Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results
- Autores
- Benozzi, Silvia; Unger, Gisela; Campión, Amparo; Milano, Pablo Gustavo; Pennacchiotti, Graciela Laura
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction: Although current guidelines recommend not drinking coffee prior to phlebotomy, our hypothesis is that drinking coffee does not affect the clinical interpretation of biochemical and haematological test results. Materials and methods: Twenty-seven volunteers were studied in basal state (T0) and 1h after (T1) drinking coffee. Routine haematological (Sysmex-XN1000 analyser) and biochemistry parameters (Vitros 4600 analyser) were studied. Results were compared using the Wilcoxon test (P < 0.05). A clinical change was considered when mean percent difference (MD%) was higher than the reference change value (RCV). Results: Coffee intake produced statistically, but not clinically, significant: i) increases in haemoglobin (P = 0.009), mean cell haemoglobin concentration (P = 0.044), neutrophils (P = 0.001), albumin (P = 0.001), total protein (P = 0.000), cholesterol (P = 0.025), high density lipoprotein cholesterol (P = 0.007), uric acid (P = 0.011), calcium (P = 0.001), potassium (P = 0.010), aspartate aminotransferase (P = 0.001), amylase (P = 0.026), and lactate dehydrogenase (P = 0.001), and ii) decreases in mean cell volume (P = 0.002), red cell distribution width (P = 0.001), eosinophils (P = 0.002), and lymphocytes (P = 0.001), creatinine (P = 0.001), total bilirubin (P = 0.012), phosphorus (P = 0.001), magnesium (P = 0.007), and chloride (P = 0.001). Conclusion: Drinking a cup of coffee 1 hour prior to phlebotomy produces no clinically significant changes in routine biochemical and haematological test results
Fil: Benozzi, Silvia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Unger, Gisela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Campión, Amparo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; Argentina
Fil: Milano, Pablo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Pennacchiotti, Graciela Laura. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; Argentina - Materia
-
fasting
coffee intake
blood sample collection
preanalytical variability
biochemical tests - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/243178
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Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test resultsBenozzi, SilviaUnger, GiselaCampión, AmparoMilano, Pablo GustavoPennacchiotti, Graciela Laurafastingcoffee intakeblood sample collectionpreanalytical variabilitybiochemical testshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Although current guidelines recommend not drinking coffee prior to phlebotomy, our hypothesis is that drinking coffee does not affect the clinical interpretation of biochemical and haematological test results. Materials and methods: Twenty-seven volunteers were studied in basal state (T0) and 1h after (T1) drinking coffee. Routine haematological (Sysmex-XN1000 analyser) and biochemistry parameters (Vitros 4600 analyser) were studied. Results were compared using the Wilcoxon test (P < 0.05). A clinical change was considered when mean percent difference (MD%) was higher than the reference change value (RCV). Results: Coffee intake produced statistically, but not clinically, significant: i) increases in haemoglobin (P = 0.009), mean cell haemoglobin concentration (P = 0.044), neutrophils (P = 0.001), albumin (P = 0.001), total protein (P = 0.000), cholesterol (P = 0.025), high density lipoprotein cholesterol (P = 0.007), uric acid (P = 0.011), calcium (P = 0.001), potassium (P = 0.010), aspartate aminotransferase (P = 0.001), amylase (P = 0.026), and lactate dehydrogenase (P = 0.001), and ii) decreases in mean cell volume (P = 0.002), red cell distribution width (P = 0.001), eosinophils (P = 0.002), and lymphocytes (P = 0.001), creatinine (P = 0.001), total bilirubin (P = 0.012), phosphorus (P = 0.001), magnesium (P = 0.007), and chloride (P = 0.001). Conclusion: Drinking a cup of coffee 1 hour prior to phlebotomy produces no clinically significant changes in routine biochemical and haematological test resultsFil: Benozzi, Silvia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Unger, Gisela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Campión, Amparo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; ArgentinaFil: Milano, Pablo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Pennacchiotti, Graciela Laura. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; ArgentinaCroatian Soc Medical Biochemists2023-04-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243178Benozzi, Silvia; Unger, Gisela; Campión, Amparo; Milano, Pablo Gustavo; Pennacchiotti, Graciela Laura; Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results; Croatian Soc Medical Biochemists; Biochemia Medica; 33; 2; 25-4-2023; 1-81330-09621846-7482CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.biochemia-medica.com/en/journal/33/2/10.11613/BM.2023.020705info:eu-repo/semantics/altIdentifier/doi/10.11613/BM.2023.020705info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:49Zoai:ri.conicet.gov.ar:11336/243178instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:49.324CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results |
title |
Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results |
spellingShingle |
Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results Benozzi, Silvia fasting coffee intake blood sample collection preanalytical variability biochemical tests |
title_short |
Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results |
title_full |
Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results |
