Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial

Autores
Rodriguez, Alfredo E.; Vigo, Cesar F.; Delacasa, Alejandro; Mieres, Juan; Fernandez Pereira, Carlos; Bernardi, Victor; Bettinoti, Marcelo; Rodriguez Granillo, Gaston Alfredo; Curotto, Valeria; Rubilar, Bibiana; Tronge, Jorge; Palacios, Igor F.; Antoniucci, David
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: The aim of this study was the comparison of a new double-coated paclitaxel-eluting coronary stent with bare-metal stent (BMS) in patients undergoing percutaneous coronary intervention. Background: Stent coating with biodegradable polymers as a platform for elution of drugs has the potential for complete elution of drugs and for decreasing the risk of late complications. Methods: Multicenter randomized trial comparing a paclitaxel-eluting stent (PES) coated with a biodegradable polymer and glycocalyx with the equivalent BMS. We randomly assigned 422 patients with de novo coronary lesions to PES (211 patients) or to BMS (211 patients). Primary end point was target vessel failure (TVF) defined as cardiac death, myocardial infarction, and target vessel revascularization. Clinical secondary end points were target vessel revascularization, target lesion revascularization, stent thrombosis (ST), and major adverse cardiovascular events (MACE). Angiographic secondary end points were late loss and binary restenosis. Results: At 1 year of follow-up, TVF rate was 9.5% in the PES group and 17.1% in the BMS group (P = 0.02), and MACE rate was 10% in PES and 19% in BMS arm (P = 0.009). All other secondary end points were reached but ST. ST rate was low and similar in both study arms. Conclusions: The study shows that patients treated with PES with dual coating technology had significantly lower incidence of TVF and MACE than those treated with BMS design; however, longer follow-up should be necessary to assess true advantages of this technology compared with the previous one.
Fil: Rodriguez, Alfredo E.. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Vigo, Cesar F.. Sanatorio del Salvador S. A.; Argentina
Fil: Delacasa, Alejandro. Sanatorio Belgrano; Argentina
Fil: Mieres, Juan. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Fernandez Pereira, Carlos. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Bernardi, Victor. Clinica del Sol;
Fil: Bettinoti, Marcelo. Sanatorio Guemes Sociedad Anonima.; Argentina
Fil: Rodriguez Granillo, Gaston Alfredo. Sanatorio "Otamendi y Miroli S.A.". Servicio de Diagnóstico por Imágenes. Departamento de Imágenes en Cardiología. Centro de Investigaciones Cardiovasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Curotto, Valeria. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Rubilar, Bibiana. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Tronge, Jorge. No especifíca;
Fil: Palacios, Igor F.. Massachusetts General Hospital; Estados Unidos
Fil: Antoniucci, David. Careggi Hospital; Italia
Materia
ACUTE CORONARY SYNDROME (ACS)
DRUG DELIVERY (DDEL)
PERCUTANEOUS CORONARY INTERVENTION (PCI)
QUANTITATIVE CORONARY ANGIOGRAPHY (QCA)
RESTENOSIS (RSTN)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/198331
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/198331
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trialRodriguez, Alfredo E.Vigo, Cesar F.Delacasa, AlejandroMieres, JuanFernandez Pereira, CarlosBernardi, VictorBettinoti, MarceloRodriguez Granillo, Gaston AlfredoCurotto, ValeriaRubilar, BibianaTronge, JorgePalacios, Igor F.Antoniucci, DavidACUTE CORONARY SYNDROME (ACS)DRUG DELIVERY (DDEL)PERCUTANEOUS CORONARY INTERVENTION (PCI)QUANTITATIVE CORONARY ANGIOGRAPHY (QCA)RESTENOSIS (RSTN)https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objectives: The aim of this study was the comparison of a new double-coated paclitaxel-eluting coronary stent with bare-metal stent (BMS) in patients undergoing percutaneous coronary intervention. Background: Stent coating with biodegradable polymers as a platform for elution of drugs has the potential for complete elution of drugs and for decreasing the risk of late complications. Methods: Multicenter randomized trial comparing a paclitaxel-eluting stent (PES) coated with a biodegradable polymer and glycocalyx