Regional brain susceptibility to neurodegeneration: What is the role of glial cells?

Autores
Cragnolini, Andrea Beatriz; Lampitella, Giorgia; Virtuoso, Assunta; Viscovo, Immacolata; Panetsos, Fivos; Papa, Michele; Cirillo, Giovanni
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events. Early in the neurodegenerative process, glial cells (including astrocytes, microglial cells, and oligodendrocytes) activate and trigger an insidious neuroinflammatory reaction, metabolic decay, blood brain barrier dysfunction and energy impairment, boosting neuronal death. How these mechanisms might induce selective neuronal death in specific brain areas are far from being elucidated. The last two decades of neurobiological studies have provided evidence of the main role of glial cells in most of the processes of the central nervous system, from development to synaptogenesis, neuronal homeostasis and integration into, highly specific neuro-glial networks. In this mini-review, we moved from in vitro and in vivo models of neurodegeneration to analyze the putative role of glial cells in the early mechanisms of neurodegeneration. We report changes of transcriptional, genetic, morphological, and metabolic activity in astrocytes and microglial cells in specific brain areas before neuronal degeneration, providing evidence in experimental models of neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. Understanding these mechanisms might increase the insight of these processes and pave the way for new specific glia-targeted therapeutic strategies for neurodegenerative disorders.
Fil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Lampitella, Giorgia. Università degli Studi della Campania Luigi Vanvitelli; Italia
Fil: Virtuoso, Assunta. Università degli Studi della Campania Luigi Vanvitelli; Italia
Fil: Viscovo, Immacolata. Università degli Studi della Campania Luigi Vanvitelli; Italia
Fil: Panetsos, Fivos. Universidad Complutense de Madrid; España
Fil: Papa, Michele. Università degli Studi della Campania Luigi Vanvitelli; Italia
Fil: Cirillo, Giovanni. Università degli Studi della Campania Luigi Vanvitelli; Italia
Materia
ASTROCYTES
GLIAL CELLS
MICROGLIA
NEURODEGENERATIVE DISEASES
NEUROINFLAMMATION
PARKINSON'S DISEASE
REACTIVE GLIOSIS
SELECTIVE NEURONAL DEGENERATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/118426
Acceder
id CONICETDig_82ec97f40992bc6b00214c22abd1cfd0
oai_identifier_str oai:ri.conicet.gov.ar:11336/118426
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regional brain susceptibility to neurodegeneration: What is the role of glial cells?Cragnolini, Andrea BeatrizLampitella, GiorgiaVirtuoso, AssuntaViscovo, ImmacolataPanetsos, FivosPapa, MicheleCirillo, GiovanniASTROCYTESGLIAL CELLSMICROGLIANEURODEGENERATIVE DISEASESNEUROINFLAMMATIONPARKINSON'S DISEASEREACTIVE GLIOSISSELECTIVE NEURONAL DEGENERATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events. Early in the neurodegenerative process, glial cells (including astrocytes, microglial cells, and oligodendrocytes) activate and trigger an insidious neuroinflammatory reaction, metabolic decay, blood brain barrier dysfunction and energy impairment, boosting neuronal death. How these mechanisms might induce selective neuronal death in specific brain areas are far from being elucidated. The last two decades of neurobiological studies have provided evidence of the main role of glial cells in most of the processes of the central nervous system, from development to synaptogenesis, neuronal homeostasis and integration into, highly specific neuro-glial networks. In this mini-review, we moved from in vitro and in vivo models of neurodegeneration to analyze the putative role of glial cells in the early mechanisms of neurodegeneration. We report changes of transcriptional, genetic, morphological, and metabolic activity in astrocytes and microglial cells in specific brain areas before neuronal degeneration, providing evidence in experimental models of neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. Understanding these mechanisms might increase the insight of these processes and pave the way for new specific glia-targeted therapeutic strategies for neurodegenerative disorders.Fil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Lampitella, Giorgia. Università degli Studi della Campania Luigi Vanvitelli; ItaliaFil: Virtuoso, Assunta. Università degli Studi della Campania Luigi Vanvitelli; ItaliaFil: Viscovo, Immacolata. Università degli Studi della Campania Luigi Vanvitelli; ItaliaFil: Panetsos, Fivos. Universidad Complutense de Madrid; EspañaFil: Papa, Michele. Università degli Studi della Campania Luigi Vanvitelli; ItaliaFil: Cirillo, Giovanni. Università degli Studi della Campania Luigi Vanvitelli; ItaliaMedknow Publications2020-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/118426Cragnolini, Andrea Beatriz; Lampitella, Giorgia; Virtuoso, Assunta; Viscovo, Immacolata; Panetsos, Fivos; et al.; Regional brain susceptibility to neurodegeneration: What is the role of glial cells?; Medknow Publications; Neural Regeneration Research; 15; 5; 5-2020; 838-8421673-53741876-7958CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=5;spage=838;epage=842;aulast=Cragnoliniinfo:eu-repo/semantics/altIdentifier/doi/10.4103/1673-5374.268897info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:10Zoai:ri.conicet.gov.ar:11336/118426instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:10.948CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
title Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
spellingShingle Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
Cragnolini, Andrea Beatriz
ASTROCYTES
GLIAL CELLS
MICROGLIA
NEURODEGENERATIVE DISEASES
