Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair

Autores
Liu, Fan; Chen, Yan; Zhu, Gu; Hysi, Pirro G.; Wu, Sijie; Adhikari, Kaustubh; Breslin, Krystal; Pośpiech, Ewelina; Hamer, Merel A.; Peng, Fuduan; Muralidharan, Charanya; Acuna Alonzo, Victor; Canizales Quinteros, Samuel; Bedoya, Gabriel; Gallo, Carla; Poletti, Giovanni; Rothhammer, Francisco; Bortolini, Maria Catira; González José, Rolando; Zeng, Changqing; Xu, Shuhua; Jin, Li; Uitterlinden, André G.; Ikram, M. Arfan; van Duijn, Cornelia M.; Nijsten, Tamar; Walsh, Susan; Branicki, Wojciech; Wang, Sijia; Ruiz Linares, Andrés; Spector, Timothy D.; Martin, Nicholas G.; Medland, Sarah E.; Kayser, Manfred
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P<5e-8). All except one (1p36.22 PEX14) were replicated with nominal significance in at least one of the 6 additional cohorts of European, Native American and East Asian origins. Three additional previously known genes (EDAR, OFCC1, and PRSS53) were confirmed at the nominal significance level. A multivariable regression model revealed that 14 SNPs from different genes significantly and independently contribute to hair shape variation, reaching a cross-validated AUC value of 0.66 (95% CI: 0.62-0.70) and an AUC value of 0.64 in an independent validation cohort, providing an improved accuracy compared with a previous model. Prediction outcomes of 2504 individuals from a multiethnic sample were largely consistent with general knowledge on the global distribution of hair shape variation. Our study thus delivers target genes and DNA variants for future functional studies to further evaluate the molecular basis of hair shape in humans.
Fil: Liu, Fan. Chinese Academy of Sciences; República de China. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Chen, Yan. Chinese Academy of Sciences; República de China
Fil: Zhu, Gu. QIMR Berghofer Medical Research Institute; Australia
Fil: Hysi, Pirro G.. King’s College London; Reino Unido
Fil: Wu, Sijie. Chinese Academy of Sciences; República de China
Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido
Fil: Breslin, Krystal. Indiana University; Estados Unidos. Purdue University; Estados Unidos
Fil: Pośpiech, Ewelina. Jagiellonian University; Polonia
Fil: Hamer, Merel A.. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Peng, Fuduan. Chinese Academy of Sciences; República de China
Fil: Muralidharan, Charanya. Indiana University; Estados Unidos. Purdue University; Estados Unidos
Fil: Acuna Alonzo, Victor. Escuela Nacional de Antropologia e Historia; México
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Zeng, Changqing. Chinese Academy of Sciences; República de China
Fil: Xu, Shuhua. Chinese Academy of Sciences; República de China. Fudan University; China. Shanghai Tech University; China
Fil: Jin, Li. University of Chinese Academy of Sciences; China. Fudan University; China
Fil: Uitterlinden, André G.. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Ikram, M. Arfan. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: van Duijn, Cornelia M.. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Nijsten, Tamar. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Walsh, Susan. Indiana University; Estados Unidos. Purdue University; Estados Unidos
Fil: Branicki, Wojciech. Jagiellonian University; Polonia. Central Forensic Laboratory of the Police; Polonia
Fil: Wang, Sijia. Chinese Academy of Sciences; República de China. Fudan University; China
Fil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido. Fudan University; China. Aix-Marseille Université; Francia
Fil: Spector, Timothy D.. King’s College London; Reino Unido
Fil: Martin, Nicholas G.. QIMR Berghofer Medical Research Institute; Australia
Fil: Medland, Sarah E.. QIMR Berghofer Medical Research Institute; Australia
Fil: Kayser, Manfred. Erasmus MC University Medical Center Rotterdam; Países Bajos
Materia
Genes
Genome
Hair
Single Nucleotide Polymorphism
Genetics
Native Americans
Asian
Genome-Wide Association Study
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40412

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oai_identifier_str oai:ri.conicet.gov.ar:11336/40412
