Impaired reproductive function in equines: From genetics to genomics

Autores
Laseca, Nora; Anaya, Gabriel; Peña, Zahira; Pirosanto, Yamila; Molina, Antonio; Demyda Peyrás, Sebastián
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fertility is one of the key factors in the economic and productive success of the equine industry. Despite this, studies on the genetic causes affecting reproductive performance are scarce, especially in mares, where the genetic architecture of the reproductive traits is extremely complex. Today, with the increasing availability of new genomic methodologies for this species, we are presented with an interesting opportunity to understand the genetic basis of equine reproductive disorders. These include, among others, novel techniques for detecting chromosomal abnormalities, whose association with infertility in horses was established over 50 years ago; new sequencing technologies permitting an accurate detection of point mutations influencing fertility, as well as the study of inbreeding and molecular homozygosity, which has been widely suggested as one of the main causes of low reproductive performance in horses. Finally, over the last few years, reproductive performance has also been associated with copy number variants and candidate genes detected by genome-wide association studies on fertility traits. However, such studies are still scarce, probably because they depend on the existence of large and accurate phenotypic datasets of reproductive and/or fertility traits, which are still difficult to obtain in equines.
Fil: Laseca, Nora. Universidad de Córdoba; España
Fil: Anaya, Gabriel. Universidad de Córdoba; España
Fil: Peña, Zahira. Universidad de Córdoba; España
Fil: Pirosanto, Yamila. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Molina, Antonio. Universidad de Córdoba; España
Fil: Demyda Peyrás, Sebastián. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
CANDIDATE GENES
COPY NUMBER VARIATIONS
FERTILITY
GENOME-WIDE ASSOCIATION STUDIES
GENOMICS
INBREEDING
MARES
REPRODUCTIVE TRAITS
STALLIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/154654
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Impaired reproductive function in equines: From genetics to genomicsLaseca, NoraAnaya, GabrielPeña, ZahiraPirosanto, YamilaMolina, AntonioDemyda Peyrás, SebastiánCANDIDATE GENESCOPY NUMBER VARIATIONSFERTILITYGENOME-WIDE ASSOCIATION STUDIESGENOMICSINBREEDINGMARESREPRODUCTIVE TRAITSSTALLIONShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Fertility is one of the key factors in the economic and productive success of the equine industry. Despite this, studies on the genetic causes affecting reproductive performance are scarce, especially in mares, where the genetic architecture of the reproductive traits is extremely complex. Today, with the increasing availability of new genomic methodologies for this species, we are presented with an interesting opportunity to understand the genetic basis of equine reproductive disorders. These include, among others, novel techniques for detecting chromosomal abnormalities, whose association with infertility in horses was established over 50 years ago; new sequencing technologies permitting an accurate detection of point mutations influencing fertility, as well as the study of inbreeding and molecular homozygosity, which has been widely suggested as one of the main causes of low reproductive performance in horses. Finally, over the last few years, reproductive performance has also been associated with copy number variants and candidate genes detected by genome-wide association studies on fertility traits. However, such studies are still scarce, probably because they depend on the existence of large and accurate phenotypic datasets of reproductive and/or fertility traits, which are still difficult to obtain in equines.Fil: Laseca, Nora. Universidad de Córdoba; EspañaFil: Anaya, Gabriel. Universidad de Córdoba; EspañaFil: Peña, Zahira. Universidad de Córdoba; EspañaFil: Pirosanto, Yamila. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Molina, Antonio. Universidad de Córdoba; EspañaFil: Demyda Peyrás, Sebastián. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaMultidisciplinary Digital Publishing Institute2021-02-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154654Laseca, Nora; Anaya, Gabriel; Peña, Zahira; Pirosanto, Yamila; Molina, Antonio; et al.; Impaired reproductive function in equines: From genetics to genomics; Multidisciplinary Digital Publishing Institute; Animals; 11; 2; 03-2-2021; 1-152076-2615CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/ani11020393info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2615/11/2/393info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:32Zoai:ri.conicet.gov.ar:11336/154654instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:32.892CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impaired reproductive function in equines: From genetics to genomics
title Impaired reproductive function in equines: From genetics to genomics
spellingShingle Impaired reproductive function in equines: From genetics to genomics
Laseca, Nora
CANDIDATE GENES
