Diabetogenic action of purified anterior pituitary hormones

Autores
Houssay, Bernardo A.; Anderson, Evelyn
Año de publicación
1949
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This communication deals with the diabetogenic action of three of the anterior pituitary hormones, namely growth hormone, adrenocorticotrophic hormone (ACTH) and prolactin. Previous work has indicated that purified growth hormone is diabetogenic (Marx et al., 1943; Houssay, 1945). The growth hormone, which had been prepared by Armour and Co. (lots #8KR32 and #3PKR3) exhibited a purity, as judged by the electrophoretic diagram, of approximately 84 per cent of a single component which had a mobility comparable to that of purified growth hormone. Assay of the material in a 60–70 gram hypophysectomized rat showed that a 50 gamma dose per day caused a body increment of 1.0 gram per day. The ACTH, which was also supplied by the Armour Laboratories (lot #45-A-4), had been prepared by a modification of the Sayers method. Biological assay on hypophysectomized rats, making use of the ascorbic acid depletion method of Sayers et al. (1948), showed a potency of 96 per cent.
Fil: Houssay, Bernardo A.. Fundación de Instituto de Biología y Medicina Experimental; Argentina
Fil: Anderson, Evelyn. National Institutes of Health; Estados Unidos
papel
AR02675-AC3der-0335
Unidad documental simple
Materia
HOUSSAY, BERNARDO ALBERTO
EL INVESTIGADOR
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
ENDOCRINOLOGY
DIABETES
PITUITARY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/156697
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/156697
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diabetogenic action of purified anterior pituitary hormonesHoussay, Bernardo A.Anderson, EvelynHOUSSAY, BERNARDO ALBERTOEL INVESTIGADORHOUSSAY EL INVESTIGADORPUBLICACIONES CIENTIFICASPUBLICACIONESENDOCRINOLOGYDIABETESPITUITARYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This communication deals with the diabetogenic action of three of the anterior pituitary hormones, namely growth hormone, adrenocorticotrophic hormone (ACTH) and prolactin. Previous work has indicated that purified growth hormone is diabetogenic (Marx et al., 1943; Houssay, 1945). The growth hormone, which had been prepared by Armour and Co. (lots #8KR32 and #3PKR3) exhibited a purity, as judged by the electrophoretic diagram, of approximately 84 per cent of a single component which had a mobility comparable to that of purified growth hormone. Assay of the material in a 60–70 gram hypophysectomized rat showed that a 50 gamma dose per day caused a body increment of 1.0 gram per day. The ACTH, which was also supplied by the Armour Laboratories (lot #45-A-4), had been prepared by a modification of the Sayers method. Biological assay on hypophysectomized rats, making use of the ascorbic acid depletion method of Sayers et al. (1948), showed a potency of 96 per cent.Fil: Houssay, Bernardo A.. Fundación de Instituto de Biología y Medicina Experimental; ArgentinaFil: Anderson, Evelyn. National Institutes of Health; Estados UnidospapelAR02675-AC3der-0335Unidad documental simpleEndocrine Society1949-01-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulotext/plainBlancoNegroSiapplication/pdfhttp://hdl.handle.net/11336/156697Houssay, Bernardo A.; Anderson, Evelyn; Diabetogenic action of purified anterior pituitary hormones; Endocrine Society; Endocrinology; 45; 6; 12-1-1949; 627-6290013-7227enghttp://hdl.handle.net/11336/126924info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/45/6/627/2774616info:eu-repo/semantics/altIdentifier/doi/10.1210/endo-45-6-627Ciudad de Buenos AiresFundación de Instituto de Biología y Medicina ExperimentalFundacion Williams.Consejo Nacional de Investigaciones Científicas y TécnicasProyecto Houssay y LeloirIBYMEinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:46Zoai:ri.conicet.gov.ar:11336/156697instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:47.11CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diabetogenic action of purified anterior pituitary hormones
title Diabetogenic action of purified anterior pituitary hormones
spellingShingle Diabetogenic action of purified anterior pituitary hormones
Houssay, Bernardo A.
