Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil

Autores
Antezana, Pablo Edmundo; Municoy, Sofia; Orive, Gorka; Desimone, Martín Federico
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is an increasing medical need for the development of new materials that could replace damaged organs, improve healing of critical wounds or provide the environment required for the formation of a new healthy tissue. The three-dimensional (3D) printing approach has emerged to overcome several of the major deficiencies of tissue engineering. The use of Cannabis sativa as a therapy for some diseases has spread throughout the world thanks to its benefits for patients. In this work, we developed a bioink made with gelatin and alginate that was able to be printed using an extrusion 3D bioprinter. The scaffolds obtained were lyophilized, characterized and the swelling was assessed. In addition, the scaffolds were loaded with Cannabis sativa oil extract. The presence of the extract provided antimicrobial and antioxidant activity to the 3D scaffolds. Altogether, our results suggest that the new biocompatible material printed with 3D technology and with the addition of Cannabis sativa oil could become an attractive alternative to common treatments of soft-tissue infections and wound repair.
Fil: Antezana, Pablo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad del País Vasco; España
Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Orive, Gorka. Universidad del País Vasco; España. Nanobiocel Research Group; España. Instituto de Salud Carlos III; España. University Institute For Regenerative Medicine And Oral Implantology; España. Singapore Eye Research Institute; Singapur
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Materia
ALGINATE
BIOPRINTING
CANNABIS SATIVA
GELATIN
SCAFFOLD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/204729
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa OilAntezana, Pablo EdmundoMunicoy, SofiaOrive, GorkaDesimone, Martín FedericoALGINATEBIOPRINTINGCANNABIS SATIVAGELATINSCAFFOLDhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2There is an increasing medical need for the development of new materials that could replace damaged organs, improve healing of critical wounds or provide the environment required for the formation of a new healthy tissue. The three-dimensional (3D) printing approach has emerged to overcome several of the major deficiencies of tissue engineering. The use of Cannabis sativa as a therapy for some diseases has spread throughout the world thanks to its benefits for patients. In this work, we developed a bioink made with gelatin and alginate that was able to be printed using an extrusion 3D bioprinter. The scaffolds obtained were lyophilized, characterized and the swelling was assessed. In addition, the scaffolds were loaded with Cannabis sativa oil extract. The presence of the extract provided antimicrobial and antioxidant activity to the 3D scaffolds. Altogether, our results suggest that the new biocompatible material printed with 3D technology and with the addition of Cannabis sativa oil could become an attractive alternative to common treatments of soft-tissue infections and wound repair.Fil: Antezana, Pablo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad del País Vasco; EspañaFil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Orive, Gorka. Universidad del País Vasco; España. Nanobiocel Research Group; España. Instituto de Salud Carlos III; España. University Institute For Regenerative Medicine And Oral Implantology; España. Singapore Eye Research Institute; SingapurFil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaMultidisciplinary Digital Publishing Institute2022-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/204729Antezana, Pablo Edmundo; Municoy, Sofia; Orive, Gorka; Desimone, Martín Federico; Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil; Multidisciplinary Digital Publishing Institute; Polymers; 14; 21; 11-2022; 1-172073-4360CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/14/21/4506info:eu-repo/semantics/altIdentifier/doi/10.3390/polym14214506info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:19:35Zoai:ri.conicet.gov.ar:11336/204729instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:19:36.191CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil
title Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil
spellingShingle Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil
Antezana, Pablo Edmundo
ALGINATE
BIOPRINTING
CANNABIS SATIVA
GELATIN
SCAFFOLD
title_short Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil
title_full Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil
title_fullStr Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil
title_full_unstemmed Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil
title_sort Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil
dc.creator.none.fl_str_mv Antezana, Pablo Edmundo
Municoy, Sofia
Orive, Gorka
Desimone, Martín Federico
author Antezana, Pablo Edmundo
author_facet Antezana, Pablo Edmundo
Municoy, Sofia
Orive, Gorka
Desimone, Martín Federico
author_role author
author2 Municoy, Sofia
Orive, Gorka
Desimone, Martín Federico
author2_role author
author
author
dc.subject.none.fl_str_mv ALGINATE
BIOPRINTING
CANNABIS SATIVA
GELATIN
SCAFFOLD
topic ALGINATE
BIOPRINTING
CANNABIS SATIVA
GELATIN
SCAFFOLD
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv There is an increasing medical need for the development of new materials that could replace damaged organs, improve healing of critical wounds or provide the environment required for the formation of a new healthy tissue. The three-dimensional (3D) printing approach has emerged to overcome several of the major deficiencies of tissue engineering. The use of Cannabis sativa as a therapy for some diseases has spread throughout the world thanks to its benefits for patients. In this work, we developed a bioink made with gelatin and alginate that was able to be printed using an extrusion 3D bioprinter. The scaffolds obtained were lyophilized, characterized and the swelling was assessed. In addition, the scaffolds were loaded with Cannabis sativa oil extract. The presence of the extract provided antimicrobial and antioxidant activity to the 3D scaffolds. Altogether, our results suggest that the new biocompatible material printed with 3D technology and with the addition of Cannabis sativa oil could become an attractive alternative to common treatments of soft-tissue infections and wound repair.
Fil: Antezana, Pablo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad del País Vasco; España
Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Orive, Gorka. Universidad del País Vasco; España. Nanobiocel Research Group; España. Instituto de Salud Carlos III; España. University Institute For Regenerative Medicine And Oral Implantology; España. Singapore Eye Research Institute; Singapur
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
description There is an increasing medical need for the development of new materials that could replace damaged organs, improve healing of critical wounds or provide the environment required for the formation of a new healthy tissue. The three-dimensional (3D) printing approach has emerged to overcome several of the major deficiencies of tissue engineering. The use of Cannabis sativa as a therapy for some diseases has spread throughout the world thanks to its benefits for patients. In this work, we developed a bioink made with gelatin and alginate that was able to be printed using an extrusion 3D bioprinter. The scaffolds obtained were lyophilized, characterized and the swelling was assessed. In addition, the scaffolds were loaded with Cannabis sativa oil extract. The presence of the extract provided antimicrobial and antioxidant activity to the 3D scaffolds. Altogether, our results suggest that the new biocompatible material printed with 3D technology and with the addition of Cannabis sativa oil could become an attractive alternative to common treatments of soft-tissue infections and wound repair.
publishDate 2022
dc.date.none.fl_str_mv 2022-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/204729
Antezana, Pablo Edmundo; Municoy, Sofia; Orive, Gorka; Desimone, Martín Federico; Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil; Multidisciplinary Digital Publishing Institute; Polymers; 14; 21; 11-2022; 1-17
2073-4360
CONICET Digital
CONICET
url http://hdl.handle.net/11336/204729
identifier_str_mv Antezana, Pablo Edmundo; Municoy, Sofia; Orive, Gorka; Desimone, Martín Federico; Design of a New 3D Gelatin—Alginate Scaffold Loaded with Cannabis sativa Oil; Multidisciplinary Digital Publishing Institute; Polymers; 14; 21; 11-2022; 1-17
2073-4360
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/14/21/4506
info:eu-repo/semantics/altIdentifier/doi/10.3390/polym14214506
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781675444371456
score 12.982451

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