Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model

Autores
Bibas Bonet, María Eugenia; Mesón, Oscar Enrique; de Moreno, Maria Alejandra; Dogi, Cecilia Ana; Chaves, Analia Silvina; Kortsarz González, Alejandra María; Grau, Alfredo; Perdigon, Gabriela del Valle
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Prebiotics are non-digestible but fermentable oligosaccharides that can influence the composition and the activity of some intestinal bacteria to promote the health of the host. Smallanthus sonchifolius (yacon) contains beta-1,2-oligofructans as the main saccharides and its roots are consumed in South American countries. The aim of the study was to evaluate the prebiotic property of yacon root flour. Its influence on the intestinal microbiota and gut immune system were evaluated using a mice model. The results show the prebiotic effects of yacon root flour, stimulating the growth of bifidobacteria and lactobacilli and the intestinal immune system with increases in IgA and different cytokines. Cells from the innate response were mainly involved in the effect of yacon root flour. T cells were also activated and able to induce IL-10 and IFNg production. The long term administration of yacon root flour maintained the intestinal homeostasis without inflammatory effect regulated mainly through IL-10 and IL-4 regulatory cytokines.
Fil: Bibas Bonet, María Eugenia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Mesón, Oscar Enrique. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Dogi, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Chaves, Analia Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Kortsarz González, Alejandra María. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; Argentina
Fil: Grau, Alfredo. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
INTESTINAL IMMUNITY
INTESTINAL MICROBIOTA
PREBIOTIC
YACON
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96645
Acceder
id CONICETDig_fd224ee110cc1238f35e72b36d495a0d
oai_identifier_str oai:ri.conicet.gov.ar:11336/96645
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse modelBibas Bonet, María EugeniaMesón, Oscar Enriquede Moreno, Maria AlejandraDogi, Cecilia AnaChaves, Analia SilvinaKortsarz González, Alejandra MaríaGrau, AlfredoPerdigon, Gabriela del ValleINTESTINAL IMMUNITYINTESTINAL MICROBIOTAPREBIOTICYACONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Prebiotics are non-digestible but fermentable oligosaccharides that can influence the composition and the activity of some intestinal bacteria to promote the health of the host. Smallanthus sonchifolius (yacon) contains beta-1,2-oligofructans as the main saccharides and its roots are consumed in South American countries. The aim of the study was to evaluate the prebiotic property of yacon root flour. Its influence on the intestinal microbiota and gut immune system were evaluated using a mice model. The results show the prebiotic effects of yacon root flour, stimulating the growth of bifidobacteria and lactobacilli and the intestinal immune system with increases in IgA and different cytokines. Cells from the innate response were mainly involved in the effect of yacon root flour. T cells were also activated and able to induce IL-10 and IFNg production. The long term administration of yacon root flour maintained the intestinal homeostasis without inflammatory effect regulated mainly through IL-10 and IL-4 regulatory cytokines.Fil: Bibas Bonet, María Eugenia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Mesón, Oscar Enrique. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Dogi, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Chaves, Analia Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Kortsarz González, Alejandra María. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; ArgentinaFil: Grau, Alfredo. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; ArgentinaFil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaTaylor & Francis Ltd2010-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96645Bibas Bonet, María Eugenia; Mesón, Oscar Enrique; de Moreno, Maria Alejandra; Dogi, Cecilia Ana; Chaves, Analia Silvina; et al.; Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model; Taylor & Francis Ltd; Food And Agricultural Immunology; 21; 2; 6-2010; 175-1890954-01050954-0105CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/09540100903563589info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09540100903563589info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:36:33Zoai:ri.conicet.gov.ar:11336/96645instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:36:34.197CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model
title Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model
spellingShingle Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model
Bibas Bonet, María Eugenia
