Comparative diabetogenic action of the hypophysis from various animals

Autores
Houssay, Bernardo Alberto; Smyth, F. S.; Foglia, Virgilio; Houssay, Alberto B.
Año de publicación
1942
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The role of the anterior portion of the hypophysis in the production or intensification of diabetes was discovered in this Institute in 1929 and 1930 and since then has been studied continuously. An abstract of this work up to 1935 was published by Houssay in 1936. Some of the extracts of anterior hypophysis in animals without hypophysis and pancreas and with mild diabetes, intensified the hyperglycemia and glycosuria to a degree exceeding the intensity of the diabetes associated with pancreatectomy alone. This was observed in the toad (Houssay and Biasotti, 1930), and in the dog (Houssay and Biasotti, 1932; Houssay, Biasotti, and Rietti, 1932; Houssay, Biasotti, Di Benedetti, and Rietti, 1932). These latter observations suggested a possible method of biological assay of the diabetogenic factor. The present experiments were undertaken to demonstrate the relative potency of the diabetogenic principle in extracts of the anterior hypophysis from various species.
Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Smyth, F. S.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Foglia, Virgilio. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Houssay, Alberto B.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
fondo
Materia
HISTORIA DE LA CIENCIA ARGENTINA
HOUSSAY BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES
DIABETOGENIC ACTION
TEST ANIMALS
HYPOPHYSYS
EL INVESTIGADOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123758
Acceder
id CONICETDig_7990ee9810247728100ac18793b89752
oai_identifier_str oai:ri.conicet.gov.ar:11336/123758
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative diabetogenic action of the hypophysis from various animalsHoussay, Bernardo AlbertoSmyth, F. S.Foglia, VirgilioHoussay, Alberto B.HISTORIA DE LA CIENCIA ARGENTINAHOUSSAY BERNARDO ALBERTOHOUSSAY EL INVESTIGADORPUBLICACIONESDIABETOGENIC ACTIONTEST ANIMALSHYPOPHYSYSEL INVESTIGADORhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/6.1https://purl.org/becyt/ford/6https://purl.org/becyt/ford/6.3https://purl.org/becyt/ford/6The role of the anterior portion of the hypophysis in the production or intensification of diabetes was discovered in this Institute in 1929 and 1930 and since then has been studied continuously. An abstract of this work up to 1935 was published by Houssay in 1936. Some of the extracts of anterior hypophysis in animals without hypophysis and pancreas and with mild diabetes, intensified the hyperglycemia and glycosuria to a degree exceeding the intensity of the diabetes associated with pancreatectomy alone. This was observed in the toad (Houssay and Biasotti, 1930), and in the dog (Houssay and Biasotti, 1932; Houssay, Biasotti, and Rietti, 1932; Houssay, Biasotti, Di Benedetti, and Rietti, 1932). These latter observations suggested a possible method of biological assay of the diabetogenic factor. The present experiments were undertaken to demonstrate the relative potency of the diabetogenic principle in extracts of the anterior hypophysis from various species.Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Smyth, F. S.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Foglia, Virgilio. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Houssay, Alberto B.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinafondoThe Rockefeller University Press1942info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulotext/plainBlancoNegroSiapplication/pdfhttp://hdl.handle.net/11336/123758Houssay, Bernardo Alberto; Smyth, F. S.; Foglia, Virgilio; Houssay, Alberto B.; Comparative diabetogenic action of the hypophysis from various animals; The Rockefeller University Press; Journal of Experimental Medicine; 75; 1; 1942; 93-1060022-1007enginfo:eu-repo/semantics/altIdentifier/doi/10.1084/jem.75.1.93info:eu-repo/semantics/altIdentifier/url/https://rupress.org/jem/article/75/1/93/4586/COMPARATIVE-DIABETOGENIC-ACTION-OF-THE-HYPOPHYSISCiudad de Buenos AiresFundacion Williams.Fundación de Instituto de Biología y Medicina ExperimentalConsejo Nacional de Investigaciones Científicas y TécnicasProyecto Houssay y Leloirinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:43:40Zoai:ri.conicet.gov.ar:11336/123758instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:43:40.424CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative diabetogenic action of the hypophysis from various animals
title Comparative diabetogenic action of the hypophysis from various animals
spellingShingle Comparative diabetogenic action of the hypophysis from various animals
Houssay, Bernardo Alberto
HISTORIA DE LA CIENCIA ARGENTINA
HOUSSAY BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES
DIABETOGENIC ACTION
TEST ANIMALS
HYPOPHYSYS
EL INVESTIGADOR
title_short Comparative diabetogenic action of the hypophysis from various animals
title_full Comparative diabetogenic action of the hypophysis from various animals
title_fullStr Comparative diabetogenic action of the hypophysis from various animals
title_full_unstemmed Comparative diabetogenic action of the hypophysis from various animals
title_sort Comparative diabetogenic action of the hypophysis from various animals
dc.creator.none.fl_str_mv Houssay, Bernardo Alberto
Smyth, F. S.
