Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series

Autores
Löwensteyn, Yvette N.; Willemsen, Joukje E.; Mazur, Natalie I.; Scheltema, Nienke M.; Van Haastregt, Nynke C. J.; Ten Buuren, Amber A. A.; Van Roessel, Ichelle; Scheepmaker, Dunja; Nair, Harish; Van De Ven, Peter M.; Bont, Louis J.; Caballero, Mauricio Tomás
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. Materials: RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. Results: We included 231 nosocomial and 931 community-acquired RSVrelated in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively). Conclusions: This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.
Fil: Löwensteyn, Yvette N.. University Medical Center Utrecht; Países Bajos
Fil: Willemsen, Joukje E.. University Medical Center Utrecht; Países Bajos
Fil: Mazur, Natalie I.. University Medical Center Utrecht; Países Bajos
Fil: Scheltema, Nienke M.. University Medical Center Utrecht; Países Bajos
Fil: Van Haastregt, Nynke C. J.. University Medical Center Utrecht; Países Bajos
Fil: Ten Buuren, Amber A. A.. University Medical Center Utrecht; Países Bajos
Fil: Van Roessel, Ichelle. University Medical Center Utrecht; Países Bajos
Fil: Scheepmaker, Dunja. University Medical Center Utrecht; Países Bajos
Fil: Nair, Harish. Respiratory Syncytial Virus Network Foundation; Países Bajos. University of Edinburgh; Reino Unido
Fil: Van De Ven, Peter M.. University Medical Center Utrecht; Países Bajos
Fil: Bont, Louis J.. University Medical Center Utrecht; Países Bajos. Respiratory Syncytial Virus Network Foundation; Países Bajos
Fil: Caballero, Mauricio Tomás. Fundación Infant; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CHILD MORTALITY
COMMUNITY-ACQUIRED INFECTION
GLOBAL HEALTH
NOSOCOMIAL INFECTION
RESPIRATORY SYNCYTIAL VIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/220090

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oai_identifier_str oai:ri.conicet.gov.ar:11336/220090
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case SeriesLöwensteyn, Yvette N.Willemsen, Joukje E.Mazur, Natalie I.Scheltema, Nienke M.Van Haastregt, Nynke C. J.Ten Buuren, Amber A. A.Van Roessel, IchelleScheepmaker, DunjaNair, HarishVan De Ven, Peter M.Bont, Louis J.Caballero, Mauricio TomásCHILD MORTALITYCOMMUNITY-ACQUIRED INFECTIONGLOBAL HEALTHNOSOCOMIAL INFECTIONRESPIRATORY SYNCYTIAL VIRUShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. Materials: RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. Results: We included 231 nosocomial and 931 community-acquired RSVrelated in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively). Conclusions: This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.Fil: Löwensteyn, Yvette N.. University Medical Center Utrecht; Países BajosFil: Willemsen, Joukje E.. University Medical Center Utrecht; Países BajosFil: Mazur, Natalie I.. University Medical Center Utrecht; Países BajosFil: Scheltema, Nienke M.. University Medical Center Utrecht; Países BajosFil: Van Haastregt, Nynke C. J.. University Medical Center Utrecht; Países BajosFil: Ten Buuren, Amber A. A.. University Medical Center Utrecht; Países BajosFil: Van Roessel, Ichelle. University Medical Center Utrecht; Países BajosFil: Scheepmaker, Dunja. University Medical Center Utrecht; Países BajosFil: Nair, Harish. Respiratory Syncytial Virus Network Foundation; Países Bajos. University of Edinburgh; Reino UnidoFil: Van De Ven, Peter M.. University Medical Center Utrecht; Países BajosFil: Bont, Louis J.. University Medical Center Utrecht; Países Bajos. Respiratory Syncytial Virus Network Foundation; Países BajosFil: Caballero, Mauricio Tomás. Fundación Infant; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaLippincott Williams2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220090Löwensteyn, Yvette N.; Willemsen, Joukje E.; Mazur, Natalie I.; Scheltema, Nienke M.; Van Haastregt, Nynke C. J.; et al.; Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series; Lippincott Williams; Pediatric Infectious Disease Journal; 42; 1; 1-2023; 1-70891-3668CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/INF.0000000000003747info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891274/info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/pidj/fulltext/2023/01000/nosocomial_rsv_related_in_hospital_mortality_in.1.aspxinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:20:08Zoai:ri.conicet.gov.ar:11336/220090instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:20:08.362CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series
title Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series
spellingShingle Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series
Löwensteyn, Yvette N.
