings indicate that SBP was significantly higher in M-CKD-HDys (149 ± 2 mmHg) than in PMW-CKD-HDys (141 ± 3 mmHg; P < 0.05), whereas EFn was similar in both groups. We observed a negative correlation between endothelial function and FTI only in PMW-CKD-HDys, where an increased adipose tissue negatively correlated with a reduced endothelial function. Interestingly, this endothelial function finding suggests a worse effect on PMM-CKD-HDys, considering that, in general, healthy women have better EFn than healthy men. In addition, a subgroup of patients who contracted COVID-19 exhibited further deterioration in EFn. The results underscore the critical role of body fat in influencing vascular health in this high-risk population, indicating that interventions aimed at weight management could be pivotal in improving cardiovascular outcomes for postmenopausal women with CKD. These findings highlight the need for tailored therapeutic strategies to enhance endothelial function and overall cardiovascular health in patients with CKD, particularly those postmenopausal women with increased adipose tissue undergoing hemodialysis.
Fil: Santos, Juan C.. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Lepera, Mabel. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Fernández Serra, Rocío. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Alanoca, Saul Pablo. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Quipildor, Daniel Franco. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: de Piero Belmonte, Alexia Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Joo Turoni, Claudio Martín. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Peral de Bruno, Maria. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Juncos, Luis A.. University of Arkansas for Medical Sciences; Estados Unidos
Fil: Marañón, Rodrigo Oscar. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Materia
hronic kidney disease
hemodialysis
obesity
postmenopausal women
vascular function
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/270904
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/270904
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Increased adiposity impairs vascular function in postmenopausal women in hemodialysisSantos, Juan C.Lepera, MabelFernández Serra, RocíoAlanoca, Saul PabloQuipildor, Daniel Francode Piero Belmonte, Alexia JulianaJoo Turoni, Claudio MartínPeral de Bruno, MariaJuncos, Luis A.Marañón, Rodrigo Oscarhronic kidney diseasehemodialysisobesitypostmenopausal womenvascular functionhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3This study examines the impact of increased body fat on vascular function in postmenopausal women and old men with chronic kidney disease (CKD) undergoing hemodialysis. We included 34 postmenopausal women with CKD under hemodialysis (PMW-CKD-HDys) and 31 age-matched men with CKD also under hemodialysis (M-CKD-HDys). We assessed blood pressure and endothelial function (EFn) through measurements of flow-mediated dilation (FMD). We also evaluated systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI), fat total index (FTI), and lean total index (LTI). A subgroup of patients with CKD-HDys infected with COVID 19 were also evaluated on their endothelial function. Our findings indicate that SBP was significantly higher in M-CKD-HDys (149 ± 2 mmHg) than in PMW-CKD-HDys (141 ± 3 mmHg; P < 0.05), whereas EFn was similar in both groups. We observed a negative correlation between endothelial function and FTI only in PMW-CKD-HDys, where an increased adipose tissue negatively correlated with a reduced endothelial function. Interestingly, this endothelial function finding suggests a worse effect on PMM-CKD-HDys, considering that, in general, healthy women have better EFn than healthy men. In addition, a subgroup of patients who contracted COVID-19 exhibited further deterioration in EFn. The results underscore the critical role of body fat in influencing vascular health in this high-risk population, indicating that interventions aimed at weight management could be pivotal in improving cardiovascular outcomes for postmenopausal women with CKD. These findings highlight the need for tailored therapeutic strategies to enhance endothelial function and overall cardiovascular health in patients with CKD, particularly those postmenopausal women with increased adipose tissue undergoing hemodialysis.Fil: Santos, Juan C.. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Lepera, Mabel. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Fernández Serra, Rocío. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Alanoca, Saul Pablo. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Quipildor, Daniel Franco. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: de Piero Belmonte, Alexia Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Joo Turoni, Claudio Martín. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Peral de Bruno, Maria. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Juncos, Luis A.. University of Arkansas for Medical Sciences; Estados UnidosFil: Marañón, Rodrigo Oscar. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaAmerican Physiological Society2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/270904Santos, Juan C.; Lepera, Mabel; Fernández Serra, Rocío; Alanoca, Saul Pablo; Quipildor, Daniel Franco; et al.; Increased adiposity impairs vascular function in postmenopausal women in hemodialysis; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 329; 2; 8-2025; H592-H5990363-6135CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpheart.00430.2025?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orginfo:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.00430.2025info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:00Zoai:ri.conicet.gov.ar:11336/270904instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:01.002CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Increased adiposity impairs vascular function in postmenopausal women in hemodialysis
title Increased adiposity impairs vascular function in postmenopausal women in hemodialysis
spellingShingle Increased adiposity impairs vascular function in postmenopausal women in hemodialysis
Santos, Juan C.
hronic kidney disease
hemodialysis
obesity
postmenopausal women
vascular function
title_short Increased adiposity impairs vascular function in postmenopausal women in hemodialysis
title_full Increased adiposity impairs vascular function in postmenopausal women in hemodialysis
title_fullStr Increased adiposity impairs vascular function in postmenopausal women in hemodialysis
title_full_unstemmed Increased adiposity impairs vascular function in postmenopausal women in hemodialysis
title_sort Increased adiposity impairs vascular function in postmenopausal women in hemodialysis
dc.creator.none.fl_str_mv Santos, Juan C.
