Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus

Autores
Iturburu, Fernando Gastón; Zömisch, Markus; Panzeri, Ana María; Crupkin, Andrea Carina; Contardo Jara, Valeska; Pflugmacher, Stephan; Menone, Mirta Lujan
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The neonicotinoid imidacloprid is under re-evaluation by regulatory agencies because of the poor current information available regarding its potential effects. One of the goals of the present study was to determine imidacloprid uptake and distribution in the freshwater fish Australoheros facetus experimentally exposed for 24 h and 48 h to 100 μg/L, 300 μg/L, and 2500 μg/L. The toxicity of imidacloprid to fish reported in the literature is in the milligrams per liter or gram per liter range, but sublethal effects at micrograms per liter in some groups other than fish have been described. Another goal of the present study was to evaluate imidacloprid's potential genotoxicity and to compare it between the individual compound and a commercial formulation. Concentrations of imidacloprid were measured in water, brain, muscle, gills, gut, liver, and blood by liquid chromatography-tandem mass spectrometry. Imidacloprid was detected in all the tissues tested. Concentrations were higher after 48 h than after 24 h in liver, gills, gut, and muscle, whereas in brain and blood they were similar at both exposure times. Although there was no accumulation, only uptake, of imidacloprid, genotoxicity was observed. In fish exposed to IMIDA NOVA 35®, increased micronucleus frequency at 100 µg/L and 1000 µg/L was detected, whereas in the imidacloprid active ingredient bioassay it increased only at 1000 µg/L imidacloprid. The present findings warn of the possible consequences that fish living in freshwater ecosystems can suffer. Environ Toxicol Chem 2017;36:699–708. © 2016 SETAC.
Fil: Iturburu, Fernando Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Zömisch, Markus. Technishe Universitat Berlin; Alemania
Fil: Panzeri, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Crupkin, Andrea Carina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina
Fil: Contardo Jara, Valeska. Technishe Universitat Berlin; Alemania
Fil: Pflugmacher, Stephan. Technishe Universitat Berlin; Alemania
Fil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Materia
Bioaccumulation
Contaminant of Emerging Concern
Fish
Freshwater Toxicology
Micronucleus Assay
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64443
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/64443
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetusIturburu, Fernando GastónZömisch, MarkusPanzeri, Ana MaríaCrupkin, Andrea CarinaContardo Jara, ValeskaPflugmacher, StephanMenone, Mirta LujanBioaccumulationContaminant of Emerging ConcernFishFreshwater ToxicologyMicronucleus Assayhttps://purl.org/becyt/ford/1.5https://purl.org/becyt/ford/1The neonicotinoid imidacloprid is under re-evaluation by regulatory agencies because of the poor current information available regarding its potential effects. One of the goals of the present study was to determine imidacloprid uptake and distribution in the freshwater fish Australoheros facetus experimentally exposed for 24 h and 48 h to 100 μg/L, 300 μg/L, and 2500 μg/L. The toxicity of imidacloprid to fish reported in the literature is in the milligrams per liter or gram per liter range, but sublethal effects at micrograms per liter in some groups other than fish have been described. Another goal of the present study was to evaluate imidacloprid's potential genotoxicity and to compare it between the individual compound and a commercial formulation. Concentrations of imidacloprid were measured in water, brain, muscle, gills, gut, liver, and blood by liquid chromatography-tandem mass spectrometry. Imidacloprid was detected in all the tissues tested. Concentrations were higher after 48 h than after 24 h in liver, gills, gut, and muscle, whereas in brain and blood they were similar at both exposure times. Although there was no accumulation, only uptake, of imidacloprid, genotoxicity was observed. In fish exposed to IMIDA NOVA 35®, increased micronucleus frequency at 100 µg/L and 1000 µg/L was detected, whereas in the imidacloprid active ingredient bioassay it increased only at 1000 µg/L imidacloprid. The present findings warn of the possible consequences that fish living in freshwater ecosystems can suffer. Environ Toxicol Chem 2017;36:699–708. © 2016 SETAC.Fil: Iturburu, Fernando Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Zömisch, Markus. Technishe Universitat Berlin; AlemaniaFil: Panzeri, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Crupkin, Andrea Carina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; ArgentinaFil: Contardo Jara, Valeska. Technishe Universitat Berlin; AlemaniaFil: Pflugmacher, Stephan. Technishe Universitat Berlin; AlemaniaFil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaSociety of Environmental Toxicology and Chemistry2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64443Iturburu, Fernando Gastón; Zömisch, Markus; Panzeri, Ana María; Crupkin, Andrea Carina; Contardo Jara, Valeska; et al.; Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 36; 3; 3-2017; 699-7080730-72681552-8618CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/etc.3574info:eu-repo/semantics/altIdentifier/url/https://setac.onlinelibrary.wiley.com/doi/abs/10.1002/etc.3574info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:19Zoai:ri.conicet.gov.ar:11336/64443instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:19.336CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus
title Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus
spellingShingle Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus
Iturburu, Fernando Gastón
Bioaccumulation
Contaminant of Emerging Concern
Fish
Freshwater Toxicology
