Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs
- Autores
- Houssay, Bernardo Alberto; Penhos, J. C.
- Año de publicación
- 1956
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- THE diabetogenic action of the anterior pituitary extracts was demonstrated in hypophysectomized-pancreatectomized toads by Houssay and Biasotti (1). This action was not obtained in pancreatectomized cats and rats in the absence of adrenals (2, 3). But the diabetogenic action of the anterior pituitary extract was obtained in other adrenalectomized animals : a) toads deprived of adrenals and pancreas (4); b) toads deprived of hypophysis, pancreas, kidney and adrenals (5): c) toads deprived of hypophysis, pancreas and adrenals (4, 6); in cases 6 and c, the diabetogenic action was diminished by the absence of the adrenals. The diabetogenic action of the pituitary was also observed in mammals deprived of the adrenals such as: d) dogs with reduction of the pancreatic mass, deprived of both adrenals and maintained with cortico-adrenal extract (7, 8) or with desoxycorticosterone (8); e) dogs with reduction of the pancreatic mass, deprived of the adrenals, maintained only with sodium chloride and not receiving adrenal hormones (8); some of these dogs were also deprived of the thyroid. All these experiments demonstrated that hypophyseal diabetes may be obtained without the presence or participation of the adrenals.
Fil: Houssay, Bernardo Alberto. Fundación de Instituto de Biología y Medicina Experimental; Argentina
Fil: Penhos, J. C.. Fundación de Instituto de Biología y Medicina Experimental; Argentina
fondo - Materia
-
HOUSSAY, BERNARDO A.
HOUSSAY EL INVESTIGADOR
PUBLICACIONES
PUBLICACIONES CIENTIFICAS
ENDOCRINOLOGY
PITUITARY
HIDROCORTISONE
DIABETOGENIC ACTION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/163211
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/163211 |
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Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogsHoussay, Bernardo AlbertoPenhos, J. C.HOUSSAY, BERNARDO A.HOUSSAY EL INVESTIGADORPUBLICACIONESPUBLICACIONES CIENTIFICASENDOCRINOLOGYPITUITARYHIDROCORTISONEDIABETOGENIC ACTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3THE diabetogenic action of the anterior pituitary extracts was demonstrated in hypophysectomized-pancreatectomized toads by Houssay and Biasotti (1). This action was not obtained in pancreatectomized cats and rats in the absence of adrenals (2, 3). But the diabetogenic action of the anterior pituitary extract was obtained in other adrenalectomized animals : a) toads deprived of adrenals and pancreas (4); b) toads deprived of hypophysis, pancreas, kidney and adrenals (5): c) toads deprived of hypophysis, pancreas and adrenals (4, 6); in cases 6 and c, the diabetogenic action was diminished by the absence of the adrenals. The diabetogenic action of the pituitary was also observed in mammals deprived of the adrenals such as: d) dogs with reduction of the pancreatic mass, deprived of both adrenals and maintained with cortico-adrenal extract (7, 8) or with desoxycorticosterone (8); e) dogs with reduction of the pancreatic mass, deprived of the adrenals, maintained only with sodium chloride and not receiving adrenal hormones (8); some of these dogs were also deprived of the thyroid. All these experiments demonstrated that hypophyseal diabetes may be obtained without the presence or participation of the adrenals.Fil: Houssay, Bernardo Alberto. Fundación de Instituto de Biología y Medicina Experimental; ArgentinaFil: Penhos, J. C.. Fundación de Instituto de Biología y Medicina Experimental; ArgentinafondoEndocrine Society1956-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulotext/plainBlancoNegroSiapplication/octet-streamapplication/pdfhttp://hdl.handle.net/11336/163211Houssay, Bernardo Alberto; Penhos, J. C.; Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs; Endocrine Society; Endocrinology; 59; 6; 12-1956; 637-6410013-7227enginfo:eu-repo/semantics/altIdentifier/doi/10.1210/endo-59-6-637info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article-abstract/59/6/637/2736534?redirectedFrom=fulltext&login=falseCiudad de Buenos AiresFundación de Instituto de Biología y Medicina ExperimentalFundacion Williams.Consejo Nacional de Investigaciones Científicas y TécnicasProyecto Houssay y Leloirinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:15Zoai:ri.conicet.gov.ar:11336/163211instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:15.626CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs |
title |
Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs |
spellingShingle |
Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs Houssay, Bernardo Alberto HOUSSAY, BERNARDO A. HOUSSAY EL INVESTIGADOR PUBLICACIONES PUBLICACIONES CIENTIFICAS ENDOCRINOLOGY PITUITARY HIDROCORTISONE DIABETOGENIC ACTION |