Lepera, Mabel
Fernández Serra, Rocío
Alanoca, Saul Pablo
Quipildor, Daniel Franco
de Piero Belmonte, Alexia Juliana
Joo Turoni, Claudio Martín
Peral de Bruno, Maria
Juncos, Luis A.
Marañón, Rodrigo Oscar
author Santos, Juan C.
author_facet Santos, Juan C.
Lepera, Mabel
Fernández Serra, Rocío
Alanoca, Saul Pablo
Quipildor, Daniel Franco
de Piero Belmonte, Alexia Juliana
Joo Turoni, Claudio Martín
Peral de Bruno, Maria
Juncos, Luis A.
Marañón, Rodrigo Oscar
author_role author
author2 Lepera, Mabel
Fernández Serra, Rocío
Alanoca, Saul Pablo
Quipildor, Daniel Franco
de Piero Belmonte, Alexia Juliana
Joo Turoni, Claudio Martín
Peral de Bruno, Maria
Juncos, Luis A.
Marañón, Rodrigo Oscar
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv hronic kidney disease
hemodialysis
obesity
postmenopausal women
vascular function
topic hronic kidney disease
hemodialysis
obesity
postmenopausal women
vascular function
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This study examines the impact of increased body fat on vascular function in postmenopausal women and old men with chronic kidney disease (CKD) undergoing hemodialysis. We included 34 postmenopausal women with CKD under hemodialysis (PMW-CKD-HDys) and 31 age-matched men with CKD also under hemodialysis (M-CKD-HDys). We assessed blood pressure and endothelial function (EFn) through measurements of flow-mediated dilation (FMD). We also evaluated systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI), fat total index (FTI), and lean total index (LTI). A subgroup of patients with CKD-HDys infected with COVID 19 were also evaluated on their endothelial function. Our findings indicate that SBP was significantly higher in M-CKD-HDys (149 ± 2 mmHg) than in PMW-CKD-HDys (141 ± 3 mmHg; P < 0.05), whereas EFn was similar in both groups. We observed a negative correlation between endothelial function and FTI only in PMW-CKD-HDys, where an increased adipose tissue negatively correlated with a reduced endothelial function. Interestingly, this endothelial function finding suggests a worse effect on PMM-CKD-HDys, considering that, in general, healthy women have better EFn than healthy men. In addition, a subgroup of patients who contracted COVID-19 exhibited further deterioration in EFn. The results underscore the critical role of body fat in influencing vascular health in this high-risk population, indicating that interventions aimed at weight management could be pivotal in improving cardiovascular outcomes for postmenopausal women with CKD. These findings highlight the need for tailored therapeutic strategies to enhance endothelial function and overall cardiovascular health in patients with CKD, particularly those postmenopausal women with increased adipose tissue undergoing hemodialysis.
Fil: Santos, Juan C.. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Lepera, Mabel. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Fernández Serra, Rocío. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Alanoca, Saul Pablo. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Quipildor, Daniel Franco. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: de Piero Belmonte, Alexia Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Joo Turoni, Claudio Martín. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Peral de Bruno, Maria. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Juncos, Luis A.. University of Arkansas for Medical Sciences; Estados Unidos
Fil: Marañón, Rodrigo Oscar. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
description This study examines the impact of increased body fat on vascular function in postmenopausal women and old men with chronic kidney disease (CKD) undergoing hemodialysis. We included 34 postmenopausal women with CKD under hemodialysis (PMW-CKD-HDys) and 31 age-matched men with CKD also under hemodialysis (M-CKD-HDys). We assessed blood pressure and endothelial function (EFn) through measurements of flow-mediated dilation (FMD). We also evaluated systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI), fat total index (FTI), and lean total index (LTI). A subgroup of patients with CKD-HDys infected with COVID 19 were also evaluated on their endothelial function. Our findings indicate that SBP was significantly higher in M-CKD-HDys (149 ± 2 mmHg) than in PMW-CKD-HDys (141 ± 3 mmHg; P < 0.05), whereas EFn was similar in both groups. We observed a negative correlation between endothelial function and FTI only in PMW-CKD-HDys, where an increased adipose tissue negatively correlated with a reduced endothelial function. Interestingly, this endothelial function finding suggests a worse effect on PMM-CKD-HDys, considering that, in general, healthy women have better EFn than healthy men. In addition, a subgroup of patients who contracted COVID-19 exhibited further deterioration in EFn. The results underscore the critical role of body fat in influencing vascular health in this high-risk population, indicating that interventions aimed at weight management could be pivotal in improving cardiovascular outcomes for postmenopausal women with CKD. These findings highlight the need for tailored therapeutic strategies to enhance endothelial function and overall cardiovascular health in patients with CKD, particularly those postmenopausal women with increased adipose tissue undergoing hemodialysis.
publishDate 2025
dc.date.none.fl_str_mv 2025-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/270904
Santos, Juan C.; Lepera, Mabel; Fernández Serra, Rocío; Alanoca, Saul Pablo; Quipildor, Daniel Franco; et al.; Increased adiposity impairs vascular function in postmenopausal women in hemodialysis; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 329; 2; 8-2025; H592-H599
0363-6135
CONICET Digital
CONICET
url http://hdl.handle.net/11336/270904
identifier_str_mv Santos, Juan C.; Lepera, Mabel; Fernández Serra, Rocío; Alanoca, Saul Pablo; Quipildor, Daniel Franco; et al.; Increased adiposity impairs vascular function in postmenopausal women in hemodialysis; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 329; 2; 8-2025; H592-H599
0363-6135
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpheart.00430.2025?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.00430.2025
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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