Involvement of galectin-1 in reproduction: past, present and future

Autores
Barrientos, Gabriela Laura; Freitag, Nancy; Tirado González, Irene; Unverdorben, Laura; Jeschke, Udo; Thijssen, Victor L. J. L.; Blois, Sandra M.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal–maternal interface, many functional aspects of this lectin in reproduction are only emerging. Methods: The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal–fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. Results: This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation. We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytium formation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. Conclusion: The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy.
Fil: Barrientos, Gabriela Laura. Universitätsmedizin Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Freitag, Nancy. Universitätsmedizin Berlin; Alemania
Fil: Tirado González, Irene. Universitätsmedizin Berlin; Alemania
Fil: Unverdorben, Laura. Ludwig Maximilians Universitat; Alemania
Fil: Jeschke, Udo. Ludwig Maximilians Universitat; Alemania
Fil: Thijssen, Victor L. J. L.. VU University Medical Center; Países Bajos
Fil: Blois, Sandra M.. Universitätsmedizin Berlin; Alemania
Materia
Angiogenesis
Cancer
Galectin-1
Pregnancy
Progesterone
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30707
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/30707
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Involvement of galectin-1 in reproduction: past, present and futureBarrientos, Gabriela LauraFreitag, NancyTirado González, IreneUnverdorben, LauraJeschke, UdoThijssen, Victor L. J. L.Blois, Sandra M.AngiogenesisCancerGalectin-1PregnancyProgesteronehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal–maternal interface, many functional aspects of this lectin in reproduction are only emerging. Methods: The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal–fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. Results: This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation. We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytium formation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. Conclusion: The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy.Fil: Barrientos, Gabriela Laura. Universitätsmedizin Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Freitag, Nancy. Universitätsmedizin Berlin; AlemaniaFil: Tirado González, Irene. Universitätsmedizin Berlin; AlemaniaFil: Unverdorben, Laura. Ludwig Maximilians Universitat; AlemaniaFil: Jeschke, Udo. Ludwig Maximilians Universitat; AlemaniaFil: Thijssen, Victor L. J. L.. VU University Medical Center; Países BajosFil: Blois, Sandra M.. Universitätsmedizin Berlin; AlemaniaOxford University Press2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30707Barrientos, Gabriela Laura; Freitag, Nancy; Tirado González, Irene; Unverdorben, Laura; Jeschke, Udo; et al.; Involvement of galectin-1 in reproduction: past, present and future; Oxford University Press; Human Reproduction Update; 20; 2; 9-2013; 175-1931355-4786CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/humupd/dmt040info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/humupd/article/20/2/175/662478info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:46Zoai:ri.conicet.gov.ar:11336/30707instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:46.539CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Involvement of galectin-1 in reproduction: past, present and future
title Involvement of galectin-1 in reproduction: past, present and future
spellingShingle Involvement of galectin-1 in reproduction: past, present and future
Barrientos, Gabriela Laura
Angiogenesis
Cancer
Galectin-1
Pregnancy
Progesterone
title_short Involvement of galectin-1 in reproduction: past, present and future
title_full Involvement of galectin-1 in reproduction: past, present and future
title_fullStr Involvement of galectin-1 in reproduction: past, present and future
title_full_unstemmed Involvement of galectin-1 in reproduction: past, present and future
title_sort Involvement of galectin-1 in reproduction: past, present and future
dc.creator.none.fl_str_mv Barrientos, Gabriela Laura
Freitag, Nancy
Tirado González, Irene
Unverdorben, Laura
Jeschke, Udo
Thijssen, Victor L. J. L.
Blois, Sandra M.
author Barrientos, Gabriela Laura
author_facet Barrientos, Gabriela Laura
Freitag, Nancy
Tirado González, Irene
Unverdorben, Laura
Jeschke, Udo
Thijssen, Victor L. J. L.
Blois, Sandra M.
author_role author
author2 Freitag, Nancy
Tirado González, Irene
Unverdorben, Laura
Jeschke, Udo
Thijssen, Victor L. J. L.
Blois, Sandra M.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Angiogenesis
Cancer
Galectin-1
Pregnancy
Progesterone
topic Angiogenesis
Cancer
Galectin-1
Pregnancy
Progesterone
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal–maternal interface, many functional aspects of this lectin in reproduction are only emerging. Methods: The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal–fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. Results: This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation. We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytium formation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. Conclusion: The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy.
Fil: Barrientos, Gabriela Laura. Universitätsmedizin Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Freitag, Nancy. Universitätsmedizin Berlin; Alemania
Fil: Tirado González, Irene. Universitätsmedizin Berlin; Alemania
Fil: Unverdorben, Laura. Ludwig Maximilians Universitat; Alemania
Fil: Jeschke, Udo. Ludwig Maximilians Universitat; Alemania
Fil: Thijssen, Victor L. J. L.. VU University Medical Center; Países Bajos
Fil: Blois, Sandra M.. Universitätsmedizin Berlin; Alemania
description Background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal–maternal interface, many functional aspects of this lectin in reproduction are only emerging. Methods: The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal–fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. Results: This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation. We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytium formation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. Conclusion: The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30707
Barrientos, Gabriela Laura; Freitag, Nancy; Tirado González, Irene; Unverdorben, Laura; Jeschke, Udo; et al.; Involvement of galectin-1 in reproduction: past, present and future; Oxford University Press; Human Reproduction Update; 20; 2; 9-2013; 175-193
1355-4786
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30707
identifier_str_mv Barrientos, Gabriela Laura; Freitag, Nancy; Tirado González, Irene; Unverdorben, Laura; Jeschke, Udo; et al.; Involvement of galectin-1 in reproduction: past, present and future; Oxford University Press; Human Reproduction Update; 20; 2; 9-2013; 175-193
1355-4786
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/humupd/dmt040
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/humupd/article/20/2/175/662478
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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