INTESTINAL IMMUNITY
INTESTINAL MICROBIOTA
PREBIOTIC
YACON
title_short Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model
title_full Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model
title_fullStr Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model
title_full_unstemmed Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model
title_sort Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model
dc.creator.none.fl_str_mv Bibas Bonet, María Eugenia
Mesón, Oscar Enrique
de Moreno, Maria Alejandra
Dogi, Cecilia Ana
Chaves, Analia Silvina
Kortsarz González, Alejandra María
Grau, Alfredo
Perdigon, Gabriela del Valle
author Bibas Bonet, María Eugenia
author_facet Bibas Bonet, María Eugenia
Mesón, Oscar Enrique
de Moreno, Maria Alejandra
Dogi, Cecilia Ana
Chaves, Analia Silvina
Kortsarz González, Alejandra María
Grau, Alfredo
Perdigon, Gabriela del Valle
author_role author
author2 Mesón, Oscar Enrique
de Moreno, Maria Alejandra
Dogi, Cecilia Ana
Chaves, Analia Silvina
Kortsarz González, Alejandra María
Grau, Alfredo
Perdigon, Gabriela del Valle
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv INTESTINAL IMMUNITY
INTESTINAL MICROBIOTA
PREBIOTIC
YACON
topic INTESTINAL IMMUNITY
INTESTINAL MICROBIOTA
PREBIOTIC
YACON
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Prebiotics are non-digestible but fermentable oligosaccharides that can influence the composition and the activity of some intestinal bacteria to promote the health of the host. Smallanthus sonchifolius (yacon) contains beta-1,2-oligofructans as the main saccharides and its roots are consumed in South American countries. The aim of the study was to evaluate the prebiotic property of yacon root flour. Its influence on the intestinal microbiota and gut immune system were evaluated using a mice model. The results show the prebiotic effects of yacon root flour, stimulating the growth of bifidobacteria and lactobacilli and the intestinal immune system with increases in IgA and different cytokines. Cells from the innate response were mainly involved in the effect of yacon root flour. T cells were also activated and able to induce IL-10 and IFNg production. The long term administration of yacon root flour maintained the intestinal homeostasis without inflammatory effect regulated mainly through IL-10 and IL-4 regulatory cytokines.
Fil: Bibas Bonet, María Eugenia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Mesón, Oscar Enrique. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Dogi, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Chaves, Analia Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Kortsarz González, Alejandra María. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; Argentina
Fil: Grau, Alfredo. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Prebiotics are non-digestible but fermentable oligosaccharides that can influence the composition and the activity of some intestinal bacteria to promote the health of the host. Smallanthus sonchifolius (yacon) contains beta-1,2-oligofructans as the main saccharides and its roots are consumed in South American countries. The aim of the study was to evaluate the prebiotic property of yacon root flour. Its influence on the intestinal microbiota and gut immune system were evaluated using a mice model. The results show the prebiotic effects of yacon root flour, stimulating the growth of bifidobacteria and lactobacilli and the intestinal immune system with increases in IgA and different cytokines. Cells from the innate response were mainly involved in the effect of yacon root flour. T cells were also activated and able to induce IL-10 and IFNg production. The long term administration of yacon root flour maintained the intestinal homeostasis without inflammatory effect regulated mainly through IL-10 and IL-4 regulatory cytokines.
publishDate 2010
dc.date.none.fl_str_mv 2010-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96645
Bibas Bonet, María Eugenia; Mesón, Oscar Enrique; de Moreno, Maria Alejandra; Dogi, Cecilia Ana; Chaves, Analia Silvina; et al.; Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model; Taylor & Francis Ltd; Food And Agricultural Immunology; 21; 2; 6-2010; 175-189
0954-0105
0954-0105
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96645
identifier_str_mv Bibas Bonet, María Eugenia; Mesón, Oscar Enrique; de Moreno, Maria Alejandra; Dogi, Cecilia Ana; Chaves, Analia Silvina; et al.; Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model; Taylor & Francis Ltd; Food And Agricultural Immunology; 21; 2; 6-2010; 175-189
0954-0105
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/09540100903563589
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09540100903563589
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.142177

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