An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid

Autores
Iturburu, Fernando Gastón; Bertrand, Lidwina; Mendieta, Julieta Renee; Amé, María V.; Menone, Mirta Lujan
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Integrated Biomarkers Response (IBR) index have been developed as a practical and robust tool to assess the susceptibility to pollutants using multiple biomarker responses. Neonicotinoid insecticides are nowadays one of the most sold pesticides worldwide. Nevertheless, imidacloprid (IMI) sub-lethal effects such as oxidative stress (OS) on fishes are scarcely studied. Hence, the aims of this work were: (1) to evaluate exposure- and damage biomarkers related to OS in the freshwater fish Australoheros facetus exposed to IMI and (2) to apply the IBR index to achieve a comprehensive understanding of OS in the fish. The results of the present study showed that all the biomarkers presented different responses in the three monitored tissues: liver, brain and gills. Results for an initial battery of 19 biomarkers were obtained and for the IBR index only those with significant differences have been considered. The biomarkers that had the most important weight on the IBR index were SOD activity in brain and gills, H2O2 concentration in liver, and carbonyl groups concentration in gills in fishes exposed to 100 and 1000 μg L−1 IMI. This index allowed affirming that a short term exposure to environmentally relevant concentrations of IMI (≥10 μg L−1) produces OS in A. facetus. However, a more deep understanding of some biomarkers response is necessary to improve the index and for finally apply it in field studies.
Fil: Iturburu, Fernando Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Bertrand, Lidwina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Mendieta, Julieta Renee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Amé, María V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Subsede Instituto Nacional de Investigación y Desarrollo Pesquero; Argentina
Materia
ANTIOXIDANT ENZYMES
FISHES
INTEGRATED BIOMARKER RESPONSE INDEX
NEONICOTINOID
OXIDATIVE DAMAGE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/90893
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/90893
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidaclopridIturburu, Fernando GastónBertrand, LidwinaMendieta, Julieta ReneeAmé, María V.Menone, Mirta LujanANTIOXIDANT ENZYMESFISHESINTEGRATED BIOMARKER RESPONSE INDEXNEONICOTINOIDOXIDATIVE DAMAGEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Integrated Biomarkers Response (IBR) index have been developed as a practical and robust tool to assess the susceptibility to pollutants using multiple biomarker responses. Neonicotinoid insecticides are nowadays one of the most sold pesticides worldwide. Nevertheless, imidacloprid (IMI) sub-lethal effects such as oxidative stress (OS) on fishes are scarcely studied. Hence, the aims of this work were: (1) to evaluate exposure- and damage biomarkers related to OS in the freshwater fish Australoheros facetus exposed to IMI and (2) to apply the IBR index to achieve a comprehensive understanding of OS in the fish. The results of the present study showed that all the biomarkers presented different responses in the three monitored tissues: liver, brain and gills. Results for an initial battery of 19 biomarkers were obtained and for the IBR index only those with significant differences have been considered. The biomarkers that had the most important weight on the IBR index were SOD activity in brain and gills, H2O2 concentration in liver, and carbonyl groups concentration in gills in fishes exposed to 100 and 1000 μg L−1 IMI. This index allowed affirming that a short term exposure to environmentally relevant concentrations of IMI (≥10 μg L−1) produces OS in A. facetus. However, a more deep understanding of some biomarkers response is necessary to improve the index and for finally apply it in field studies.Fil: Iturburu, Fernando Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Bertrand, Lidwina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Mendieta, Julieta Renee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Amé, María V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Subsede Instituto Nacional de Investigación y Desarrollo Pesquero; ArgentinaElsevier Science2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/90893Iturburu, Fernando Gastón; Bertrand, Lidwina; Mendieta, Julieta Renee; Amé, María V.; Menone, Mirta Lujan; An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid; Elsevier Science; Ecological Indicators; 93; 10-2018; 351-3571470-160XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1470160X18303601info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ecolind.2018.05.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:46:34Zoai:ri.conicet.gov.ar:11336/90893instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:46:34.618CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid
title An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid
spellingShingle An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid
Iturburu, Fernando Gastón
ANTIOXIDANT ENZYMES
FISHES
INTEGRATED BIOMARKER RESPONSE INDEX
NEONICOTINOID
OXIDATIVE DAMAGE
title_short An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid
title_full An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid
title_fullStr An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid
title_full_unstemmed An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid
title_sort An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid
dc.creator.none.fl_str_mv Iturburu, Fernando Gastón
Bertrand, Lidwina
Mendieta, Julieta Renee
Amé, María V.
