Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study

Autores
Andreoli, Maria Florencia; Gentreau, Mélissa; Rukh, Gull; Perello, Mario; Schiöth, Helgi Birgir
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aim: To test the hypothesis that liver-expressed antimicrobial peptide 2 (LEAP2) genetic variants might influence the susceptibility to human obesity.Methods: Using data from the UK Biobank, we identified independent LEAP2 gene single nucleotide polymorphisms (SNPs) and examined their associations with obesity traits and serum insulin-like growth factor-1 (IGF-1) concentration. These associations were evaluated for both individual SNPs and after combining them into a genetic risk score (GRSLEAP2) using linear and logistic regression models. Sex-stratified analyses were also conducted.Results: Five SNPs showed positive associations with obesity-related traits. rs57880964 was associated with body mass index (BMI) and waist-to-hip ratio adjusted for BMI (WHRadjBMI), in the total population and among women. Four independent SNPs were positively associated with higher serum IGF-1 concentrations in both men and women. GRSLEAP2 was associated with BMI and WHRadjBMI only in women and with serum IGF-1 concentration in both sexes.Conclusions: These findings reveal sex-specific associations between key LEAP2 gene variants and several obesity traits, while also indicating a strong independent association of LEAP2 variants with serum IGF-1 concentration.
Fil: Andreoli, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Uppsala Universitet; Suecia
Fil: Gentreau, Mélissa. Uppsala Universitet; Suecia
Fil: Rukh, Gull. Uppsala Universitet; Suecia
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Schiöth, Helgi Birgir. Uppsala Universitet; Suecia
Materia
IGF‐1
LEAP2 genetic variants
obesity traits
Ghrelin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/263964
Acceder
id CONICETDig_875f3189fe9345c68c66a670fe0d2357
oai_identifier_str oai:ri.conicet.gov.ar:11336/263964
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank studyAndreoli, Maria FlorenciaGentreau, MélissaRukh, GullPerello, MarioSchiöth, Helgi BirgirIGF‐1LEAP2 genetic variantsobesity traitsGhrelinhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Aim: To test the hypothesis that liver-expressed antimicrobial peptide 2 (LEAP2) genetic variants might influence the susceptibility to human obesity.Methods: Using data from the UK Biobank, we identified independent LEAP2 gene single nucleotide polymorphisms (SNPs) and examined their associations with obesity traits and serum insulin-like growth factor-1 (IGF-1) concentration. These associations were evaluated for both individual SNPs and after combining them into a genetic risk score (GRSLEAP2) using linear and logistic regression models. Sex-stratified analyses were also conducted.Results: Five SNPs showed positive associations with obesity-related traits. rs57880964 was associated with body mass index (BMI) and waist-to-hip ratio adjusted for BMI (WHRadjBMI), in the total population and among women. Four independent SNPs were positively associated with higher serum IGF-1 concentrations in both men and women. GRSLEAP2 was associated with BMI and WHRadjBMI only in women and with serum IGF-1 concentration in both sexes.Conclusions: These findings reveal sex-specific associations between key LEAP2 gene variants and several obesity traits, while also indicating a strong independent association of LEAP2 variants with serum IGF-1 concentration.Fil: Andreoli, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Uppsala Universitet; SueciaFil: Gentreau, Mélissa. Uppsala Universitet; SueciaFil: Rukh, Gull. Uppsala Universitet; SueciaFil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Schiöth, Helgi Birgir. Uppsala Universitet; SueciaWiley Blackwell Publishing, Inc2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/263964Andreoli, Maria Florencia; Gentreau, Mélissa; Rukh, Gull; Perello, Mario; Schiöth, Helgi Birgir; Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study; Wiley Blackwell Publishing, Inc; Diabetes Obesity & Metabolism; 26; 9; 6-2024; 3565-35751462-8902CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.15695info:eu-repo/semantics/altIdentifier/doi/10.1111/dom.15695info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:07:44Zoai:ri.conicet.gov.ar:11336/263964instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:07:44.736CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study
title Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study
spellingShingle Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study
Andreoli, Maria Florencia
IGF‐1
LEAP2 genetic variants
obesity traits
