Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity

Autores
Rojas Delgado, Ricardo; Jimenez Kairuz, Alvaro Federico; Manzo, Ruben Hilario; Giacomelli, Carla Eugenia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceeding the anion exchange capacity of the solid especially with the more apolar drugs. The structure and interfacial properties of the particulate LDH-D hybrids were also dependent on the polarity of the loaded drug. Finally, the release mechanisms in neutral and acidic media were studied with compressed LDH-D hybrids. The hybrids compression leaded to highly stacked platelets that caused a slower and steadier drug release rate than particulate LDH-D hybrids in all cases. In neutral medium, the drugs were exclusively released by anion exchange with HPO42− ions and the release rate was determined by the drug polarity. In acidic medium, weathering was the main release mechanism. However, additional processes (anion exchange, drug solubilization) were concurrent in the latter media, the overall mechanism and release rate being dependent on the drug solubility.
Fil: Rojas Delgado, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Giacomelli, Carla Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Materia
Zeta Potential
Organic/Inorganic Hybrids
Hydrophobic Interactions
Release Mechanism
Kinetic
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31555
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/31555
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarityRojas Delgado, RicardoJimenez Kairuz, Alvaro FedericoManzo, Ruben HilarioGiacomelli, Carla EugeniaZeta PotentialOrganic/Inorganic HybridsHydrophobic InteractionsRelease MechanismKinetichttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceeding the anion exchange capacity of the solid especially with the more apolar drugs. The structure and interfacial properties of the particulate LDH-D hybrids were also dependent on the polarity of the loaded drug. Finally, the release mechanisms in neutral and acidic media were studied with compressed LDH-D hybrids. The hybrids compression leaded to highly stacked platelets that caused a slower and steadier drug release rate than particulate LDH-D hybrids in all cases. In neutral medium, the drugs were exclusively released by anion exchange with HPO42− ions and the release rate was determined by the drug polarity. In acidic medium, weathering was the main release mechanism. However, additional processes (anion exchange, drug solubilization) were concurrent in the latter media, the overall mechanism and release rate being dependent on the drug solubility.Fil: Rojas Delgado, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Giacomelli, Carla Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaElsevier Science2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31555Manzo, Ruben Hilario; Giacomelli, Carla Eugenia; Jimenez Kairuz, Alvaro Federico; Rojas Delgado, Ricardo; Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 463; 9-2014; 37-430927-7757CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.colsurfa.2014.09.031info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0927775714007535info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:43Zoai:ri.conicet.gov.ar:11336/31555instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:43.823CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
title Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
spellingShingle Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
Rojas Delgado, Ricardo
Zeta Potential
Organic/Inorganic Hybrids
Hydrophobic Interactions
Release Mechanism
Kinetic
title_short Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
title_full Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
title_fullStr Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
title_full_unstemmed Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
title_sort Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
dc.creator.none.fl_str_mv Rojas Delgado, Ricardo
Jimenez Kairuz, Alvaro Federico
Manzo, Ruben Hilario
Giacomelli, Carla Eugenia
author Rojas Delgado, Ricardo
author_facet Rojas Delgado, Ricardo
Jimenez Kairuz, Alvaro Federico
Manzo, Ruben Hilario
Giacomelli, Carla Eugenia
author_role author
author2 Jimenez Kairuz, Alvaro Federico
Manzo, Ruben Hilario
Giacomelli, Carla Eugenia
author2_role author
author
author
dc.subject.none.fl_str_mv Zeta Potential
Organic/Inorganic Hybrids
Hydrophobic Interactions
Release Mechanism
Kinetic
topic Zeta Potential
Organic/Inorganic Hybrids
Hydrophobic Interactions
Release Mechanism
Kinetic
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceeding the anion exchange capacity of the solid especially with the more apolar drugs. The structure and interfacial properties of the particulate LDH-D hybrids were also dependent on the polarity of the loaded drug. Finally, the release mechanisms in neutral and acidic media were studied with compressed LDH-D hybrids. The hybrids compression leaded to highly stacked platelets that caused a slower and steadier drug release rate than particulate LDH-D hybrids in all cases. In neutral medium, the drugs were exclusively released by anion exchange with HPO42− ions and the release rate was determined by the drug polarity. In acidic medium, weathering was the main release mechanism. However, additional processes (anion exchange, drug solubilization) were concurrent in the latter media, the overall mechanism and release rate being dependent on the drug solubility.
Fil: Rojas Delgado, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Giacomelli, Carla Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
description This work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceeding the anion exchange capacity of the solid especially with the more apolar drugs. The structure and interfacial properties of the particulate LDH-D hybrids were also dependent on the polarity of the loaded drug. Finally, the release mechanisms in neutral and acidic media were studied with compressed LDH-D hybrids. The hybrids compression leaded to highly stacked platelets that caused a slower and steadier drug release rate than particulate LDH-D hybrids in all cases. In neutral medium, the drugs were exclusively released by anion exchange with HPO42− ions and the release rate was determined by the drug polarity. In acidic medium, weathering was the main release mechanism. However, additional processes (anion exchange, drug solubilization) were concurrent in the latter media, the overall mechanism and release rate being dependent on the drug solubility.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31555
Manzo, Ruben Hilario; Giacomelli, Carla Eugenia; Jimenez Kairuz, Alvaro Federico; Rojas Delgado, Ricardo; Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 463; 9-2014; 37-43
0927-7757
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31555
identifier_str_mv Manzo, Ruben Hilario; Giacomelli, Carla Eugenia; Jimenez Kairuz, Alvaro Federico; Rojas Delgado, Ricardo; Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 463; 9-2014; 37-43
0927-7757
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.colsurfa.2014.09.031
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0927775714007535
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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