Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites

Autores
Travlou, Nikolina A.; Algarra, Manuel; Alcoholado, Cristina; Cifuentes Rueda, Manuel; Labella, Alejandro M.; Lazaro Martinez, Juan Manuel; Rodríguez Castellón, Enrique; Bandosz, Teresa J.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nanocomposites and hybrid materials of Ag-1,3,5- benzenetricarboxylic acid metal-organic frameworks (MOFs) with Sand N-carbon quantum dots (CQDs) were synthesized and evaluated for their antibacterial activity against representative Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacterial strains using the qualitative disk-diffusion approach and the quantitative minimum inhibitory concentration test. The composites and hybrids were found to be nontoxic to living cells. The composite formation fostered a synergistic effect that enhanced their antibacterial activity compared with those of their pristine components. Charge transfer from AgMOF to CQDs facilitated the electrostatic interactions of the composites and hybrids with the bacterial cell membranes. Enhanced bactericidal activity was linked to morphological features (a nanorod-like morphology) and specific surface chemistry. The latter affected the release of silver. Silver on the surface of the MOFs rather than silver in the bulk was found to be important. The destruction of the MOF component in the extracellular environment led to the release of silver ions, which have a high affinity to S compounds of the cell physiology. The formation of metallic silver (Ago) and silver sulfides (Ag2S) was suggested as essential for the ability of the composites and hybrids to inhibit bacterial growth. To the best of our knowledge, this is the first study that introduces the bactericidal effect of AgMOF-CQDs composites and hybrids.
Fil: Travlou, Nikolina A.. City University of New York; Estados Unidos
Fil: Algarra, Manuel. Universidad de Málaga; España
Fil: Alcoholado, Cristina. Universidad de Málaga; España. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; España
Fil: Cifuentes Rueda, Manuel. Universidad de Málaga; España. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; España
Fil: Labella, Alejandro M.. Universidad de Málaga; España
Fil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Rodríguez Castellón, Enrique. Universidad de Málaga; España
Fil: Bandosz, Teresa J.. City University of New York; Estados Unidos
Materia
ANTIBACTERIAL ACTIVITY
CARBON QUANTUM DOTS
COMPOSITES
METAL-ORGANIC FRAMEWORK
SILVER
SYNERGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87020
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/87020
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework compositesTravlou, Nikolina A.Algarra, ManuelAlcoholado, CristinaCifuentes Rueda, ManuelLabella, Alejandro M.Lazaro Martinez, Juan ManuelRodríguez Castellón, EnriqueBandosz, Teresa J.ANTIBACTERIAL ACTIVITYCARBON QUANTUM DOTSCOMPOSITESMETAL-ORGANIC FRAMEWORKSILVERSYNERGYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Nanocomposites and hybrid materials of Ag-1,3,5- benzenetricarboxylic acid metal-organic frameworks (MOFs) with Sand N-carbon quantum dots (CQDs) were synthesized and evaluated for their antibacterial activity against representative Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacterial strains using the qualitative disk-diffusion approach and the quantitative minimum inhibitory concentration test. The composites and hybrids were found to be nontoxic to living cells. The composite formation fostered a synergistic effect that enhanced their antibacterial activity compared with those of their pristine components. Charge transfer from AgMOF to CQDs facilitated the electrostatic interactions of the composites and hybrids with the bacterial cell membranes. Enhanced bactericidal activity was linked to morphological features (a nanorod-like morphology) and specific surface chemistry. The latter affected the release of silver. Silver on the surface of the MOFs rather than silver in the bulk was found to be important. The destruction of the MOF component in the extracellular environment led to the release of silver ions, which have a high affinity to S compounds of the cell physiology. The formation of metallic silver (Ago) and silver sulfides (Ag2S) was suggested as essential for the ability of the composites and hybrids to inhibit bacterial growth. To the best of our knowledge, this is the first study that introduces the bactericidal effect of AgMOF-CQDs composites and hybrids.Fil: Travlou, Nikolina A.. City University of New York; Estados UnidosFil: Algarra, Manuel. Universidad de Málaga; EspañaFil: Alcoholado, Cristina. Universidad de Málaga; España. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Cifuentes Rueda, Manuel. Universidad de Málaga; España. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Labella, Alejandro M.. Universidad de Málaga; EspañaFil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Rodríguez Castellón, Enrique. Universidad de Málaga; EspañaFil: Bandosz, Teresa J.. City University of New York; Estados UnidosAmerican Chemical Society2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87020Travlou, Nikolina A.; Algarra, Manuel; Alcoholado, Cristina; Cifuentes Rueda, Manuel; Labella, Alejandro M.; et al.; Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites; American Chemical Society; ACS Applied Bio Materials; 1; 3; 8-2018; 693-7072576-6422CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsabm.8b00166info:eu-repo/semantics/altIdentifier/doi/10.1021/acsabm.8b00166info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:37:58Zoai:ri.conicet.gov.ar:11336/87020instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:37:59.101CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites
title Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites
spellingShingle Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites
Travlou, Nikolina A.
