Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction

Autores
Kang Miller, Jae Eun; Granados Fuentes, Daniel; Wang, Thomas; Marpegan, Luciano; Holy, Timothy E.; Herzog, Erik D.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Accumulating evidence suggests that the olfactory bulbs (OBs) function as an independent circadian system regulating daily rhythms in olfactory performance. However, the cells and signals in the olfactory system that generate and coordinate these circadian rhythms are unknown. Using real-time imaging of gene expression, we found that the isolated olfactory epithelium and OB, but not the piriform cortex, express similar, sustained circadian rhythms in PERIOD2 (PER2). In vivo, PER2 expression in the OB of mice is circadian, approximately doubling with a peak around subjective dusk. Furthermore, mice exhibit circadian rhythms in odor detection performance with a peak at approximately subjective dusk. We also found that circadian rhythms in gene expression and odor detection performance require vasoactive intestinal polypeptide (VIP) or its receptor VPAC2R. VIP is expressed, in a circadian manner, in interneurons in the external plexiform and periglomerular layers, whereas VPAC2R is expressed in mitral and external tufted cells in the OB. Together, these results indicate that VIP signaling modulates the output from the OB to maintain circadian rhythms in the mammalian olfactory system.
Fil: Kang Miller, Jae Eun. Washington University in St. Louis; Estados Unidos
Fil: Granados Fuentes, Daniel. Washington University in St. Louis; Estados Unidos
Fil: Wang, Thomas. Washington University in St. Louis; Estados Unidos
Fil: Marpegan, Luciano. Washington University in St. Louis; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Holy, Timothy E.. Washington University in St. Louis; Estados Unidos
Fil: Herzog, Erik D.. Washington University in St. Louis; Estados Unidos
Materia
VIP
CIRCADIAN
CLOCK
OLFACTION
OLFACTORY DISCRIMINATION
RHYTHMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/33417
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/33417
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and OlfactionKang Miller, Jae EunGranados Fuentes, DanielWang, ThomasMarpegan, LucianoHoly, Timothy E.Herzog, Erik D.VIPCIRCADIANCLOCKOLFACTIONOLFACTORY DISCRIMINATIONRHYTHMShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Accumulating evidence suggests that the olfactory bulbs (OBs) function as an independent circadian system regulating daily rhythms in olfactory performance. However, the cells and signals in the olfactory system that generate and coordinate these circadian rhythms are unknown. Using real-time imaging of gene expression, we found that the isolated olfactory epithelium and OB, but not the piriform cortex, express similar, sustained circadian rhythms in PERIOD2 (PER2). In vivo, PER2 expression in the OB of mice is circadian, approximately doubling with a peak around subjective dusk. Furthermore, mice exhibit circadian rhythms in odor detection performance with a peak at approximately subjective dusk. We also found that circadian rhythms in gene expression and odor detection performance require vasoactive intestinal polypeptide (VIP) or its receptor VPAC2R. VIP is expressed, in a circadian manner, in interneurons in the external plexiform and periglomerular layers, whereas VPAC2R is expressed in mitral and external tufted cells in the OB. Together, these results indicate that VIP signaling modulates the output from the OB to maintain circadian rhythms in the mammalian olfactory system.Fil: Kang Miller, Jae Eun. Washington University in St. Louis; Estados UnidosFil: Granados Fuentes, Daniel. Washington University in St. Louis; Estados UnidosFil: Wang, Thomas. Washington University in St. Louis; Estados UnidosFil: Marpegan, Luciano. Washington University in St. Louis; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Holy, Timothy E.. Washington University in St. Louis; Estados UnidosFil: Herzog, Erik D.. Washington University in St. Louis; Estados UnidosSociety for Neuroscience2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33417Herzog, Erik D.; Kang Miller, Jae Eun; Holy, Timothy E.; Wang, Thomas; Granados Fuentes, Daniel; Marpegan, Luciano; et al.; Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction; Society for Neuroscience; Journal of Neuroscience; 34; 17; 4-2014; 6040-60460270-6474CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996221/info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.4713-13.2014info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/34/17/6040.longinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:40Zoai:ri.conicet.gov.ar:11336/33417instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:40.843CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction
title Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction
spellingShingle Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction
Kang Miller, Jae Eun
VIP
CIRCADIAN
CLOCK
OLFACTION
OLFACTORY DISCRIMINATION
RHYTHMS
title_short Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction
title_full Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction
title_fullStr Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction
title_full_unstemmed Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction
title_sort Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction
dc.creator.none.fl_str_mv Kang Miller, Jae Eun
Granados Fuentes, Daniel
Wang, Thomas
Marpegan, Luciano
Holy, Timothy E.