with the equivalent BMS. We randomly assigned 422 patients with de novo coronary lesions to PES (211 patients) or to BMS (211 patients). Primary end point was target vessel failure (TVF) defined as cardiac death, myocardial infarction, and target vessel revascularization. Clinical secondary end points were target vessel revascularization, target lesion revascularization, stent thrombosis (ST), and major adverse cardiovascular events (MACE). Angiographic secondary end points were late loss and binary restenosis. Results: At 1 year of follow-up, TVF rate was 9.5% in the PES group and 17.1% in the BMS group (P = 0.02), and MACE rate was 10% in PES and 19% in BMS arm (P = 0.009). All other secondary end points were reached but ST. ST rate was low and similar in both study arms. Conclusions: The study shows that patients treated with PES with dual coating technology had significantly lower incidence of TVF and MACE than those treated with BMS design; however, longer follow-up should be necessary to assess true advantages of this technology compared with the previous one.Fil: Rodriguez, Alfredo E.. Sanatorio "Otamendi y Miroli S. A."; ArgentinaFil: Vigo, Cesar F.. Sanatorio del Salvador S. A.; ArgentinaFil: Delacasa, Alejandro. Sanatorio Belgrano; ArgentinaFil: Mieres, Juan. Sanatorio "Otamendi y Miroli S. A."; ArgentinaFil: Fernandez Pereira, Carlos. Sanatorio "Otamendi y Miroli S. A."; ArgentinaFil: Bernardi, Victor. Clinica del Sol;Fil: Bettinoti, Marcelo. Sanatorio Guemes Sociedad Anonima.; ArgentinaFil: Rodriguez Granillo, Gaston Alfredo. Sanatorio "Otamendi y Miroli S.A.". Servicio de Diagnóstico por Imágenes. Departamento de Imágenes en Cardiología. Centro de Investigaciones Cardiovasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Curotto, Valeria. Sanatorio "Otamendi y Miroli S. A."; ArgentinaFil: Rubilar, Bibiana. Sanatorio "Otamendi y Miroli S. A."; ArgentinaFil: Tronge, Jorge. No especifíca;Fil: Palacios, Igor F.. Massachusetts General Hospital; Estados UnidosFil: Antoniucci, David. Careggi Hospital; ItaliaWiley-liss, div John Wiley & Sons Inc.2011-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/198331Rodriguez, Alfredo E.; Vigo, Cesar F.; Delacasa, Alejandro; Mieres, Juan; Fernandez Pereira, Carlos; et al.; Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial; Wiley-liss, div John Wiley & Sons Inc.; Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions.; 77; 3; 2-2011; 335-3421522-1946CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccd.22769info:eu-repo/semantics/altIdentifier/doi/10.1002/ccd.22769info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:20Zoai:ri.conicet.gov.ar:11336/198331instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:20.974CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial
title Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial
spellingShingle Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial
Rodriguez, Alfredo E.
ACUTE CORONARY SYNDROME (ACS)
DRUG DELIVERY (DDEL)
PERCUTANEOUS CORONARY INTERVENTION (PCI)
QUANTITATIVE CORONARY ANGIOGRAPHY (QCA)
RESTENOSIS (RSTN)
title_short Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial
title_full Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial
title_fullStr Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial
title_full_unstemmed Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial
title_sort Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial
dc.creator.none.fl_str_mv Rodriguez, Alfredo E.
Vigo, Cesar F.
Delacasa, Alejandro
Mieres, Juan
Fernandez Pereira, Carlos
Bernardi, Victor
Bettinoti, Marcelo
Rodriguez Granillo, Gaston Alfredo
Curotto, Valeria
Rubilar, Bibiana
Tronge, Jorge
Palacios, Igor F.
Antoniucci, David
author Rodriguez, Alfredo E.
author_facet Rodriguez, Alfredo E.
Vigo, Cesar F.
Delacasa, Alejandro
Mieres, Juan
Fernandez Pereira, Carlos
Bernardi, Victor
Bettinoti, Marcelo
Rodriguez Granillo, Gaston Alfredo
Curotto, Valeria
Rubilar, Bibiana
Tronge, Jorge
Palacios, Igor F.
Antoniucci, David
author_role author
author2 Vigo, Cesar F.
Delacasa, Alejandro
Mieres, Juan
Fernandez Pereira, Carlos
Bernardi, Victor
Bettinoti, Marcelo
Rodriguez Granillo, Gaston Alfredo
Curotto, Valeria
Rubilar, Bibiana
Tronge, Jorge
Palacios, Igor F.