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hairLiu, FanChen, YanZhu, GuHysi, Pirro G.Wu, SijieAdhikari, KaustubhBreslin, KrystalPośpiech, EwelinaHamer, Merel A.Peng, FuduanMuralidharan, CharanyaAcuna Alonzo, VictorCanizales Quinteros, SamuelBedoya, GabrielGallo, CarlaPoletti, GiovanniRothhammer, FranciscoBortolini, Maria CatiraGonzález José, RolandoZeng, ChangqingXu, ShuhuaJin, LiUitterlinden, André G.Ikram, M. Arfanvan Duijn, Cornelia M.Nijsten, TamarWalsh, SusanBranicki, WojciechWang, SijiaRuiz Linares, AndrésSpector, Timothy D.Martin, Nicholas G.Medland, Sarah E.Kayser, ManfredGenesGenomeHairSingle Nucleotide PolymorphismGeneticsNative AmericansAsianGenome-Wide Association Studyhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P<5e-8). All except one (1p36.22 PEX14) were replicated with nominal significance in at least one of the 6 additional cohorts of European, Native American and East Asian origins. Three additional previously known genes (EDAR, OFCC1, and PRSS53) were confirmed at the nominal significance level. A multivariable regression model revealed that 14 SNPs from different genes significantly and independently contribute to hair shape variation, reaching a cross-validated AUC value of 0.66 (95% CI: 0.62-0.70) and an AUC value of 0.64 in an independent validation cohort, providing an improved accuracy compared with a previous model. Prediction outcomes of 2504 individuals from a multiethnic sample were largely consistent with general knowledge on the global distribution of hair shape variation. Our study thus delivers target genes and DNA variants for future functional studies to further evaluate the molecular basis of hair shape in humans.Fil: Liu, Fan. Chinese Academy of Sciences; República de China. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Chen, Yan. Chinese Academy of Sciences; República de ChinaFil: Zhu, Gu. QIMR Berghofer Medical Research Institute; AustraliaFil: Hysi, Pirro G.. King’s College London; Reino UnidoFil: Wu, Sijie. Chinese Academy of Sciences; República de ChinaFil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino UnidoFil: Breslin, Krystal. Indiana University; Estados Unidos. Purdue University; Estados UnidosFil: Pośpiech, Ewelina. Jagiellonian University; PoloniaFil: Hamer, Merel A.. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Peng, Fuduan. Chinese Academy of Sciences; República de ChinaFil: Muralidharan, Charanya. Indiana University; Estados Unidos. Purdue University; Estados UnidosFil: Acuna Alonzo, Victor. Escuela Nacional de Antropologia e Historia; MéxicoFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Bedoya, Gabriel. Universidad de Antioquia; ColombiaFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; PerúFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; BrasilFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Zeng, Changqing. Chinese Academy of Sciences; República de ChinaFil: Xu, Shuhua. Chinese Academy of Sciences; República de China. Fudan University; China. Shanghai Tech University; ChinaFil: Jin, Li. University of Chinese Academy of Sciences; China. Fudan University; ChinaFil: Uitterlinden, André G.. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Ikram, M. Arfan. Erasmus MC University Medical Center Rotterdam; Países BajosFil: van Duijn, Cornelia M.. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Nijsten, Tamar. Erasmus MC University Medical Center Rotterdam; Países BajosFil: Walsh, Susan. Indiana University; Estados Unidos. Purdue University; Estados UnidosFil: Branicki, Wojciech. Jagiellonian University; Polonia. Central Forensic Laboratory of the Police; PoloniaFil: Wang, Sijia. Chinese Academy of Sciences; República de China. Fudan University; ChinaFil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido. Fudan University; China. Aix-Marseille Université; FranciaFil: Spector, Timothy D.. King’s College London; Reino UnidoFil: Martin, Nicholas G.. QIMR Berghofer Medical Research Institute; AustraliaFil: Medland, Sarah E.. QIMR Berghofer Medical Research Institute; AustraliaFil: Kayser, Manfred. Erasmus MC University Medical Center Rotterdam; Países BajosOxford University Press2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40412Liu, Fan; Chen, Yan; Zhu, Gu; Hysi, Pirro G.; Wu, Sijie; et al.; Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair; Oxford University Press; Human Molecular Genetics; 27; 3; 2-2018; 559-5750964-69061460-2083CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddx416/4693879info:eu-repo/semantics/altIdentifier/doi/10.1093/hmg/ddx416info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:16:03Zoai:ri.conicet.gov.ar:11336/40412instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:16:03.662CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
title Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
spellingShingle Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
Liu, Fan
Genes
Genome
Hair
Single Nucleotide Polymorphism
Genetics
Native Americans
Asian
Genome-Wide Association Study
title_short Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
title_full Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
title_fullStr Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
title_full_unstemmed Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
title_sort Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
dc.creator.none.fl_str_mv Liu, Fan
Chen, Yan
Zhu, Gu
Hysi, Pirro G.
