Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
- Autores
- Liu, Fan; Chen, Yan; Zhu, Gu; Hysi, Pirro G.; Wu, Sijie; Adhikari, Kaustubh; Breslin, Krystal; Pośpiech, Ewelina; Hamer, Merel A.; Peng, Fuduan; Muralidharan, Charanya; Acuna Alonzo, Victor; Canizales Quinteros, Samuel; Bedoya, Gabriel; Gallo, Carla; Poletti, Giovanni; Rothhammer, Francisco; Bortolini, Maria Catira; González José, Rolando; Zeng, Changqing; Xu, Shuhua; Jin, Li; Uitterlinden, André G.; Ikram, M. Arfan; van Duijn, Cornelia M.; Nijsten, Tamar; Walsh, Susan; Branicki, Wojciech; Wang, Sijia; Ruiz Linares, Andrés; Spector, Timothy D.; Martin, Nicholas G.; Medland, Sarah E.; Kayser, Manfred
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P<5e-8). All except one (1p36.22 PEX14) were replicated with nominal significance in at least one of the 6 additional cohorts of European, Native American and East Asian origins. Three additional previously known genes (EDAR, OFCC1, and PRSS53) were confirmed at the nominal significance level. A multivariable regression model revealed that 14 SNPs from different genes significantly and independently contribute to hair shape variation, reaching a cross-validated AUC value of 0.66 (95% CI: 0.62-0.70) and an AUC value of 0.64 in an independent validation cohort, providing an improved accuracy compared with a previous model. Prediction outcomes of 2504 individuals from a multiethnic sample were largely consistent with general knowledge on the global distribution of hair shape variation. Our study thus delivers target genes and DNA variants for future functional studies to further evaluate the molecular basis of hair shape in humans.
Fil: Liu, Fan. Chinese Academy of Sciences; República de China. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Chen, Yan. Chinese Academy of Sciences; República de China
Fil: Zhu, Gu. QIMR Berghofer Medical Research Institute; Australia
Fil: Hysi, Pirro G.. King’s College London; Reino Unido
Fil: Wu, Sijie. Chinese Academy of Sciences; República de China
Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido
Fil: Breslin, Krystal. Indiana University; Estados Unidos. Purdue University; Estados Unidos
Fil: Pośpiech, Ewelina. Jagiellonian University; Polonia
Fil: Hamer, Merel A.. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Peng, Fuduan. Chinese Academy of Sciences; República de China
Fil: Muralidharan, Charanya. Indiana University; Estados Unidos. Purdue University; Estados Unidos
Fil: Acuna Alonzo, Victor. Escuela Nacional de Antropologia e Historia; México
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Zeng, Changqing. Chinese Academy of Sciences; República de China
Fil: Xu, Shuhua. Chinese Academy of Sciences; República de China. Fudan University; China. Shanghai Tech University; China
Fil: Jin, Li. University of Chinese Academy of Sciences; China. Fudan University; China
Fil: Uitterlinden, André G.. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Ikram, M. Arfan. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: van Duijn, Cornelia M.. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Nijsten, Tamar. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Walsh, Susan. Indiana University; Estados Unidos. Purdue University; Estados Unidos
Fil: Branicki, Wojciech. Jagiellonian University; Polonia. Central Forensic Laboratory of the Police; Polonia
Fil: Wang, Sijia. Chinese Academy of Sciences; República de China. Fudan University; China
Fil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido. Fudan University; China. Aix-Marseille Université; Francia
Fil: Spector, Timothy D.. King’s College London; Reino Unido
Fil: Martin, Nicholas G.. QIMR Berghofer Medical Research Institute; Australia
Fil: Medland, Sarah E.. QIMR Berghofer Medical Research Institute; Australia
Fil: Kayser, Manfred. Erasmus MC University Medical Center Rotterdam; Países Bajos - Materia
-
Genes
Genome
Hair
Single Nucleotide Polymorphism
Genetics
Native Americans
Asian
Genome-Wide Association Study - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/40412
Ver los metadatos del registro completo
