Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model

Autores
Velez, Eva Maria del Mar; Perdigon, Gabriela del Valle; Castillo, Natalia Alejandra; Mesón, Oscar Enrique; Grau, Alfredo; Perdigon, Gabriela del Valle
Año de publicación
2011
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Fructooligosacharides (FOS), obtained from Yacon roots, have a prebiotic effect when used as a dietary supplement. We studied if FOS from Yacón can prevent enteric infection against Salmonella Typhimurium and the mechanism involved. BALB/c mice were divided into 4 groups: normal control, Basal (45days with FOS-340mg/kg/day), infection control (IC?without FOS administration) and treated group (TG?45d with FOS+S. Typhimurium); IC and TG groups were challenged at days 15, 30 and 45 with S. Typhimurium. Translocation to liver and spleen, total and specific s-IgA, IgA+, TLR4+, CD206+, IL6+, TNFalfa, IFNgamma and MIP 1alfa + cells were analyzed after challenge. We found protection only at 30 days of FOS administration with an increase in the total s-IgA but not in the specific s-IgA levels for TG compared with IC group. In TG as regard IC group the N° IgA+, TLR4+, CD206+, IL6+ and MIP 1alfa+, TNFalfa and IFNgamma cells were increased. We demonstrate that FOS from Yacón roots prevent S. Typhimurium infections up to 30 days of administration through non-specific immunity with increased total s-IgA, expression of TLR4 and CD206 receptors and IL6+ and MIP1alfa + cells, that would improve immunological barrier mechanisms against S. Typhimurium infection.
Fil: Velez, Eva Maria del Mar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología. Cátedra de Inmunología; Argentina
Fil: Castillo, Natalia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Mesón, Oscar Enrique. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología. Cátedra de Inmunología; Argentina
Fil: Grau, Alfredo. Universidad Tecnológica Nacional; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
15th International Congress of Mucosal Immunology
Paris
Francia
Universidad de París Descartes
Materia
PREBIOTICS
YACON
SALMONELLA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/194937
Acceder
id CONICETDig_8154e051a1ffa06a2c2b9636ffb0fa82
oai_identifier_str oai:ri.conicet.gov.ar:11336/194937
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection modelVelez, Eva Maria del MarPerdigon, Gabriela del ValleCastillo, Natalia AlejandraMesón, Oscar EnriqueGrau, AlfredoPerdigon, Gabriela del VallePREBIOTICSYACONSALMONELLAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Fructooligosacharides (FOS), obtained from Yacon roots, have a prebiotic effect when used as a dietary supplement. We studied if FOS from Yacón can prevent enteric infection against Salmonella Typhimurium and the mechanism involved. BALB/c mice were divided into 4 groups: normal control, Basal (45days with FOS-340mg/kg/day), infection control (IC?without FOS administration) and treated group (TG?45d with FOS+S. Typhimurium); IC and TG groups were challenged at days 15, 30 and 45 with S. Typhimurium. Translocation to liver and spleen, total and specific s-IgA, IgA+, TLR4+, CD206+, IL6+, TNFalfa, IFNgamma and MIP 1alfa + cells were analyzed after challenge. We found protection only at 30 days of FOS administration with an increase in the total s-IgA but not in the specific s-IgA levels for TG compared with IC group. In TG as regard IC group the N° IgA+, TLR4+, CD206+, IL6+ and MIP 1alfa+, TNFalfa and IFNgamma cells were increased. We demonstrate that FOS from Yacón roots prevent S. Typhimurium infections up to 30 days of administration through non-specific immunity with increased total s-IgA, expression of TLR4 and CD206 receptors and IL6+ and MIP1alfa + cells, that would improve immunological barrier mechanisms against S. Typhimurium infection.Fil: Velez, Eva Maria del Mar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología. Cátedra de Inmunología; ArgentinaFil: Castillo, Natalia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Mesón, Oscar Enrique. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología. Cátedra de Inmunología; ArgentinaFil: Grau, Alfredo. Universidad Tecnológica Nacional; ArgentinaFil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina15th International Congress of Mucosal ImmunologyParisFranciaUniversidad de París DescartesUniversidad de París Descartes2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194937Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model; 15th International Congress of Mucosal Immunology; Paris; Francia; 2011; 113-114CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.socmucimm.org/media/i0wjjgsp/abstract-supplement-chronological-final-6-29-11.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:20Zoai:ri.conicet.gov.ar:11336/194937instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:20.344CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model
title Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model
