Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology

Autores
Tomadoni, Bárbara María; Ponce, Alejandra Graciela; Pereda, Mariana; Ansorena, Maria Roberta
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
One way of improving mechanical and water barrier properties of chitosan films is through cross-linking reactions. Cross-linking agents usually used for this purpose include glutaraldehyde, glyoxal, and formaldehyde, which may cause some undesirable side effects and are consider health hazards. Hence, the objective of this work was to optimize the formulation of chitosan (CH) films with vanillin as a natural antioxidant cross-linking agent, to simultaneously improve their physical, barrier, antioxidant and mechanical properties. Three parameters were studied at three levels: vanillin content (0, 25 and 50% w/w chitosan), glycerol content (30, 45 and 60% w/w chitosan) and drying temperature (35, 50 and 65 °C). Response surface methodology (RSM) and desirability function (D) were used to find the levels of each factor that simultaneously optimize different properties of the films: opacity value, total soluble matter (TSM), Young modulus (YM), T0 and Tmax parameters (obtained from thermogravimetric analysis), water vapor permeability (WVP), total phenolic content (TPC) and antioxidant capacity by DPPH method. Fifteen formulations combining the studied factors were prepared according to a Box-Behnken design. An optimal chitosan film formulation was found, with vanillin content of 37.5% (w/w of CH), glycerol content of 45% (w/w of CH) and drying temperature of 57.5 °C. RSM approach using the desirability function was found to be an effective tool to investigate changes in films properties and to search for the optimal active chitosan film formulation with a natural cross-linking agent, such as vanillin.
Fil: Tomadoni, Bárbara María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ponce, Alejandra Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pereda, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ansorena, Maria Roberta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CHITOSAN FILM
RESPONSE SURFACE METHODOLOGY
VANILLIN
ANTIOXIDANT FILM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120218
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/120218
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodologyTomadoni, Bárbara MaríaPonce, Alejandra GracielaPereda, MarianaAnsorena, Maria RobertaCHITOSAN FILMRESPONSE SURFACE METHODOLOGYVANILLINANTIOXIDANT FILMhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2One way of improving mechanical and water barrier properties of chitosan films is through cross-linking reactions. Cross-linking agents usually used for this purpose include glutaraldehyde, glyoxal, and formaldehyde, which may cause some undesirable side effects and are consider health hazards. Hence, the objective of this work was to optimize the formulation of chitosan (CH) films with vanillin as a natural antioxidant cross-linking agent, to simultaneously improve their physical, barrier, antioxidant and mechanical properties. Three parameters were studied at three levels: vanillin content (0, 25 and 50% w/w chitosan), glycerol content (30, 45 and 60% w/w chitosan) and drying temperature (35, 50 and 65 °C). Response surface methodology (RSM) and desirability function (D) were used to find the levels of each factor that simultaneously optimize different properties of the films: opacity value, total soluble matter (TSM), Young modulus (YM), T0 and Tmax parameters (obtained from thermogravimetric analysis), water vapor permeability (WVP), total phenolic content (TPC) and antioxidant capacity by DPPH method. Fifteen formulations combining the studied factors were prepared according to a Box-Behnken design. An optimal chitosan film formulation was found, with vanillin content of 37.5% (w/w of CH), glycerol content of 45% (w/w of CH) and drying temperature of 57.5 °C. RSM approach using the desirability function was found to be an effective tool to investigate changes in films properties and to search for the optimal active chitosan film formulation with a natural cross-linking agent, such as vanillin.Fil: Tomadoni, Bárbara María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Ponce, Alejandra Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pereda, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Ansorena, Maria Roberta. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120218Tomadoni, Bárbara María; Ponce, Alejandra Graciela; Pereda, Mariana; Ansorena, Maria Roberta; Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology; Elsevier; Polymer Testing; 78; 6-20190142-9418CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.polymertesting.2019.105935info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:46:13Zoai:ri.conicet.gov.ar:11336/120218instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:46:13.746CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology
title Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology
spellingShingle Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology
Tomadoni, Bárbara María
CHITOSAN FILM
RESPONSE SURFACE METHODOLOGY
VANILLIN
ANTIOXIDANT FILM