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Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hairLiu, FanChen, YanZhu, GuHysi, Pirro G.Wu, SijieAdhikari, KaustubhBreslin, KrystalPośpiech, EwelinaHamer, Merel A.Peng, FuduanMuralidharan, CharanyaAcuna Alonzo, VictorCanizales Quinteros, SamuelBedoya, GabrielGallo, CarlaPoletti, GiovanniRothhammer, FranciscoBortolini, Maria CatiraGonzález José, RolandoZeng, ChangqingXu, ShuhuaJin, LiUitterlinden, André G.Ikram, M. Arfanvan Duijn, Cornelia M.Nijsten, TamarWalsh, SusanBranicki, WojciechWang, SijiaRuiz Linares, AndrésSpector, Timothy D.Martin, Nicholas G.Medland, Sarah E.Kayser, ManfredGenesGenomeHairSingle Nucleotide PolymorphismGeneticsNative AmericansAsianGenome-Wide Association Studyhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P<5e-8). All except one (1p36.22 PEX14) were replicated with nominal significance in at least one of the 6 additional cohorts of European, Native American and East Asian origins. Three additional previously known genes (EDAR, OFCC1, and PRSS53) were confirmed at the nominal significance level. A multivariable regression model revealed that 14 SNPs from different genes significantly and independently contribute to hair shape variation, reaching a cross-validated AUC value of 0.66 (95% CI: 0.62-0.70) and an AUC value of 0.64 in an independent validation cohort, providing an improved accuracy compared with a previous model. Prediction outcomes of 2504 individuals from a multiethnic sample were largely consistent with general knowledge on the global distribution of hair shape variation. Our study thus delivers target genes and DNA variants for future functional studies to further evaluate the molecular basis of hair shape in humans.Fil: Liu, Fan. Chinese Academy of Sciences; República de China. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Chen, Yan. Chinese Academy of Sciences; República de ChinaFil: Zhu, Gu. QIMR Berghofer Medical Research Institute; AustraliaFil: Hysi, Pirro G.. King’s College London; Reino UnidoFil: Wu, Sijie. Chinese Academy of Sciences; República de ChinaFil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino UnidoFil: Breslin, Krystal. Indiana University; Estados Unidos. Purdue University; Estados UnidosFil: Pośpiech, Ewelina. Jagiellonian University; PoloniaFil: Hamer, Merel A.. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Peng, Fuduan. Chinese Academy of Sciences; República de ChinaFil: Muralidharan, Charanya. Indiana University; Estados Unidos. Purdue University; Estados UnidosFil: Acuna Alonzo, Victor. Escuela Nacional de Antropologia e Historia; MéxicoFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Bedoya, Gabriel. Universidad de Antioquia; ColombiaFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; PerúFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; BrasilFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Zeng, Changqing. Chinese Academy of Sciences; República de ChinaFil: Xu, Shuhua. Chinese Academy of Sciences; República de China. Fudan University; China. Shanghai Tech University; ChinaFil: Jin, Li. University of Chinese Academy of Sciences; China. Fudan University; ChinaFil: Uitterlinden, André G.. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Ikram, M. Arfan. Erasmus MC University Medical Center Rotterdam; Países BajosFil: van Duijn, Cornelia M.. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Nijsten, Tamar. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Walsh, Susan. Indiana University; Estados Unidos. Purdue University; Estados UnidosFil: Branicki, Wojciech. Jagiellonian University; Polonia. Central Forensic Laboratory of the Police; PoloniaFil: Wang, Sijia. Chinese Academy of Sciences; República de China. Fudan University; ChinaFil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido. Fudan University; China. Aix-Marseille Université; FranciaFil: Spector, Timothy D.. King’s College London; Reino UnidoFil: Martin, Nicholas G.. QIMR Berghofer Medical Research Institute; AustraliaFil: Medland, Sarah E.. QIMR Berghofer Medical Research Institute; AustraliaFil: Kayser, Manfred. Erasmus MC University Medical Center Rotterdam; Países BajosOxford University Press2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40412Liu, Fan; Chen, Yan; Zhu, Gu; Hysi, Pirro G.; Wu, Sijie; et al.; Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair; Oxford University Press; Human Molecular Genetics; 27; 3; 2-2018; 559-5750964-69061460-2083CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddx416/4693879info:eu-repo/semantics/altIdentifier/doi/10.1093/hmg/ddx416info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:16:03Zoai:ri.conicet.gov.ar:11336/40412instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:16:03.662CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair |
