Fosfomycin concentrations in epithelial lining fluid in weaning piglets

Autores
Soraci, Alejandro Luis; Pérez, Denisa Soledad; Martínez, Guadalupe; Amanto, F.; Tapia, Maria Ofelia; Dieguez, S.; Fernández Paggi, María Belén
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Concentrations of fosfomycin into the epithelial lining fluid (ELF) were studied by bronchoalveolar lavage (BAL) on 6 healthy weaning piglets after the administration of disodium fosfomycin 15 mg/kg intramuscularly (IM). The mean concentrations of fosfomycin in ELF were lower than those in plasma at all sampling time points. Fosfomycin concentrations in ELF were 12.1 % of those in serum. The degree of penetration of fosfomycin into the ELF was determined by comparing the AUC0–8 in ELF with the AUC0–8 in serum. The ratio AUCELF / AUCserum was 0.15 ± 0.02. The Cmax in serum and in ELF were 45.00 ± 2.51 and 3.10 ± 0.95 µg/ml, respectively. These concentrations were achieved at different times (Tmax in serum and ELF: 1.00 ± 0.00 and 2.58 ± 0.49 h, respectively). Effective bacterial killing can be expected from the first antibiotic dosage when the pathogen’s MIC is covered for at least 60–70% of the dosing interval. Different authors have determined a fosfomycin MIC90 for Streptococcus sp (important respiratory pathogens in piglets) of 0.25 µg/ml. Fosfomycin concentrations in ELF remained above the MIC90 value for Streptococcus during more than 8 h post IM administration of 15 mg/kg in weaning piglets. However, additional studies should be carried out in the lungs of infected pigs.
Fil: Soraci, Alejandro Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez, Denisa Soledad. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martínez, Guadalupe. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Amanto, F.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Producción Animal; Argentina
Fil: Tapia, Maria Ofelia. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dieguez, S.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina
Fil: Fernández Paggi, María Belén. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Fosfomycin
Epithelial Lining Fluid
Bronchoalveolar Lavage
Weaning Piglets
Respiratory Pathogens
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/70856
Acceder
id CONICETDig_81084ac8288d86c28305cf599d3504d8
oai_identifier_str oai:ri.conicet.gov.ar:11336/70856
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fosfomycin concentrations in epithelial lining fluid in weaning pigletsSoraci, Alejandro LuisPérez, Denisa SoledadMartínez, GuadalupeAmanto, F.Tapia, Maria OfeliaDieguez, S.Fernández Paggi, María BelénFosfomycinEpithelial Lining FluidBronchoalveolar LavageWeaning PigletsRespiratory Pathogenshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Concentrations of fosfomycin into the epithelial lining fluid (ELF) were studied by bronchoalveolar lavage (BAL) on 6 healthy weaning piglets after the administration of disodium fosfomycin 15 mg/kg intramuscularly (IM). The mean concentrations of fosfomycin in ELF were lower than those in plasma at all sampling time points. Fosfomycin concentrations in ELF were 12.1 % of those in serum. The degree of penetration of fosfomycin into the ELF was determined by comparing the AUC0–8 in ELF with the AUC0–8 in serum. The ratio AUCELF / AUCserum was 0.15 ± 0.02. The Cmax in serum and in ELF were 45.00 ± 2.51 and 3.10 ± 0.95 µg/ml, respectively. These concentrations were achieved at different times (Tmax in serum and ELF: 1.00 ± 0.00 and 2.58 ± 0.49 h, respectively). Effective bacterial killing can be expected from the first antibiotic dosage when the pathogen’s MIC is covered for at least 60–70% of the dosing interval. Different authors have determined a fosfomycin MIC90 for Streptococcus sp (important respiratory pathogens in piglets) of 0.25 µg/ml. Fosfomycin concentrations in ELF remained above the MIC90 value for Streptococcus during more than 8 h post IM administration of 15 mg/kg in weaning piglets. However, additional studies should be carried out in the lungs of infected pigs.Fil: Soraci, Alejandro Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pérez, Denisa Soledad. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martínez, Guadalupe. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Amanto, F.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Producción Animal; ArgentinaFil: Tapia, Maria Ofelia. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dieguez, S.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; ArgentinaFil: Fernández Paggi, María Belén. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley Blackwell Publishing, Inc2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/70856Soraci, Alejandro Luis; Pérez, Denisa Soledad; Martínez, Guadalupe; Amanto, F.; Tapia, Maria Ofelia; et al.; Fosfomycin concentrations in epithelial lining fluid in weaning piglets; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; 4; 8-2012; 406-4090140-7783CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2011.01344.x/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2011.01344.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:36Zoai:ri.conicet.gov.ar:11336/70856instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:36.602CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fosfomycin concentrations in epithelial lining fluid in weaning piglets
title Fosfomycin concentrations in epithelial lining fluid in weaning piglets
spellingShingle Fosfomycin concentrations in epithelial lining fluid in weaning piglets
Soraci, Alejandro Luis
Fosfomycin
Epithelial Lining Fluid
Bronchoalveolar Lavage
Weaning Piglets
Respiratory Pathogens
title_short Fosfomycin concentrations in epithelial lining fluid in weaning piglets
title_full Fosfomycin concentrations in epithelial lining fluid in weaning piglets
title_fullStr Fosfomycin concentrations in epithelial lining fluid in weaning piglets
title_full_unstemmed Fosfomycin concentrations in epithelial lining fluid in weaning piglets
title_sort Fosfomycin concentrations in epithelial lining fluid in weaning piglets
dc.creator.none.fl_str_mv Soraci, Alejandro Luis
Pérez, Denisa Soledad
Martínez, Guadalupe
Amanto, F.
