Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men

Autores
Andreoli, Maria Florencia; de Francesco, Pablo Nicolás; Titova, Olga E.; Perello, Mario; Schiöth, Helgi B.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: While LEAP2 is increasingly recognized as an appetite-regulating hormone, its role in meal regulation and the dynamics of postprandial LEAP2 concentrations remain poorly understood in humans. The aim of the study was to (1) assess postprandial LEAP2 concentrations following a recommended-energy breakfast, exploring potential association with voluntary energy intake and modulation by weight status and (2) to examine the interplay between postprandial LEAP2 and insulin concentrations. Materials and methods: Eighty-four men with normal weight (NW) and 48 with overweight or obesity (OW/OB) received a test meal; pre- and postprandial LEAP2 and insulin concentrations were assessed. Energy intake was calculated by multiplying the weight of the food items consumed by their energy content according to their label. Results: Fasting LEAP2 was positively associated with glycaemia in participants with NW [Beta (95% CI): 0.289 (0.058, 0.520), p = 0.015] but not with OW/OB. Sixty-seven participants consumed the entire test meal (CMC, complete meal consumption); the rest consumed only part (PMC, partial meal consumption). Postprandial LEAP2 concentration was higher in the PMC (p = 0.017) than in the CMC group and in participants with OW/OB (p = 0.046). Pre (p = 0.027) and postprandial (p = 0.031) LEAP2 was inversely related to ingested calories, but only in PMC and independent of weight status. Postprandial insulin increase (p < 0.001) depended on LEAP2 only in CMC (p = 0.017) and was independent of weight status. Conclusions: The relationship of LEAP2 with energy intake and postprandial insulin increase is influenced by meal size but not weight status. Keywords: LEAP2; energy intake; insulin; meal size.
Fil: Andreoli, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: de Francesco, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Titova, Olga E.. Uppsala Universitet; Suecia
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Schiöth, Helgi B.. Uppsala Universitet; Suecia
Materia
LEAP2
ENERGY INTAKE
INSULIN
MEAL SIZE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/277049
Acceder
id CONICETDig_33558fb1bd88c82342eaeca7c2807969
oai_identifier_str oai:ri.conicet.gov.ar:11336/277049
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in menAndreoli, Maria Florenciade Francesco, Pablo NicolásTitova, Olga E.Perello, MarioSchiöth, Helgi B.LEAP2ENERGY INTAKEINSULINMEAL SIZEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aims: While LEAP2 is increasingly recognized as an appetite-regulating hormone, its role in meal regulation and the dynamics of postprandial LEAP2 concentrations remain poorly understood in humans. The aim of the study was to (1) assess postprandial LEAP2 concentrations following a recommended-energy breakfast, exploring potential association with voluntary energy intake and modulation by weight status and (2) to examine the interplay between postprandial LEAP2 and insulin concentrations. Materials and methods: Eighty-four men with normal weight (NW) and 48 with overweight or obesity (OW/OB) received a test meal; pre- and postprandial LEAP2 and insulin concentrations were assessed. Energy intake was calculated by multiplying the weight of the food items consumed by their energy content according to their label. Results: Fasting LEAP2 was positively associated with glycaemia in participants with NW [Beta (95% CI): 0.289 (0.058, 0.520), p = 0.015] but not with OW/OB. Sixty-seven participants consumed the entire test meal (CMC, complete meal consumption); the rest consumed only part (PMC, partial meal consumption). Postprandial LEAP2 concentration was higher in the PMC (p = 0.017) than in the CMC group and in participants with OW/OB (p = 0.046). Pre (p = 0.027) and postprandial (p = 0.031) LEAP2 was inversely related to ingested calories, but only in PMC and independent of weight status. Postprandial insulin increase (p < 0.001) depended on LEAP2 only in CMC (p = 0.017) and was independent of weight status. Conclusions: The relationship of LEAP2 with energy intake and postprandial insulin increase is influenced by meal size but not weight status. Keywords: LEAP2; energy intake; insulin; meal size.Fil: Andreoli, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; ArgentinaFil: de Francesco, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Titova, Olga E.. Uppsala Universitet; SueciaFil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Schiöth, Helgi B.. Uppsala Universitet; SueciaWiley Blackwell Publishing, Inc2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/277049Andreoli, Maria Florencia; de Francesco, Pablo Nicolás; Titova, Olga E.; Perello, Mario; Schiöth, Helgi B.; Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men; Wiley Blackwell Publishing, Inc; Diabetes Obesity & Metabolism; 5-2025; 1-91462-8902CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.16483info:eu-repo/semantics/altIdentifier/doi/10.1111/dom.16483info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T13:56:41Zoai:ri.conicet.gov.ar:11336/277049instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 13:56:41.846CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
title Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
spellingShingle Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
Andreoli, Maria Florencia
LEAP2
ENERGY INTAKE
INSULIN
MEAL SIZE
title_short Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
title_full Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
title_fullStr Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
title_full_unstemmed Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
title_sort Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
dc.creator.none.fl_str_mv Andreoli, Maria Florencia
de Francesco, Pablo Nicolás
Titova, Olga E.
