The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia

Autores
Gamberale, Romina; Fernández Calotti, Paula; Sánchez Ávalos, Julio César Américo; Alberto, Maria Fabiana; Geffner, Jorge Raúl; Giordano, Mirta Nilda
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently illdefined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-g, a key cytokine in the pathogenesis of AHA.

Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Fernández Calotti, Paula. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Sánchez Ávalos, Julio César Américo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Alberto, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Materia
Fludarabine
IFNg production
Autoimmune hemolytic anemia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55901
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic LeukemiaGamberale, RominaFernández Calotti, PaulaSánchez Ávalos, Julio César AméricoAlberto, Maria FabianaGeffner, Jorge RaúlGiordano, Mirta NildaFludarabineIFNg productionAutoimmune hemolytic anemiahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently illdefined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-g, a key cytokine in the pathogenesis of AHA.<br />Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Fernández Calotti, Paula. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Sánchez Ávalos, Julio César Américo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Alberto, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFerrata Storti Foundation2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55901Gamberale, Romina; Fernández Calotti, Paula; Sánchez Ávalos, Julio César Américo; Alberto, Maria Fabiana; Geffner, Jorge Raúl; et al.; The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia; Ferrata Storti Foundation; Haematologica; 91; 4; 12-2006; 574-5760390-60781592-8721CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.haematologica.org/content/91/4/574info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:53:02Zoai:ri.conicet.gov.ar:11336/55901instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:53:02.667CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
title The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
spellingShingle The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
Gamberale, Romina
Fludarabine
IFNg production
Autoimmune hemolytic anemia
title_short The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
title_full The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
title_fullStr The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
title_full_unstemmed The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
title_sort The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
dc.creator.none.fl_str_mv Gamberale, Romina
Fernández Calotti, Paula
Sánchez Ávalos, Julio César Américo
Alberto, Maria Fabiana
Geffner, Jorge Raúl
Giordano, Mirta Nilda
author Gamberale, Romina
author_facet Gamberale, Romina
Fernández Calotti, Paula
Sánchez Ávalos, Julio César Américo
Alberto, Maria Fabiana
Geffner, Jorge Raúl
Giordano, Mirta Nilda
author_role author
author2 Fernández Calotti, Paula
Sánchez Ávalos, Julio César Américo
Alberto, Maria Fabiana
Geffner, Jorge Raúl
Giordano, Mirta Nilda
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Fludarabine
IFNg production
Autoimmune hemolytic anemia
topic Fludarabine
IFNg production
Autoimmune hemolytic anemia
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently illdefined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-g, a key cytokine in the pathogenesis of AHA.<br />
Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Fernández Calotti, Paula. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Sánchez Ávalos, Julio César Américo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Alberto, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
description Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently illdefined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-g, a key cytokine in the pathogenesis of AHA.<br />
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55901
Gamberale, Romina; Fernández Calotti, Paula; Sánchez Ávalos, Julio César Américo; Alberto, Maria Fabiana; Geffner, Jorge Raúl; et al.; The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia; Ferrata Storti Foundation; Haematologica; 91; 4; 12-2006; 574-576
0390-6078
1592-8721
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55901
identifier_str_mv Gamberale, Romina; Fernández Calotti, Paula; Sánchez Ávalos, Julio César Américo; Alberto, Maria Fabiana; Geffner, Jorge Raúl; et al.; The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia; Ferrata Storti Foundation; Haematologica; 91; 4; 12-2006; 574-576
0390-6078
1592-8721
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.haematologica.org/content/91/4/574
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Ferrata Storti Foundation
publisher.none.fl_str_mv Ferrata Storti Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1849872956936683520
score 13.011256

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