title |
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair |
spellingShingle |
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair Liu, Fan Genes Genome Hair Single Nucleotide Polymorphism Genetics Native Americans Asian Genome-Wide Association Study |
title_short |
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair |
title_full |
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair |
title_fullStr |
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair |
title_full_unstemmed |
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair |
title_sort |
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair |
dc.creator.none.fl_str_mv |
Liu, Fan Chen, Yan Zhu, Gu Hysi, Pirro G. Wu, Sijie Adhikari, Kaustubh Breslin, Krystal Pośpiech, Ewelina Hamer, Merel A. Peng, Fuduan Muralidharan, Charanya Acuna Alonzo, Victor Canizales Quinteros, Samuel Bedoya, Gabriel Gallo, Carla Poletti, Giovanni Rothhammer, Francisco Bortolini, Maria Catira González José, Rolando Zeng, Changqing Xu, Shuhua Jin, Li Uitterlinden, André G. Ikram, M. Arfan van Duijn, Cornelia M. Nijsten, Tamar Walsh, Susan Branicki, Wojciech Wang, Sijia Ruiz Linares, Andrés Spector, Timothy D. Martin, Nicholas G. Medland, Sarah E. Kayser, Manfred |
author |
Liu, Fan |
author_facet |
Liu, Fan Chen, Yan Zhu, Gu Hysi, Pirro G. Wu, Sijie Adhikari, Kaustubh Breslin, Krystal Pośpiech, Ewelina Hamer, Merel A. Peng, Fuduan Muralidharan, Charanya Acuna Alonzo, Victor Canizales Quinteros, Samuel Bedoya, Gabriel Gallo, Carla Poletti, Giovanni Rothhammer, Francisco Bortolini, Maria Catira González José, Rolando Zeng, Changqing Xu, Shuhua Jin, Li Uitterlinden, André G. Ikram, M. Arfan van Duijn, Cornelia M. Nijsten, Tamar Walsh, Susan Branicki, Wojciech Wang, Sijia Ruiz Linares, Andrés Spector, Timothy D. Martin, Nicholas G. Medland, Sarah E. Kayser, Manfred |
author_role |
author |
author2 |
Chen, Yan Zhu, Gu Hysi, Pirro G. Wu, Sijie Adhikari, Kaustubh Breslin, Krystal Pośpiech, Ewelina Hamer, Merel A. Peng, Fuduan Muralidharan, Charanya Acuna Alonzo, Victor Canizales Quinteros, Samuel Bedoya, Gabriel Gallo, Carla Poletti, Giovanni Rothhammer, Francisco Bortolini, Maria Catira González José, Rolando Zeng, Changqing Xu, Shuhua Jin, Li Uitterlinden, André G. Ikram, M. Arfan van Duijn, Cornelia M. Nijsten, Tamar Walsh, Susan Branicki, Wojciech Wang, Sijia Ruiz Linares, Andrés Spector, Timothy D. Martin, Nicholas G. Medland, Sarah E. Kayser, Manfred |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Genes Genome Hair Single Nucleotide Polymorphism Genetics Native Americans Asian Genome-Wide Association Study |
topic |
Genes Genome Hair Single Nucleotide Polymorphism Genetics Native Americans Asian Genome-Wide Association Study |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P<5e-8). All except one (1p36.22 PEX14) were replicated with nominal significance in at least one of the 6 additional cohorts of European, Native American and East Asian origins. Three additional previously known genes (EDAR, OFCC1, and PRSS53) were confirmed at the nominal significance level. A multivariable regression model revealed that 14 SNPs from different genes significantly and independently contribute to hair shape variation, reaching a cross-validated AUC value of 0.66 (95% CI: 0.62-0.70) and an AUC value of 0.64 in an independent validation cohort, providing an improved accuracy compared with a previous model. Prediction outcomes of 2504 individuals from a multiethnic sample were largely consistent with general knowledge on the global distribution of hair shape variation. Our study thus delivers target genes and DNA variants for future functional studies to