CHILD MORTALITY
COMMUNITY-ACQUIRED INFECTION
GLOBAL HEALTH
NOSOCOMIAL INFECTION
RESPIRATORY SYNCYTIAL VIRUS
title_short Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series
title_full Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series
title_fullStr Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series
title_full_unstemmed Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series
title_sort Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series
dc.creator.none.fl_str_mv Löwensteyn, Yvette N.
Willemsen, Joukje E.
Mazur, Natalie I.
Scheltema, Nienke M.
Van Haastregt, Nynke C. J.
Ten Buuren, Amber A. A.
Van Roessel, Ichelle
Scheepmaker, Dunja
Nair, Harish
Van De Ven, Peter M.
Bont, Louis J.
Caballero, Mauricio Tomás
author Löwensteyn, Yvette N.
author_facet Löwensteyn, Yvette N.
Willemsen, Joukje E.
Mazur, Natalie I.
Scheltema, Nienke M.
Van Haastregt, Nynke C. J.
Ten Buuren, Amber A. A.
Van Roessel, Ichelle
Scheepmaker, Dunja
Nair, Harish
Van De Ven, Peter M.
Bont, Louis J.
Caballero, Mauricio Tomás
author_role author
author2 Willemsen, Joukje E.
Mazur, Natalie I.
Scheltema, Nienke M.
Van Haastregt, Nynke C. J.
Ten Buuren, Amber A. A.
Van Roessel, Ichelle
Scheepmaker, Dunja
Nair, Harish
Van De Ven, Peter M.
Bont, Louis J.
Caballero, Mauricio Tomás
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHILD MORTALITY
COMMUNITY-ACQUIRED INFECTION
GLOBAL HEALTH
NOSOCOMIAL INFECTION
RESPIRATORY SYNCYTIAL VIRUS
topic CHILD MORTALITY
COMMUNITY-ACQUIRED INFECTION
GLOBAL HEALTH
NOSOCOMIAL INFECTION
RESPIRATORY SYNCYTIAL VIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. Materials: RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. Results: We included 231 nosocomial and 931 community-acquired RSVrelated in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively). Conclusions: This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.
Fil: Löwensteyn, Yvette N.. University Medical Center Utrecht; Países Bajos
Fil: Willemsen, Joukje E.. University Medical Center Utrecht; Países Bajos
Fil: Mazur, Natalie I.. University Medical Center Utrecht; Países Bajos
Fil: Scheltema, Nienke M.. University Medical Center Utrecht; Países Bajos
Fil: Van Haastregt, Nynke C. J.. University Medical Center Utrecht; Países Bajos
Fil: Ten Buuren, Amber A. A.. University Medical Center Utrecht; Países Bajos
Fil: Van Roessel, Ichelle. University Medical Center Utrecht; Países Bajos
Fil: Scheepmaker, Dunja. University Medical Center Utrecht; Países Bajos
Fil: Nair, Harish. Respiratory Syncytial Virus Network Foundation; Países Bajos. University of Edinburgh; Reino Unido
Fil: Van De Ven, Peter M.. University Medical Center Utrecht; Países Bajos
Fil: Bont, Louis J.. University Medical Center Utrecht; Países Bajos. Respiratory Syncytial Virus Network Foundation; Países Bajos
Fil: Caballero, Mauricio Tomás. Fundación Infant; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. Materials: RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. Results: We included 231 nosocomial and 931 community-acquired RSVrelated in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively). Conclusions: This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.
publishDate 2023
dc.date.none.fl_str_mv 2023-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/220090
Löwensteyn, Yvette N.; Willemsen, Joukje E.; Mazur, Natalie I.; Scheltema, Nienke M.; Van Haastregt, Nynke C. J.; et al.; Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series; Lippincott Williams; Pediatric Infectious Disease Journal; 42; 1; 1-2023; 1-7
0891-3668
CONICET Digital
CONICET
url http://hdl.handle.net/11336/220090
identifier_str_mv Löwensteyn, Yvette N.; Willemsen, Joukje E.; Mazur, Natalie I.; Scheltema, Nienke M.; Van Haastregt, Nynke C. J.; et al.; Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series; Lippincott Williams; Pediatric Infectious Disease Journal; 42; 1; 1-2023; 1-7
0891-3668
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1097/INF.0000000000003747
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891274/
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/pidj/fulltext/2023/01000/nosocomial_rsv_related_in_hospital_mortality_in.1.aspx
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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