Foglia, Virgilio
Houssay, Alberto B.
author Houssay, Bernardo Alberto
author_facet Houssay, Bernardo Alberto
Smyth, F. S.
Foglia, Virgilio
Houssay, Alberto B.
author_role author
author2 Smyth, F. S.
Foglia, Virgilio
Houssay, Alberto B.
author2_role author
author
author
dc.subject.none.fl_str_mv HISTORIA DE LA CIENCIA ARGENTINA
HOUSSAY BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES
DIABETOGENIC ACTION
TEST ANIMALS
HYPOPHYSYS
EL INVESTIGADOR
topic HISTORIA DE LA CIENCIA ARGENTINA
HOUSSAY BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES
DIABETOGENIC ACTION
TEST ANIMALS
HYPOPHYSYS
EL INVESTIGADOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/6.1
https://purl.org/becyt/ford/6
https://purl.org/becyt/ford/6.3
https://purl.org/becyt/ford/6
dc.description.none.fl_txt_mv The role of the anterior portion of the hypophysis in the production or intensification of diabetes was discovered in this Institute in 1929 and 1930 and since then has been studied continuously. An abstract of this work up to 1935 was published by Houssay in 1936. Some of the extracts of anterior hypophysis in animals without hypophysis and pancreas and with mild diabetes, intensified the hyperglycemia and glycosuria to a degree exceeding the intensity of the diabetes associated with pancreatectomy alone. This was observed in the toad (Houssay and Biasotti, 1930), and in the dog (Houssay and Biasotti, 1932; Houssay, Biasotti, and Rietti, 1932; Houssay, Biasotti, Di Benedetti, and Rietti, 1932). These latter observations suggested a possible method of biological assay of the diabetogenic factor. The present experiments were undertaken to demonstrate the relative potency of the diabetogenic principle in extracts of the anterior hypophysis from various species.
Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Smyth, F. S.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Foglia, Virgilio. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Houssay, Alberto B.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
fondo
description The role of the anterior portion of the hypophysis in the production or intensification of diabetes was discovered in this Institute in 1929 and 1930 and since then has been studied continuously. An abstract of this work up to 1935 was published by Houssay in 1936. Some of the extracts of anterior hypophysis in animals without hypophysis and pancreas and with mild diabetes, intensified the hyperglycemia and glycosuria to a degree exceeding the intensity of the diabetes associated with pancreatectomy alone. This was observed in the toad (Houssay and Biasotti, 1930), and in the dog (Houssay and Biasotti, 1932; Houssay, Biasotti, and Rietti, 1932; Houssay, Biasotti, Di Benedetti, and Rietti, 1932). These latter observations suggested a possible method of biological assay of the diabetogenic factor. The present experiments were undertaken to demonstrate the relative potency of the diabetogenic principle in extracts of the anterior hypophysis from various species.
publishDate 1942
dc.date.none.fl_str_mv 1942
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123758
Houssay, Bernardo Alberto; Smyth, F. S.; Foglia, Virgilio; Houssay, Alberto B.; Comparative diabetogenic action of the hypophysis from various animals; The Rockefeller University Press; Journal of Experimental Medicine; 75; 1; 1942; 93-106
0022-1007
url http://hdl.handle.net/11336/123758
identifier_str_mv Houssay, Bernardo Alberto; Smyth, F. S.; Foglia, Virgilio; Houssay, Alberto B.; Comparative diabetogenic action of the hypophysis from various animals; The Rockefeller University Press; Journal of Experimental Medicine; 75; 1; 1942; 93-106
0022-1007
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1084/jem.75.1.93
info:eu-repo/semantics/altIdentifier/url/https://rupress.org/jem/article/75/1/93/4586/COMPARATIVE-DIABETOGENIC-ACTION-OF-THE-HYPOPHYSIS
Ciudad de Buenos Aires
Fundacion Williams.
Fundación de Instituto de Biología y Medicina Experimental
Consejo Nacional de Investigaciones Científicas y Técnicas
Proyecto Houssay y Leloir
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv text/plain
BlancoNegro
Si
application/pdf
dc.publisher.none.fl_str_mv The Rockefeller University Press
publisher.none.fl_str_mv The Rockefeller University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1843606787897425920
score 13.000565

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