Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin

Autores
Chattah, Ana Karina; Mroue, Kamal H.; Pfund, Laura Y.; Ramamoorthy, Ayyalusamy; Longhi, Marcela Raquel; Garnero, Claudia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The solid-state properties of novel complexes of -cyclodextrin and two different solid forms of norfloxacin were investigated at the molecular level, in an attempt to obtain promising candidates for the preparation of alternative matrices used in pharmaceutical oral formulations. In order to evaluate the physical properties inherited from the different polymorphs, these supramolecular systems were characterized using a variety of spectroscopic techniques including natural-abundance 13C cross-polarization magic-angle-spinning (CP-MAS) nuclear magnetic resonance (NMR), powder X-ray diffraction, and Fourier transform infrared spectroscopy. The intrinsic proton spin-lattice relaxation times detected in 13C CP-MAS NMR spectra are used to confirm and distinguish the complex formation, as well as to provide better insights into the molecular fragments that are involved in the interaction with -cyclodextrin.
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Mroue, Kamal H.. University of Michigan; Estados Unidos
Fil: Pfund, Laura Y.. University of Michigan; Estados Unidos
Fil: Ramamoorthy, Ayyalusamy. University of Michigan; Estados Unidos
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
Norfloxacin
Polymorphism
Complexation
Solid State Nmr
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25862
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-CyclodextrinChattah, Ana KarinaMroue, Kamal H.Pfund, Laura Y.Ramamoorthy, AyyalusamyLonghi, Marcela RaquelGarnero, ClaudiaNorfloxacinPolymorphismComplexationSolid State Nmrhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1The solid-state properties of novel complexes of -cyclodextrin and two different solid forms of norfloxacin were investigated at the molecular level, in an attempt to obtain promising candidates for the preparation of alternative matrices used in pharmaceutical oral formulations. In order to evaluate the physical properties inherited from the different polymorphs, these supramolecular systems were characterized using a variety of spectroscopic techniques including natural-abundance 13C cross-polarization magic-angle-spinning (CP-MAS) nuclear magnetic resonance (NMR), powder X-ray diffraction, and Fourier transform infrared spectroscopy. The intrinsic proton spin-lattice relaxation times detected in 13C CP-MAS NMR spectra are used to confirm and distinguish the complex formation, as well as to provide better insights into the molecular fragments that are involved in the interaction with -cyclodextrin.Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Mroue, Kamal H.. University of Michigan; Estados UnidosFil: Pfund, Laura Y.. University of Michigan; Estados UnidosFil: Ramamoorthy, Ayyalusamy. University of Michigan; Estados UnidosFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaWiley2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25862Chattah, Ana Karina; Mroue, Kamal H.; Pfund, Laura Y.; Ramamoorthy, Ayyalusamy; Longhi, Marcela Raquel; et al.; Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin; Wiley; Journal of Pharmaceutical Sciences; 102; 10; 7-2013; 3717-37240022-3549CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/jps.23683info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jps.23683/abstractinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S002235491530890Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:39Zoai:ri.conicet.gov.ar:11336/25862instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:39.648CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin
title Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin
spellingShingle Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin
Chattah, Ana Karina
Norfloxacin
Polymorphism
Complexation
Solid State Nmr
title_short Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin
title_full Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin
title_fullStr Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin
title_full_unstemmed Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin
title_sort Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin
dc.creator.none.fl_str_mv Chattah, Ana Karina
Mroue, Kamal H.
Pfund, Laura Y.
Ramamoorthy, Ayyalusamy
Longhi, Marcela Raquel
Garnero, Claudia
author Chattah, Ana Karina
author_facet Chattah, Ana Karina
Mroue, Kamal H.
Pfund, Laura Y.
Ramamoorthy, Ayyalusamy
Longhi, Marcela Raquel
Garnero, Claudia
author_role author
author2 Mroue, Kamal H.
Pfund, Laura Y.
Ramamoorthy, Ayyalusamy
Longhi, Marcela Raquel
Garnero, Claudia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Norfloxacin
Polymorphism
Complexation
Solid State Nmr
topic Norfloxacin
Polymorphism
Complexation
Solid State Nmr
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The solid-state properties of novel complexes of -cyclodextrin and two different solid forms of norfloxacin were investigated at the molecular level, in an attempt to obtain promising candidates for the preparation of alternative matrices used in pharmaceutical oral formulations. In order to evaluate the physical properties inherited from the different polymorphs, these supramolecular systems were characterized using a variety of spectroscopic techniques including natural-abundance 13C cross-polarization magic-angle-spinning (CP-MAS) nuclear magnetic resonance (NMR), powder X-ray diffraction, and Fourier transform infrared spectroscopy. The intrinsic proton spin-lattice relaxation times detected in 13C CP-MAS NMR spectra are used to confirm and distinguish the complex formation, as well as to provide better insights into the molecular fragments that are involved in the interaction with -cyclodextrin.
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Mroue, Kamal H.. University of Michigan; Estados Unidos
Fil: Pfund, Laura Y.. University of Michigan; Estados Unidos
Fil: Ramamoorthy, Ayyalusamy. University of Michigan; Estados Unidos
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description The solid-state properties of novel complexes of -cyclodextrin and two different solid forms of norfloxacin were investigated at the molecular level, in an attempt to obtain promising candidates for the preparation of alternative matrices used in pharmaceutical oral formulations. In order to evaluate the physical properties inherited from the different polymorphs, these supramolecular systems were characterized using a variety of spectroscopic techniques including natural-abundance 13C cross-polarization magic-angle-spinning (CP-MAS) nuclear magnetic resonance (NMR), powder X-ray diffraction, and Fourier transform infrared spectroscopy. The intrinsic proton spin-lattice relaxation times detected in 13C CP-MAS NMR spectra are used to confirm and distinguish the complex formation, as well as to provide better insights into the molecular fragments that are involved in the interaction with -cyclodextrin.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25862
Chattah, Ana Karina; Mroue, Kamal H.; Pfund, Laura Y.; Ramamoorthy, Ayyalusamy; Longhi, Marcela Raquel; et al.; Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin; Wiley; Journal of Pharmaceutical Sciences; 102; 10; 7-2013; 3717-3724
0022-3549
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25862
identifier_str_mv Chattah, Ana Karina; Mroue, Kamal H.; Pfund, Laura Y.; Ramamoorthy, Ayyalusamy; Longhi, Marcela Raquel; et al.; Insights into novel supramolecular complexes of two solid forms of Norfloxacin and β-Cyclodextrin; Wiley; Journal of Pharmaceutical Sciences; 102; 10; 7-2013; 3717-3724
0022-3549
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/jps.23683
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jps.23683/abstract
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S002235491530890X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269921343438848
score 13.13397

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