Antoniucci, David
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACUTE CORONARY SYNDROME (ACS)
DRUG DELIVERY (DDEL)
PERCUTANEOUS CORONARY INTERVENTION (PCI)
QUANTITATIVE CORONARY ANGIOGRAPHY (QCA)
RESTENOSIS (RSTN)
topic ACUTE CORONARY SYNDROME (ACS)
DRUG DELIVERY (DDEL)
PERCUTANEOUS CORONARY INTERVENTION (PCI)
QUANTITATIVE CORONARY ANGIOGRAPHY (QCA)
RESTENOSIS (RSTN)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: The aim of this study was the comparison of a new double-coated paclitaxel-eluting coronary stent with bare-metal stent (BMS) in patients undergoing percutaneous coronary intervention. Background: Stent coating with biodegradable polymers as a platform for elution of drugs has the potential for complete elution of drugs and for decreasing the risk of late complications. Methods: Multicenter randomized trial comparing a paclitaxel-eluting stent (PES) coated with a biodegradable polymer and glycocalyx with the equivalent BMS. We randomly assigned 422 patients with de novo coronary lesions to PES (211 patients) or to BMS (211 patients). Primary end point was target vessel failure (TVF) defined as cardiac death, myocardial infarction, and target vessel revascularization. Clinical secondary end points were target vessel revascularization, target lesion revascularization, stent thrombosis (ST), and major adverse cardiovascular events (MACE). Angiographic secondary end points were late loss and binary restenosis. Results: At 1 year of follow-up, TVF rate was 9.5% in the PES group and 17.1% in the BMS group (P = 0.02), and MACE rate was 10% in PES and 19% in BMS arm (P = 0.009). All other secondary end points were reached but ST. ST rate was low and similar in both study arms. Conclusions: The study shows that patients treated with PES with dual coating technology had significantly lower incidence of TVF and MACE than those treated with BMS design; however, longer follow-up should be necessary to assess true advantages of this technology compared with the previous one.
Fil: Rodriguez, Alfredo E.. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Vigo, Cesar F.. Sanatorio del Salvador S. A.; Argentina
Fil: Delacasa, Alejandro. Sanatorio Belgrano; Argentina
Fil: Mieres, Juan. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Fernandez Pereira, Carlos. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Bernardi, Victor. Clinica del Sol;
Fil: Bettinoti, Marcelo. Sanatorio Guemes Sociedad Anonima.; Argentina
Fil: Rodriguez Granillo, Gaston Alfredo. Sanatorio "Otamendi y Miroli S.A.". Servicio de Diagnóstico por Imágenes. Departamento de Imágenes en Cardiología. Centro de Investigaciones Cardiovasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Curotto, Valeria. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Rubilar, Bibiana. Sanatorio "Otamendi y Miroli S. A."; Argentina
Fil: Tronge, Jorge. No especifíca;
Fil: Palacios, Igor F.. Massachusetts General Hospital; Estados Unidos
Fil: Antoniucci, David. Careggi Hospital; Italia
description Objectives: The aim of this study was the comparison of a new double-coated paclitaxel-eluting coronary stent with bare-metal stent (BMS) in patients undergoing percutaneous coronary intervention. Background: Stent coating with biodegradable polymers as a platform for elution of drugs has the potential for complete elution of drugs and for decreasing the risk of late complications. Methods: Multicenter randomized trial comparing a paclitaxel-eluting stent (PES) coated with a biodegradable polymer and glycocalyx with the equivalent BMS. We randomly assigned 422 patients with de novo coronary lesions to PES (211 patients) or to BMS (211 patients). Primary end point was target vessel failure (TVF) defined as cardiac death, myocardial infarction, and target vessel revascularization. Clinical secondary end points were target vessel revascularization, target lesion revascularization, stent thrombosis (ST), and major adverse cardiovascular events (MACE). Angiographic secondary end points were late loss and binary restenosis. Results: At 1 year of follow-up, TVF rate was 9.5% in the PES group and 17.1% in the BMS group (P = 0.02), and MACE rate was 10% in PES and 19% in BMS arm (P = 0.009). All other secondary end points were reached but ST. ST rate was low and similar in both study arms. Conclusions: The study shows that patients treated with PES with dual coating technology had significantly lower incidence of TVF and MACE than those treated with BMS design; however, longer follow-up should be necessary to assess true advantages of this technology compared with the previous one.
publishDate 2011
dc.date.none.fl_str_mv 2011-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/198331
Rodriguez, Alfredo E.; Vigo, Cesar F.; Delacasa, Alejandro; Mieres, Juan; Fernandez Pereira, Carlos; et al.; Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial; Wiley-liss, div John Wiley & Sons Inc.; Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions.; 77; 3; 2-2011; 335-342
1522-1946
CONICET Digital
CONICET
url http://hdl.handle.net/11336/198331
identifier_str_mv Rodriguez, Alfredo E.; Vigo, Cesar F.; Delacasa, Alejandro; Mieres, Juan; Fernandez Pereira, Carlos; et al.; Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial; Wiley-liss, div John Wiley & Sons Inc.; Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions.; 77; 3; 2-2011; 335-342
1522-1946
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccd.22769
info:eu-repo/semantics/altIdentifier/doi/10.1002/ccd.22769
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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