further evaluate the molecular basis of hair shape in humans. Fil: Liu, Fan. Chinese Academy of Sciences; República de China. Erasmus MC University Medical Center Rotterdam; Países Bajos Fil: Chen, Yan. Chinese Academy of Sciences; República de China Fil: Zhu, Gu. QIMR Berghofer Medical Research Institute; Australia Fil: Hysi, Pirro G.. King’s College London; Reino Unido Fil: Wu, Sijie. Chinese Academy of Sciences; República de China Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido Fil: Breslin, Krystal. Indiana University; Estados Unidos. Purdue University; Estados Unidos Fil: Pośpiech, Ewelina. Jagiellonian University; Polonia Fil: Hamer, Merel A.. Erasmus MC University Medical Center Rotterdam; Países Bajos Fil: Peng, Fuduan. Chinese Academy of Sciences; República de China Fil: Muralidharan, Charanya. Indiana University; Estados Unidos. Purdue University; Estados Unidos Fil: Acuna Alonzo, Victor. Escuela Nacional de Antropologia e Historia; México Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Zeng, Changqing. Chinese Academy of Sciences; República de China Fil: Xu, Shuhua. Chinese Academy of Sciences; República de China. Fudan University; China. Shanghai Tech University; China Fil: Jin, Li. University of Chinese Academy of Sciences; China. Fudan University; China Fil: Uitterlinden, André G.. Erasmus MC University Medical Center Rotterdam; Países Bajos Fil: Ikram, M. Arfan. Erasmus MC University Medical Center Rotterdam; Países Bajos Fil: van Duijn, Cornelia M.. Erasmus MC University Medical Center Rotterdam; Países Bajos Fil: Nijsten, Tamar. Erasmus MC University Medical Center Rotterdam; Países Bajos Fil: Walsh, Susan. Indiana University; Estados Unidos. Purdue University; Estados Unidos Fil: Branicki, Wojciech. Jagiellonian University; Polonia. Central Forensic Laboratory of the Police; Polonia Fil: Wang, Sijia. Chinese Academy of Sciences; República de China. Fudan University; China Fil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido. Fudan University; China. Aix-Marseille Université; Francia Fil: Spector, Timothy D.. King’s College London; Reino Unido Fil: Martin, Nicholas G.. QIMR Berghofer Medical Research Institute; Australia Fil: Medland, Sarah E.. QIMR Berghofer Medical Research Institute; Australia Fil: Kayser, Manfred. Erasmus MC University Medical Center Rotterdam; Países Bajos |
description |
Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P<5e-8). All except one (1p36.22 PEX14) were replicated with nominal significance in at least one of the 6 additional cohorts of European, Native American and East Asian origins. Three additional previously known genes (EDAR, OFCC1, and PRSS53) were confirmed at the nominal significance level. A multivariable regression model revealed that 14 SNPs from different genes significantly and independently contribute to hair shape variation, reaching a cross-validated AUC value of 0.66 (95% CI: 0.62-0.70) and an AUC value of 0.64 in an independent validation cohort, providing an improved accuracy compared with a previous model. Prediction outcomes of 2504 individuals from a multiethnic sample were largely consistent with general knowledge on the global distribution of hair shape variation. Our study thus delivers target genes and DNA variants for future functional studies to further evaluate the molecular basis of hair shape in humans. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/40412 Liu, Fan; Chen, Yan; Zhu, Gu; Hysi, Pirro G.; Wu, Sijie; et al.; Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair; Oxford University Press; Human Molecular Genetics; 27; 3; 2-2018; 559-575 0964-6906 1460-2083 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/40412 |
identifier_str_mv |
Liu, Fan; Chen, Yan; Zhu, Gu; Hysi, Pirro G.; Wu, Sijie; et al.; Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair; Oxford University Press; Human Molecular Genetics; 27; 3; 2-2018; 559-575 0964-6906 1460-2083 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddx416/4693879 info:eu-repo/semantics/altIdentifier/doi/10.1093/hmg/ddx416 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846083308551667712 |
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13.22299 |