Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results

Autores
Benozzi, Silvia; Unger, Gisela; Campión, Amparo; Milano, Pablo Gustavo; Pennacchiotti, Graciela Laura
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Although current guidelines recommend not drinking coffee prior to phlebotomy, our hypothesis is that drinking coffee does not affect the clinical interpretation of biochemical and haematological test results. Materials and methods: Twenty-seven volunteers were studied in basal state (T0) and 1h after (T1) drinking coffee. Routine haematological (Sysmex-XN1000 analyser) and biochemistry parameters (Vitros 4600 analyser) were studied. Results were compared using the Wilcoxon test (P < 0.05). A clinical change was considered when mean percent difference (MD%) was higher than the reference change value (RCV). Results: Coffee intake produced statistically, but not clinically, significant: i) increases in haemoglobin (P = 0.009), mean cell haemoglobin concentration (P = 0.044), neutrophils (P = 0.001), albumin (P = 0.001), total protein (P = 0.000), cholesterol (P = 0.025), high density lipoprotein cholesterol (P = 0.007), uric acid (P = 0.011), calcium (P = 0.001), potassium (P = 0.010), aspartate aminotransferase (P = 0.001), amylase (P = 0.026), and lactate dehydrogenase (P = 0.001), and ii) decreases in mean cell volume (P = 0.002), red cell distribution width (P = 0.001), eosinophils (P = 0.002), and lymphocytes (P = 0.001), creatinine (P = 0.001), total bilirubin (P = 0.012), phosphorus (P = 0.001), magnesium (P = 0.007), and chloride (P = 0.001). Conclusion: Drinking a cup of coffee 1 hour prior to phlebotomy produces no clinically significant changes in routine biochemical and haematological test results
Fil: Benozzi, Silvia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Unger, Gisela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Campión, Amparo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; Argentina
Fil: Milano, Pablo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Pennacchiotti, Graciela Laura. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; Argentina
Materia
fasting
coffee intake
blood sample collection
preanalytical variability
biochemical tests
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/243178
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/243178
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test resultsBenozzi, SilviaUnger, GiselaCampión, AmparoMilano, Pablo GustavoPennacchiotti, Graciela Laurafastingcoffee intakeblood sample collectionpreanalytical variabilitybiochemical testshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Although current guidelines recommend not drinking coffee prior to phlebotomy, our hypothesis is that drinking coffee does not affect the clinical interpretation of biochemical and haematological test results. Materials and methods: Twenty-seven volunteers were studied in basal state (T0) and 1h after (T1) drinking coffee. Routine haematological (Sysmex-XN1000 analyser) and biochemistry parameters (Vitros 4600 analyser) were studied. Results were compared using the Wilcoxon test (P < 0.05). A clinical change was considered when mean percent difference (MD%) was higher than the reference change value (RCV). Results: Coffee intake produced statistically, but not clinically, significant: i) increases in haemoglobin (P = 0.009), mean cell haemoglobin concentration (P = 0.044), neutrophils (P = 0.001), albumin (P = 0.001), total protein (P = 0.000), cholesterol (P = 0.025), high density lipoprotein cholesterol (P = 0.007), uric acid (P = 0.011), calcium (P = 0.001), potassium (P = 0.010), aspartate aminotransferase (P = 0.001), amylase (P = 0.026), and lactate dehydrogenase (P = 0.001), and ii) decreases in mean cell volume (P = 0.002), red cell distribution width (P = 0.001), eosinophils (P = 0.002), and lymphocytes (P = 0.001), creatinine (P = 0.001), total bilirubin (P = 0.012), phosphorus (P = 0.001), magnesium (P = 0.007), and chloride (P = 0.001). Conclusion: Drinking a cup of coffee 1 hour prior to phlebotomy produces no clinically significant changes in routine biochemical and haematological test resultsFil: Benozzi, Silvia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Unger, Gisela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Campión, Amparo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; ArgentinaFil: Milano, Pablo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Pennacchiotti, Graciela Laura. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; ArgentinaCroatian Soc Medical Biochemists2023-04-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243178Benozzi, Silvia; Unger, Gisela; Campión, Amparo; Milano, Pablo Gustavo; Pennacchiotti, Graciela Laura; Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results; Croatian Soc Medical Biochemists; Biochemia Medica; 33; 2; 25-4-2023; 1-81330-09621846-7482CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.biochemia-medica.com/en/journal/33/2/10.11613/BM.2023.020705info:eu-repo/semantics/altIdentifier/doi/10.11613/BM.2023.020705info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:18:04Zoai:ri.conicet.gov.ar:11336/243178instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:18:05.032CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results
title Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results
spellingShingle Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results
Benozzi, Silvia
fasting
coffee intake
blood sample collection
preanalytical variability
biochemical tests
