Elevated systemic galectin-1 levels characterize HELLP syndrome.
- Autores
- Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; Barrientos, Gabriela Laura; Conrad, Melanie L.; Rose, Matthias; Seelbach-Göbel, Birgit
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development
Fil: Schnabel, Annegret. Universitat Regensburg; Alemania
Fil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; Alemania
Fil: Meint, Peter. Universitat Regensburg; Alemania
Fil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; Alemania
Fil: Ernst, Wolfgang. Universitat Regensburg; Alemania
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; Alemania
Fil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; Alemania
Fil: Rose, Matthias. Charité-Universitätsmedizin Berlin; Alemania
Fil: Seelbach-Göbel, Birgit. Universitat Regensburg; Alemania - Materia
-
Angiogenic Factors
Galectin-1
Hellp
Pregnancy - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/43966
Ver los metadatos del registro completo
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Elevated systemic galectin-1 levels characterize HELLP syndrome.Schnabel, AnnegretBlois, Sandra M.Meint, PeterFreitag, NancyErnst, WolfgangBarrientos, Gabriela LauraConrad, Melanie L.Rose, MatthiasSeelbach-Göbel, BirgitAngiogenic FactorsGalectin-1HellpPregnancyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome developmentFil: Schnabel, Annegret. Universitat Regensburg; AlemaniaFil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; AlemaniaFil: Meint, Peter. Universitat Regensburg; AlemaniaFil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; AlemaniaFil: Ernst, Wolfgang. Universitat Regensburg; AlemaniaFil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; AlemaniaFil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; AlemaniaFil: Rose, Matthias. Charité-Universitätsmedizin Berlin; AlemaniaFil: Seelbach-Göbel, Birgit. Universitat Regensburg; AlemaniaElsevier Ireland2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43966Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; et al.; Elevated systemic galectin-1 levels characterize HELLP syndrome.; Elsevier Ireland; Journal of Reproductive Immunology; 114; 4-2016; 38-430165-0378CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jri.2016.02.002info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165037815300735info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:16Zoai:ri.conicet.gov.ar:11336/43966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:17.3CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Elevated systemic galectin-1 levels characterize HELLP syndrome. |
title |
Elevated systemic galectin-1 levels characterize HELLP syndrome. |
spellingShingle |
Elevated systemic galectin-1 levels characterize HELLP syndrome. Schnabel, Annegret Angiogenic Factors Galectin-1 Hellp Pregnancy |
title_short |
Elevated systemic galectin-1 levels characterize HELLP syndrome. |
title_full |
Elevated systemic galectin-1 levels characterize HELLP syndrome. |
title_fullStr |
Elevated systemic galectin-1 levels characterize HELLP syndrome. |
title_full_unstemmed |
Elevated systemic galectin-1 levels characterize HELLP syndrome. |
title_sort |
Elevated systemic galectin-1 levels characterize HELLP syndrome. |
dc.creator.none.fl_str_mv |
Schnabel, Annegret Blois, Sandra M. Meint, Peter Freitag, Nancy Ernst, Wolfgang Barrientos, Gabriela Laura Conrad, Melanie L. Rose, Matthias Seelbach-Göbel, Birgit |
author |
Schnabel, Annegret |
author_facet |
Schnabel, Annegret Blois, Sandra M. Meint, Peter Freitag, Nancy Ernst, Wolfgang Barrientos, Gabriela Laura Conrad, Melanie L. Rose, Matthias Seelbach-Göbel, Birgit |
author_role |
author |
author2 |
Blois, Sandra M. Meint, Peter Freitag, Nancy Ernst, Wolfgang Barrientos, Gabriela Laura Conrad, Melanie L. Rose, Matthias Seelbach-Göbel, Birgit |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Angiogenic Factors Galectin-1 Hellp Pregnancy |
topic |
Angiogenic Factors Galectin-1 Hellp Pregnancy |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development Fil: Schnabel, Annegret. Universitat Regensburg; Alemania Fil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; Alemania Fil: Meint, Peter. Universitat Regensburg; Alemania Fil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; Alemania Fil: Ernst, Wolfgang. Universitat Regensburg; Alemania Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; Alemania Fil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; Alemania Fil: Rose, Matthias. Charité-Universitätsmedizin Berlin; Alemania Fil: Seelbach-Göbel, Birgit. Universitat Regensburg; Alemania |
description |
Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/43966 Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; et al.; Elevated systemic galectin-1 levels characterize HELLP syndrome.; Elsevier Ireland; Journal of Reproductive Immunology; 114; 4-2016; 38-43 0165-0378 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/43966 |
identifier_str_mv |
Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; et al.; Elevated systemic galectin-1 levels characterize HELLP syndrome.; Elsevier Ireland; Journal of Reproductive Immunology; 114; 4-2016; 38-43 0165-0378 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jri.2016.02.002 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165037815300735 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Ireland |
publisher.none.fl_str_mv |
Elsevier Ireland |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268591170256896 |
score |
13.13397 |