Menone, Mirta Lujan
author Iturburu, Fernando Gastón
author_facet Iturburu, Fernando Gastón
Bertrand, Lidwina
Mendieta, Julieta Renee
Amé, María V.
Menone, Mirta Lujan
author_role author
author2 Bertrand, Lidwina
Mendieta, Julieta Renee
Amé, María V.
Menone, Mirta Lujan
author2_role author
author
author
author
dc.subject.none.fl_str_mv ANTIOXIDANT ENZYMES
FISHES
INTEGRATED BIOMARKER RESPONSE INDEX
NEONICOTINOID
OXIDATIVE DAMAGE
topic ANTIOXIDANT ENZYMES
FISHES
INTEGRATED BIOMARKER RESPONSE INDEX
NEONICOTINOID
OXIDATIVE DAMAGE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Integrated Biomarkers Response (IBR) index have been developed as a practical and robust tool to assess the susceptibility to pollutants using multiple biomarker responses. Neonicotinoid insecticides are nowadays one of the most sold pesticides worldwide. Nevertheless, imidacloprid (IMI) sub-lethal effects such as oxidative stress (OS) on fishes are scarcely studied. Hence, the aims of this work were: (1) to evaluate exposure- and damage biomarkers related to OS in the freshwater fish Australoheros facetus exposed to IMI and (2) to apply the IBR index to achieve a comprehensive understanding of OS in the fish. The results of the present study showed that all the biomarkers presented different responses in the three monitored tissues: liver, brain and gills. Results for an initial battery of 19 biomarkers were obtained and for the IBR index only those with significant differences have been considered. The biomarkers that had the most important weight on the IBR index were SOD activity in brain and gills, H2O2 concentration in liver, and carbonyl groups concentration in gills in fishes exposed to 100 and 1000 μg L−1 IMI. This index allowed affirming that a short term exposure to environmentally relevant concentrations of IMI (≥10 μg L−1) produces OS in A. facetus. However, a more deep understanding of some biomarkers response is necessary to improve the index and for finally apply it in field studies.
Fil: Iturburu, Fernando Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Bertrand, Lidwina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Mendieta, Julieta Renee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Amé, María V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Subsede Instituto Nacional de Investigación y Desarrollo Pesquero; Argentina
description Integrated Biomarkers Response (IBR) index have been developed as a practical and robust tool to assess the susceptibility to pollutants using multiple biomarker responses. Neonicotinoid insecticides are nowadays one of the most sold pesticides worldwide. Nevertheless, imidacloprid (IMI) sub-lethal effects such as oxidative stress (OS) on fishes are scarcely studied. Hence, the aims of this work were: (1) to evaluate exposure- and damage biomarkers related to OS in the freshwater fish Australoheros facetus exposed to IMI and (2) to apply the IBR index to achieve a comprehensive understanding of OS in the fish. The results of the present study showed that all the biomarkers presented different responses in the three monitored tissues: liver, brain and gills. Results for an initial battery of 19 biomarkers were obtained and for the IBR index only those with significant differences have been considered. The biomarkers that had the most important weight on the IBR index were SOD activity in brain and gills, H2O2 concentration in liver, and carbonyl groups concentration in gills in fishes exposed to 100 and 1000 μg L−1 IMI. This index allowed affirming that a short term exposure to environmentally relevant concentrations of IMI (≥10 μg L−1) produces OS in A. facetus. However, a more deep understanding of some biomarkers response is necessary to improve the index and for finally apply it in field studies.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/90893
Iturburu, Fernando Gastón; Bertrand, Lidwina; Mendieta, Julieta Renee; Amé, María V.; Menone, Mirta Lujan; An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid; Elsevier Science; Ecological Indicators; 93; 10-2018; 351-357
1470-160X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/90893
identifier_str_mv Iturburu, Fernando Gastón; Bertrand, Lidwina; Mendieta, Julieta Renee; Amé, María V.; Menone, Mirta Lujan; An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid; Elsevier Science; Ecological Indicators; 93; 10-2018; 351-357
1470-160X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1470160X18303601
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ecolind.2018.05.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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