Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease

Autores
Cabezas, Ricardo; Ávila, Marcos; Gonzalez Santos, Janneth; El Bachá, Ramon Santos; Báez, Eliana; Garcia Segura, Luis Miguel; Coronel, Juan Camilo Jurado; Capani, Francisco; Cardona Gomez, Gloria Patricia; Barreto, George E.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The blood-brain barrier (BBB) is a tightly regulated interface in the Central Nervous System (CNS) that regulates the exchange of molecules in and out from the brain thus maintaining the CNS homeostasis. It is mainly composed of endothelial cells (ECs), pericytes and astrocytes that create a neurovascular unit (NVU) with the adjacent neurons. Astrocytes are essential for the formation and maintenance of the BBB by providing secreted factors that lead to the adequate association between the cells of the BBB and the formation of strong tight junctions. Under neurological disorders, such as chronic cerebral ischemia, brain trauma, Epilepsy, Alzheimer and Parkinson's Diseases, a disruption of the BBB takes place, involving a lost in the permeability of the barrier and phenotypical changes in both the ECs and astrocytes. In this aspect, it has been established that the process of reactive gliosis is a common feature of astrocytes during BBB disruption, which has a detrimental effect on the barrier function and a subsequent damage in neuronal survival. In this review we discuss the implications of astrocyte functions in the protection of the BBB, and in the development of Parkinson's disease (PD) and related disorders. Additionally, we highlight the current and future strategies in astrocyte protection aimed at the development of restorative therapies for the BBB in pathological conditions.
Fil: Cabezas, Ricardo. Pontificia Universidad Javeriana; Colombia
Fil: Ávila, Marcos. Pontificia Universidad Javeriana; Colombia
Fil: Gonzalez Santos, Janneth. Pontificia Universidad Javeriana; Colombia
Fil: El Bachá, Ramon Santos. Universidade Federal da Bahia; Brasil
Fil: Báez, Eliana. Pontificia Universidad Javeriana; Colombia
Fil: Garcia Segura, Luis Miguel. Consejo Superior de Investigaciones Científicas; España
Fil: Coronel, Juan Camilo Jurado. Pontificia Universidad Javeriana; Colombia
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Cardona Gomez, Gloria Patricia. Universidad de Antioquia; Colombia
Fil: Barreto, George E.. Pontificia Universidad Javeriana; Colombia
Materia
ASTROCYTES
BBB
ENDOTHELIAL CELLS
PARKINSON DISEASE
REACTIVE ASTROGLIOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85837
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/85837
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's diseaseCabezas, RicardoÁvila, MarcosGonzalez Santos, JannethEl Bachá, Ramon SantosBáez, ElianaGarcia Segura, Luis MiguelCoronel, Juan Camilo JuradoCapani, FranciscoCardona Gomez, Gloria PatriciaBarreto, George E.ASTROCYTESBBBENDOTHELIAL CELLSPARKINSON DISEASEREACTIVE ASTROGLIOSIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The blood-brain barrier (BBB) is a tightly regulated interface in the Central Nervous System (CNS) that regulates the exchange of molecules in and out from the brain thus maintaining the CNS homeostasis. It is mainly composed of endothelial cells (ECs), pericytes and astrocytes that create a neurovascular unit (NVU) with the adjacent neurons. Astrocytes are essential for the formation and maintenance of the BBB by providing secreted factors that lead to the adequate association between the cells of the BBB and the formation of strong tight junctions. Under neurological disorders, such as chronic cerebral ischemia, brain trauma, Epilepsy, Alzheimer and Parkinson's Diseases, a disruption of the BBB takes place, involving a lost in the permeability of the barrier and phenotypical changes in both the ECs and astrocytes. In this aspect, it has been established that the process of reactive gliosis is a common feature of astrocytes during BBB disruption, which has a detrimental effect on the barrier function and a subsequent damage in neuronal survival. In this review we discuss the implications of astrocyte functions in the protection of the BBB, and in the development of Parkinson's disease (PD) and related disorders. Additionally, we highlight the current and future strategies in astrocyte protection aimed at the development of restorative therapies for the BBB in pathological conditions.Fil: Cabezas, Ricardo. Pontificia Universidad Javeriana; ColombiaFil: Ávila, Marcos. Pontificia Universidad Javeriana; ColombiaFil: Gonzalez Santos, Janneth. Pontificia Universidad Javeriana; ColombiaFil: El Bachá, Ramon Santos. Universidade Federal da Bahia; BrasilFil: Báez, Eliana. Pontificia Universidad Javeriana; ColombiaFil: Garcia Segura, Luis Miguel. Consejo Superior de Investigaciones Científicas; EspañaFil: Coronel, Juan Camilo Jurado. Pontificia Universidad Javeriana; ColombiaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Cardona Gomez, Gloria Patricia. Universidad de Antioquia; ColombiaFil: Barreto, George E.. Pontificia Universidad Javeriana; ColombiaFrontiers Research Foundation2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85837Cabezas, Ricardo; Ávila, Marcos; Gonzalez Santos, Janneth; El Bachá, Ramon Santos; Báez, Eliana; et al.; Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease; Frontiers Research Foundation; Frontiers in Cellular Neuroscience; 8; AUG; 8-2014; 1-111662-5102CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fncel.2014.00211info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fncel.2014.00211/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:07Zoai:ri.conicet.gov.ar:11336/85837instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:07.582CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
title Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
spellingShingle Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
Cabezas, Ricardo
ASTROCYTES
BBB
ENDOTHELIAL CELLS
PARKINSON DISEASE
REACTIVE ASTROGLIOSIS
title_short Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
title_full Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
title_fullStr Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
title_full_unstemmed Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
title_sort Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
dc.creator.none.fl_str_mv Cabezas, Ricardo
Ávila, Marcos
Gonzalez Santos, Janneth
El Bachá, Ramon Santos
Báez, Eliana
Garcia Segura, Luis Miguel
Coronel, Juan Camilo Jurado
Capani, Francisco
Cardona Gomez, Gloria Patricia
Barreto, George E.
