Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome

Autores
Naesgaard, Patrycja A.; Leon de la Fuente, Ricardo Alfonso; Nilsen, Stein Tore; Pönitz, Volker; Brügger Andersen, Trygve; Grundt, Heidi; Staines, Harry; Nilsen, Dennis W. T.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate.Objectives: To assess two cut-off levels, 40 and 70 nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome.Methods: We investigated 1853 patients from coastal-Norway and inland NorthernArgentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis.Results: Two hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40 nmol/L and a decrease in cardiac death above a cut-off level of 70 nmol/L [HRs of 0.66 (95% CI, 0.50?0.88), p = 0.004 and 0.46 (95% CI, 0.22?0.94), p = 0.034, respectively].Conclusion: Vitamin D cut-off levels of 40 and 70 nmol/L were related to total mortality and cardiac death, respectively.
Fil: Naesgaard, Patrycja A.. Stavanger University Hospital; Noruega. University Of Bergen; Noruega
Fil: Leon de la Fuente, Ricardo Alfonso. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Stavanger University Hospital; Noruega. University Of Bergen; Noruega. Universidad Católica de Salta; Argentina
Fil: Nilsen, Stein Tore. Stavanger University Hospital; Noruega. University Of Bergen; Noruega
Fil: Pönitz, Volker. Stavanger University Hospital; Noruega
Fil: Brügger Andersen, Trygve. Stavanger University Hospital; Noruega
Fil: Grundt, Heidi. University Of Bergen; Noruega. Stavanger University Hospital; Noruega
Fil: Staines, Harry. Sigma Statistical Services; Reino Unido
Fil: Nilsen, Dennis W. T.. Stavanger University Hospital; Noruega. University Of Bergen; Noruega
Materia
VITAMIN D
ACUTE CORONARY SYNDROME
TOTAL MORTALITY
CARDIAC DEATH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/74911
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/74911
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary SyndromeNaesgaard, Patrycja A.Leon de la Fuente, Ricardo AlfonsoNilsen, Stein TorePönitz, VolkerBrügger Andersen, TrygveGrundt, HeidiStaines, HarryNilsen, Dennis W. T.VITAMIN DACUTE CORONARY SYNDROMETOTAL MORTALITYCARDIAC DEATHhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate.Objectives: To assess two cut-off levels, 40 and 70 nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome.Methods: We investigated 1853 patients from coastal-Norway and inland NorthernArgentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis.Results: Two hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40 nmol/L and a decrease in cardiac death above a cut-off level of 70 nmol/L [HRs of 0.66 (95% CI, 0.50?0.88), p = 0.004 and 0.46 (95% CI, 0.22?0.94), p = 0.034, respectively].Conclusion: Vitamin D cut-off levels of 40 and 70 nmol/L were related to total mortality and cardiac death, respectively.Fil: Naesgaard, Patrycja A.. Stavanger University Hospital; Noruega. University Of Bergen; NoruegaFil: Leon de la Fuente, Ricardo Alfonso. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Stavanger University Hospital; Noruega. University Of Bergen; Noruega. Universidad Católica de Salta; ArgentinaFil: Nilsen, Stein Tore. Stavanger University Hospital; Noruega. University Of Bergen; NoruegaFil: Pönitz, Volker. Stavanger University Hospital; NoruegaFil: Brügger Andersen, Trygve. Stavanger University Hospital; NoruegaFil: Grundt, Heidi. University Of Bergen; Noruega. Stavanger University Hospital; NoruegaFil: Staines, Harry. Sigma Statistical Services; Reino UnidoFil: Nilsen, Dennis W. T.. Stavanger University Hospital; Noruega. University Of Bergen; NoruegaFrontiers Media S.A.2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/74911Naesgaard, Patrycja A.; Leon de la Fuente, Ricardo Alfonso; Nilsen, Stein Tore; Pönitz, Volker; Brügger Andersen, Trygve; et al.; Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome; Frontiers Media S.A.; Frontiers in Cardiovascular Medicine; 3; 2-20162297-055XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcvm.2016.00004info:eu-repo/semantics/altIdentifier/doi/10.3389/fcvm.2016.00004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:19Zoai:ri.conicet.gov.ar:11336/74911instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:19.545CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome
title Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome
spellingShingle Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome
Naesgaard, Patrycja A.