Perello, Mario
Schiöth, Helgi B.
author Andreoli, Maria Florencia
author_facet Andreoli, Maria Florencia
de Francesco, Pablo Nicolás
Titova, Olga E.
Perello, Mario
Schiöth, Helgi B.
author_role author
author2 de Francesco, Pablo Nicolás
Titova, Olga E.
Perello, Mario
Schiöth, Helgi B.
author2_role author
author
author
author
dc.subject.none.fl_str_mv LEAP2
ENERGY INTAKE
INSULIN
MEAL SIZE
topic LEAP2
ENERGY INTAKE
INSULIN
MEAL SIZE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims: While LEAP2 is increasingly recognized as an appetite-regulating hormone, its role in meal regulation and the dynamics of postprandial LEAP2 concentrations remain poorly understood in humans. The aim of the study was to (1) assess postprandial LEAP2 concentrations following a recommended-energy breakfast, exploring potential association with voluntary energy intake and modulation by weight status and (2) to examine the interplay between postprandial LEAP2 and insulin concentrations. Materials and methods: Eighty-four men with normal weight (NW) and 48 with overweight or obesity (OW/OB) received a test meal; pre- and postprandial LEAP2 and insulin concentrations were assessed. Energy intake was calculated by multiplying the weight of the food items consumed by their energy content according to their label. Results: Fasting LEAP2 was positively associated with glycaemia in participants with NW [Beta (95% CI): 0.289 (0.058, 0.520), p = 0.015] but not with OW/OB. Sixty-seven participants consumed the entire test meal (CMC, complete meal consumption); the rest consumed only part (PMC, partial meal consumption). Postprandial LEAP2 concentration was higher in the PMC (p = 0.017) than in the CMC group and in participants with OW/OB (p = 0.046). Pre (p = 0.027) and postprandial (p = 0.031) LEAP2 was inversely related to ingested calories, but only in PMC and independent of weight status. Postprandial insulin increase (p < 0.001) depended on LEAP2 only in CMC (p = 0.017) and was independent of weight status. Conclusions: The relationship of LEAP2 with energy intake and postprandial insulin increase is influenced by meal size but not weight status. Keywords: LEAP2; energy intake; insulin; meal size.
Fil: Andreoli, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: de Francesco, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Titova, Olga E.. Uppsala Universitet; Suecia
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Schiöth, Helgi B.. Uppsala Universitet; Suecia
description Aims: While LEAP2 is increasingly recognized as an appetite-regulating hormone, its role in meal regulation and the dynamics of postprandial LEAP2 concentrations remain poorly understood in humans. The aim of the study was to (1) assess postprandial LEAP2 concentrations following a recommended-energy breakfast, exploring potential association with voluntary energy intake and modulation by weight status and (2) to examine the interplay between postprandial LEAP2 and insulin concentrations. Materials and methods: Eighty-four men with normal weight (NW) and 48 with overweight or obesity (OW/OB) received a test meal; pre- and postprandial LEAP2 and insulin concentrations were assessed. Energy intake was calculated by multiplying the weight of the food items consumed by their energy content according to their label. Results: Fasting LEAP2 was positively associated with glycaemia in participants with NW [Beta (95% CI): 0.289 (0.058, 0.520), p = 0.015] but not with OW/OB. Sixty-seven participants consumed the entire test meal (CMC, complete meal consumption); the rest consumed only part (PMC, partial meal consumption). Postprandial LEAP2 concentration was higher in the PMC (p = 0.017) than in the CMC group and in participants with OW/OB (p = 0.046). Pre (p = 0.027) and postprandial (p = 0.031) LEAP2 was inversely related to ingested calories, but only in PMC and independent of weight status. Postprandial insulin increase (p < 0.001) depended on LEAP2 only in CMC (p = 0.017) and was independent of weight status. Conclusions: The relationship of LEAP2 with energy intake and postprandial insulin increase is influenced by meal size but not weight status. Keywords: LEAP2; energy intake; insulin; meal size.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/277049
Andreoli, Maria Florencia; de Francesco, Pablo Nicolás; Titova, Olga E.; Perello, Mario; Schiöth, Helgi B.; Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men; Wiley Blackwell Publishing, Inc; Diabetes Obesity & Metabolism; 5-2025; 1-9
1462-8902
CONICET Digital
CONICET
url http://hdl.handle.net/11336/277049
identifier_str_mv Andreoli, Maria Florencia; de Francesco, Pablo Nicolás; Titova, Olga E.; Perello, Mario; Schiöth, Helgi B.; Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men; Wiley Blackwell Publishing, Inc; Diabetes Obesity & Metabolism; 5-2025; 1-9
1462-8902
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.16483
info:eu-repo/semantics/altIdentifier/doi/10.1111/dom.16483
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.952241

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