Tapia, Maria Ofelia
Dieguez, S.
Fernández Paggi, María Belén
author Soraci, Alejandro Luis
author_facet Soraci, Alejandro Luis
Pérez, Denisa Soledad
Martínez, Guadalupe
Amanto, F.
Tapia, Maria Ofelia
Dieguez, S.
Fernández Paggi, María Belén
author_role author
author2 Pérez, Denisa Soledad
Martínez, Guadalupe
Amanto, F.
Tapia, Maria Ofelia
Dieguez, S.
Fernández Paggi, María Belén
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Fosfomycin
Epithelial Lining Fluid
Bronchoalveolar Lavage
Weaning Piglets
Respiratory Pathogens
topic Fosfomycin
Epithelial Lining Fluid
Bronchoalveolar Lavage
Weaning Piglets
Respiratory Pathogens
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Concentrations of fosfomycin into the epithelial lining fluid (ELF) were studied by bronchoalveolar lavage (BAL) on 6 healthy weaning piglets after the administration of disodium fosfomycin 15 mg/kg intramuscularly (IM). The mean concentrations of fosfomycin in ELF were lower than those in plasma at all sampling time points. Fosfomycin concentrations in ELF were 12.1 % of those in serum. The degree of penetration of fosfomycin into the ELF was determined by comparing the AUC0–8 in ELF with the AUC0–8 in serum. The ratio AUCELF / AUCserum was 0.15 ± 0.02. The Cmax in serum and in ELF were 45.00 ± 2.51 and 3.10 ± 0.95 µg/ml, respectively. These concentrations were achieved at different times (Tmax in serum and ELF: 1.00 ± 0.00 and 2.58 ± 0.49 h, respectively). Effective bacterial killing can be expected from the first antibiotic dosage when the pathogen’s MIC is covered for at least 60–70% of the dosing interval. Different authors have determined a fosfomycin MIC90 for Streptococcus sp (important respiratory pathogens in piglets) of 0.25 µg/ml. Fosfomycin concentrations in ELF remained above the MIC90 value for Streptococcus during more than 8 h post IM administration of 15 mg/kg in weaning piglets. However, additional studies should be carried out in the lungs of infected pigs.
Fil: Soraci, Alejandro Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pérez, Denisa Soledad. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martínez, Guadalupe. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Amanto, F.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Producción Animal; Argentina
Fil: Tapia, Maria Ofelia. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dieguez, S.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina
Fil: Fernández Paggi, María Belén. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Concentrations of fosfomycin into the epithelial lining fluid (ELF) were studied by bronchoalveolar lavage (BAL) on 6 healthy weaning piglets after the administration of disodium fosfomycin 15 mg/kg intramuscularly (IM). The mean concentrations of fosfomycin in ELF were lower than those in plasma at all sampling time points. Fosfomycin concentrations in ELF were 12.1 % of those in serum. The degree of penetration of fosfomycin into the ELF was determined by comparing the AUC0–8 in ELF with the AUC0–8 in serum. The ratio AUCELF / AUCserum was 0.15 ± 0.02. The Cmax in serum and in ELF were 45.00 ± 2.51 and 3.10 ± 0.95 µg/ml, respectively. These concentrations were achieved at different times (Tmax in serum and ELF: 1.00 ± 0.00 and 2.58 ± 0.49 h, respectively). Effective bacterial killing can be expected from the first antibiotic dosage when the pathogen’s MIC is covered for at least 60–70% of the dosing interval. Different authors have determined a fosfomycin MIC90 for Streptococcus sp (important respiratory pathogens in piglets) of 0.25 µg/ml. Fosfomycin concentrations in ELF remained above the MIC90 value for Streptococcus during more than 8 h post IM administration of 15 mg/kg in weaning piglets. However, additional studies should be carried out in the lungs of infected pigs.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/70856
Soraci, Alejandro Luis; Pérez, Denisa Soledad; Martínez, Guadalupe; Amanto, F.; Tapia, Maria Ofelia; et al.; Fosfomycin concentrations in epithelial lining fluid in weaning piglets; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; 4; 8-2012; 406-409
0140-7783
CONICET Digital
CONICET
url http://hdl.handle.net/11336/70856
identifier_str_mv Soraci, Alejandro Luis; Pérez, Denisa Soledad; Martínez, Guadalupe; Amanto, F.; Tapia, Maria Ofelia; et al.; Fosfomycin concentrations in epithelial lining fluid in weaning piglets; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; 4; 8-2012; 406-409
0140-7783
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2011.01344.x/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2011.01344.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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