Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n

Autores
Mosconi, Natalia Ester; Giulidori, Cecilia María del Luján; Velluti, Francesca; Hure, Estela María; Postigo, Agustina; Borthagaray, Graciela; Back, Davi Fernando; Torre, María H.; Rizzotto, Marcela Adriana
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We report the synthesis, characterization, antibacterial and antifungal activities, phytotoxicity, and genotoxicity of two new complexes of silver(I) with sulfachloropyridazine (SCP), one of which is heteroleptic with SCP and SCN- ligands (Ag-SCP-SCN), the other of which is homoleptic (Ag-SCP); furthermore, the crystal structure of the homoleptic complex is disclosed. The heterocyclic N atom nearest to the Cl atom and the Nsulfonamide atom could be coordination sites for the silver ion in the Ag-SCP-SCN complex. The Ag-SCP complex is a polymeric compound with metal-metal bonds, and the heterocyclic and sulfonamide N atoms are points of coordination for Ag I. Both complexes showed activity against all the tested bacteria, and in the cases of Escherichia coli and Pseudomonas aeruginosa, the action was better than that of SCP. In all cases, both silver-SCP complexes showed better antifungal activity than SCP, which was inactive against the tested fungi. Notably, the activity against P. aeruginosa, a nosocomial multidrug-resistant pathogen, was better than that of the reference antibiotic cefotaxim. Both silver-sulfa complexes displayed moderate activity against the tested yeast, especially for C. neoformans, which is an important fact considering the incidence of cryptococcosis, mainly in immune-deficient patients. No chromosomal aberrations were observed with the Allium cepa test, which is auspicious for further study of these complexes as potential drugs. Silver surfers: Two complexes of AgI with sulfachloropyridazine (SCP) were synthesized and characterized, and their antibacterial and antifungal activities, phytotoxicity, and genotoxicity were evaluated. Both complexes are more active than free SCP against bacteria and fungi. Neither complex shows cytotoxic effects or produces chromosome aberrations in the Allium cepa test.
Fil: Mosconi, Natalia Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Giulidori, Cecilia María del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Velluti, Francesca. Universidad de la República Facultad de Química; Uruguay
Fil: Hure, Estela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Postigo, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Borthagaray, Graciela. Universidad de la República Facultad de Química; Uruguay
Fil: Back, Davi Fernando. Universidade Federal de Santa Maria; Brasil
Fil: Torre, María H.. Universidad de la República Facultad de Química; Uruguay
Fil: Rizzotto, Marcela Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Materia
ALLIUM TEST
ANTIBACTERIAL AGENTS
ANTIFUNGAL AGENTS
SILVER
SULFONAMIDES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95110
Acceder
id CONICETDig_07536160ac23577ca88dab5f227cc8d6
oai_identifier_str oai:ri.conicet.gov.ar:11336/95110
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]nMosconi, Natalia EsterGiulidori, Cecilia María del LujánVelluti, FrancescaHure, Estela MaríaPostigo, AgustinaBorthagaray, GracielaBack, Davi FernandoTorre, María H.Rizzotto, Marcela AdrianaALLIUM TESTANTIBACTERIAL AGENTSANTIFUNGAL AGENTSSILVERSULFONAMIDEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1We report the synthesis, characterization, antibacterial and antifungal activities, phytotoxicity, and genotoxicity of two new complexes of silver(I) with sulfachloropyridazine (SCP), one of which is heteroleptic with SCP and SCN- ligands (Ag-SCP-SCN), the other of which is homoleptic (Ag-SCP); furthermore, the crystal structure of the homoleptic complex is disclosed. The heterocyclic N atom nearest to the Cl atom and the Nsulfonamide atom could be coordination