title_short |
Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs |
title_full |
Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs |
title_fullStr |
Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs |
title_full_unstemmed |
Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs |
title_sort |
Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs |
dc.creator.none.fl_str_mv |
Houssay, Bernardo Alberto Penhos, J. C. |
author |
Houssay, Bernardo Alberto |
author_facet |
Houssay, Bernardo Alberto Penhos, J. C. |
author_role |
author |
author2 |
Penhos, J. C. |
author2_role |
author |
dc.subject.none.fl_str_mv |
HOUSSAY, BERNARDO A. HOUSSAY EL INVESTIGADOR PUBLICACIONES PUBLICACIONES CIENTIFICAS ENDOCRINOLOGY PITUITARY HIDROCORTISONE DIABETOGENIC ACTION |
topic |
HOUSSAY, BERNARDO A. HOUSSAY EL INVESTIGADOR PUBLICACIONES PUBLICACIONES CIENTIFICAS ENDOCRINOLOGY PITUITARY HIDROCORTISONE DIABETOGENIC ACTION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
THE diabetogenic action of the anterior pituitary extracts was demonstrated in hypophysectomized-pancreatectomized toads by Houssay and Biasotti (1). This action was not obtained in pancreatectomized cats and rats in the absence of adrenals (2, 3). But the diabetogenic action of the anterior pituitary extract was obtained in other adrenalectomized animals : a) toads deprived of adrenals and pancreas (4); b) toads deprived of hypophysis, pancreas, kidney and adrenals (5): c) toads deprived of hypophysis, pancreas and adrenals (4, 6); in cases 6 and c, the diabetogenic action was diminished by the absence of the adrenals. The diabetogenic action of the pituitary was also observed in mammals deprived of the adrenals such as: d) dogs with reduction of the pancreatic mass, deprived of both adrenals and maintained with cortico-adrenal extract (7, 8) or with desoxycorticosterone (8); e) dogs with reduction of the pancreatic mass, deprived of the adrenals, maintained only with sodium chloride and not receiving adrenal hormones (8); some of these dogs were also deprived of the thyroid. All these experiments demonstrated that hypophyseal diabetes may be obtained without the presence or participation of the adrenals. Fil: Houssay, Bernardo Alberto. Fundación de Instituto de Biología y Medicina Experimental; Argentina Fil: Penhos, J. C.. Fundación de Instituto de Biología y Medicina Experimental; Argentina fondo |
description |
THE diabetogenic action of the anterior pituitary extracts was demonstrated in hypophysectomized-pancreatectomized toads by Houssay and Biasotti (1). This action was not obtained in pancreatectomized cats and rats in the absence of adrenals (2, 3). But the diabetogenic action of the anterior pituitary extract was obtained in other adrenalectomized animals : a) toads deprived of adrenals and pancreas (4); b) toads deprived of hypophysis, pancreas, kidney and adrenals (5): c) toads deprived of hypophysis, pancreas and adrenals (4, 6); in cases 6 and c, the diabetogenic action was diminished by the absence of the adrenals. The diabetogenic action of the pituitary was also observed in mammals deprived of the adrenals such as: d) dogs with reduction of the pancreatic mass, deprived of both adrenals and maintained with cortico-adrenal extract (7, 8) or with desoxycorticosterone (8); e) dogs with reduction of the pancreatic mass, deprived of the adrenals, maintained only with sodium chloride and not receiving adrenal hormones (8); some of these dogs were also deprived of the thyroid. All these experiments demonstrated that hypophyseal diabetes may be obtained without the presence or participation of the adrenals. |
publishDate |
1956 |
dc.date.none.fl_str_mv |
1956-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/163211 Houssay, Bernardo Alberto; Penhos, J. C.; Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs; Endocrine Society; Endocrinology; 59; 6; 12-1956; 637-641 0013-7227 |
url |
http://hdl.handle.net/11336/163211 |
identifier_str_mv |
Houssay, Bernardo Alberto; Penhos, J. C.; Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs; Endocrine Society; Endocrinology; 59; 6; 12-1956; 637-641 0013-7227 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1210/endo-59-6-637 info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article-abstract/59/6/637/2736534?redirectedFrom=fulltext&login=false Ciudad de Buenos Aires Fundación de Instituto de Biología y Medicina Experimental Fundacion Williams. Consejo Nacional de Investigaciones Científicas y Técnicas Proyecto Houssay y Leloir |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
text/plain BlancoNegro Si application/octet-stream application/pdf |
dc.publisher.none.fl_str_mv |
Endocrine Society |
publisher.none.fl_str_mv |
Endocrine Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613135500050432 |
score |
13.070432 |