Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions

Autores
Chanquia, Santiago Nahuel; Huang, Lei; Garcia Liñares, Guadalupe Eugenia; Domínguez de María, Pablo; Kara, Selin
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alcohol dehydrogenase (ADH) catalyzed reductions in deep eutectic solvents (DESs) may become efficient and sustainable alternatives to afford alcohols. This paper successfully explores the ADH-catalyzed reduction of ketones and aldehydes in a DES composed of choline chloride and 1,4-butanediol, in combination with buffer (Tris-HCl, 20% v/v). 1,4-butanediol (a DES component), acts as a smart cosubstrate for the enzymatic cofactor regeneration, shifting the thermodynamic equilibrium to the product side. By means of the novel DES media, cyclohexanone reduction was optimized to yield maximum productivity with low enzyme amounts (in the range of 10 g L−1 d−1). Notably, with the herein developed reaction media, cinnamaldehyde was reduced to cinnamyl alcohol, an important compound for the fragrance industry, with promising high productivities of ~75 g L−1 d−1.
Fil: Chanquia, Santiago Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Huang, Lei. University Aarhus; Dinamarca
Fil: Garcia Liñares, Guadalupe Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Domínguez de María, Pablo. Sustainable Momentum; España
Fil: Kara, Selin. University Aarhus; Dinamarca
Materia
ALCOHOL DEHYDROGENASES
CINNAMYL ALCOHOL
DEEP EUTECTIC SOLVENTS
REDUCTIONS
SMART COSUBSTRATE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/141355
Acceder
id CONICETDig_73e9c9f8338be89ee275510d4d3e182c
oai_identifier_str oai:ri.conicet.gov.ar:11336/141355
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductionsChanquia, Santiago NahuelHuang, LeiGarcia Liñares, Guadalupe EugeniaDomínguez de María, PabloKara, SelinALCOHOL DEHYDROGENASESCINNAMYL ALCOHOLDEEP EUTECTIC SOLVENTSREDUCTIONSSMART COSUBSTRATEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Alcohol dehydrogenase (ADH) catalyzed reductions in deep eutectic solvents (DESs) may become efficient and sustainable alternatives to afford alcohols. This paper successfully explores the ADH-catalyzed reduction of ketones and aldehydes in a DES composed of choline chloride and 1,4-butanediol, in combination with buffer (Tris-HCl, 20% v/v). 1,4-butanediol (a DES component), acts as a smart cosubstrate for the enzymatic cofactor regeneration, shifting the thermodynamic equilibrium to the product side. By means of the novel DES media, cyclohexanone reduction was optimized to yield maximum productivity with low enzyme amounts (in the range of 10 g L−1 d−1). Notably, with the herein developed reaction media, cinnamaldehyde was reduced to cinnamyl alcohol, an important compound for the fragrance industry, with promising high productivities of ~75 g L−1 d−1.Fil: Chanquia, Santiago Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; ArgentinaFil: Huang, Lei. University Aarhus; DinamarcaFil: Garcia Liñares, Guadalupe Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; ArgentinaFil: Domínguez de María, Pablo. Sustainable Momentum; EspañaFil: Kara, Selin. University Aarhus; DinamarcaMDPI2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/141355Chanquia, Santiago Nahuel; Huang, Lei; Garcia Liñares, Guadalupe Eugenia; Domínguez de María, Pablo; Kara, Selin; Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions; MDPI; Catalysts; 10; 9; 9-2020; 1-82073-4344CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4344/10/9/1013info:eu-repo/semantics/altIdentifier/doi/10.3390/catal10091013info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:38Zoai:ri.conicet.gov.ar:11336/141355instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:39.11CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions
title Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions
spellingShingle Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions
Chanquia, Santiago Nahuel
ALCOHOL DEHYDROGENASES
CINNAMYL ALCOHOL