sites for the silver ion in the Ag-SCP-SCN complex. The Ag-SCP complex is a polymeric compound with metal-metal bonds, and the heterocyclic and sulfonamide N atoms are points of coordination for Ag I. Both complexes showed activity against all the tested bacteria, and in the cases of Escherichia coli and Pseudomonas aeruginosa, the action was better than that of SCP. In all cases, both silver-SCP complexes showed better antifungal activity than SCP, which was inactive against the tested fungi. Notably, the activity against P. aeruginosa, a nosocomial multidrug-resistant pathogen, was better than that of the reference antibiotic cefotaxim. Both silver-sulfa complexes displayed moderate activity against the tested yeast, especially for C. neoformans, which is an important fact considering the incidence of cryptococcosis, mainly in immune-deficient patients. No chromosomal aberrations were observed with the Allium cepa test, which is auspicious for further study of these complexes as potential drugs. Silver surfers: Two complexes of AgI with sulfachloropyridazine (SCP) were synthesized and characterized, and their antibacterial and antifungal activities, phytotoxicity, and genotoxicity were evaluated. Both complexes are more active than free SCP against bacteria and fungi. Neither complex shows cytotoxic effects or produces chromosome aberrations in the Allium cepa test.Fil: Mosconi, Natalia Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Giulidori, Cecilia María del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Velluti, Francesca. Universidad de la República Facultad de Química; UruguayFil: Hure, Estela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Postigo, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Borthagaray, Graciela. Universidad de la República Facultad de Química; UruguayFil: Back, Davi Fernando. Universidade Federal de Santa Maria; BrasilFil: Torre, María H.. Universidad de la República Facultad de Química; UruguayFil: Rizzotto, Marcela Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaWiley VCH Verlag2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95110Mosconi, Natalia Ester; Giulidori, Cecilia María del Luján; Velluti, Francesca; Hure, Estela María; Postigo, Agustina; et al.; Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n; Wiley VCH Verlag; Chemmedchem; 9; 6; 6-2014; 1211-12201860-7179CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201400071info:eu-repo/semantics/altIdentifier/doi/10.1002/cmdc.201400071info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:03:13Zoai:ri.conicet.gov.ar:11336/95110instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:03:13.288CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n
title Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n
spellingShingle Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n
Mosconi, Natalia Ester
ALLIUM TEST
ANTIBACTERIAL AGENTS
ANTIFUNGAL AGENTS
SILVER
SULFONAMIDES
title_short Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n
title_full Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n
title_fullStr Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n
title_full_unstemmed Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n
title_sort Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n
dc.creator.none.fl_str_mv Mosconi, Natalia Ester
Giulidori, Cecilia María del Luján
Velluti, Francesca
Hure, Estela María
Postigo, Agustina
Borthagaray, Graciela
Back, Davi Fernando
Torre, María H.
Rizzotto, Marcela Adriana
author Mosconi, Natalia Ester
author_facet Mosconi, Natalia Ester
Giulidori, Cecilia María del Luján
Velluti, Francesca
Hure, Estela María
Postigo, Agustina
Borthagaray, Graciela
Back, Davi Fernando
Torre, María H.
Rizzotto, Marcela Adriana
author_role author
author2 Giulidori, Cecilia María del Luján
Velluti, Francesca
Hure, Estela María
Postigo, Agustina
Borthagaray, Graciela
Back, Davi Fernando
Torre, María H.
