Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series
- Autores
- Löwensteyn, Yvette N.; Willemsen, Joukje E.; Mazur, Natalie I.; Scheltema, Nienke M.; Van Haastregt, Nynke C. J.; Ten Buuren, Amber A. A.; Van Roessel, Ichelle; Scheepmaker, Dunja; Nair, Harish; Van De Ven, Peter M.; Bont, Louis J.; Caballero, Mauricio Tomás
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. Materials: RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. Results: We included 231 nosocomial and 931 community-acquired RSVrelated in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively). Conclusions: This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.
Fil: Löwensteyn, Yvette N.. University Medical Center Utrecht; Países Bajos
Fil: Willemsen, Joukje E.. University Medical Center Utrecht; Países Bajos
Fil: Mazur, Natalie I.. University Medical Center Utrecht; Países Bajos
Fil: Scheltema, Nienke M.. University Medical Center Utrecht; Países Bajos
Fil: Van Haastregt, Nynke C. J.. University Medical Center Utrecht; Países Bajos
Fil: Ten Buuren, Amber A. A.. University Medical Center Utrecht; Países Bajos
Fil: Van Roessel, Ichelle. University Medical Center Utrecht; Países Bajos
Fil: Scheepmaker, Dunja. University Medical Center Utrecht; Países Bajos
Fil: Nair, Harish. Respiratory Syncytial Virus Network Foundation; Países Bajos. University of Edinburgh; Reino Unido
Fil: Van De Ven, Peter M.. University Medical Center Utrecht; Países Bajos
Fil: Bont, Louis J.. University Medical Center Utrecht; Países Bajos. Respiratory Syncytial Virus Network Foundation; Países Bajos
Fil: Caballero, Mauricio Tomás. Fundación Infant; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
CHILD MORTALITY
COMMUNITY-ACQUIRED INFECTION
GLOBAL HEALTH
NOSOCOMIAL INFECTION
RESPIRATORY SYNCYTIAL VIRUS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/220090
Ver los metadatos del registro completo
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Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case SeriesLöwensteyn, Yvette N.Willemsen, Joukje E.Mazur, Natalie I.Scheltema, Nienke M.Van Haastregt, Nynke C. J.Ten Buuren, Amber A. A.Van Roessel, IchelleScheepmaker, DunjaNair, HarishVan De Ven, Peter M.Bont, Louis J.Caballero, Mauricio TomásCHILD MORTALITYCOMMUNITY-ACQUIRED INFECTIONGLOBAL HEALTHNOSOCOMIAL INFECTIONRESPIRATORY SYNCYTIAL VIRUShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. Materials: RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. Results: We included 231 nosocomial and 931 community-acquired RSVrelated in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively). Conclusions: This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.Fil: Löwensteyn, Yvette N.. University Medical Center Utrecht; Países BajosFil: Willemsen, Joukje E.. University Medical Center Utrecht; Países BajosFil: Mazur, Natalie I.. University Medical Center Utrecht; Países BajosFil: Scheltema, Nienke M.. University Medical Center Utrecht; Países BajosFil: Van Haastregt, Nynke C. J.. University Medical Center Utrecht; Países BajosFil: Ten Buuren, Amber A. A.. University Medical Center Utrecht; Países BajosFil: Van Roessel, Ichelle. University Medical Center Utrecht; Países BajosFil: Scheepmaker, Dunja. University Medical Center Utrecht; Países BajosFil: Nair, Harish. Respiratory Syncytial Virus Network Foundation; Países Bajos. University of Edinburgh; Reino UnidoFil: Van De Ven, Peter M.. University Medical Center Utrecht; Países BajosFil: Bont, Louis J.. University Medical Center Utrecht; Países Bajos. Respiratory Syncytial Virus Network Foundation; Países BajosFil: Caballero, Mauricio Tomás. Fundación Infant; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaLippincott Williams2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220090Löwensteyn, Yvette N.; Willemsen, Joukje E.; Mazur, Natalie I.; Scheltema, Nienke M.; Van Haastregt, Nynke C. J.; et al.; Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series; Lippincott Williams; Pediatric Infectious Disease Journal; 42; 1; 1-2023; 1-70891-3668CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/INF.0000000000003747info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891274/info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/pidj/fulltext/2023/01000/nosocomial_rsv_related_in_hospital_mortality_in.1.aspxinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:20:08Zoai:ri.conicet.gov.ar:11336/220090instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:20:08.362CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series |
title |
