Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis

Autores
Moreno, María Alejandra; Córdoba, Susana Beatríz; Zampini, Iris Catiana; Mercado, Maria Ines; Ponessa, Graciela Ines; Sayago, Jorge Esteban; Pino Ramos, Liudis Leydi; Schmeda Hirschmann, Guillermo; Isla, Maria Ines
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Larrea divaricata (Ld), Larrea cuneifolia (Lc) and Larrea nitida (Ln) are shrubs occurring in Northwestern Argentina used in traditional medicine to treatfungal and bacterial infections and as anti-inflammatory. Antibacterial and antifungal activity of several Larrea species has been reported. However, theirpotential use in vaginal infections has been so far not assessed. The aim of this work was to determine the botanical difference between Larrea species, thechemical composition and the activity of Larrea dry extracts (DE) on Candida species isolated from vaginal infections and to assess their potential asantioxidant agents because infections are usually associated with oxidative processes. The main botanical difference between Larrea species resides in themorphology and shape of leaf, leaflets and stipules, presence or absence of mucron and rachis, percentage of coalescence of the leaflets. The position andabundance of the sclerenchymatic tissue at the mind vein and petiole transection allows the differentiation of the three species. The profile of phenoliccompounds in the Larrea DE was determined. HPLC-ESI-MS/MS analysis of DE allowed the identification of 2 flavonoids and 10 lignans. Trihydroxy-6,7´cyclolignan was found only in L. divaricata and dihydroxy-methoxy-epoxylignan in L. cuneifolia and L. nitida, nordihydroguaiaretic acid (NDGA) wasfound in the three species. All extracts showed antioxidant capacity. The DE showed to be effective against Candida albicans and non-albicans strains.According to our results, the local vaginal use of Larrea DE in the concentration range of MIC values for Candida species does not affect the Lactobacillusnormal vaginal microbiota. This work adds evidence to the potential use of Larrea DE as phytomedicine in vulvovaginal candidiasis with multiple effects,including antifungal and antioxidant activity.
Fil: Moreno, María Alejandra. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Córdoba, Susana Beatríz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Mercado, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; Argentina
Fil: Ponessa, Graciela Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; Argentina
Fil: Sayago, Jorge Esteban. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Pino Ramos, Liudis Leydi. Universidad de Talca; Chile
Fil: Schmeda Hirschmann, Guillermo. Universidad de Talca; Chile
Fil: Isla, Maria Ines. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Materia
Larrea species
Dry extracts
Antioxidant
Anti-Candida
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/102098
Acceder
id CONICETDig_77263c71e0aeca6ca07f4c10babbe9c5
oai_identifier_str oai:ri.conicet.gov.ar:11336/102098
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Argentinean Larrea Dry Extracts with Potential Use in Vaginal CandidiasisMoreno, María AlejandraCórdoba, Susana BeatrízZampini, Iris CatianaMercado, Maria InesPonessa, Graciela InesSayago, Jorge EstebanPino Ramos, Liudis LeydiSchmeda Hirschmann, GuillermoIsla, Maria InesLarrea speciesDry extractsAntioxidantAnti-Candidahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Larrea divaricata (Ld), Larrea cuneifolia (Lc) and Larrea nitida (Ln) are shrubs occurring in Northwestern Argentina used in traditional medicine to treatfungal and bacterial infections and as anti-inflammatory. Antibacterial and antifungal activity of several Larrea species has been reported. However, theirpotential use in vaginal infections has been so far not assessed. The aim of this work was to determine the botanical difference between Larrea species, thechemical composition and the activity of Larrea dry extracts (DE) on Candida species isolated from vaginal infections and to assess their potential asantioxidant agents because infections are usually associated with oxidative processes. The main botanical difference between Larrea species resides in themorphology and shape of leaf, leaflets and stipules, presence or absence of mucron and rachis, percentage of coalescence of the leaflets. The position andabundance of the sclerenchymatic tissue at the mind vein and petiole transection allows the differentiation of the three species. The profile of phenoliccompounds in the Larrea DE was determined. HPLC-ESI-MS/MS analysis of DE allowed the identification of 2 flavonoids and 10 lignans. Trihydroxy-6,7´cyclolignan was found only in L. divaricata and dihydroxy-methoxy-epoxylignan in L. cuneifolia and L. nitida, nordihydroguaiaretic acid (NDGA) wasfound in the three species. All extracts showed antioxidant capacity. The DE showed to be effective against Candida albicans and non-albicans strains.According to our results, the local vaginal use of Larrea DE in the concentration range of MIC values for Candida species does not affect the Lactobacillusnormal vaginal microbiota. This work adds evidence to the potential use of Larrea DE as phytomedicine in vulvovaginal candidiasis with multiple effects,including antifungal and antioxidant activity.Fil: Moreno, María Alejandra. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Córdoba, Susana Beatríz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Mercado, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; ArgentinaFil: Ponessa, Graciela Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; ArgentinaFil: Sayago, Jorge Esteban. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Pino Ramos, Liudis Leydi. Universidad de Talca; ChileFil: Schmeda Hirschmann, Guillermo. Universidad de Talca; ChileFil: Isla, Maria Ines. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaNatural Products2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/102098Moreno, María Alejandra; Córdoba, Susana Beatríz; Zampini, Iris Catiana; Mercado, Maria Ines; Ponessa, Graciela Ines; et al.; Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis; Natural Products; Natural Product Communications; 13; 2; 2-2018; 171-1741934-578X1555-9475CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1801300215info:eu-repo/semantics/altIdentifier/doi/10.1177%2F1934578X1801300215info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:31Zoai:ri.conicet.gov.ar:11336/102098instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:31.819CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis
title Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis
spellingShingle Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis
Moreno, María Alejandra
Larrea species
Dry extracts
Antioxidant
Anti-Candida
title_short Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis
title_full Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis
title_fullStr Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis
title_full_unstemmed Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis
title_sort Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis
dc.creator.none.fl_str_mv Moreno, María Alejandra
Córdoba, Susana Beatríz
Zampini, Iris Catiana
Mercado, Maria Ines
Ponessa, Graciela Ines
Sayago, Jorge Esteban
Pino Ramos, Liudis Leydi
Schmeda Hirschmann, Guillermo
Isla, Maria Ines
author Moreno, María Alejandra
author_facet Moreno, María Alejandra
Córdoba, Susana Beatríz
Zampini, Iris Catiana
Mercado, Maria Ines
Ponessa, Graciela Ines
Sayago, Jorge Esteban
Pino Ramos, Liudis Leydi
Schmeda Hirschmann, Guillermo
Isla, Maria Ines
author_role author
author2 Córdoba, Susana Beatríz
Zampini, Iris Catiana
Mercado, Maria Ines
Ponessa, Graciela Ines
Sayago, Jorge Esteban
Pino Ramos, Liudis Leydi
Schmeda Hirschmann, Guillermo
Isla, Maria Ines
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Larrea species
Dry extracts
Antioxidant
Anti-Candida
topic Larrea species
Dry extracts
Antioxidant
Anti-Candida
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Larrea divaricata (Ld), Larrea cuneifolia (Lc) and Larrea nitida (Ln) are shrubs occurring in Northwestern Argentina used in traditional medicine to treatfungal and bacterial infections and as anti-inflammatory. Antibacterial and antifungal activity of several Larrea species has been reported. However, theirpotential use in vaginal infections has been so far not assessed. The aim of this work was to determine the botanical difference between Larrea species, thechemical composition and the activity of Larrea dry extracts (DE) on Candida species isolated from vaginal infections and to assess their potential asantioxidant agents because infections are usually associated with oxidative processes. The main botanical difference between Larrea species resides in themorphology and shape of leaf, leaflets and stipules, presence or absence of mucron and rachis, percentage of coalescence of the leaflets. The position andabundance of the sclerenchymatic tissue at the mind vein and petiole transection allows the differentiation of the three species. The profile of phenoliccompounds in the Larrea DE was determined. HPLC-ESI-MS/MS analysis of DE allowed the identification of 2 flavonoids and 10 lignans. Trihydroxy-6,7´cyclolignan was found only in L. divaricata and dihydroxy-methoxy-epoxylignan in L. cuneifolia and L. nitida, nordihydroguaiaretic acid (NDGA) wasfound in the three species. All extracts showed antioxidant capacity. The DE showed to be effective against Candida albicans and non-albicans strains.According to our results, the local vaginal use of Larrea DE in the concentration range of MIC values for Candida species does not affect the Lactobacillusnormal vaginal microbiota. This work adds evidence to the potential use of Larrea DE as phytomedicine in vulvovaginal candidiasis with multiple effects,including antifungal and antioxidant activity.
