Embryonic somite formation generated by genetic network oscillations with noise

Autores
Mazzitello, Karina Irma; Arizmendi, Constancio M.; Salas Brito, Alvaro L.; Hentschel, Hilary G. E.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In most vertebrate species, the body axis is generated bythe formation of repeated transient structures called somites. Thisspatial periodicity in somitogenesis has been related to the geneticnetwork oscillations in certain mRNAs and  their associated geneproducts in the cells forming the presomitic mesoderm. The currentmolecular view of the mechanism underlying these oscillationsinvolves negative-feedback regulation at transcriptional andtranslational levels. The spatially periodic nature of somiteformation suggests that the genetic network  involved must displayintracellular oscillations that interact with a longitudinalpositional information gradient, called determination front, downthe axis of vertebrate embryos to create this spatial patterning.Here we consider a simple model for diploid cells based on thiscurrent biological picture  considering  gene regulation  as a noisyprocess relevant in a real developmental situation and study itsconsequences for somitogenesis. Comparison is made with the known properties of somite formation in the zebrafish embryo.
Fil: Mazzitello, Karina Irma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina
Fil: Arizmendi, Constancio M.. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
Fil: Salas Brito, Alvaro L.. Universidad Autónoma Metropolitana Azcapotzalca; Argentina
Fil: Hentschel, Hilary G. E.. University of Emory; Estados Unidos
Materia
SOMITOGENESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/242484
Acceder
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spelling Embryonic somite formation generated by genetic network oscillations with noiseMazzitello, Karina IrmaArizmendi, Constancio M.Salas Brito, Alvaro L.Hentschel, Hilary G. E.SOMITOGENESIShttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2In most vertebrate species, the body axis is generated bythe formation of repeated transient structures called somites. Thisspatial periodicity in somitogenesis has been related to the geneticnetwork oscillations in certain mRNAs and  their associated geneproducts in the cells forming the presomitic mesoderm. The currentmolecular view of the mechanism underlying these oscillationsinvolves negative-feedback regulation at transcriptional andtranslational levels. The spatially periodic nature of somiteformation suggests that the genetic network  involved must displayintracellular oscillations that interact with a longitudinalpositional information gradient, called determination front, downthe axis of vertebrate embryos to create this spatial patterning.Here we consider a simple model for diploid cells based on thiscurrent biological picture  considering  gene regulation  as a noisyprocess relevant in a real developmental situation and study itsconsequences for somitogenesis. Comparison is made with the known properties of somite formation in the zebrafish embryo.Fil: Mazzitello, Karina Irma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Arizmendi, Constancio M.. Universidad de Buenos Aires. Facultad de Ingeniería; ArgentinaFil: Salas Brito, Alvaro L.. Universidad Autónoma Metropolitana Azcapotzalca; ArgentinaFil: Hentschel, Hilary G. E.. University of Emory; Estados UnidosWorld Scientific2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/242484Mazzitello, Karina Irma; Arizmendi, Constancio M.; Salas Brito, Alvaro L.; Hentschel, Hilary G. E.; Embryonic somite formation generated by genetic network oscillations with noise; World Scientific; International Journal Of Bifurcation And Chaos; 20; 02; 5-2012; 341-3470218-1274CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.worldscinet.com/ijbc/20/2002/S021812741002579X.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1142/S021812741002579Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:15:44Zoai:ri.conicet.gov.ar:11336/242484instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:15:44.389CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Embryonic somite formation generated by genetic network oscillations with noise
title Embryonic somite formation generated by genetic network oscillations with noise
spellingShingle Embryonic somite formation generated by genetic network oscillations with noise
Mazzitello, Karina Irma
SOMITOGENESIS
title_short Embryonic somite formation generated by genetic network oscillations with noise
title_full Embryonic somite formation generated by genetic network oscillations with noise
title_fullStr Embryonic somite formation generated by genetic network oscillations with noise
title_full_unstemmed Embryonic somite formation generated by genetic network oscillations with noise
title_sort Embryonic somite formation generated by genetic network oscillations with noise
dc.creator.none.fl_str_mv Mazzitello, Karina Irma
Arizmendi, Constancio M.
Salas Brito, Alvaro L.
Hentschel, Hilary G. E.
author Mazzitello, Karina Irma
author_facet Mazzitello, Karina Irma
Arizmendi, Constancio M.
Salas Brito, Alvaro L.
Hentschel, Hilary G. E.
author_role author
author2 Arizmendi, Constancio M.
Salas Brito, Alvaro L.
Hentschel, Hilary G. E.
author2_role author
author
author
dc.subject.none.fl_str_mv SOMITOGENESIS
topic SOMITOGENESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In most vertebrate species, the body axis is generated bythe formation of repeated transient structures called somites. Thisspatial periodicity in somitogenesis has been related to the geneticnetwork oscillations in certain mRNAs and  their associated geneproducts in the cells forming the presomitic mesoderm. The currentmolecular view of the mechanism underlying these oscillationsinvolves negative-feedback regulation at transcriptional andtranslational levels. The spatially periodic nature of somiteformation suggests that the genetic network  involved must displayintracellular oscillations that interact with a longitudinalpositional information gradient, called determination front, downthe axis of vertebrate embryos to create this spatial patterning.Here we consider a simple model for diploid cells based on thiscurrent biological picture  considering  gene regulation  as a noisyprocess relevant in a real developmental situation and study itsconsequences for somitogenesis. Comparison is made with the known properties of somite formation in the zebrafish embryo.
Fil: Mazzitello, Karina Irma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina
Fil: Arizmendi, Constancio M.. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
Fil: Salas Brito, Alvaro L.. Universidad Autónoma Metropolitana Azcapotzalca; Argentina
Fil: Hentschel, Hilary G. E.. University of Emory; Estados Unidos
description In most vertebrate species, the body axis is generated bythe formation of repeated transient structures called somites. Thisspatial periodicity in somitogenesis has been related to the geneticnetwork oscillations in certain mRNAs and  their associated geneproducts in the cells forming the presomitic mesoderm. The currentmolecular view of the mechanism underlying these oscillationsinvolves negative-feedback regulation at transcriptional andtranslational levels. The spatially periodic nature of somiteformation suggests that the genetic network  involved must displayintracellular oscillations that interact with a longitudinalpositional information gradient, called determination front, downthe axis of vertebrate embryos to create this spatial patterning.Here we consider a simple model for diploid cells based on thiscurrent biological picture  considering  gene regulation  as a noisyprocess relevant in a real developmental situation and study itsconsequences for somitogenesis. Comparison is made with the known properties of somite formation in the zebrafish embryo.
publishDate 2012
dc.date.none.fl_str_mv 2012-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/242484
Mazzitello, Karina Irma; Arizmendi, Constancio M.; Salas Brito, Alvaro L.; Hentschel, Hilary G. E.; Embryonic somite formation generated by genetic network oscillations with noise; World Scientific; International Journal Of Bifurcation And Chaos; 20; 02; 5-2012; 341-347
0218-1274
CONICET Digital
CONICET
url http://hdl.handle.net/11336/242484
identifier_str_mv Mazzitello, Karina Irma; Arizmendi, Constancio M.; Salas Brito, Alvaro L.; Hentschel, Hilary G. E.; Embryonic somite formation generated by genetic network oscillations with noise; World Scientific; International Journal Of Bifurcation And Chaos; 20; 02; 5-2012; 341-347
0218-1274
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.worldscinet.com/ijbc/20/2002/S021812741002579X.html
info:eu-repo/semantics/altIdentifier/doi/10.1142/S021812741002579X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv World Scientific
publisher.none.fl_str_mv World Scientific
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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