Wu, Sijie
Adhikari, Kaustubh
Breslin, Krystal
Pośpiech, Ewelina
Hamer, Merel A.
Peng, Fuduan
Muralidharan, Charanya
Acuna Alonzo, Victor
Canizales Quinteros, Samuel
Bedoya, Gabriel
Gallo, Carla
Poletti, Giovanni
Rothhammer, Francisco
Bortolini, Maria Catira
González José, Rolando
Zeng, Changqing
Xu, Shuhua
Jin, Li
Uitterlinden, André G.
Ikram, M. Arfan
van Duijn, Cornelia M.
Nijsten, Tamar
Walsh, Susan
Branicki, Wojciech
Wang, Sijia
Ruiz Linares, Andrés
Spector, Timothy D.
Martin, Nicholas G.
Medland, Sarah E.
Kayser, Manfred
author Liu, Fan
author_facet Liu, Fan
Chen, Yan
Zhu, Gu
Hysi, Pirro G.
Wu, Sijie
Adhikari, Kaustubh
Breslin, Krystal
Pośpiech, Ewelina
Hamer, Merel A.
Peng, Fuduan
Muralidharan, Charanya
Acuna Alonzo, Victor
Canizales Quinteros, Samuel
Bedoya, Gabriel
Gallo, Carla
Poletti, Giovanni
Rothhammer, Francisco
Bortolini, Maria Catira
González José, Rolando
Zeng, Changqing
Xu, Shuhua
Jin, Li
Uitterlinden, André G.
Ikram, M. Arfan
van Duijn, Cornelia M.
Nijsten, Tamar
Walsh, Susan
Branicki, Wojciech
Wang, Sijia
Ruiz Linares, Andrés
Spector, Timothy D.
Martin, Nicholas G.
Medland, Sarah E.
Kayser, Manfred
author_role author
author2 Chen, Yan
Zhu, Gu
Hysi, Pirro G.
Wu, Sijie
Adhikari, Kaustubh
Breslin, Krystal
Pośpiech, Ewelina
Hamer, Merel A.
Peng, Fuduan
Muralidharan, Charanya
Acuna Alonzo, Victor
Canizales Quinteros, Samuel
Bedoya, Gabriel
Gallo, Carla
Poletti, Giovanni
Rothhammer, Francisco
Bortolini, Maria Catira
González José, Rolando
Zeng, Changqing
Xu, Shuhua
Jin, Li
Uitterlinden, André G.
Ikram, M. Arfan
van Duijn, Cornelia M.
Nijsten, Tamar
Walsh, Susan
Branicki, Wojciech
Wang, Sijia
Ruiz Linares, Andrés
Spector, Timothy D.
Martin, Nicholas G.
Medland, Sarah E.
Kayser, Manfred
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genes
Genome
Hair
Single Nucleotide Polymorphism
Genetics
Native Americans
Asian
Genome-Wide Association Study
topic Genes
Genome
Hair
Single Nucleotide Polymorphism
Genetics
Native Americans
Asian
Genome-Wide Association Study
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P<5e-8). All except one (1p36.22 PEX14) were replicated with nominal significance in at least one of the 6 additional cohorts of European, Native American and East Asian origins. Three additional previously known genes (EDAR, OFCC1, and PRSS53) were confirmed at the nominal significance level. A multivariable regression model revealed that 14 SNPs from different genes significantly and independently contribute to hair shape variation, reaching a cross-validated AUC value of 0.66 (95% CI: 0.62-0.70) and an AUC value of 0.64 in an independent validation cohort, providing an improved accuracy compared with a previous model. Prediction outcomes of 2504 individuals from a multiethnic sample were largely consistent with general knowledge on the global distribution of hair shape variation. Our study thus delivers target genes and DNA variants for future functional studies to further evaluate the molecular basis of hair shape in humans.
