A genome-wide association study of mare fertility in the Pura Raza Español horse

Autores
Laseca, Nora; Demyda Peyrás, Sebastián; Valera Córdoba, Mercedes; Ramón, Manuel; Escribano, Begoña María; Perdomo González, Davinia Isabel; Molina, Antonio José
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Despite the economic importance of fertility for the horse industry, few efforts have been made to achieve a better understanding of the genetic mechanisms underlying its control. This is probably due to the difficulty of obtaining reliable phenotypes and the complexity of modelling the environmental and management factors. This work is novel in that we propose to use reproductive efficiency (RE) as an indicator of mare fertility. To achieve this, we performed a genome-wide association study in the Pura Raza Español horse aimed at identifying genomic variants, regions, and candidate genes associated with fertility in mares. The dataset included 819 animals genotyped with the Affymetrix Axiom™ Equine 670 K single-nucleotide polymorphisms (SNPs) Genotyping Array and the deregressed breeding values for RE trait, obtained using a ssBLUP model, employed as pseudo-phenotypic data. Our results showed 28 SNPs potentially associated with RE, which explained 87.19% of the genetic variance and 6.61% of the phenotypic variance. Those results were further validated in BayesB, showing a correlation between observed and predicted RE of 0.57. In addition, 15 candidate genes (HTRA3, SPIRE1, APOE, ERCC1, FOXA3, NECTIN-2, KLC3, RSPH6A, PDPK1, MEIOB, PAQR4, NM3, PKD1, PRSS21, IFT140) previously related to fertility in mammals were associated with the markers and genomic regions significantly associated with RE. To our knowledge, this is the first genome-wide association study performed on mare fertility.
Fil: Laseca, Nora. Universidad de Córdoba; España
Fil: Demyda Peyrás, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Valera Córdoba, Mercedes. Universidad de Sevilla; España
Fil: Ramón, Manuel. Centro Regional de Selección y Reproducción Animal; España
Fil: Escribano, Begoña María. Universidad de Córdoba; España
Fil: Perdomo González, Davinia Isabel. Universidad de Sevilla; España
Fil: Molina, Antonio José. Universidad de Córdoba; España
Materia
ASSOCIATION ANALYSIS
CANDIDATE GENES
EQUINE
REPRODUCTIVE TRAITS
SINGLE-NUCLEOTIDE POLYMORPHISMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/161517
Acceder
id CONICETDig_81e3af9966b75e2102b925e094a56fc8
oai_identifier_str oai:ri.conicet.gov.ar:11336/161517
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A genome-wide association study of mare fertility in the Pura Raza Español horseLaseca, NoraDemyda Peyrás, SebastiánValera Córdoba, MercedesRamón, ManuelEscribano, Begoña MaríaPerdomo González, Davinia IsabelMolina, Antonio JoséASSOCIATION ANALYSISCANDIDATE GENESEQUINEREPRODUCTIVE TRAITSSINGLE-NUCLEOTIDE POLYMORPHISMShttps://purl.org/becyt/ford/4.4https://purl.org/becyt/ford/4Despite the economic importance of fertility for the horse industry, few efforts have been made to achieve a better understanding of the genetic mechanisms underlying its control. This is probably due to the difficulty of obtaining reliable phenotypes and the complexity of modelling the environmental and management factors. This work is novel in that we propose to use reproductive efficiency (RE) as an indicator of mare fertility. To achieve this, we performed a genome-wide association study in the Pura Raza Español horse aimed at identifying genomic variants, regions, and candidate genes associated with fertility in mares. The dataset included 819 animals genotyped with the Affymetrix Axiom™ Equine 670 K single-nucleotide polymorphisms (SNPs) Genotyping Array and the deregressed breeding values for RE trait, obtained using a ssBLUP model, employed as pseudo-phenotypic data. Our results showed 28 SNPs potentially associated with RE, which explained 87.19% of the genetic variance and 6.61% of the phenotypic variance. Those results were further validated in BayesB, showing a correlation between observed and predicted RE of 0.57. In addition, 15 candidate genes (HTRA3, SPIRE1, APOE, ERCC1, FOXA3, NECTIN-2, KLC3, RSPH6A, PDPK1, MEIOB, PAQR4, NM3, PKD1, PRSS21, IFT140) previously related to fertility in mammals were associated with the markers and genomic regions significantly associated with RE. To our knowledge, this is the first genome-wide association study performed on mare fertility.Fil: Laseca, Nora. Universidad de Córdoba; EspañaFil: Demyda Peyrás, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Valera Córdoba, Mercedes. Universidad de Sevilla; EspañaFil: Ramón, Manuel. Centro Regional de Selección y Reproducción Animal; EspañaFil: Escribano, Begoña María. Universidad de Córdoba; EspañaFil: Perdomo González, Davinia Isabel. Universidad de Sevilla; EspañaFil: Molina, Antonio José. Universidad de Córdoba; EspañaElsevier2022-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/161517Laseca, Nora; Demyda Peyrás, Sebastián; Valera Córdoba, Mercedes; Ramón, Manuel; Escribano, Begoña María; et al.; A genome-wide association study of mare fertility in the Pura Raza Español horse; Elsevier; Animal; 16; 3; 3-2022; 1-81751-7311CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1751731122000234info:eu-repo/semantics/altIdentifier/doi/10.1016/j.animal.2022.100476info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:38Zoai:ri.conicet.gov.ar:11336/161517instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:39.038CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A genome-wide association study of mare fertility in the Pura Raza Español horse
title A genome-wide association study of mare fertility in the Pura Raza Español horse
spellingShingle A genome-wide association study of mare fertility in the Pura Raza Español horse
Laseca, Nora
ASSOCIATION ANALYSIS