Micronucleus Assay
title_short Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus
title_full Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus
title_fullStr Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus
title_full_unstemmed Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus
title_sort Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus
dc.creator.none.fl_str_mv Iturburu, Fernando Gastón
Zömisch, Markus
Panzeri, Ana María
Crupkin, Andrea Carina
Contardo Jara, Valeska
Pflugmacher, Stephan
Menone, Mirta Lujan
author Iturburu, Fernando Gastón
author_facet Iturburu, Fernando Gastón
Zömisch, Markus
Panzeri, Ana María
Crupkin, Andrea Carina
Contardo Jara, Valeska
Pflugmacher, Stephan
Menone, Mirta Lujan
author_role author
author2 Zömisch, Markus
Panzeri, Ana María
Crupkin, Andrea Carina
Contardo Jara, Valeska
Pflugmacher, Stephan
Menone, Mirta Lujan
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bioaccumulation
Contaminant of Emerging Concern
Fish
Freshwater Toxicology
Micronucleus Assay
topic Bioaccumulation
Contaminant of Emerging Concern
Fish
Freshwater Toxicology
Micronucleus Assay
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.5
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The neonicotinoid imidacloprid is under re-evaluation by regulatory agencies because of the poor current information available regarding its potential effects. One of the goals of the present study was to determine imidacloprid uptake and distribution in the freshwater fish Australoheros facetus experimentally exposed for 24 h and 48 h to 100 μg/L, 300 μg/L, and 2500 μg/L. The toxicity of imidacloprid to fish reported in the literature is in the milligrams per liter or gram per liter range, but sublethal effects at micrograms per liter in some groups other than fish have been described. Another goal of the present study was to evaluate imidacloprid's potential genotoxicity and to compare it between the individual compound and a commercial formulation. Concentrations of imidacloprid were measured in water, brain, muscle, gills, gut, liver, and blood by liquid chromatography-tandem mass spectrometry. Imidacloprid was detected in all the tissues tested. Concentrations were higher after 48 h than after 24 h in liver, gills, gut, and muscle, whereas in brain and blood they were similar at both exposure times. Although there was no accumulation, only uptake, of imidacloprid, genotoxicity was observed. In fish exposed to IMIDA NOVA 35®, increased micronucleus frequency at 100 µg/L and 1000 µg/L was detected, whereas in the imidacloprid active ingredient bioassay it increased only at 1000 µg/L imidacloprid. The present findings warn of the possible consequences that fish living in freshwater ecosystems can suffer. Environ Toxicol Chem 2017;36:699–708. © 2016 SETAC.
Fil: Iturburu, Fernando Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Zömisch, Markus. Technishe Universitat Berlin; Alemania
Fil: Panzeri, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Crupkin, Andrea Carina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina
Fil: Contardo Jara, Valeska. Technishe Universitat Berlin; Alemania
Fil: Pflugmacher, Stephan. Technishe Universitat Berlin; Alemania
Fil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
description The neonicotinoid imidacloprid is under re-evaluation by regulatory agencies because of the poor current information available regarding its potential effects. One of the goals of the present study was to determine imidacloprid uptake and distribution in the freshwater fish Australoheros facetus experimentally exposed for 24 h and 48 h to 100 μg/L, 300 μg/L, and 2500 μg/L. The toxicity of imidacloprid to fish reported in the literature is in the milligrams per liter or gram per liter range, but sublethal effects at micrograms per liter in some groups other than fish have been described. Another goal of the present study was to evaluate imidacloprid's potential genotoxicity and to compare it between the individual compound and a commercial formulation. Concentrations of imidacloprid were measured in water, brain, muscle, gills, gut, liver, and blood by liquid chromatography-tandem mass spectrometry. Imidacloprid was detected in all the tissues tested. Concentrations were higher after 48 h than after 24 h in liver, gills, gut, and muscle, whereas in brain and blood they were similar at both exposure times. Although there was no accumulation, only uptake, of imidacloprid, genotoxicity was observed. In fish exposed to IMIDA NOVA 35®, increased micronucleus frequency at 100 µg/L and 1000 µg/L was detected, whereas in the imidacloprid active ingredient bioassay it increased only at 1000 µg/L imidacloprid. The present findings warn of the possible consequences that fish living in freshwater ecosystems can suffer. Environ Toxicol Chem 2017;36:699–708. © 2016 SETAC.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64443
Iturburu, Fernando Gastón; Zömisch, Markus; Panzeri, Ana María; Crupkin, Andrea Carina; Contardo Jara, Valeska; et al.; Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 36; 3; 3-2017; 699-708
0730-7268
1552-8618
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64443
identifier_str_mv Iturburu, Fernando Gastón; Zömisch, Markus; Panzeri, Ana María; Crupkin, Andrea Carina; Contardo Jara, Valeska; et al.; Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 36; 3; 3-2017; 699-708
0730-7268
1552-8618
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/etc.3574
info:eu-repo/semantics/altIdentifier/url/https://setac.onlinelibrary.wiley.com/doi/abs/10.1002/etc.3574
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society of Environmental Toxicology and Chemistry
publisher.none.fl_str_mv Society of Environmental Toxicology and Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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