Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population

Autores
Bestach, Yesica Soledad; Sieza, Yamila; Attie, Myriam; Riccheri, Cecilia; Verri, Verónica; Bolesina, Moira; Bengió, Raquel; Larripa, Irene Beatriz; Belli, Carolina Bárbara
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The impaired hematopoiesis in acquired aplastic anemia (AA) results from immune-mediated mechanisms. We characterized polymorphisms implicated in controlling type-1 cytokine production in 69 patients with AA. Our data suggest that the studied polymorphisms are not associated with susceptibility in the overall AA population. However, the presence of the higher expressing TNF - 308A allele was associated with younger age (p = 0.0297) and more profound neutropenia (p = 0.0312), and over-represented in patients with very severe AA (p = 0.0168). The higher producing IFNG 12 CA-repeat allele showed strong linkage disequilibrium with the + 874T allele, and was associated with a lower hemoglobin level (p = 0.0351). Also, the presence of at least one higher expressing variant was more frequent among patients responding to immunosuppressive treatment (p = 0.0519). Our findings suggest that the presence of higher expressing variants of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in AA patient genotypes could be related to clinical parameters, disease severity and therapy outcomes.
Fil: Bestach, Yesica Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Sieza, Yamila. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martín; Argentina
Fil: Attie, Myriam. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Departamento de Medicina; Argentina
Fil: Riccheri, Cecilia. Hospital Nacional Profesor Alejandro Posadas; Argentina
Fil: Verri, Verónica. Hospital General de Agudos “ C. G. Durand ”; Argentina
Fil: Bolesina, Moira. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Bengió, Raquel. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Instituto de Investigaciones Hematológicas; Argentina
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Instituto de Investigaciones Hematológicas; Argentina
Fil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
APLASTIC ANEMIA
IFNG
INTERFERON-Γ
POLYMORPHISMS
TNF
TUMOR NECROSIS FACTOR-Α
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/128607
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/128607
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean populationBestach, Yesica SoledadSieza, YamilaAttie, MyriamRiccheri, CeciliaVerri, VerónicaBolesina, MoiraBengió, RaquelLarripa, Irene BeatrizBelli, Carolina BárbaraAPLASTIC ANEMIAIFNGINTERFERON-ΓPOLYMORPHISMSTNFTUMOR NECROSIS FACTOR-Αhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The impaired hematopoiesis in acquired aplastic anemia (AA) results from immune-mediated mechanisms. We characterized polymorphisms implicated in controlling type-1 cytokine production in 69 patients with AA. Our data suggest that the studied polymorphisms are not associated with susceptibility in the overall AA population. However, the presence of the higher expressing TNF - 308A allele was associated with younger age (p = 0.0297) and more profound neutropenia (p = 0.0312), and over-represented in patients with very severe AA (p = 0.0168). The higher producing IFNG 12 CA-repeat allele showed strong linkage disequilibrium with the + 874T allele, and was associated with a lower hemoglobin level (p = 0.0351). Also, the presence of at least one higher expressing variant was more frequent among patients responding to immunosuppressive treatment (p = 0.0519). Our findings suggest that the presence of higher expressing variants of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in AA patient genotypes could be related to clinical parameters, disease severity and therapy outcomes.Fil: Bestach, Yesica Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Sieza, Yamila. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martín; ArgentinaFil: Attie, Myriam. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Departamento de Medicina; ArgentinaFil: Riccheri, Cecilia. Hospital Nacional Profesor Alejandro Posadas; ArgentinaFil: Verri, Verónica. Hospital General de Agudos “ C. G. Durand ”; ArgentinaFil: Bolesina, Moira. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Bengió, Raquel. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Instituto de Investigaciones Hematológicas; ArgentinaFil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Instituto de Investigaciones Hematológicas; ArgentinaFil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaTaylor & Francis Ltd2015-06-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128607Bestach, Yesica Soledad; Sieza, Yamila; Attie, Myriam; Riccheri, Cecilia; Verri, Verónica; et al.; Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population; Taylor & Francis Ltd; Leukemia and Lymphoma; 56; 6; 24-6-2015; 1793-17981042-8194CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/10428194.2014.966707info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/10428194.2014.966707info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:40:59Zoai:ri.conicet.gov.ar:11336/128607instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:40:59.35CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population
title Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population
spellingShingle Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population
Bestach, Yesica Soledad
APLASTIC ANEMIA
IFNG
INTERFERON-Γ
POLYMORPHISMS
TNF
TUMOR NECROSIS FACTOR-Α
title_short Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population
title_full Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population
title_fullStr Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population
title_full_unstemmed Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population
title_sort Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population
dc.creator.none.fl_str_mv Bestach, Yesica Soledad
Sieza, Yamila
Attie, Myriam
Riccheri, Cecilia
Verri, Verónica
Bolesina, Moira
Bengió, Raquel
Larripa, Irene Beatriz
Belli, Carolina Bárbara
author Bestach, Yesica Soledad
author_facet Bestach, Yesica Soledad
Sieza, Yamila
Attie, Myriam
Riccheri, Cecilia
Verri, Verónica
Bolesina, Moira
Bengió, Raquel
Larripa, Irene Beatriz
Belli, Carolina Bárbara
author_role author
author2 Sieza, Yamila
Attie, Myriam
Riccheri, Cecilia
Verri, Verónica
Bolesina, Moira
Bengió, Raquel
Larripa, Irene Beatriz
Belli, Carolina Bárbara
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv APLASTIC ANEMIA
IFNG
INTERFERON-Γ
POLYMORPHISMS
TNF
TUMOR NECROSIS FACTOR-Α
topic APLASTIC ANEMIA
IFNG
INTERFERON-Γ
POLYMORPHISMS
TNF
TUMOR NECROSIS FACTOR-Α
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The impaired hematopoiesis in acquired aplastic anemia (AA) results from immune-mediated mechanisms. We characterized polymorphisms implicated in controlling type-1 cytokine production in 69 patients with AA. Our data suggest that the studied polymorphisms are not associated with susceptibility in the overall AA population. However, the presence of the higher expressing TNF - 308A allele was associated with younger age (p = 0.0297) and more profound neutropenia (p = 0.0312), and over-represented in patients with very severe AA (p = 0.0168). The higher producing IFNG 12 CA-repeat allele showed strong linkage disequilibrium with the + 874T allele, and was associated with a lower hemoglobin level (p = 0.0351). Also, the presence of at least one higher expressing variant was more frequent among patients responding to immunosuppressive treatment (p = 0.0519). Our findings suggest that the presence of higher expressing variants of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in AA patient genotypes could be related to clinical parameters, disease severity and therapy outcomes.
Fil: Bestach, Yesica Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Sieza, Yamila. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martín; Argentina
Fil: Attie, Myriam. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Departamento de Medicina; Argentina
Fil: Riccheri, Cecilia. Hospital Nacional Profesor Alejandro Posadas; Argentina
Fil: Verri, Verónica. Hospital General de Agudos “ C. G. Durand ”; Argentina
Fil: Bolesina, Moira. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Bengió, Raquel. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Instituto de Investigaciones Hematológicas; Argentina
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Instituto de Investigaciones Hematológicas; Argentina
Fil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description The impaired hematopoiesis in acquired aplastic anemia (AA) results from immune-mediated mechanisms. We characterized polymorphisms implicated in controlling type-1 cytokine production in 69 patients with AA. Our data suggest that the studied polymorphisms are not associated with susceptibility in the overall AA population. However, the presence of the higher expressing TNF - 308A allele was associated with younger age (p = 0.0297) and more profound neutropenia (p = 0.0312), and over-represented in patients with very severe AA (p = 0.0168). The higher producing IFNG 12 CA-repeat allele showed strong linkage disequilibrium with the + 874T allele, and was associated with a lower hemoglobin level (p = 0.0351). Also, the presence of at least one higher expressing variant was more frequent among patients responding to immunosuppressive treatment (p = 0.0519). Our findings suggest that the presence of higher expressing variants of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in AA patient genotypes could be related to clinical parameters, disease severity and therapy outcomes.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/128607
Bestach, Yesica Soledad; Sieza, Yamila; Attie, Myriam; Riccheri, Cecilia; Verri, Verónica; et al.; Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population; Taylor & Francis Ltd; Leukemia and Lymphoma; 56; 6; 24-6-2015; 1793-1798
1042-8194
CONICET Digital
CONICET
url http://hdl.handle.net/11336/128607
identifier_str_mv Bestach, Yesica Soledad; Sieza, Yamila; Attie, Myriam; Riccheri, Cecilia; Verri, Verónica; et al.; Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population; Taylor & Francis Ltd; Leukemia and Lymphoma; 56; 6; 24-6-2015; 1793-1798
1042-8194
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/10428194.2014.966707
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/10428194.2014.966707
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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