title_fullStr |
Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results |
title_full_unstemmed |
Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results |
title_sort |
Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results |
dc.creator.none.fl_str_mv |
Benozzi, Silvia Unger, Gisela Campión, Amparo Milano, Pablo Gustavo Pennacchiotti, Graciela Laura |
author |
Benozzi, Silvia |
author_facet |
Benozzi, Silvia Unger, Gisela Campión, Amparo Milano, Pablo Gustavo Pennacchiotti, Graciela Laura |
author_role |
author |
author2 |
Unger, Gisela Campión, Amparo Milano, Pablo Gustavo Pennacchiotti, Graciela Laura |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
fasting coffee intake blood sample collection preanalytical variability biochemical tests |
topic |
fasting coffee intake blood sample collection preanalytical variability biochemical tests |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Introduction: Although current guidelines recommend not drinking coffee prior to phlebotomy, our hypothesis is that drinking coffee does not affect the clinical interpretation of biochemical and haematological test results. Materials and methods: Twenty-seven volunteers were studied in basal state (T0) and 1h after (T1) drinking coffee. Routine haematological (Sysmex-XN1000 analyser) and biochemistry parameters (Vitros 4600 analyser) were studied. Results were compared using the Wilcoxon test (P < 0.05). A clinical change was considered when mean percent difference (MD%) was higher than the reference change value (RCV). Results: Coffee intake produced statistically, but not clinically, significant: i) increases in haemoglobin (P = 0.009), mean cell haemoglobin concentration (P = 0.044), neutrophils (P = 0.001), albumin (P = 0.001), total protein (P = 0.000), cholesterol (P = 0.025), high density lipoprotein cholesterol (P = 0.007), uric acid (P = 0.011), calcium (P = 0.001), potassium (P = 0.010), aspartate aminotransferase (P = 0.001), amylase (P = 0.026), and lactate dehydrogenase (P = 0.001), and ii) decreases in mean cell volume (P = 0.002), red cell distribution width (P = 0.001), eosinophils (P = 0.002), and lymphocytes (P = 0.001), creatinine (P = 0.001), total bilirubin (P = 0.012), phosphorus (P = 0.001), magnesium (P = 0.007), and chloride (P = 0.001). Conclusion: Drinking a cup of coffee 1 hour prior to phlebotomy produces no clinically significant changes in routine biochemical and haematological test results Fil: Benozzi, Silvia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Fil: Unger, Gisela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Fil: Campión, Amparo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; Argentina Fil: Milano, Pablo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Fil: Pennacchiotti, Graciela Laura. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Hospital Municipal Doctor Leónidas Lucero; Argentina |
description |
Introduction: Although current guidelines recommend not drinking coffee prior to phlebotomy, our hypothesis is that drinking coffee does not affect the clinical interpretation of biochemical and haematological test results. Materials and methods: Twenty-seven volunteers were studied in basal state (T0) and 1h after (T1) drinking coffee. Routine haematological (Sysmex-XN1000 analyser) and biochemistry parameters (Vitros 4600 analyser) were studied. Results were compared using the Wilcoxon test (P < 0.05). A clinical change was considered when mean percent difference (MD%) was higher than the reference change value (RCV). Results: Coffee intake produced statistically, but not clinically, significant: i) increases in haemoglobin (P = 0.009), mean cell haemoglobin concentration (P = 0.044), neutrophils (P = 0.001), albumin (P = 0.001), total protein (P = 0.000), cholesterol (P = 0.025), high density lipoprotein cholesterol (P = 0.007), uric acid (P = 0.011), calcium (P = 0.001), potassium (P = 0.010), aspartate aminotransferase (P = 0.001), amylase (P = 0.026), and lactate dehydrogenase (P = 0.001), and ii) decreases in mean cell volume (P = 0.002), red cell distribution width (P = 0.001), eosinophils (P = 0.002), and lymphocytes (P = 0.001), creatinine (P = 0.001), total bilirubin (P = 0.012), phosphorus (P = 0.001), magnesium (P = 0.007), and chloride (P = 0.001). Conclusion: Drinking a cup of coffee 1 hour prior to phlebotomy produces no clinically significant changes in routine biochemical and haematological test results |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-25 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/243178 Benozzi, Silvia; Unger, Gisela; Campión, Amparo; Milano, Pablo Gustavo; Pennacchiotti, Graciela Laura; Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results; Croatian Soc Medical Biochemists; Biochemia Medica; 33; 2; 25-4-2023; 1-8 1330-0962 1846-7482 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/243178 |
identifier_str_mv |
Benozzi, Silvia; Unger, Gisela; Campión, Amparo; Milano, Pablo Gustavo; Pennacchiotti, Graciela Laura; Coffee intake one hour prior to phlebotomy produces no clinically significant changes in routine biochemical test results; Croatian Soc Medical Biochemists; Biochemia Medica; 33; 2; 25-4-2023; 1-8 1330-0962 1846-7482 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.biochemia-medica.com/en/journal/33/2/10.11613/BM.2023.020705 info:eu-repo/semantics/altIdentifier/doi/10.11613/BM.2023.020705 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Croatian Soc Medical Biochemists |
publisher.none.fl_str_mv |
Croatian Soc Medical Biochemists |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614486360588288 |
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13.070432 |