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series |
spellingShingle |
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series Löwensteyn, Yvette N. CHILD MORTALITY COMMUNITY-ACQUIRED INFECTION GLOBAL HEALTH NOSOCOMIAL INFECTION RESPIRATORY SYNCYTIAL VIRUS |
title_short |
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series |
title_full |
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series |
title_fullStr |
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series |
title_full_unstemmed |
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series |
title_sort |
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series |
dc.creator.none.fl_str_mv |
Löwensteyn, Yvette N. Willemsen, Joukje E. Mazur, Natalie I. Scheltema, Nienke M. Van Haastregt, Nynke C. J. Ten Buuren, Amber A. A. Van Roessel, Ichelle Scheepmaker, Dunja Nair, Harish Van De Ven, Peter M. Bont, Louis J. Caballero, Mauricio Tomás |
author |
Löwensteyn, Yvette N. |
author_facet |
Löwensteyn, Yvette N. Willemsen, Joukje E. Mazur, Natalie I. Scheltema, Nienke M. Van Haastregt, Nynke C. J. Ten Buuren, Amber A. A. Van Roessel, Ichelle Scheepmaker, Dunja Nair, Harish Van De Ven, Peter M. Bont, Louis J. Caballero, Mauricio Tomás |
author_role |
author |
author2 |
Willemsen, Joukje E. Mazur, Natalie I. Scheltema, Nienke M. Van Haastregt, Nynke C. J. Ten Buuren, Amber A. A. Van Roessel, Ichelle Scheepmaker, Dunja Nair, Harish Van De Ven, Peter M. Bont, Louis J. Caballero, Mauricio Tomás |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
CHILD MORTALITY COMMUNITY-ACQUIRED INFECTION GLOBAL HEALTH NOSOCOMIAL INFECTION RESPIRATORY SYNCYTIAL VIRUS |
topic |
CHILD MORTALITY COMMUNITY-ACQUIRED INFECTION GLOBAL HEALTH NOSOCOMIAL INFECTION RESPIRATORY SYNCYTIAL VIRUS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. Materials: RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. Results: We included 231 nosocomial and 931 community-acquired RSVrelated in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively). Conclusions: This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs. Fil: Löwensteyn, Yvette N.. University Medical Center Utrecht; Países Bajos Fil: Willemsen, Joukje E.. University Medical Center Utrecht; Países Bajos Fil: Mazur, Natalie I.. University Medical Center Utrecht; Países Bajos Fil: Scheltema, Nienke M.. University Medical Center Utrecht; Países Bajos Fil: Van Haastregt, Nynke C. J.. University Medical Center Utrecht; Países Bajos Fil: Ten Buuren, Amber A. A.. University Medical Center Utrecht; Países Bajos Fil: Van Roessel, Ichelle. University Medical Center Utrecht; Países Bajos Fil: Scheepmaker, Dunja. University Medical Center Utrecht; Países Bajos Fil: Nair, Harish. Respiratory Syncytial Virus Network Foundation; Países Bajos. University of Edinburgh; Reino Unido Fil: Van De Ven, Peter M.. University Medical Center Utrecht; Países Bajos Fil: Bont, Louis J.. University Medical Center Utrecht; Países Bajos. Respiratory Syncytial Virus Network Foundation; Países Bajos Fil: Caballero, Mauricio Tomás. Fundación Infant; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Background: According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. Materials: RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. Results: We included 231 nosocomial and 931 community-acquired RSVrelated in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively). Conclusions: This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/220090 Löwensteyn, Yvette N.; Willemsen, Joukje E.; Mazur, Natalie I.; Scheltema, Nienke M.; Van Haastregt, Nynke C. J.; et al.; Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series; Lippincott Williams; Pediatric Infectious Disease Journal; 42; 1; 1-2023; 1-7 0891-3668 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/220090 |
identifier_str_mv |
Löwensteyn, Yvette N.; Willemsen, Joukje E.; Mazur, Natalie I.; Scheltema, Nienke M.; Van Haastregt, Nynke C. J.; et al.; Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series; Lippincott Williams; Pediatric Infectious Disease Journal; 42; 1; 1-2023; 1-7 0891-3668 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1097/INF.0000000000003747 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891274/ info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/pidj/fulltext/2023/01000/nosocomial_rsv_related_in_hospital_mortality_in.1.aspx |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Lippincott Williams |
publisher.none.fl_str_mv |
Lippincott Williams |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.229304 |