title_short Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology
title_full Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology
title_fullStr Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology
title_full_unstemmed Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology
title_sort Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology
dc.creator.none.fl_str_mv Tomadoni, Bárbara María
Ponce, Alejandra Graciela
Pereda, Mariana
Ansorena, Maria Roberta
author Tomadoni, Bárbara María
author_facet Tomadoni, Bárbara María
Ponce, Alejandra Graciela
Pereda, Mariana
Ansorena, Maria Roberta
author_role author
author2 Ponce, Alejandra Graciela
Pereda, Mariana
Ansorena, Maria Roberta
author2_role author
author
author
dc.subject.none.fl_str_mv CHITOSAN FILM
RESPONSE SURFACE METHODOLOGY
VANILLIN
ANTIOXIDANT FILM
topic CHITOSAN FILM
RESPONSE SURFACE METHODOLOGY
VANILLIN
ANTIOXIDANT FILM
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv One way of improving mechanical and water barrier properties of chitosan films is through cross-linking reactions. Cross-linking agents usually used for this purpose include glutaraldehyde, glyoxal, and formaldehyde, which may cause some undesirable side effects and are consider health hazards. Hence, the objective of this work was to optimize the formulation of chitosan (CH) films with vanillin as a natural antioxidant cross-linking agent, to simultaneously improve their physical, barrier, antioxidant and mechanical properties. Three parameters were studied at three levels: vanillin content (0, 25 and 50% w/w chitosan), glycerol content (30, 45 and 60% w/w chitosan) and drying temperature (35, 50 and 65 °C). Response surface methodology (RSM) and desirability function (D) were used to find the levels of each factor that simultaneously optimize different properties of the films: opacity value, total soluble matter (TSM), Young modulus (YM), T0 and Tmax parameters (obtained from thermogravimetric analysis), water vapor permeability (WVP), total phenolic content (TPC) and antioxidant capacity by DPPH method. Fifteen formulations combining the studied factors were prepared according to a Box-Behnken design. An optimal chitosan film formulation was found, with vanillin content of 37.5% (w/w of CH), glycerol content of 45% (w/w of CH) and drying temperature of 57.5 °C. RSM approach using the desirability function was found to be an effective tool to investigate changes in films properties and to search for the optimal active chitosan film formulation with a natural cross-linking agent, such as vanillin.
Fil: Tomadoni, Bárbara María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ponce, Alejandra Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pereda, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ansorena, Maria Roberta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description One way of improving mechanical and water barrier properties of chitosan films is through cross-linking reactions. Cross-linking agents usually used for this purpose include glutaraldehyde, glyoxal, and formaldehyde, which may cause some undesirable side effects and are consider health hazards. Hence, the objective of this work was to optimize the formulation of chitosan (CH) films with vanillin as a natural antioxidant cross-linking agent, to simultaneously improve their physical, barrier, antioxidant and mechanical properties. Three parameters were studied at three levels: vanillin content (0, 25 and 50% w/w chitosan), glycerol content (30, 45 and 60% w/w chitosan) and drying temperature (35, 50 and 65 °C). Response surface methodology (RSM) and desirability function (D) were used to find the levels of each factor that simultaneously optimize different properties of the films: opacity value, total soluble matter (TSM), Young modulus (YM), T0 and Tmax parameters (obtained from thermogravimetric analysis), water vapor permeability (WVP), total phenolic content (TPC) and antioxidant capacity by DPPH method. Fifteen formulations combining the studied factors were prepared according to a Box-Behnken design. An optimal chitosan film formulation was found, with vanillin content of 37.5% (w/w of CH), glycerol content of 45% (w/w of CH) and drying temperature of 57.5 °C. RSM approach using the desirability function was found to be an effective tool to investigate changes in films properties and to search for the optimal active chitosan film formulation with a natural cross-linking agent, such as vanillin.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120218
Tomadoni, Bárbara María; Ponce, Alejandra Graciela; Pereda, Mariana; Ansorena, Maria Roberta; Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology; Elsevier; Polymer Testing; 78; 6-2019
0142-9418
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120218
identifier_str_mv Tomadoni, Bárbara María; Ponce, Alejandra Graciela; Pereda, Mariana; Ansorena, Maria Roberta; Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology; Elsevier; Polymer Testing; 78; 6-2019
0142-9418
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.polymertesting.2019.105935
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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