spellingShingle Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model
Velez, Eva Maria del Mar
PREBIOTICS
YACON
SALMONELLA
title_short Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model
title_full Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model
title_fullStr Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model
title_full_unstemmed Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model
title_sort Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model
dc.creator.none.fl_str_mv Velez, Eva Maria del Mar
Perdigon, Gabriela del Valle
Castillo, Natalia Alejandra
Mesón, Oscar Enrique
Grau, Alfredo
Perdigon, Gabriela del Valle
author Velez, Eva Maria del Mar
author_facet Velez, Eva Maria del Mar
Perdigon, Gabriela del Valle
Castillo, Natalia Alejandra
Mesón, Oscar Enrique
Grau, Alfredo
author_role author
author2 Perdigon, Gabriela del Valle
Castillo, Natalia Alejandra
Mesón, Oscar Enrique
Grau, Alfredo
author2_role author
author
author
author
dc.subject.none.fl_str_mv PREBIOTICS
YACON
SALMONELLA
topic PREBIOTICS
YACON
SALMONELLA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Fructooligosacharides (FOS), obtained from Yacon roots, have a prebiotic effect when used as a dietary supplement. We studied if FOS from Yacón can prevent enteric infection against Salmonella Typhimurium and the mechanism involved. BALB/c mice were divided into 4 groups: normal control, Basal (45days with FOS-340mg/kg/day), infection control (IC?without FOS administration) and treated group (TG?45d with FOS+S. Typhimurium); IC and TG groups were challenged at days 15, 30 and 45 with S. Typhimurium. Translocation to liver and spleen, total and specific s-IgA, IgA+, TLR4+, CD206+, IL6+, TNFalfa, IFNgamma and MIP 1alfa + cells were analyzed after challenge. We found protection only at 30 days of FOS administration with an increase in the total s-IgA but not in the specific s-IgA levels for TG compared with IC group. In TG as regard IC group the N° IgA+, TLR4+, CD206+, IL6+ and MIP 1alfa+, TNFalfa and IFNgamma cells were increased. We demonstrate that FOS from Yacón roots prevent S. Typhimurium infections up to 30 days of administration through non-specific immunity with increased total s-IgA, expression of TLR4 and CD206 receptors and IL6+ and MIP1alfa + cells, that would improve immunological barrier mechanisms against S. Typhimurium infection.
Fil: Velez, Eva Maria del Mar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología. Cátedra de Inmunología; Argentina
Fil: Castillo, Natalia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Mesón, Oscar Enrique. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología. Cátedra de Inmunología; Argentina
Fil: Grau, Alfredo. Universidad Tecnológica Nacional; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
15th International Congress of Mucosal Immunology
Paris
Francia
Universidad de París Descartes
description Fructooligosacharides (FOS), obtained from Yacon roots, have a prebiotic effect when used as a dietary supplement. We studied if FOS from Yacón can prevent enteric infection against Salmonella Typhimurium and the mechanism involved. BALB/c mice were divided into 4 groups: normal control, Basal (45days with FOS-340mg/kg/day), infection control (IC?without FOS administration) and treated group (TG?45d with FOS+S. Typhimurium); IC and TG groups were challenged at days 15, 30 and 45 with S. Typhimurium. Translocation to liver and spleen, total and specific s-IgA, IgA+, TLR4+, CD206+, IL6+, TNFalfa, IFNgamma and MIP 1alfa + cells were analyzed after challenge. We found protection only at 30 days of FOS administration with an increase in the total s-IgA but not in the specific s-IgA levels for TG compared with IC group. In TG as regard IC group the N° IgA+, TLR4+, CD206+, IL6+ and MIP 1alfa+, TNFalfa and IFNgamma cells were increased. We demonstrate that FOS from Yacón roots prevent S. Typhimurium infections up to 30 days of administration through non-specific immunity with increased total s-IgA, expression of TLR4 and CD206 receptors and IL6+ and MIP1alfa + cells, that would improve immunological barrier mechanisms against S. Typhimurium infection.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194937
Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model; 15th International Congress of Mucosal Immunology; Paris; Francia; 2011; 113-114
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194937
identifier_str_mv Study of the mechanisms exerted by fructooligosaccharides from Yacon in an intestinal infection model; 15th International Congress of Mucosal Immunology; Paris; Francia; 2011; 113-114
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.socmucimm.org/media/i0wjjgsp/abstract-supplement-chronological-final-6-29-11.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Universidad de París Descartes
publisher.none.fl_str_mv Universidad de París Descartes
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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