Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs

Autores
Houssay, Bernardo Alberto; Penhos, J. C.
Año de publicación
1956
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
THE diabetogenic action of the anterior pituitary extracts was demonstrated in hypophysectomized-pancreatectomized toads by Houssay and Biasotti (1). This action was not obtained in pancreatectomized cats and rats in the absence of adrenals (2, 3). But the diabetogenic action of the anterior pituitary extract was obtained in other adrenalectomized animals : a) toads deprived of adrenals and pancreas (4); b) toads deprived of hypophysis, pancreas, kidney and adrenals (5): c) toads deprived of hypophysis, pancreas and adrenals (4, 6); in cases 6 and c, the diabetogenic action was diminished by the absence of the adrenals. The diabetogenic action of the pituitary was also observed in mammals deprived of the adrenals such as: d) dogs with reduction of the pancreatic mass, deprived of both adrenals and maintained with cortico-adrenal extract (7, 8) or with desoxycorticosterone (8); e) dogs with reduction of the pancreatic mass, deprived of the adrenals, maintained only with sodium chloride and not receiving adrenal hormones (8); some of these dogs were also deprived of the thyroid. All these experiments demonstrated that hypophyseal diabetes may be obtained without the presence or participation of the adrenals.
Fil: Houssay, Bernardo Alberto. Fundación de Instituto de Biología y Medicina Experimental; Argentina
Fil: Penhos, J. C.. Fundación de Instituto de Biología y Medicina Experimental; Argentina
fondo
Materia
HOUSSAY, BERNARDO A.
HOUSSAY EL INVESTIGADOR
PUBLICACIONES
PUBLICACIONES CIENTIFICAS
ENDOCRINOLOGY
PITUITARY
HIDROCORTISONE
DIABETOGENIC ACTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/163211

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oai_identifier_str oai:ri.conicet.gov.ar:11336/163211
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogsHoussay, Bernardo AlbertoPenhos, J. C.HOUSSAY, BERNARDO A.HOUSSAY EL INVESTIGADORPUBLICACIONESPUBLICACIONES CIENTIFICASENDOCRINOLOGYPITUITARYHIDROCORTISONEDIABETOGENIC ACTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3THE diabetogenic action of the anterior pituitary extracts was demonstrated in hypophysectomized-pancreatectomized toads by Houssay and Biasotti (1). This action was not obtained in pancreatectomized cats and rats in the absence of adrenals (2, 3). But the diabetogenic action of the anterior pituitary extract was obtained in other adrenalectomized animals : a) toads deprived of adrenals and pancreas (4); b) toads deprived of hypophysis, pancreas, kidney and adrenals (5): c) toads deprived of hypophysis, pancreas and adrenals (4, 6); in cases 6 and c, the diabetogenic action was diminished by the absence of the adrenals. The diabetogenic action of the pituitary was also observed in mammals deprived of the adrenals such as: d) dogs with reduction of the pancreatic mass, deprived of both adrenals and maintained with cortico-adrenal extract (7, 8) or with desoxycorticosterone (8); e) dogs with reduction of the pancreatic mass, deprived of the adrenals, maintained only with sodium chloride and not receiving adrenal hormones (8); some of these dogs were also deprived of the thyroid. All these experiments demonstrated that hypophyseal diabetes may be obtained without the presence or participation of the adrenals.Fil: Houssay, Bernardo Alberto. Fundación de Instituto de Biología y Medicina Experimental; ArgentinaFil: Penhos, J. C.. Fundación de Instituto de Biología y Medicina Experimental; ArgentinafondoEndocrine Society1956-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulotext/plainBlancoNegroSiapplication/octet-streamapplication/pdfhttp://hdl.handle.net/11336/163211Houssay, Bernardo Alberto; Penhos, J. C.; Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs; Endocrine Society; Endocrinology; 59; 6; 12-1956; 637-6410013-7227enginfo:eu-repo/semantics/altIdentifier/doi/10.1210/endo-59-6-637info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article-abstract/59/6/637/2736534?redirectedFrom=fulltext&login=falseCiudad de Buenos AiresFundación de Instituto de Biología y Medicina ExperimentalFundacion Williams.Consejo Nacional de Investigaciones Científicas y TécnicasProyecto Houssay y Leloirinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:15Zoai:ri.conicet.gov.ar:11336/163211instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:15.626CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs
title Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs
spellingShingle Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs
Houssay, Bernardo Alberto
HOUSSAY, BERNARDO A.