ANTIBACTERIAL ACTIVITY
CARBON QUANTUM DOTS
COMPOSITES
METAL-ORGANIC FRAMEWORK
SILVER
SYNERGY
title_short Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites
title_full Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites
title_fullStr Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites
title_full_unstemmed Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites
title_sort Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites
dc.creator.none.fl_str_mv Travlou, Nikolina A.
Algarra, Manuel
Alcoholado, Cristina
Cifuentes Rueda, Manuel
Labella, Alejandro M.
Lazaro Martinez, Juan Manuel
Rodríguez Castellón, Enrique
Bandosz, Teresa J.
author Travlou, Nikolina A.
author_facet Travlou, Nikolina A.
Algarra, Manuel
Alcoholado, Cristina
Cifuentes Rueda, Manuel
Labella, Alejandro M.
Lazaro Martinez, Juan Manuel
Rodríguez Castellón, Enrique
Bandosz, Teresa J.
author_role author
author2 Algarra, Manuel
Alcoholado, Cristina
Cifuentes Rueda, Manuel
Labella, Alejandro M.
Lazaro Martinez, Juan Manuel
Rodríguez Castellón, Enrique
Bandosz, Teresa J.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIBACTERIAL ACTIVITY
CARBON QUANTUM DOTS
COMPOSITES
METAL-ORGANIC FRAMEWORK
SILVER
SYNERGY
topic ANTIBACTERIAL ACTIVITY
CARBON QUANTUM DOTS
COMPOSITES
METAL-ORGANIC FRAMEWORK
SILVER
SYNERGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Nanocomposites and hybrid materials of Ag-1,3,5- benzenetricarboxylic acid metal-organic frameworks (MOFs) with Sand N-carbon quantum dots (CQDs) were synthesized and evaluated for their antibacterial activity against representative Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacterial strains using the qualitative disk-diffusion approach and the quantitative minimum inhibitory concentration test. The composites and hybrids were found to be nontoxic to living cells. The composite formation fostered a synergistic effect that enhanced their antibacterial activity compared with those of their pristine components. Charge transfer from AgMOF to CQDs facilitated the electrostatic interactions of the composites and hybrids with the bacterial cell membranes. Enhanced bactericidal activity was linked to morphological features (a nanorod-like morphology) and specific surface chemistry. The latter affected the release of silver. Silver on the surface of the MOFs rather than silver in the bulk was found to be important. The destruction of the MOF component in the extracellular environment led to the release of silver ions, which have a high affinity to S compounds of the cell physiology. The formation of metallic silver (Ago) and silver sulfides (Ag2S) was suggested as essential for the ability of the composites and hybrids to inhibit bacterial growth. To the best of our knowledge, this is the first study that introduces the bactericidal effect of AgMOF-CQDs composites and hybrids.
Fil: Travlou, Nikolina A.. City University of New York; Estados Unidos
Fil: Algarra, Manuel. Universidad de Málaga; España
Fil: Alcoholado, Cristina. Universidad de Málaga; España. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; España
Fil: Cifuentes Rueda, Manuel. Universidad de Málaga; España. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; España
Fil: Labella, Alejandro M.. Universidad de Málaga; España
Fil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Rodríguez Castellón, Enrique. Universidad de Málaga; España
Fil: Bandosz, Teresa J.. City University of New York; Estados Unidos
description Nanocomposites and hybrid materials of Ag-1,3,5- benzenetricarboxylic acid metal-organic frameworks (MOFs) with Sand N-carbon quantum dots (CQDs) were synthesized and evaluated for their antibacterial activity against representative Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacterial strains using the qualitative disk-diffusion approach and the quantitative minimum inhibitory concentration test. The composites and hybrids were found to be nontoxic to living cells. The composite formation fostered a synergistic effect that enhanced their antibacterial activity compared with those of their pristine components. Charge transfer from AgMOF to CQDs facilitated the electrostatic interactions of the composites and hybrids with the bacterial cell membranes. Enhanced bactericidal activity was linked to morphological features (a nanorod-like morphology) and specific surface chemistry. The latter affected the release of silver. Silver on the surface of the MOFs rather than silver in the bulk was found to be important. The destruction of the MOF component in the extracellular environment led to the release of silver ions, which have a high affinity to S compounds of the cell physiology. The formation of metallic silver (Ago) and silver sulfides (Ag2S) was suggested as essential for the ability of the composites and hybrids to inhibit bacterial growth. To the best of our knowledge, this is the first study that introduces the bactericidal effect of AgMOF-CQDs composites and hybrids.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87020
Travlou, Nikolina A.; Algarra, Manuel; Alcoholado, Cristina; Cifuentes Rueda, Manuel; Labella, Alejandro M.; et al.; Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites; American Chemical Society; ACS Applied Bio Materials; 1; 3; 8-2018; 693-707
2576-6422
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87020
identifier_str_mv Travlou, Nikolina A.; Algarra, Manuel; Alcoholado, Cristina; Cifuentes Rueda, Manuel; Labella, Alejandro M.; et al.; Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites; American Chemical Society; ACS Applied Bio Materials; 1; 3; 8-2018; 693-707
2576-6422
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsabm.8b00166
info:eu-repo/semantics/altIdentifier/doi/10.1021/acsabm.8b00166
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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