NEUROINFLAMMATION
PARKINSON'S DISEASE
REACTIVE GLIOSIS
SELECTIVE NEURONAL DEGENERATION
title_short Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
title_full Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
title_fullStr Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
title_full_unstemmed Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
title_sort Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
dc.creator.none.fl_str_mv Cragnolini, Andrea Beatriz
Lampitella, Giorgia
Virtuoso, Assunta
Viscovo, Immacolata
Panetsos, Fivos
Papa, Michele
Cirillo, Giovanni
author Cragnolini, Andrea Beatriz
author_facet Cragnolini, Andrea Beatriz
Lampitella, Giorgia
Virtuoso, Assunta
Viscovo, Immacolata
Panetsos, Fivos
Papa, Michele
Cirillo, Giovanni
author_role author
author2 Lampitella, Giorgia
Virtuoso, Assunta
Viscovo, Immacolata
Panetsos, Fivos
Papa, Michele
Cirillo, Giovanni
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ASTROCYTES
GLIAL CELLS
MICROGLIA
NEURODEGENERATIVE DISEASES
NEUROINFLAMMATION
PARKINSON'S DISEASE
REACTIVE GLIOSIS
SELECTIVE NEURONAL DEGENERATION
topic ASTROCYTES
GLIAL CELLS
MICROGLIA
NEURODEGENERATIVE DISEASES
NEUROINFLAMMATION
PARKINSON'S DISEASE
REACTIVE GLIOSIS
SELECTIVE NEURONAL DEGENERATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events. Early in the neurodegenerative process, glial cells (including astrocytes, microglial cells, and oligodendrocytes) activate and trigger an insidious neuroinflammatory reaction, metabolic decay, blood brain barrier dysfunction and energy impairment, boosting neuronal death. How these mechanisms might induce selective neuronal death in specific brain areas are far from being elucidated. The last two decades of neurobiological studies have provided evidence of the main role of glial cells in most of the processes of the central nervous system, from development to synaptogenesis, neuronal homeostasis and integration into, highly specific neuro-glial networks. In this mini-review, we moved from in vitro and in vivo models of neurodegeneration to analyze the putative role of glial cells in the early mechanisms of neurodegeneration. We report changes of transcriptional, genetic, morphological, and metabolic activity in astrocytes and microglial cells in specific brain areas before neuronal degeneration, providing evidence in experimental models of neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. Understanding these mechanisms might increase the insight of these processes and pave the way for new specific glia-targeted therapeutic strategies for neurodegenerative disorders.
Fil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Lampitella, Giorgia. Università degli Studi della Campania Luigi Vanvitelli; Italia
Fil: Virtuoso, Assunta. Università degli Studi della Campania Luigi Vanvitelli; Italia
Fil: Viscovo, Immacolata. Università degli Studi della Campania Luigi Vanvitelli; Italia
Fil: Panetsos, Fivos. Universidad Complutense de Madrid; España
Fil: Papa, Michele. Università degli Studi della Campania Luigi Vanvitelli; Italia
Fil: Cirillo, Giovanni. Università degli Studi della Campania Luigi Vanvitelli; Italia
description The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events. Early in the neurodegenerative process, glial cells (including astrocytes, microglial cells, and oligodendrocytes) activate and trigger an insidious neuroinflammatory reaction, metabolic decay, blood brain barrier dysfunction and energy impairment, boosting neuronal death. How these mechanisms might induce selective neuronal death in specific brain areas are far from being elucidated. The last two decades of neurobiological studies have provided evidence of the main role of glial cells in most of the processes of the central nervous system, from development to synaptogenesis, neuronal homeostasis and integration into, highly specific neuro-glial networks. In this mini-review, we moved from in vitro and in vivo models of neurodegeneration to analyze the putative role of glial cells in the early mechanisms of neurodegeneration. We report changes of transcriptional, genetic, morphological, and metabolic activity in astrocytes and microglial cells in specific brain areas before neuronal degeneration, providing evidence in experimental models of neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. Understanding these mechanisms might increase the insight of these processes and pave the way for new specific glia-targeted therapeutic strategies for neurodegenerative disorders.
publishDate 2020
dc.date.none.fl_str_mv 2020-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/118426
Cragnolini, Andrea Beatriz; Lampitella, Giorgia; Virtuoso, Assunta; Viscovo, Immacolata; Panetsos, Fivos; et al.; Regional brain susceptibility to neurodegeneration: What is the role of glial cells?; Medknow Publications; Neural Regeneration Research; 15; 5; 5-2020; 838-842
1673-5374
1876-7958
CONICET Digital
CONICET
url http://hdl.handle.net/11336/118426
identifier_str_mv Cragnolini, Andrea Beatriz; Lampitella, Giorgia; Virtuoso, Assunta; Viscovo, Immacolata; Panetsos, Fivos; et al.; Regional brain susceptibility to neurodegeneration: What is the role of glial cells?; Medknow Publications; Neural Regeneration Research; 15; 5; 5-2020; 838-842
1673-5374
1876-7958
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=5;spage=838;epage=842;aulast=Cragnolini
info:eu-repo/semantics/altIdentifier/doi/10.4103/1673-5374.268897
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Medknow Publications
publisher.none.fl_str_mv Medknow Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613359163408384
score 13.070432

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