CANDIDATE GENES
EQUINE
REPRODUCTIVE TRAITS
SINGLE-NUCLEOTIDE POLYMORPHISMS
title_short A genome-wide association study of mare fertility in the Pura Raza Español horse
title_full A genome-wide association study of mare fertility in the Pura Raza Español horse
title_fullStr A genome-wide association study of mare fertility in the Pura Raza Español horse
title_full_unstemmed A genome-wide association study of mare fertility in the Pura Raza Español horse
title_sort A genome-wide association study of mare fertility in the Pura Raza Español horse
dc.creator.none.fl_str_mv Laseca, Nora
Demyda Peyrás, Sebastián
Valera Córdoba, Mercedes
Ramón, Manuel
Escribano, Begoña María
Perdomo González, Davinia Isabel
Molina, Antonio José
author Laseca, Nora
author_facet Laseca, Nora
Demyda Peyrás, Sebastián
Valera Córdoba, Mercedes
Ramón, Manuel
Escribano, Begoña María
Perdomo González, Davinia Isabel
Molina, Antonio José
author_role author
author2 Demyda Peyrás, Sebastián
Valera Córdoba, Mercedes
Ramón, Manuel
Escribano, Begoña María
Perdomo González, Davinia Isabel
Molina, Antonio José
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ASSOCIATION ANALYSIS
CANDIDATE GENES
EQUINE
REPRODUCTIVE TRAITS
SINGLE-NUCLEOTIDE POLYMORPHISMS
topic ASSOCIATION ANALYSIS
CANDIDATE GENES
EQUINE
REPRODUCTIVE TRAITS
SINGLE-NUCLEOTIDE POLYMORPHISMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.4
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Despite the economic importance of fertility for the horse industry, few efforts have been made to achieve a better understanding of the genetic mechanisms underlying its control. This is probably due to the difficulty of obtaining reliable phenotypes and the complexity of modelling the environmental and management factors. This work is novel in that we propose to use reproductive efficiency (RE) as an indicator of mare fertility. To achieve this, we performed a genome-wide association study in the Pura Raza Español horse aimed at identifying genomic variants, regions, and candidate genes associated with fertility in mares. The dataset included 819 animals genotyped with the Affymetrix Axiom™ Equine 670 K single-nucleotide polymorphisms (SNPs) Genotyping Array and the deregressed breeding values for RE trait, obtained using a ssBLUP model, employed as pseudo-phenotypic data. Our results showed 28 SNPs potentially associated with RE, which explained 87.19% of the genetic variance and 6.61% of the phenotypic variance. Those results were further validated in BayesB, showing a correlation between observed and predicted RE of 0.57. In addition, 15 candidate genes (HTRA3, SPIRE1, APOE, ERCC1, FOXA3, NECTIN-2, KLC3, RSPH6A, PDPK1, MEIOB, PAQR4, NM3, PKD1, PRSS21, IFT140) previously related to fertility in mammals were associated with the markers and genomic regions significantly associated with RE. To our knowledge, this is the first genome-wide association study performed on mare fertility.
Fil: Laseca, Nora. Universidad de Córdoba; España
Fil: Demyda Peyrás, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Valera Córdoba, Mercedes. Universidad de Sevilla; España
Fil: Ramón, Manuel. Centro Regional de Selección y Reproducción Animal; España
Fil: Escribano, Begoña María. Universidad de Córdoba; España
Fil: Perdomo González, Davinia Isabel. Universidad de Sevilla; España
Fil: Molina, Antonio José. Universidad de Córdoba; España
description Despite the economic importance of fertility for the horse industry, few efforts have been made to achieve a better understanding of the genetic mechanisms underlying its control. This is probably due to the difficulty of obtaining reliable phenotypes and the complexity of modelling the environmental and management factors. This work is novel in that we propose to use reproductive efficiency (RE) as an indicator of mare fertility. To achieve this, we performed a genome-wide association study in the Pura Raza Español horse aimed at identifying genomic variants, regions, and candidate genes associated with fertility in mares. The dataset included 819 animals genotyped with the Affymetrix Axiom™ Equine 670 K single-nucleotide polymorphisms (SNPs) Genotyping Array and the deregressed breeding values for RE trait, obtained using a ssBLUP model, employed as pseudo-phenotypic data. Our results showed 28 SNPs potentially associated with RE, which explained 87.19% of the genetic variance and 6.61% of the phenotypic variance. Those results were further validated in BayesB, showing a correlation between observed and predicted RE of 0.57. In addition, 15 candidate genes (HTRA3, SPIRE1, APOE, ERCC1, FOXA3, NECTIN-2, KLC3, RSPH6A, PDPK1, MEIOB, PAQR4, NM3, PKD1, PRSS21, IFT140) previously related to fertility in mammals were associated with the markers and genomic regions significantly associated with RE. To our knowledge, this is the first genome-wide association study performed on mare fertility.
publishDate 2022
dc.date.none.fl_str_mv 2022-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/161517
Laseca, Nora; Demyda Peyrás, Sebastián; Valera Córdoba, Mercedes; Ramón, Manuel; Escribano, Begoña María; et al.; A genome-wide association study of mare fertility in the Pura Raza Español horse; Elsevier; Animal; 16; 3; 3-2022; 1-8
1751-7311
CONICET Digital
CONICET
url http://hdl.handle.net/11336/161517
identifier_str_mv Laseca, Nora; Demyda Peyrás, Sebastián; Valera Córdoba, Mercedes; Ramón, Manuel; Escribano, Begoña María; et al.; A genome-wide association study of mare fertility in the Pura Raza Español horse; Elsevier; Animal; 16; 3; 3-2022; 1-8
1751-7311
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1751731122000234
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.animal.2022.100476
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269867749670912
score 13.13397

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