Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration

Autores
Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Calcium fosfomycin pharmacokinetics and bioavailability were studied in post weaning piglets after oral administration at 30 mg/kg of bodyweight (BW)). Fosfomycin plasma concentrations were measured by high-performance liquid chromatography MS/MS. The T1/2 was of 1.80 ± 0.89 h. Cmax, Tmax and bioavailability were 3.60 ± 0.96 µg/mL, 3.00 ± 0.00 h and 20.0 ± 1.85 %, respectively. The area under the fosfomycin concentration:time curve in plasma AUC(0-∞) was 45.48 ± 9.20 µg h/mL. Different authors have determined a minimum inhibitory concentration ranging from 0.25 - 0.5 µg/mL for Streptococcus sp. and Escherichia coli, respectively. Considering these minimum inhibitory concentrations of sensitive bacteria to fosfomycin, taking into account fosfomycin is a time-dependent antimicrobial and according to the values of fosfomycin plasma concentration vs. time profiles observed in this study, it was determined that effective plasma concentrations of fosfomycin for sensitive bacteria can be obtained following oral administration of fosfomycin at a dose of 30 mg/kg in piglets.
Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Tapia, Maria Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Materia
Calcium Fosfomycin
Post Weaning Piglets
Pharamcokinetics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71513
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/71513
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administrationPérez, Denisa SoledadSoraci, Alejandro LuisTapia, Maria OfeliaCalcium FosfomycinPost Weaning PigletsPharamcokineticshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Calcium fosfomycin pharmacokinetics and bioavailability were studied in post weaning piglets after oral administration at 30 mg/kg of bodyweight (BW)). Fosfomycin plasma concentrations were measured by high-performance liquid chromatography MS/MS. The T1/2 was of 1.80 ± 0.89 h. Cmax, Tmax and bioavailability were 3.60 ± 0.96 µg/mL, 3.00 ± 0.00 h and 20.0 ± 1.85 %, respectively. The area under the fosfomycin concentration:time curve in plasma AUC(0-∞) was 45.48 ± 9.20 µg h/mL. Different authors have determined a minimum inhibitory concentration ranging from 0.25 - 0.5 µg/mL for Streptococcus sp. and Escherichia coli, respectively. Considering these minimum inhibitory concentrations of sensitive bacteria to fosfomycin, taking into account fosfomycin is a time-dependent antimicrobial and according to the values of fosfomycin plasma concentration vs. time profiles observed in this study, it was determined that effective plasma concentrations of fosfomycin for sensitive bacteria can be obtained following oral administration of fosfomycin at a dose of 30 mg/kg in piglets.Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Tapia, Maria Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaPeriodical of Shahzad & Co2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71513Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration; Periodical of Shahzad & Co; International Journal for Agro Veterinary and Medical Sciences; 6; 6; 7-2012; 424-4351999-96662075-423XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ejmanager.com/mnstemps/25/25-1353685416.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.5455/ijavms.20130111041914info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:55Zoai:ri.conicet.gov.ar:11336/71513instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:55.373CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration
title Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration
spellingShingle Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration
Pérez, Denisa Soledad
Calcium Fosfomycin
Post Weaning Piglets
Pharamcokinetics
title_short Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration
title_full Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration
title_fullStr Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration
title_full_unstemmed Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration
title_sort Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration
dc.creator.none.fl_str_mv Pérez, Denisa Soledad
Soraci, Alejandro Luis
Tapia, Maria Ofelia
author Pérez, Denisa Soledad
author_facet Pérez, Denisa Soledad
Soraci, Alejandro Luis
Tapia, Maria Ofelia
author_role author
author2 Soraci, Alejandro Luis
Tapia, Maria Ofelia
author2_role author
author
dc.subject.none.fl_str_mv Calcium Fosfomycin
Post Weaning Piglets
Pharamcokinetics
topic Calcium Fosfomycin
Post Weaning Piglets
Pharamcokinetics
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Calcium fosfomycin pharmacokinetics and bioavailability were studied in post weaning piglets after oral administration at 30 mg/kg of bodyweight (BW)). Fosfomycin plasma concentrations were measured by high-performance liquid chromatography MS/MS. The T1/2 was of 1.80 ± 0.89 h. Cmax, Tmax and bioavailability were 3.60 ± 0.96 µg/mL, 3.00 ± 0.00 h and 20.0 ± 1.85 %, respectively. The area under the fosfomycin concentration:time curve in plasma AUC(0-∞) was 45.48 ± 9.20 µg h/mL. Different authors have determined a minimum inhibitory concentration ranging from 0.25 - 0.5 µg/mL for Streptococcus sp. and Escherichia coli, respectively. Considering these minimum inhibitory concentrations of sensitive bacteria to fosfomycin, taking into account fosfomycin is a time-dependent antimicrobial and according to the values of fosfomycin plasma concentration vs. time profiles observed in this study, it was determined that effective plasma concentrations of fosfomycin for sensitive bacteria can be obtained following oral administration of fosfomycin at a dose of 30 mg/kg in piglets.
Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Tapia, Maria Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
description Calcium fosfomycin pharmacokinetics and bioavailability were studied in post weaning piglets after oral administration at 30 mg/kg of bodyweight (BW)). Fosfomycin plasma concentrations were measured by high-performance liquid chromatography MS/MS. The T1/2 was of 1.80 ± 0.89 h. Cmax, Tmax and bioavailability were 3.60 ± 0.96 µg/mL, 3.00 ± 0.00 h and 20.0 ± 1.85 %, respectively. The area under the fosfomycin concentration:time curve in plasma AUC(0-∞) was 45.48 ± 9.20 µg h/mL. Different authors have determined a minimum inhibitory concentration ranging from 0.25 - 0.5 µg/mL for Streptococcus sp. and Escherichia coli, respectively. Considering these minimum inhibitory concentrations of sensitive bacteria to fosfomycin, taking into account fosfomycin is a time-dependent antimicrobial and according to the values of fosfomycin plasma concentration vs. time profiles observed in this study, it was determined that effective plasma concentrations of fosfomycin for sensitive bacteria can be obtained following oral administration of fosfomycin at a dose of 30 mg/kg in piglets.
publishDate 2012
dc.date.none.fl_str_mv 2012-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71513
Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration; Periodical of Shahzad & Co; International Journal for Agro Veterinary and Medical Sciences; 6; 6; 7-2012; 424-435
1999-9666
2075-423X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71513
identifier_str_mv Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Pharmacokinetics and bioavailability of calcium fosfomycin in post weaning piglets after oral administration; Periodical of Shahzad & Co; International Journal for Agro Veterinary and Medical Sciences; 6; 6; 7-2012; 424-435
1999-9666
2075-423X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ejmanager.com/mnstemps/25/25-1353685416.pdf
info:eu-repo/semantics/altIdentifier/doi/10.5455/ijavms.20130111041914
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Periodical of Shahzad & Co
publisher.none.fl_str_mv Periodical of Shahzad & Co
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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