Influence of β-cyclodextrin on the Properties of Norfloxacin Form A

Autores
Chierentin, Lucas; Garnero, Claudia; Chattah, Ana Karina; Delvadia, Poonam; Karnes, Thomas; Longhi, Marcela Raquel; Salgado, Hérida Regina Nunes
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.
Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Delvadia, Poonam. Virginia Commonwealth University; Estados Unidos
Fil: Karnes, Thomas. Virginia Commonwealth University; Estados Unidos
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Salgado, Hérida Regina Nunes. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Materia
Bioassay
Complexation
Intrinsic Dissolution
Norfloxacin
Β-Cyclodextrin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37312

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network_name_str CONICET Digital (CONICET)
spelling Influence of β-cyclodextrin on the Properties of Norfloxacin Form AChierentin, LucasGarnero, ClaudiaChattah, Ana KarinaDelvadia, PoonamKarnes, ThomasLonghi, Marcela RaquelSalgado, Hérida Regina NunesBioassayComplexationIntrinsic DissolutionNorfloxacinΒ-Cyclodextrinhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Delvadia, Poonam. Virginia Commonwealth University; Estados UnidosFil: Karnes, Thomas. Virginia Commonwealth University; Estados UnidosFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Salgado, Hérida Regina Nunes. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilSpringer2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37312Chierentin, Lucas; Garnero, Claudia; Chattah, Ana Karina; Delvadia, Poonam; Karnes, Thomas; et al.; Influence of β-cyclodextrin on the Properties of Norfloxacin Form A; Springer; AAPS Pharmscitech; 16; 3; 1-2015; 683-6911530-9932CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444636/info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1208%2Fs12249-014-0259-8info:eu-repo/semantics/altIdentifier/doi/10.1208/s12249-014-0259-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:12:08Zoai:ri.conicet.gov.ar:11336/37312instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:12:08.386CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
spellingShingle Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
Chierentin, Lucas
Bioassay
Complexation
Intrinsic Dissolution
Norfloxacin
Β-Cyclodextrin
title_short Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title_full Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title_fullStr Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title_full_unstemmed Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title_sort Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
dc.creator.none.fl_str_mv Chierentin, Lucas
Garnero, Claudia
Chattah, Ana Karina
Delvadia, Poonam
Karnes, Thomas
Longhi, Marcela Raquel
Salgado, Hérida Regina Nunes
author Chierentin, Lucas
author_facet Chierentin, Lucas
Garnero, Claudia
Chattah, Ana Karina
Delvadia, Poonam
Karnes, Thomas
Longhi, Marcela Raquel
Salgado, Hérida Regina Nunes
author_role author
author2 Garnero, Claudia
Chattah, Ana Karina
Delvadia, Poonam
Karnes, Thomas
Longhi, Marcela Raquel
Salgado, Hérida Regina Nunes
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bioassay
Complexation
Intrinsic Dissolution
Norfloxacin
Β-Cyclodextrin
topic Bioassay
Complexation
Intrinsic Dissolution
Norfloxacin
Β-Cyclodextrin
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.
Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Delvadia, Poonam. Virginia Commonwealth University; Estados Unidos
Fil: Karnes, Thomas. Virginia Commonwealth University; Estados Unidos
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Salgado, Hérida Regina Nunes. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
description Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37312
Chierentin, Lucas; Garnero, Claudia; Chattah, Ana Karina; Delvadia, Poonam; Karnes, Thomas; et al.; Influence of β-cyclodextrin on the Properties of Norfloxacin Form A; Springer; AAPS Pharmscitech; 16; 3; 1-2015; 683-691
1530-9932
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37312
identifier_str_mv Chierentin, Lucas; Garnero, Claudia; Chattah, Ana Karina; Delvadia, Poonam; Karnes, Thomas; et al.; Influence of β-cyclodextrin on the Properties of Norfloxacin Form A; Springer; AAPS Pharmscitech; 16; 3; 1-2015; 683-691
1530-9932
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444636/
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1208%2Fs12249-014-0259-8
info:eu-repo/semantics/altIdentifier/doi/10.1208/s12249-014-0259-8
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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