DEEP EUTECTIC SOLVENTS
REDUCTIONS
SMART COSUBSTRATE
title_short Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions
title_full Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions
title_fullStr Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions
title_full_unstemmed Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions
title_sort Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions
dc.creator.none.fl_str_mv Chanquia, Santiago Nahuel
Huang, Lei
Garcia Liñares, Guadalupe Eugenia
Domínguez de María, Pablo
Kara, Selin
author Chanquia, Santiago Nahuel
author_facet Chanquia, Santiago Nahuel
Huang, Lei
Garcia Liñares, Guadalupe Eugenia
Domínguez de María, Pablo
Kara, Selin
author_role author
author2 Huang, Lei
Garcia Liñares, Guadalupe Eugenia
Domínguez de María, Pablo
Kara, Selin
author2_role author
author
author
author
dc.subject.none.fl_str_mv ALCOHOL DEHYDROGENASES
CINNAMYL ALCOHOL
DEEP EUTECTIC SOLVENTS
REDUCTIONS
SMART COSUBSTRATE
topic ALCOHOL DEHYDROGENASES
CINNAMYL ALCOHOL
DEEP EUTECTIC SOLVENTS
REDUCTIONS
SMART COSUBSTRATE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Alcohol dehydrogenase (ADH) catalyzed reductions in deep eutectic solvents (DESs) may become efficient and sustainable alternatives to afford alcohols. This paper successfully explores the ADH-catalyzed reduction of ketones and aldehydes in a DES composed of choline chloride and 1,4-butanediol, in combination with buffer (Tris-HCl, 20% v/v). 1,4-butanediol (a DES component), acts as a smart cosubstrate for the enzymatic cofactor regeneration, shifting the thermodynamic equilibrium to the product side. By means of the novel DES media, cyclohexanone reduction was optimized to yield maximum productivity with low enzyme amounts (in the range of 10 g L−1 d−1). Notably, with the herein developed reaction media, cinnamaldehyde was reduced to cinnamyl alcohol, an important compound for the fragrance industry, with promising high productivities of ~75 g L−1 d−1.
Fil: Chanquia, Santiago Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Huang, Lei. University Aarhus; Dinamarca
Fil: Garcia Liñares, Guadalupe Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Domínguez de María, Pablo. Sustainable Momentum; España
Fil: Kara, Selin. University Aarhus; Dinamarca
description Alcohol dehydrogenase (ADH) catalyzed reductions in deep eutectic solvents (DESs) may become efficient and sustainable alternatives to afford alcohols. This paper successfully explores the ADH-catalyzed reduction of ketones and aldehydes in a DES composed of choline chloride and 1,4-butanediol, in combination with buffer (Tris-HCl, 20% v/v). 1,4-butanediol (a DES component), acts as a smart cosubstrate for the enzymatic cofactor regeneration, shifting the thermodynamic equilibrium to the product side. By means of the novel DES media, cyclohexanone reduction was optimized to yield maximum productivity with low enzyme amounts (in the range of 10 g L−1 d−1). Notably, with the herein developed reaction media, cinnamaldehyde was reduced to cinnamyl alcohol, an important compound for the fragrance industry, with promising high productivities of ~75 g L−1 d−1.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/141355
Chanquia, Santiago Nahuel; Huang, Lei; Garcia Liñares, Guadalupe Eugenia; Domínguez de María, Pablo; Kara, Selin; Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions; MDPI; Catalysts; 10; 9; 9-2020; 1-8
2073-4344
CONICET Digital
CONICET
url http://hdl.handle.net/11336/141355
identifier_str_mv Chanquia, Santiago Nahuel; Huang, Lei; Garcia Liñares, Guadalupe Eugenia; Domínguez de María, Pablo; Kara, Selin; Deep eutectic solvents as smart cosubstrate in alcohol dehydrogenase-catalyzed reductions; MDPI; Catalysts; 10; 9; 9-2020; 1-8
2073-4344
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4344/10/9/1013
info:eu-repo/semantics/altIdentifier/doi/10.3390/catal10091013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269709382189056
score 13.13397

Publicaciones similares