COPY NUMBER VARIATIONS
FERTILITY
GENOME-WIDE ASSOCIATION STUDIES
GENOMICS
INBREEDING
MARES
REPRODUCTIVE TRAITS
STALLIONS
title_short Impaired reproductive function in equines: From genetics to genomics
title_full Impaired reproductive function in equines: From genetics to genomics
title_fullStr Impaired reproductive function in equines: From genetics to genomics
title_full_unstemmed Impaired reproductive function in equines: From genetics to genomics
title_sort Impaired reproductive function in equines: From genetics to genomics
dc.creator.none.fl_str_mv Laseca, Nora
Anaya, Gabriel
Peña, Zahira
Pirosanto, Yamila
Molina, Antonio
Demyda Peyrás, Sebastián
author Laseca, Nora
author_facet Laseca, Nora
Anaya, Gabriel
Peña, Zahira
Pirosanto, Yamila
Molina, Antonio
Demyda Peyrás, Sebastián
author_role author
author2 Anaya, Gabriel
Peña, Zahira
Pirosanto, Yamila
Molina, Antonio
Demyda Peyrás, Sebastián
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CANDIDATE GENES
COPY NUMBER VARIATIONS
FERTILITY
GENOME-WIDE ASSOCIATION STUDIES
GENOMICS
INBREEDING
MARES
REPRODUCTIVE TRAITS
STALLIONS
topic CANDIDATE GENES
COPY NUMBER VARIATIONS
FERTILITY
GENOME-WIDE ASSOCIATION STUDIES
GENOMICS
INBREEDING
MARES
REPRODUCTIVE TRAITS
STALLIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Fertility is one of the key factors in the economic and productive success of the equine industry. Despite this, studies on the genetic causes affecting reproductive performance are scarce, especially in mares, where the genetic architecture of the reproductive traits is extremely complex. Today, with the increasing availability of new genomic methodologies for this species, we are presented with an interesting opportunity to understand the genetic basis of equine reproductive disorders. These include, among others, novel techniques for detecting chromosomal abnormalities, whose association with infertility in horses was established over 50 years ago; new sequencing technologies permitting an accurate detection of point mutations influencing fertility, as well as the study of inbreeding and molecular homozygosity, which has been widely suggested as one of the main causes of low reproductive performance in horses. Finally, over the last few years, reproductive performance has also been associated with copy number variants and candidate genes detected by genome-wide association studies on fertility traits. However, such studies are still scarce, probably because they depend on the existence of large and accurate phenotypic datasets of reproductive and/or fertility traits, which are still difficult to obtain in equines.
Fil: Laseca, Nora. Universidad de Córdoba; España
Fil: Anaya, Gabriel. Universidad de Córdoba; España
Fil: Peña, Zahira. Universidad de Córdoba; España
Fil: Pirosanto, Yamila. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Molina, Antonio. Universidad de Córdoba; España
Fil: Demyda Peyrás, Sebastián. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Fertility is one of the key factors in the economic and productive success of the equine industry. Despite this, studies on the genetic causes affecting reproductive performance are scarce, especially in mares, where the genetic architecture of the reproductive traits is extremely complex. Today, with the increasing availability of new genomic methodologies for this species, we are presented with an interesting opportunity to understand the genetic basis of equine reproductive disorders. These include, among others, novel techniques for detecting chromosomal abnormalities, whose association with infertility in horses was established over 50 years ago; new sequencing technologies permitting an accurate detection of point mutations influencing fertility, as well as the study of inbreeding and molecular homozygosity, which has been widely suggested as one of the main causes of low reproductive performance in horses. Finally, over the last few years, reproductive performance has also been associated with copy number variants and candidate genes detected by genome-wide association studies on fertility traits. However, such studies are still scarce, probably because they depend on the existence of large and accurate phenotypic datasets of reproductive and/or fertility traits, which are still difficult to obtain in equines.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/154654
Laseca, Nora; Anaya, Gabriel; Peña, Zahira; Pirosanto, Yamila; Molina, Antonio; et al.; Impaired reproductive function in equines: From genetics to genomics; Multidisciplinary Digital Publishing Institute; Animals; 11; 2; 03-2-2021; 1-15
2076-2615
CONICET Digital
CONICET
url http://hdl.handle.net/11336/154654
identifier_str_mv Laseca, Nora; Anaya, Gabriel; Peña, Zahira; Pirosanto, Yamila; Molina, Antonio; et al.; Impaired reproductive function in equines: From genetics to genomics; Multidisciplinary Digital Publishing Institute; Animals; 11; 2; 03-2-2021; 1-15
2076-2615
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/ani11020393
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2615/11/2/393
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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