HOUSSAY EL INVESTIGADOR
PUBLICACIONES
PUBLICACIONES CIENTIFICAS
ENDOCRINOLOGY
PITUITARY
HIDROCORTISONE
DIABETOGENIC ACTION
title_short Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs
title_full Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs
title_fullStr Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs
title_full_unstemmed Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs
title_sort Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs
dc.creator.none.fl_str_mv Houssay, Bernardo Alberto
Penhos, J. C.
author Houssay, Bernardo Alberto
author_facet Houssay, Bernardo Alberto
Penhos, J. C.
author_role author
author2 Penhos, J. C.
author2_role author
dc.subject.none.fl_str_mv HOUSSAY, BERNARDO A.
HOUSSAY EL INVESTIGADOR
PUBLICACIONES
PUBLICACIONES CIENTIFICAS
ENDOCRINOLOGY
PITUITARY
HIDROCORTISONE
DIABETOGENIC ACTION
topic HOUSSAY, BERNARDO A.
HOUSSAY EL INVESTIGADOR
PUBLICACIONES
PUBLICACIONES CIENTIFICAS
ENDOCRINOLOGY
PITUITARY
HIDROCORTISONE
DIABETOGENIC ACTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv THE diabetogenic action of the anterior pituitary extracts was demonstrated in hypophysectomized-pancreatectomized toads by Houssay and Biasotti (1). This action was not obtained in pancreatectomized cats and rats in the absence of adrenals (2, 3). But the diabetogenic action of the anterior pituitary extract was obtained in other adrenalectomized animals : a) toads deprived of adrenals and pancreas (4); b) toads deprived of hypophysis, pancreas, kidney and adrenals (5): c) toads deprived of hypophysis, pancreas and adrenals (4, 6); in cases 6 and c, the diabetogenic action was diminished by the absence of the adrenals. The diabetogenic action of the pituitary was also observed in mammals deprived of the adrenals such as: d) dogs with reduction of the pancreatic mass, deprived of both adrenals and maintained with cortico-adrenal extract (7, 8) or with desoxycorticosterone (8); e) dogs with reduction of the pancreatic mass, deprived of the adrenals, maintained only with sodium chloride and not receiving adrenal hormones (8); some of these dogs were also deprived of the thyroid. All these experiments demonstrated that hypophyseal diabetes may be obtained without the presence or participation of the adrenals.
Fil: Houssay, Bernardo Alberto. Fundación de Instituto de Biología y Medicina Experimental; Argentina
Fil: Penhos, J. C.. Fundación de Instituto de Biología y Medicina Experimental; Argentina
fondo
description THE diabetogenic action of the anterior pituitary extracts was demonstrated in hypophysectomized-pancreatectomized toads by Houssay and Biasotti (1). This action was not obtained in pancreatectomized cats and rats in the absence of adrenals (2, 3). But the diabetogenic action of the anterior pituitary extract was obtained in other adrenalectomized animals : a) toads deprived of adrenals and pancreas (4); b) toads deprived of hypophysis, pancreas, kidney and adrenals (5): c) toads deprived of hypophysis, pancreas and adrenals (4, 6); in cases 6 and c, the diabetogenic action was diminished by the absence of the adrenals. The diabetogenic action of the pituitary was also observed in mammals deprived of the adrenals such as: d) dogs with reduction of the pancreatic mass, deprived of both adrenals and maintained with cortico-adrenal extract (7, 8) or with desoxycorticosterone (8); e) dogs with reduction of the pancreatic mass, deprived of the adrenals, maintained only with sodium chloride and not receiving adrenal hormones (8); some of these dogs were also deprived of the thyroid. All these experiments demonstrated that hypophyseal diabetes may be obtained without the presence or participation of the adrenals.
publishDate 1956
dc.date.none.fl_str_mv 1956-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163211
Houssay, Bernardo Alberto; Penhos, J. C.; Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs; Endocrine Society; Endocrinology; 59; 6; 12-1956; 637-641
0013-7227
url http://hdl.handle.net/11336/163211
identifier_str_mv Houssay, Bernardo Alberto; Penhos, J. C.; Diabetogenic action of pituitary hormones on adrenalectomized hypophysectomized dogs; Endocrine Society; Endocrinology; 59; 6; 12-1956; 637-641
0013-7227
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1210/endo-59-6-637
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article-abstract/59/6/637/2736534?redirectedFrom=fulltext&login=false
Ciudad de Buenos Aires
Fundación de Instituto de Biología y Medicina Experimental
Fundacion Williams.
Consejo Nacional de Investigaciones Científicas y Técnicas
Proyecto Houssay y Leloir
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv text/plain
BlancoNegro
Si
application/octet-stream
application/pdf
dc.publisher.none.fl_str_mv Endocrine Society
publisher.none.fl_str_mv Endocrine Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432