title_short Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results
title_full Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results
title_fullStr Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results
title_full_unstemmed Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results
title_sort Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results
dc.creator.none.fl_str_mv Benozzi, Silvia
Unger, Gisela
Campión, Amparo
Milano, Pablo Gustavo
Pennacchiotti, Graciela Laura
author Benozzi, Silvia
author_facet Benozzi, Silvia
Unger, Gisela
Campión, Amparo
Milano, Pablo Gustavo
Pennacchiotti, Graciela Laura
author_role author
author2 Unger, Gisela
Campión, Amparo
Milano, Pablo Gustavo
Pennacchiotti, Graciela Laura
author2_role author
author
author
author
dc.subject.none.fl_str_mv fasting
coffee intake
blood sample collection
preanalytical variability
biochemical tests
topic fasting
coffee intake
blood sample collection
preanalytical variability
biochemical tests
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Although current guidelines recommend not drinking coffee prior to phlebotomy, our hypothesis is that drinking coffee does not affect the clinical interpretation of biochemical and haematological test results. Materials and methods: Twenty-seven volunteers were studied in basal state (T0) and 1h after (T1) drinking coffee. Routine haematological (Sysmex-XN1000 analyser) and biochemistry parameters (Vitros 4600 analyser) were studied. Results were compared using the Wilcoxon test (P < 0.05). A clinical change was considered when mean percent difference (MD%) was higher than the reference change value (RCV). Results: Coffee intake produced statistically, but not clinically, significant: i) increases in haemoglobin (P = 0.009), mean cell haemoglobin concentration (P = 0.044), neutrophils (P = 0.001), albumin (P = 0.001), total protein (P = 0.000), cholesterol (P = 0.025), high density lipoprotein cholesterol (P = 0.007), uric acid (P = 0.011), calcium (P = 0.001), potassium (P = 0.010), aspartate aminotransferase (P = 0.001), amylase (P = 0.026), and lactate dehydrogenase (P = 0.001), and ii) decreases in mean cell volume (P = 0.002), red cell distribution width (P = 0.001), eosinophils (P = 0.002), and lymphocytes (P = 0.001), creatinine (P = 0.001), total bilirubin (P = 0.012), phosphorus (P = 0.001), magnesium (P = 0.007), and chloride (P = 0.001). Conclusion: Drinking a cup of coffee 1 hour prior to phlebotomy produces no clinically significant changes in routine biochemical and haematological test results
Fil: Benozzi, Silvia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Unger, Gisela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Campión, Amparo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; Argentina
Fil: Milano, Pablo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Pennacchiotti, Graciela Laura. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; Argentina
description Introduction: Although current guidelines recommend not drinking coffee prior to phlebotomy, our hypothesis is that drinking coffee does not affect the clinical interpretation of biochemical and haematological test results. Materials and methods: Twenty-seven volunteers were studied in basal state (T0) and 1h after (T1) drinking coffee. Routine haematological (Sysmex-XN1000 analyser) and biochemistry parameters (Vitros 4600 analyser) were studied. Results were compared using the Wilcoxon test (P < 0.05). A clinical change was considered when mean percent difference (MD%) was higher than the reference change value (RCV). Results: Coffee intake produced statistically, but not clinically, significant: i) increases in haemoglobin (P = 0.009), mean cell haemoglobin concentration (P = 0.044), neutrophils (P = 0.001), albumin (P = 0.001), total protein (P = 0.000), cholesterol (P = 0.025), high density lipoprotein cholesterol (P = 0.007), uric acid (P = 0.011), calcium (P = 0.001), potassium (P = 0.010), aspartate aminotransferase (P = 0.001), amylase (P = 0.026), and lactate dehydrogenase (P = 0.001), and ii) decreases in mean cell volume (P = 0.002), red cell distribution width (P = 0.001), eosinophils (P = 0.002), and lymphocytes (P = 0.001), creatinine (P = 0.001), total bilirubin (P = 0.012), phosphorus (P = 0.001), magnesium (P = 0.007), and chloride (P = 0.001). Conclusion: Drinking a cup of coffee 1 hour prior to phlebotomy produces no clinically significant changes in routine biochemical and haematological test results
publishDate 2023
dc.date.none.fl_str_mv 2023-04-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/243178
Benozzi, Silvia; Unger, Gisela; Campión, Amparo; Milano, Pablo Gustavo; Pennacchiotti, Graciela Laura; Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results; Croatian Soc Medical Biochemists; Biochemia Medica; 33; 2; 25-4-2023; 1-8
1330-0962
1846-7482
CONICET Digital
CONICET
url http://hdl.handle.net/11336/243178
identifier_str_mv Benozzi, Silvia; Unger, Gisela; Campión, Amparo; Milano, Pablo Gustavo; Pennacchiotti, Graciela Laura; Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results; Croatian Soc Medical Biochemists; Biochemia Medica; 33; 2; 25-4-2023; 1-8
1330-0962
1846-7482
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.biochemia-medica.com/en/journal/33/2/10.11613/BM.2023.020705
info:eu-repo/semantics/altIdentifier/doi/10.11613/BM.2023.020705
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Croatian Soc Medical Biochemists
publisher.none.fl_str_mv Croatian Soc Medical Biochemists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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