Elevated systemic galectin-1 levels characterize HELLP syndrome.

Autores
Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; Barrientos, Gabriela Laura; Conrad, Melanie L.; Rose, Matthias; Seelbach-Göbel, Birgit
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development
Fil: Schnabel, Annegret. Universitat Regensburg; Alemania
Fil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; Alemania
Fil: Meint, Peter. Universitat Regensburg; Alemania
Fil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; Alemania
Fil: Ernst, Wolfgang. Universitat Regensburg; Alemania
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; Alemania
Fil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; Alemania
Fil: Rose, Matthias. Charité-Universitätsmedizin Berlin; Alemania
Fil: Seelbach-Göbel, Birgit. Universitat Regensburg; Alemania
Materia
Angiogenic Factors
Galectin-1
Hellp
Pregnancy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43966
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Elevated systemic galectin-1 levels characterize HELLP syndrome.Schnabel, AnnegretBlois, Sandra M.Meint, PeterFreitag, NancyErnst, WolfgangBarrientos, Gabriela LauraConrad, Melanie L.Rose, MatthiasSeelbach-Göbel, BirgitAngiogenic FactorsGalectin-1HellpPregnancyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome developmentFil: Schnabel, Annegret. Universitat Regensburg; AlemaniaFil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; AlemaniaFil: Meint, Peter. Universitat Regensburg; AlemaniaFil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; AlemaniaFil: Ernst, Wolfgang. Universitat Regensburg; AlemaniaFil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; AlemaniaFil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; AlemaniaFil: Rose, Matthias. Charité-Universitätsmedizin Berlin; AlemaniaFil: Seelbach-Göbel, Birgit. Universitat Regensburg; AlemaniaElsevier Ireland2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43966Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; et al.; Elevated systemic galectin-1 levels characterize HELLP syndrome.; Elsevier Ireland; Journal of Reproductive Immunology; 114; 4-2016; 38-430165-0378CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jri.2016.02.002info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165037815300735info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:32:26Zoai:ri.conicet.gov.ar:11336/43966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:32:27.162CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Elevated systemic galectin-1 levels characterize HELLP syndrome.
title Elevated systemic galectin-1 levels characterize HELLP syndrome.
spellingShingle Elevated systemic galectin-1 levels characterize HELLP syndrome.
Schnabel, Annegret
Angiogenic Factors
Galectin-1
Hellp
Pregnancy
title_short Elevated systemic galectin-1 levels characterize HELLP syndrome.
title_full Elevated systemic galectin-1 levels characterize HELLP syndrome.
title_fullStr Elevated systemic galectin-1 levels characterize HELLP syndrome.
title_full_unstemmed Elevated systemic galectin-1 levels characterize HELLP syndrome.
title_sort Elevated systemic galectin-1 levels characterize HELLP syndrome.
dc.creator.none.fl_str_mv Schnabel, Annegret
Blois, Sandra M.
Meint, Peter
Freitag, Nancy
Ernst, Wolfgang
Barrientos, Gabriela Laura
Conrad, Melanie L.
Rose, Matthias
Seelbach-Göbel, Birgit
author Schnabel, Annegret
author_facet Schnabel, Annegret
Blois, Sandra M.
Meint, Peter
Freitag, Nancy
Ernst, Wolfgang
Barrientos, Gabriela Laura
Conrad, Melanie L.
Rose, Matthias
Seelbach-Göbel, Birgit
author_role author
author2 Blois, Sandra M.
Meint, Peter
Freitag, Nancy
Ernst, Wolfgang
Barrientos, Gabriela Laura
Conrad, Melanie L.
Rose, Matthias
Seelbach-Göbel, Birgit
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Angiogenic Factors
Galectin-1
Hellp
Pregnancy
topic Angiogenic Factors
Galectin-1
Hellp
Pregnancy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development
Fil: Schnabel, Annegret. Universitat Regensburg; Alemania
Fil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; Alemania
Fil: Meint, Peter. Universitat Regensburg; Alemania
Fil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; Alemania
Fil: Ernst, Wolfgang. Universitat Regensburg; Alemania
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; Alemania
Fil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; Alemania
Fil: Rose, Matthias. Charité-Universitätsmedizin Berlin; Alemania
Fil: Seelbach-Göbel, Birgit. Universitat Regensburg; Alemania
description Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development
publishDate 2016
dc.date.none.fl_str_mv 2016-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43966
Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; et al.; Elevated systemic galectin-1 levels characterize HELLP syndrome.; Elsevier Ireland; Journal of Reproductive Immunology; 114; 4-2016; 38-43
0165-0378
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43966
identifier_str_mv Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; et al.; Elevated systemic galectin-1 levels characterize HELLP syndrome.; Elsevier Ireland; Journal of Reproductive Immunology; 114; 4-2016; 38-43
0165-0378
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jri.2016.02.002
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165037815300735
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.976206

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