Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology

Autores
Cid, Alicia Graciela; Sonvico, Fabio; Bettini, Ruggero; Colombo, Paolo; Gonzo, Elio Emilio; Jimenez Kairuz, Alvaro Federico; Bermudez, Jose Maria
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mathematical models are an important tool in pharmaceutical formulationsdevelopment, to evaluate in vitro and in vivo drug release processes and to optimize the design of new systems. Dome Matrix technology allows the combination of modules with different types of drugs, doses, and releases kinetics. This work aimed to design drug release systems based on DomeMatrix technology, with different swelling and erosion properties, to obtain complex drug release profiles and analyze them with simple mathematical models. Most of the release profiles followed a sigmoid curve, with an inflection point corresponding to a change in the release rate behavior. The experimental data were fitted with a simple model recently developed, named the Dual Releasemodel, which consists in the combination of a modified Korsmayer-Peppas model from the beginning to the inflection point and the Lumped model from there until the end. This approach allowed determining relevant pharmaceutical parameters, such as the maximum release rate and the dissolution efficiency, among others. The use of the Dual Release model and the pharmaceutical parameters that characterize the different Dome Matrix modules allows optimizing the choice of the composition and the configuration during the development of a drug delivery system.
Fil: Cid, Alicia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina
Fil: Sonvico, Fabio. Università di Parma; Italia
Fil: Bettini, Ruggero. Università di Parma; Italia
Fil: Colombo, Paolo. Università di Parma; Italia
Fil: Gonzo, Elio Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina
Fil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina
Materia
RELEASE RATE
MATHEMATICAL MODELS
DUAL RELEASE MODEL
DRUG DELIVERY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/141120
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/141120
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix TechnologyCid, Alicia GracielaSonvico, FabioBettini, RuggeroColombo, PaoloGonzo, Elio EmilioJimenez Kairuz, Alvaro FedericoBermudez, Jose MariaRELEASE RATEMATHEMATICAL MODELSDUAL RELEASE MODELDRUG DELIVERYhttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Mathematical models are an important tool in pharmaceutical formulationsdevelopment, to evaluate in vitro and in vivo drug release processes and to optimize the design of new systems. Dome Matrix technology allows the combination of modules with different types of drugs, doses, and releases kinetics. This work aimed to design drug release systems based on DomeMatrix technology, with different swelling and erosion properties, to obtain complex drug release profiles and analyze them with simple mathematical models. Most of the release profiles followed a sigmoid curve, with an inflection point corresponding to a change in the release rate behavior. The experimental data were fitted with a simple model recently developed, named the Dual Releasemodel, which consists in the combination of a modified Korsmayer-Peppas model from the beginning to the inflection point and the Lumped model from there until the end. This approach allowed determining relevant pharmaceutical parameters, such as the maximum release rate and the dissolution efficiency, among others. The use of the Dual Release model and the pharmaceutical parameters that characterize the different Dome Matrix modules allows optimizing the choice of the composition and the configuration during the development of a drug delivery system.Fil: Cid, Alicia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; ArgentinaFil: Sonvico, Fabio. Università di Parma; ItaliaFil: Bettini, Ruggero. Università di Parma; ItaliaFil: Colombo, Paolo. Università di Parma; ItaliaFil: Gonzo, Elio Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; ArgentinaFil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; ArgentinaJohn Wiley & Sons Inc2020-06-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/141120Cid, Alicia Graciela; Sonvico, Fabio; Bettini, Ruggero; Colombo, Paolo; Gonzo, Elio Emilio; et al.; Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology; John Wiley & Sons Inc; Journal of Pharmaceutical Sciences; 109; 9; 10-6-20200022-3549CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jpharmsci.org/article/S0022-3549(20)30314-2/fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.xphs.2020.06.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:19:48Zoai:ri.conicet.gov.ar:11336/141120instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:19:49.204CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
title Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
spellingShingle Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
Cid, Alicia Graciela
RELEASE RATE