Herzog, Erik D.
author Kang Miller, Jae Eun
author_facet Kang Miller, Jae Eun
Granados Fuentes, Daniel
Wang, Thomas
Marpegan, Luciano
Holy, Timothy E.
Herzog, Erik D.
author_role author
author2 Granados Fuentes, Daniel
Wang, Thomas
Marpegan, Luciano
Holy, Timothy E.
Herzog, Erik D.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv VIP
CIRCADIAN
CLOCK
OLFACTION
OLFACTORY DISCRIMINATION
RHYTHMS
topic VIP
CIRCADIAN
CLOCK
OLFACTION
OLFACTORY DISCRIMINATION
RHYTHMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Accumulating evidence suggests that the olfactory bulbs (OBs) function as an independent circadian system regulating daily rhythms in olfactory performance. However, the cells and signals in the olfactory system that generate and coordinate these circadian rhythms are unknown. Using real-time imaging of gene expression, we found that the isolated olfactory epithelium and OB, but not the piriform cortex, express similar, sustained circadian rhythms in PERIOD2 (PER2). In vivo, PER2 expression in the OB of mice is circadian, approximately doubling with a peak around subjective dusk. Furthermore, mice exhibit circadian rhythms in odor detection performance with a peak at approximately subjective dusk. We also found that circadian rhythms in gene expression and odor detection performance require vasoactive intestinal polypeptide (VIP) or its receptor VPAC2R. VIP is expressed, in a circadian manner, in interneurons in the external plexiform and periglomerular layers, whereas VPAC2R is expressed in mitral and external tufted cells in the OB. Together, these results indicate that VIP signaling modulates the output from the OB to maintain circadian rhythms in the mammalian olfactory system.
Fil: Kang Miller, Jae Eun. Washington University in St. Louis; Estados Unidos
Fil: Granados Fuentes, Daniel. Washington University in St. Louis; Estados Unidos
Fil: Wang, Thomas. Washington University in St. Louis; Estados Unidos
Fil: Marpegan, Luciano. Washington University in St. Louis; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Holy, Timothy E.. Washington University in St. Louis; Estados Unidos
Fil: Herzog, Erik D.. Washington University in St. Louis; Estados Unidos
description Accumulating evidence suggests that the olfactory bulbs (OBs) function as an independent circadian system regulating daily rhythms in olfactory performance. However, the cells and signals in the olfactory system that generate and coordinate these circadian rhythms are unknown. Using real-time imaging of gene expression, we found that the isolated olfactory epithelium and OB, but not the piriform cortex, express similar, sustained circadian rhythms in PERIOD2 (PER2). In vivo, PER2 expression in the OB of mice is circadian, approximately doubling with a peak around subjective dusk. Furthermore, mice exhibit circadian rhythms in odor detection performance with a peak at approximately subjective dusk. We also found that circadian rhythms in gene expression and odor detection performance require vasoactive intestinal polypeptide (VIP) or its receptor VPAC2R. VIP is expressed, in a circadian manner, in interneurons in the external plexiform and periglomerular layers, whereas VPAC2R is expressed in mitral and external tufted cells in the OB. Together, these results indicate that VIP signaling modulates the output from the OB to maintain circadian rhythms in the mammalian olfactory system.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33417
Herzog, Erik D.; Kang Miller, Jae Eun; Holy, Timothy E.; Wang, Thomas; Granados Fuentes, Daniel; Marpegan, Luciano; et al.; Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction; Society for Neuroscience; Journal of Neuroscience; 34; 17; 4-2014; 6040-6046
0270-6474
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33417
identifier_str_mv Herzog, Erik D.; Kang Miller, Jae Eun; Holy, Timothy E.; Wang, Thomas; Granados Fuentes, Daniel; Marpegan, Luciano; et al.; Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction; Society for Neuroscience; Journal of Neuroscience; 34; 17; 4-2014; 6040-6046
0270-6474
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996221/
info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.4713-13.2014
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/34/17/6040.long
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269534872928256
score 13.13397

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