Rizzotto, Marcela Adriana
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALLIUM TEST
ANTIBACTERIAL AGENTS
ANTIFUNGAL AGENTS
SILVER
SULFONAMIDES
topic ALLIUM TEST
ANTIBACTERIAL AGENTS
ANTIFUNGAL AGENTS
SILVER
SULFONAMIDES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We report the synthesis, characterization, antibacterial and antifungal activities, phytotoxicity, and genotoxicity of two new complexes of silver(I) with sulfachloropyridazine (SCP), one of which is heteroleptic with SCP and SCN- ligands (Ag-SCP-SCN), the other of which is homoleptic (Ag-SCP); furthermore, the crystal structure of the homoleptic complex is disclosed. The heterocyclic N atom nearest to the Cl atom and the Nsulfonamide atom could be coordination sites for the silver ion in the Ag-SCP-SCN complex. The Ag-SCP complex is a polymeric compound with metal-metal bonds, and the heterocyclic and sulfonamide N atoms are points of coordination for Ag I. Both complexes showed activity against all the tested bacteria, and in the cases of Escherichia coli and Pseudomonas aeruginosa, the action was better than that of SCP. In all cases, both silver-SCP complexes showed better antifungal activity than SCP, which was inactive against the tested fungi. Notably, the activity against P. aeruginosa, a nosocomial multidrug-resistant pathogen, was better than that of the reference antibiotic cefotaxim. Both silver-sulfa complexes displayed moderate activity against the tested yeast, especially for C. neoformans, which is an important fact considering the incidence of cryptococcosis, mainly in immune-deficient patients. No chromosomal aberrations were observed with the Allium cepa test, which is auspicious for further study of these complexes as potential drugs. Silver surfers: Two complexes of AgI with sulfachloropyridazine (SCP) were synthesized and characterized, and their antibacterial and antifungal activities, phytotoxicity, and genotoxicity were evaluated. Both complexes are more active than free SCP against bacteria and fungi. Neither complex shows cytotoxic effects or produces chromosome aberrations in the Allium cepa test.
Fil: Mosconi, Natalia Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Giulidori, Cecilia María del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Velluti, Francesca. Universidad de la República Facultad de Química; Uruguay
Fil: Hure, Estela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Postigo, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Borthagaray, Graciela. Universidad de la República Facultad de Química; Uruguay
Fil: Back, Davi Fernando. Universidade Federal de Santa Maria; Brasil
Fil: Torre, María H.. Universidad de la República Facultad de Química; Uruguay
Fil: Rizzotto, Marcela Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
description We report the synthesis, characterization, antibacterial and antifungal activities, phytotoxicity, and genotoxicity of two new complexes of silver(I) with sulfachloropyridazine (SCP), one of which is heteroleptic with SCP and SCN- ligands (Ag-SCP-SCN), the other of which is homoleptic (Ag-SCP); furthermore, the crystal structure of the homoleptic complex is disclosed. The heterocyclic N atom nearest to the Cl atom and the Nsulfonamide atom could be coordination sites for the silver ion in the Ag-SCP-SCN complex. The Ag-SCP complex is a polymeric compound with metal-metal bonds, and the heterocyclic and sulfonamide N atoms are points of coordination for Ag I. Both complexes showed activity against all the tested bacteria, and in the cases of Escherichia coli and Pseudomonas aeruginosa, the action was better than that of SCP. In all cases, both silver-SCP complexes showed better antifungal activity than SCP, which was inactive against the tested fungi. Notably, the activity against P. aeruginosa, a nosocomial multidrug-resistant pathogen, was better than that of the reference antibiotic cefotaxim. Both silver-sulfa complexes displayed moderate activity against the tested yeast, especially for C. neoformans, which is an important fact considering the incidence of cryptococcosis, mainly in immune-deficient patients. No chromosomal aberrations were observed with the Allium cepa test, which is auspicious for further study of these complexes as potential drugs. Silver surfers: Two complexes of AgI with sulfachloropyridazine (SCP) were synthesized and characterized, and their antibacterial and antifungal activities, phytotoxicity, and genotoxicity were evaluated. Both complexes are more active than free SCP against bacteria and fungi. Neither complex shows cytotoxic effects or produces chromosome aberrations in the Allium cepa test.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95110
Mosconi, Natalia Ester; Giulidori, Cecilia María del Luján; Velluti, Francesca; Hure, Estela María; Postigo, Agustina; et al.; Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n; Wiley VCH Verlag; Chemmedchem; 9; 6; 6-2014; 1211-1220
1860-7179
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95110
identifier_str_mv Mosconi, Natalia Ester; Giulidori, Cecilia María del Luján; Velluti, Francesca; Hure, Estela María; Postigo, Agustina; et al.; Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of AgI with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n; Wiley VCH Verlag; Chemmedchem; 9; 6; 6-2014; 1211-1220
1860-7179
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201400071
info:eu-repo/semantics/altIdentifier/doi/10.1002/cmdc.201400071
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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