MATHEMATICAL MODELS
DUAL RELEASE MODEL
DRUG DELIVERY
title_short Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
title_full Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
title_fullStr Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
title_full_unstemmed Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
title_sort Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
dc.creator.none.fl_str_mv Cid, Alicia Graciela
Sonvico, Fabio
Bettini, Ruggero
Colombo, Paolo
Gonzo, Elio Emilio
Jimenez Kairuz, Alvaro Federico
Bermudez, Jose Maria
author Cid, Alicia Graciela
author_facet Cid, Alicia Graciela
Sonvico, Fabio
Bettini, Ruggero
Colombo, Paolo
Gonzo, Elio Emilio
Jimenez Kairuz, Alvaro Federico
Bermudez, Jose Maria
author_role author
author2 Sonvico, Fabio
Bettini, Ruggero
Colombo, Paolo
Gonzo, Elio Emilio
Jimenez Kairuz, Alvaro Federico
Bermudez, Jose Maria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv RELEASE RATE
MATHEMATICAL MODELS
DUAL RELEASE MODEL
DRUG DELIVERY
topic RELEASE RATE
MATHEMATICAL MODELS
DUAL RELEASE MODEL
DRUG DELIVERY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Mathematical models are an important tool in pharmaceutical formulationsdevelopment, to evaluate in vitro and in vivo drug release processes and to optimize the design of new systems. Dome Matrix technology allows the combination of modules with different types of drugs, doses, and releases kinetics. This work aimed to design drug release systems based on DomeMatrix technology, with different swelling and erosion properties, to obtain complex drug release profiles and analyze them with simple mathematical models. Most of the release profiles followed a sigmoid curve, with an inflection point corresponding to a change in the release rate behavior. The experimental data were fitted with a simple model recently developed, named the Dual Releasemodel, which consists in the combination of a modified Korsmayer-Peppas model from the beginning to the inflection point and the Lumped model from there until the end. This approach allowed determining relevant pharmaceutical parameters, such as the maximum release rate and the dissolution efficiency, among others. The use of the Dual Release model and the pharmaceutical parameters that characterize the different Dome Matrix modules allows optimizing the choice of the composition and the configuration during the development of a drug delivery system.
Fil: Cid, Alicia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina
Fil: Sonvico, Fabio. Università di Parma; Italia
Fil: Bettini, Ruggero. Università di Parma; Italia
Fil: Colombo, Paolo. Università di Parma; Italia
Fil: Gonzo, Elio Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina
Fil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina
description Mathematical models are an important tool in pharmaceutical formulationsdevelopment, to evaluate in vitro and in vivo drug release processes and to optimize the design of new systems. Dome Matrix technology allows the combination of modules with different types of drugs, doses, and releases kinetics. This work aimed to design drug release systems based on DomeMatrix technology, with different swelling and erosion properties, to obtain complex drug release profiles and analyze them with simple mathematical models. Most of the release profiles followed a sigmoid curve, with an inflection point corresponding to a change in the release rate behavior. The experimental data were fitted with a simple model recently developed, named the Dual Releasemodel, which consists in the combination of a modified Korsmayer-Peppas model from the beginning to the inflection point and the Lumped model from there until the end. This approach allowed determining relevant pharmaceutical parameters, such as the maximum release rate and the dissolution efficiency, among others. The use of the Dual Release model and the pharmaceutical parameters that characterize the different Dome Matrix modules allows optimizing the choice of the composition and the configuration during the development of a drug delivery system.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/141120
Cid, Alicia Graciela; Sonvico, Fabio; Bettini, Ruggero; Colombo, Paolo; Gonzo, Elio Emilio; et al.; Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology; John Wiley & Sons Inc; Journal of Pharmaceutical Sciences; 109; 9; 10-6-2020
0022-3549
CONICET Digital
CONICET
url http://hdl.handle.net/11336/141120
identifier_str_mv Cid, Alicia Graciela; Sonvico, Fabio; Bettini, Ruggero; Colombo, Paolo; Gonzo, Elio Emilio; et al.; Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology; John Wiley & Sons Inc; Journal of Pharmaceutical Sciences; 109; 9; 10-6-2020
0022-3549
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://jpharmsci.org/article/S0022-3549(20)30314-2/fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.xphs.2020.06.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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