Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
- Autores
- Chierentin, Lucas; Garnero, Claudia; Chattah, Ana Karina; Delvadia, Poonam; Karnes, Thomas; Longhi, Marcela Raquel; Salgado, Hérida Regina Nunes
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.
Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Delvadia, Poonam. Virginia Commonwealth University; Estados Unidos
Fil: Karnes, Thomas. Virginia Commonwealth University; Estados Unidos
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Salgado, Hérida Regina Nunes. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil - Materia
-
Bioassay
Complexation
Intrinsic Dissolution
Norfloxacin
Β-Cyclodextrin - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/37312
Ver los metadatos del registro completo
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Influence of β-cyclodextrin on the Properties of Norfloxacin Form AChierentin, LucasGarnero, ClaudiaChattah, Ana KarinaDelvadia, PoonamKarnes, ThomasLonghi, Marcela RaquelSalgado, Hérida Regina NunesBioassayComplexationIntrinsic DissolutionNorfloxacinΒ-Cyclodextrinhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Delvadia, Poonam. Virginia Commonwealth University; Estados UnidosFil: Karnes, Thomas. Virginia Commonwealth University; Estados UnidosFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Salgado, Hérida Regina Nunes. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilSpringer2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37312Chierentin, Lucas; Garnero, Claudia; Chattah, Ana Karina; Delvadia, Poonam; Karnes, Thomas; et al.; Influence of β-cyclodextrin on the Properties of Norfloxacin Form A; Springer; AAPS Pharmscitech; 16; 3; 1-2015; 683-6911530-9932CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444636/info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1208%2Fs12249-014-0259-8info:eu-repo/semantics/altIdentifier/doi/10.1208/s12249-014-0259-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:12:08Zoai:ri.conicet.gov.ar:11336/37312instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:12:08.386CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title |
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
spellingShingle |
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A Chierentin, Lucas Bioassay Complexation Intrinsic Dissolution Norfloxacin Β-Cyclodextrin |
title_short |
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title_full |
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title_fullStr |
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title_full_unstemmed |
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
title_sort |
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A |
dc.creator.none.fl_str_mv |
Chierentin, Lucas Garnero, Claudia Chattah, Ana Karina Delvadia, Poonam Karnes, Thomas Longhi, Marcela Raquel Salgado, Hérida Regina Nunes |
author |
Chierentin, Lucas |
author_facet |
Chierentin, Lucas Garnero, Claudia Chattah, Ana Karina Delvadia, Poonam Karnes, Thomas Longhi, Marcela Raquel Salgado, Hérida Regina Nunes |
author_role |
author |
author2 |
Garnero, Claudia Chattah, Ana Karina Delvadia, Poonam Karnes, Thomas Longhi, Marcela Raquel Salgado, Hérida Regina Nunes |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Bioassay Complexation Intrinsic Dissolution Norfloxacin Β-Cyclodextrin |
topic |
Bioassay Complexation Intrinsic Dissolution Norfloxacin Β-Cyclodextrin |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug. Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina Fil: Delvadia, Poonam. Virginia Commonwealth University; Estados Unidos Fil: Karnes, Thomas. Virginia Commonwealth University; Estados Unidos Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Salgado, Hérida Regina Nunes. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil |
description |
Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/37312 Chierentin, Lucas; Garnero, Claudia; Chattah, Ana Karina; Delvadia, Poonam; Karnes, Thomas; et al.; Influence of β-cyclodextrin on the Properties of Norfloxacin Form A; Springer; AAPS Pharmscitech; 16; 3; 1-2015; 683-691 1530-9932 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/37312 |
identifier_str_mv |
Chierentin, Lucas; Garnero, Claudia; Chattah, Ana Karina; Delvadia, Poonam; Karnes, Thomas; et al.; Influence of β-cyclodextrin on the Properties of Norfloxacin Form A; Springer; AAPS Pharmscitech; 16; 3; 1-2015; 683-691 1530-9932 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444636/ info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1208%2Fs12249-014-0259-8 info:eu-repo/semantics/altIdentifier/doi/10.1208/s12249-014-0259-8 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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