HOUSSAY, BERNARDO ALBERTO
EL INVESTIGADOR
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
ENDOCRINOLOGY
DIABETES
PITUITARY
title_short Diabetogenic action of purified anterior pituitary hormones
title_full Diabetogenic action of purified anterior pituitary hormones
title_fullStr Diabetogenic action of purified anterior pituitary hormones
title_full_unstemmed Diabetogenic action of purified anterior pituitary hormones
title_sort Diabetogenic action of purified anterior pituitary hormones
dc.creator.none.fl_str_mv Houssay, Bernardo A.
Anderson, Evelyn
author Houssay, Bernardo A.
author_facet Houssay, Bernardo A.
Anderson, Evelyn
author_role author
author2 Anderson, Evelyn
author2_role author
dc.subject.none.fl_str_mv HOUSSAY, BERNARDO ALBERTO
EL INVESTIGADOR
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
ENDOCRINOLOGY
DIABETES
PITUITARY
topic HOUSSAY, BERNARDO ALBERTO
EL INVESTIGADOR
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
ENDOCRINOLOGY
DIABETES
PITUITARY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This communication deals with the diabetogenic action of three of the anterior pituitary hormones, namely growth hormone, adrenocorticotrophic hormone (ACTH) and prolactin. Previous work has indicated that purified growth hormone is diabetogenic (Marx et al., 1943; Houssay, 1945). The growth hormone, which had been prepared by Armour and Co. (lots #8KR32 and #3PKR3) exhibited a purity, as judged by the electrophoretic diagram, of approximately 84 per cent of a single component which had a mobility comparable to that of purified growth hormone. Assay of the material in a 60–70 gram hypophysectomized rat showed that a 50 gamma dose per day caused a body increment of 1.0 gram per day. The ACTH, which was also supplied by the Armour Laboratories (lot #45-A-4), had been prepared by a modification of the Sayers method. Biological assay on hypophysectomized rats, making use of the ascorbic acid depletion method of Sayers et al. (1948), showed a potency of 96 per cent.
Fil: Houssay, Bernardo A.. Fundación de Instituto de Biología y Medicina Experimental; Argentina
Fil: Anderson, Evelyn. National Institutes of Health; Estados Unidos
papel
AR02675-AC3der-0335
Unidad documental simple
description This communication deals with the diabetogenic action of three of the anterior pituitary hormones, namely growth hormone, adrenocorticotrophic hormone (ACTH) and prolactin. Previous work has indicated that purified growth hormone is diabetogenic (Marx et al., 1943; Houssay, 1945). The growth hormone, which had been prepared by Armour and Co. (lots #8KR32 and #3PKR3) exhibited a purity, as judged by the electrophoretic diagram, of approximately 84 per cent of a single component which had a mobility comparable to that of purified growth hormone. Assay of the material in a 60–70 gram hypophysectomized rat showed that a 50 gamma dose per day caused a body increment of 1.0 gram per day. The ACTH, which was also supplied by the Armour Laboratories (lot #45-A-4), had been prepared by a modification of the Sayers method. Biological assay on hypophysectomized rats, making use of the ascorbic acid depletion method of Sayers et al. (1948), showed a potency of 96 per cent.
publishDate 1949
dc.date.none.fl_str_mv 1949-01-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/156697
Houssay, Bernardo A.; Anderson, Evelyn; Diabetogenic action of purified anterior pituitary hormones; Endocrine Society; Endocrinology; 45; 6; 12-1-1949; 627-629
0013-7227
url http://hdl.handle.net/11336/156697
identifier_str_mv Houssay, Bernardo A.; Anderson, Evelyn; Diabetogenic action of purified anterior pituitary hormones; Endocrine Society; Endocrinology; 45; 6; 12-1-1949; 627-629
0013-7227
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://hdl.handle.net/11336/126924
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/45/6/627/2774616
info:eu-repo/semantics/altIdentifier/doi/10.1210/endo-45-6-627
Ciudad de Buenos Aires
Fundación de Instituto de Biología y Medicina Experimental
Fundacion Williams.
Consejo Nacional de Investigaciones Científicas y Técnicas
Proyecto Houssay y Leloir
IBYME
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv text/plain
BlancoNegro
Si
application/pdf
dc.publisher.none.fl_str_mv Endocrine Society
publisher.none.fl_str_mv Endocrine Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269541145509888
score 13.13397

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