Ghrelin
title_short Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study
title_full Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study
title_fullStr Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study
title_full_unstemmed Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study
title_sort Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study
dc.creator.none.fl_str_mv Andreoli, Maria Florencia
Gentreau, Mélissa
Rukh, Gull
Perello, Mario
Schiöth, Helgi Birgir
author Andreoli, Maria Florencia
author_facet Andreoli, Maria Florencia
Gentreau, Mélissa
Rukh, Gull
Perello, Mario
Schiöth, Helgi Birgir
author_role author
author2 Gentreau, Mélissa
Rukh, Gull
Perello, Mario
Schiöth, Helgi Birgir
author2_role author
author
author
author
dc.subject.none.fl_str_mv IGF‐1
LEAP2 genetic variants
obesity traits
Ghrelin
topic IGF‐1
LEAP2 genetic variants
obesity traits
Ghrelin
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aim: To test the hypothesis that liver-expressed antimicrobial peptide 2 (LEAP2) genetic variants might influence the susceptibility to human obesity.Methods: Using data from the UK Biobank, we identified independent LEAP2 gene single nucleotide polymorphisms (SNPs) and examined their associations with obesity traits and serum insulin-like growth factor-1 (IGF-1) concentration. These associations were evaluated for both individual SNPs and after combining them into a genetic risk score (GRSLEAP2) using linear and logistic regression models. Sex-stratified analyses were also conducted.Results: Five SNPs showed positive associations with obesity-related traits. rs57880964 was associated with body mass index (BMI) and waist-to-hip ratio adjusted for BMI (WHRadjBMI), in the total population and among women. Four independent SNPs were positively associated with higher serum IGF-1 concentrations in both men and women. GRSLEAP2 was associated with BMI and WHRadjBMI only in women and with serum IGF-1 concentration in both sexes.Conclusions: These findings reveal sex-specific associations between key LEAP2 gene variants and several obesity traits, while also indicating a strong independent association of LEAP2 variants with serum IGF-1 concentration.
Fil: Andreoli, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Uppsala Universitet; Suecia
Fil: Gentreau, Mélissa. Uppsala Universitet; Suecia
Fil: Rukh, Gull. Uppsala Universitet; Suecia
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Schiöth, Helgi Birgir. Uppsala Universitet; Suecia
description Aim: To test the hypothesis that liver-expressed antimicrobial peptide 2 (LEAP2) genetic variants might influence the susceptibility to human obesity.Methods: Using data from the UK Biobank, we identified independent LEAP2 gene single nucleotide polymorphisms (SNPs) and examined their associations with obesity traits and serum insulin-like growth factor-1 (IGF-1) concentration. These associations were evaluated for both individual SNPs and after combining them into a genetic risk score (GRSLEAP2) using linear and logistic regression models. Sex-stratified analyses were also conducted.Results: Five SNPs showed positive associations with obesity-related traits. rs57880964 was associated with body mass index (BMI) and waist-to-hip ratio adjusted for BMI (WHRadjBMI), in the total population and among women. Four independent SNPs were positively associated with higher serum IGF-1 concentrations in both men and women. GRSLEAP2 was associated with BMI and WHRadjBMI only in women and with serum IGF-1 concentration in both sexes.Conclusions: These findings reveal sex-specific associations between key LEAP2 gene variants and several obesity traits, while also indicating a strong independent association of LEAP2 variants with serum IGF-1 concentration.
publishDate 2024
dc.date.none.fl_str_mv 2024-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/263964
Andreoli, Maria Florencia; Gentreau, Mélissa; Rukh, Gull; Perello, Mario; Schiöth, Helgi Birgir; Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study; Wiley Blackwell Publishing, Inc; Diabetes Obesity & Metabolism; 26; 9; 6-2024; 3565-3575
1462-8902
CONICET Digital
CONICET
url http://hdl.handle.net/11336/263964
identifier_str_mv Andreoli, Maria Florencia; Gentreau, Mélissa; Rukh, Gull; Perello, Mario; Schiöth, Helgi Birgir; Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study; Wiley Blackwell Publishing, Inc; Diabetes Obesity & Metabolism; 26; 9; 6-2024; 3565-3575
1462-8902
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.15695
info:eu-repo/semantics/altIdentifier/doi/10.1111/dom.15695
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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