VITAMIN D
ACUTE CORONARY SYNDROME
TOTAL MORTALITY
CARDIAC DEATH
title_short Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome
title_full Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome
title_fullStr Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome
title_full_unstemmed Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome
title_sort Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome
dc.creator.none.fl_str_mv Naesgaard, Patrycja A.
Leon de la Fuente, Ricardo Alfonso
Nilsen, Stein Tore
Pönitz, Volker
Brügger Andersen, Trygve
Grundt, Heidi
Staines, Harry
Nilsen, Dennis W. T.
author Naesgaard, Patrycja A.
author_facet Naesgaard, Patrycja A.
Leon de la Fuente, Ricardo Alfonso
Nilsen, Stein Tore
Pönitz, Volker
Brügger Andersen, Trygve
Grundt, Heidi
Staines, Harry
Nilsen, Dennis W. T.
author_role author
author2 Leon de la Fuente, Ricardo Alfonso
Nilsen, Stein Tore
Pönitz, Volker
Brügger Andersen, Trygve
Grundt, Heidi
Staines, Harry
Nilsen, Dennis W. T.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv VITAMIN D
ACUTE CORONARY SYNDROME
TOTAL MORTALITY
CARDIAC DEATH
topic VITAMIN D
ACUTE CORONARY SYNDROME
TOTAL MORTALITY
CARDIAC DEATH
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate.Objectives: To assess two cut-off levels, 40 and 70 nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome.Methods: We investigated 1853 patients from coastal-Norway and inland NorthernArgentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis.Results: Two hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40 nmol/L and a decrease in cardiac death above a cut-off level of 70 nmol/L [HRs of 0.66 (95% CI, 0.50?0.88), p = 0.004 and 0.46 (95% CI, 0.22?0.94), p = 0.034, respectively].Conclusion: Vitamin D cut-off levels of 40 and 70 nmol/L were related to total mortality and cardiac death, respectively.
Fil: Naesgaard, Patrycja A.. Stavanger University Hospital; Noruega. University Of Bergen; Noruega
Fil: Leon de la Fuente, Ricardo Alfonso. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Stavanger University Hospital; Noruega. University Of Bergen; Noruega. Universidad Católica de Salta; Argentina
Fil: Nilsen, Stein Tore. Stavanger University Hospital; Noruega. University Of Bergen; Noruega
Fil: Pönitz, Volker. Stavanger University Hospital; Noruega
Fil: Brügger Andersen, Trygve. Stavanger University Hospital; Noruega
Fil: Grundt, Heidi. University Of Bergen; Noruega. Stavanger University Hospital; Noruega
Fil: Staines, Harry. Sigma Statistical Services; Reino Unido
Fil: Nilsen, Dennis W. T.. Stavanger University Hospital; Noruega. University Of Bergen; Noruega
description Background: Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate.Objectives: To assess two cut-off levels, 40 and 70 nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome.Methods: We investigated 1853 patients from coastal-Norway and inland NorthernArgentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis.Results: Two hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40 nmol/L and a decrease in cardiac death above a cut-off level of 70 nmol/L [HRs of 0.66 (95% CI, 0.50?0.88), p = 0.004 and 0.46 (95% CI, 0.22?0.94), p = 0.034, respectively].Conclusion: Vitamin D cut-off levels of 40 and 70 nmol/L were related to total mortality and cardiac death, respectively.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/74911
Naesgaard, Patrycja A.; Leon de la Fuente, Ricardo Alfonso; Nilsen, Stein Tore; Pönitz, Volker; Brügger Andersen, Trygve; et al.; Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome; Frontiers Media S.A.; Frontiers in Cardiovascular Medicine; 3; 2-2016
2297-055X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/74911
identifier_str_mv Naesgaard, Patrycja A.; Leon de la Fuente, Ricardo Alfonso; Nilsen, Stein Tore; Pönitz, Volker; Brügger Andersen, Trygve; et al.; Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome; Frontiers Media S.A.; Frontiers in Cardiovascular Medicine; 3; 2-2016
2297-055X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcvm.2016.00004
info:eu-repo/semantics/altIdentifier/doi/10.3389/fcvm.2016.00004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269998608809984
score 13.13397

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