Fil: Moreno, María Alejandra. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Córdoba, Susana Beatríz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Mercado, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; Argentina
Fil: Ponessa, Graciela Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Investigaciones Ecológicas de las Yungas; Argentina
Fil: Sayago, Jorge Esteban. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Pino Ramos, Liudis Leydi. Universidad de Talca; Chile
Fil: Schmeda Hirschmann, Guillermo. Universidad de Talca; Chile
Fil: Isla, Maria Ines. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
description Larrea divaricata (Ld), Larrea cuneifolia (Lc) and Larrea nitida (Ln) are shrubs occurring in Northwestern Argentina used in traditional medicine to treatfungal and bacterial infections and as anti-inflammatory. Antibacterial and antifungal activity of several Larrea species has been reported. However, theirpotential use in vaginal infections has been so far not assessed. The aim of this work was to determine the botanical difference between Larrea species, thechemical composition and the activity of Larrea dry extracts (DE) on Candida species isolated from vaginal infections and to assess their potential asantioxidant agents because infections are usually associated with oxidative processes. The main botanical difference between Larrea species resides in themorphology and shape of leaf, leaflets and stipules, presence or absence of mucron and rachis, percentage of coalescence of the leaflets. The position andabundance of the sclerenchymatic tissue at the mind vein and petiole transection allows the differentiation of the three species. The profile of phenoliccompounds in the Larrea DE was determined. HPLC-ESI-MS/MS analysis of DE allowed the identification of 2 flavonoids and 10 lignans. Trihydroxy-6,7´cyclolignan was found only in L. divaricata and dihydroxy-methoxy-epoxylignan in L. cuneifolia and L. nitida, nordihydroguaiaretic acid (NDGA) wasfound in the three species. All extracts showed antioxidant capacity. The DE showed to be effective against Candida albicans and non-albicans strains.According to our results, the local vaginal use of Larrea DE in the concentration range of MIC values for Candida species does not affect the Lactobacillusnormal vaginal microbiota. This work adds evidence to the potential use of Larrea DE as phytomedicine in vulvovaginal candidiasis with multiple effects,including antifungal and antioxidant activity.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/102098
Moreno, María Alejandra; Córdoba, Susana Beatríz; Zampini, Iris Catiana; Mercado, Maria Ines; Ponessa, Graciela Ines; et al.; Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis; Natural Products; Natural Product Communications; 13; 2; 2-2018; 171-174
1934-578X
1555-9475
CONICET Digital
CONICET
url http://hdl.handle.net/11336/102098
identifier_str_mv Moreno, María Alejandra; Córdoba, Susana Beatríz; Zampini, Iris Catiana; Mercado, Maria Ines; Ponessa, Graciela Ines; et al.; Argentinean Larrea Dry Extracts with Potential Use in Vaginal Candidiasis; Natural Products; Natural Product Communications; 13; 2; 2-2018; 171-174
1934-578X
1555-9475
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1801300215
info:eu-repo/semantics/altIdentifier/doi/10.1177%2F1934578X1801300215
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Natural Products
publisher.none.fl_str_mv Natural Products
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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