author Cabezas, Ricardo
author_facet Cabezas, Ricardo
Ávila, Marcos
Gonzalez Santos, Janneth
El Bachá, Ramon Santos
Báez, Eliana
Garcia Segura, Luis Miguel
Coronel, Juan Camilo Jurado
Capani, Francisco
Cardona Gomez, Gloria Patricia
Barreto, George E.
author_role author
author2 Ávila, Marcos
Gonzalez Santos, Janneth
El Bachá, Ramon Santos
Báez, Eliana
Garcia Segura, Luis Miguel
Coronel, Juan Camilo Jurado
Capani, Francisco
Cardona Gomez, Gloria Patricia
Barreto, George E.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ASTROCYTES
BBB
ENDOTHELIAL CELLS
PARKINSON DISEASE
REACTIVE ASTROGLIOSIS
topic ASTROCYTES
BBB
ENDOTHELIAL CELLS
PARKINSON DISEASE
REACTIVE ASTROGLIOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The blood-brain barrier (BBB) is a tightly regulated interface in the Central Nervous System (CNS) that regulates the exchange of molecules in and out from the brain thus maintaining the CNS homeostasis. It is mainly composed of endothelial cells (ECs), pericytes and astrocytes that create a neurovascular unit (NVU) with the adjacent neurons. Astrocytes are essential for the formation and maintenance of the BBB by providing secreted factors that lead to the adequate association between the cells of the BBB and the formation of strong tight junctions. Under neurological disorders, such as chronic cerebral ischemia, brain trauma, Epilepsy, Alzheimer and Parkinson's Diseases, a disruption of the BBB takes place, involving a lost in the permeability of the barrier and phenotypical changes in both the ECs and astrocytes. In this aspect, it has been established that the process of reactive gliosis is a common feature of astrocytes during BBB disruption, which has a detrimental effect on the barrier function and a subsequent damage in neuronal survival. In this review we discuss the implications of astrocyte functions in the protection of the BBB, and in the development of Parkinson's disease (PD) and related disorders. Additionally, we highlight the current and future strategies in astrocyte protection aimed at the development of restorative therapies for the BBB in pathological conditions.
Fil: Cabezas, Ricardo. Pontificia Universidad Javeriana; Colombia
Fil: Ávila, Marcos. Pontificia Universidad Javeriana; Colombia
Fil: Gonzalez Santos, Janneth. Pontificia Universidad Javeriana; Colombia
Fil: El Bachá, Ramon Santos. Universidade Federal da Bahia; Brasil
Fil: Báez, Eliana. Pontificia Universidad Javeriana; Colombia
Fil: Garcia Segura, Luis Miguel. Consejo Superior de Investigaciones Científicas; España
Fil: Coronel, Juan Camilo Jurado. Pontificia Universidad Javeriana; Colombia
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Cardona Gomez, Gloria Patricia. Universidad de Antioquia; Colombia
Fil: Barreto, George E.. Pontificia Universidad Javeriana; Colombia
description The blood-brain barrier (BBB) is a tightly regulated interface in the Central Nervous System (CNS) that regulates the exchange of molecules in and out from the brain thus maintaining the CNS homeostasis. It is mainly composed of endothelial cells (ECs), pericytes and astrocytes that create a neurovascular unit (NVU) with the adjacent neurons. Astrocytes are essential for the formation and maintenance of the BBB by providing secreted factors that lead to the adequate association between the cells of the BBB and the formation of strong tight junctions. Under neurological disorders, such as chronic cerebral ischemia, brain trauma, Epilepsy, Alzheimer and Parkinson's Diseases, a disruption of the BBB takes place, involving a lost in the permeability of the barrier and phenotypical changes in both the ECs and astrocytes. In this aspect, it has been established that the process of reactive gliosis is a common feature of astrocytes during BBB disruption, which has a detrimental effect on the barrier function and a subsequent damage in neuronal survival. In this review we discuss the implications of astrocyte functions in the protection of the BBB, and in the development of Parkinson's disease (PD) and related disorders. Additionally, we highlight the current and future strategies in astrocyte protection aimed at the development of restorative therapies for the BBB in pathological conditions.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85837
Cabezas, Ricardo; Ávila, Marcos; Gonzalez Santos, Janneth; El Bachá, Ramon Santos; Báez, Eliana; et al.; Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease; Frontiers Research Foundation; Frontiers in Cellular Neuroscience; 8; AUG; 8-2014; 1-11
1662-5102
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85837
identifier_str_mv Cabezas, Ricardo; Ávila, Marcos; Gonzalez Santos, Janneth; El Bachá, Ramon Santos; Báez, Eliana; et al.; Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease; Frontiers Research Foundation; Frontiers in Cellular Neuroscience; 8; AUG; 8-2014; 1-11
1662-5102
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fncel.2014.00211
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fncel.2014.00211/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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