Fil: Liu, Fan. Chinese Academy of Sciences; República de China. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Chen, Yan. Chinese Academy of Sciences; República de China
Fil: Zhu, Gu. QIMR Berghofer Medical Research Institute; Australia
Fil: Hysi, Pirro G.. King’s College London; Reino Unido
Fil: Wu, Sijie. Chinese Academy of Sciences; República de China
Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido
Fil: Breslin, Krystal. Indiana University; Estados Unidos. Purdue University; Estados Unidos
Fil: Pośpiech, Ewelina. Jagiellonian University; Polonia
Fil: Hamer, Merel A.. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Peng, Fuduan. Chinese Academy of Sciences; República de China
Fil: Muralidharan, Charanya. Indiana University; Estados Unidos. Purdue University; Estados Unidos
Fil: Acuna Alonzo, Victor. Escuela Nacional de Antropologia e Historia; México
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Zeng, Changqing. Chinese Academy of Sciences; República de China
Fil: Xu, Shuhua. Chinese Academy of Sciences; República de China. Fudan University; China. Shanghai Tech University; China
Fil: Jin, Li. University of Chinese Academy of Sciences; China. Fudan University; China
Fil: Uitterlinden, André G.. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Ikram, M. Arfan. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: van Duijn, Cornelia M.. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Nijsten, Tamar. Erasmus MC University Medical Center Rotterdam; Países Bajos
Fil: Walsh, Susan. Indiana University; Estados Unidos. Purdue University; Estados Unidos
Fil: Branicki, Wojciech. Jagiellonian University; Polonia. Central Forensic Laboratory of the Police; Polonia
Fil: Wang, Sijia. Chinese Academy of Sciences; República de China. Fudan University; China
Fil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido. Fudan University; China. Aix-Marseille Université; Francia
Fil: Spector, Timothy D.. King’s College London; Reino Unido
Fil: Martin, Nicholas G.. QIMR Berghofer Medical Research Institute; Australia
Fil: Medland, Sarah E.. QIMR Berghofer Medical Research Institute; Australia
Fil: Kayser, Manfred. Erasmus MC University Medical Center Rotterdam; Países Bajos
description Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P<5e-8). All except one (1p36.22 PEX14) were replicated with nominal significance in at least one of the 6 additional cohorts of European, Native American and East Asian origins. Three additional previously known genes (EDAR, OFCC1, and PRSS53) were confirmed at the nominal significance level. A multivariable regression model revealed that 14 SNPs from different genes significantly and independently contribute to hair shape variation, reaching a cross-validated AUC value of 0.66 (95% CI: 0.62-0.70) and an AUC value of 0.64 in an independent validation cohort, providing an improved accuracy compared with a previous model. Prediction outcomes of 2504 individuals from a multiethnic sample were largely consistent with general knowledge on the global distribution of hair shape variation. Our study thus delivers target genes and DNA variants for future functional studies to further evaluate the molecular basis of hair shape in humans.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40412
Liu, Fan; Chen, Yan; Zhu, Gu; Hysi, Pirro G.; Wu, Sijie; et al.; Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair; Oxford University Press; Human Molecular Genetics; 27; 3; 2-2018; 559-575
0964-6906
1460-2083
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40412
identifier_str_mv Liu, Fan; Chen, Yan; Zhu, Gu; Hysi, Pirro G.; Wu, Sijie; et al.; Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair; Oxford University Press; Human Molecular Genetics; 27; 3; 2-2018; 559-575
0964-6906
1460-2083
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddx416/4693879
info:eu-repo/semantics/altIdentifier/doi/10.1093/hmg/ddx416
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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